Clinical trials: Tissue Plasminogen Activator
Ischemic Stroke
Predictors of Outcome in t-PA Treated Stroke.
Stroke is among the most disabilitating diseases worldwide in terms of numbers affected and its consequences. A relatively new and well documented treatment of acute ischemic stroke today is tPA (tissue plasminogen activator…
- Trial name
- NCT01498042
- Where
- Norway
- Volunteers
- 162 people
- Sponsor
- Sorlandet Hospital HF
Stroke Acute, Tenecteplase
A Real-world Study of Tenecteplase Versus Alteplase for Thrombolysis in Patients Within 4.5 H of Onset of Ischemic Stroke
Stroke is the second leading cause of death worldwide, killing nearly 7 million people every year. Acute ischemic stroke is caused by focal cerebral hypoperfusion, usually due to embolism or atherosclerotic disease .
- Conditions
- Stroke Acute, Tenecteplase, Alteplase
- Trial name
- TRANSIT (NCT06621121)
- Testing
- Tenecteplase, Alteplase
- Where
- China
- Volunteers
- 6,000 people
- Sponsor
- Tianjin Huanhu Hospital
Pulmonary Embolism, Thromboembolism
Low Dosage of rt-PA in the Treatment of Pulmonary Thromboembolism in China
Recombinant tissue plasminogen activator (rt-PA) is currently the most commonly used thrombolytic drug in patients with pulmonary thromboembolism (PTE).
- Trial name
- NCT00781378
- Testing
- rt-PA
- Where
- 23 sites in China
- Volunteers
- 118 people
- Sponsor
- Beijing Chao Yang Hospital
Aneurysmal Subarachnoid Hemorrhage, Intraventricular Hemorrhage
Intraventricular Tissue Plasminogen Activator (tPA) in the Management of Aneurysmal Subarachnoid Hemorrhage
The proposed study is to evaluate the acceleration the clearance of intraventricular blood (IVH) and subarachnoid hemorrhage (SAH) following ruptured intracranial aneurysms, thereby ameliorating complications, such as cerebral…
- Trial name
- NCT01098890
- Testing
- Tissue Plasminogen Activator
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University of Calgary
Stroke
A Study in Chinese Patients to Compare How Tenecteplase and Alteplase Given After a Stroke Improve Recovering of Physical Activity
This study is open to Chinese adults who had an ischaemic stroke, which means that blood vessels in the brain are blocked. To resolve blood clots, people in the study get either tenecteplase or alteplase within 4 hours and 30…
- Trial name
- ORIGINAL (NCT04915729)
- Testing
- tenecteplase, alteplase
- Where
- 55 sites in China
- Volunteers
- 1,489 people
- Sponsor
- Boehringer Ingelheim
Ischemic Stroke
Rt-PA Thrombolytic Therapy in Combination With Remote Ischemic Conditioning for Acute Ischemic Stroke
The purpose of this study is to determine the safety and feasibility of remote limb ischemic conditioning(RIC) in acute ischemic stroke patients who received r-tPA thrombolytic therapy.
- Trial name
- NCT03231384
- Testing
- Remote ischemic conditioning
- Where
- China
- Volunteers
- 31 people
- Sponsor
- Capital Medical University
The Aim the Study is to Collect and Analyze Data on Patients With Acute Ischemic Stroke During Intravenous Thrombolytic Therapy With Alteplase
Russian Prospective Multicenter Registry Study of Intravenous Thrombolytic Therapy for Acute Ischemic Stroke
Russian prospective multicenter registry study of intravenous thrombolytic therapy for acute ischemic stroke.
- Trial name
- IVT-AIS-R (NCT04674293)
- Testing
- Revelisa
- Where
- Russia
- Volunteers
- 500 people
- Sponsor
- Federal Center of Cerebrovascular Pathology and Stroke, Russian Federation Ministry of Health
Stroke
Alteplase-Tenecteplase Trial Evaluation for Stroke Thrombolysis- (ATTEST)
A pilot evaluation of tenecteplase compared to alteplase in acute ischaemic stroke patients currently eligible for intravenous alteplase treatment in a prospective, randomised, blinded outcome evaluation clinical trial using…
- Trial name
- ATTEST (NCT01472926)
- Testing
- Tenecteplase, alteplase
- Where
- United Kingdom
- Volunteers
- 104 people
- Sponsor
- NHS Greater Glasgow and Clyde
Acute Ischemic Stroke
Endovascular Stroke Treatment Only (ESTO) Trial
The specific aims of this study are to: 1. Determine whether the endovascular treatment (mechanical thrombectomy) alone without using intravenous (IV) recombinant tissue plasminogen activator (rt-PA) in acute ischemic stroke…
- Trial name
- NCT04240470
- Testing
- Thrombectomy
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Missouri-Columbia
Stroke
Acute Stroke Advancing Program Using Telemedicine
The purpose is to evaluate the effectiveness and safety profile of telemedicine consultation system in making decision on IV thrombolysis.
- Trial name
- ASAP-Tel (NCT02088346)
- Testing
- Telemedicine consultation system
- Where
- 4 sites in China
- Volunteers
- 300 people
- Sponsor
- Xijing Hospital
Sepsis and Septic Shock, Trauma
Fibrinolysis Resistance in Infection and Trauma
Blood coagulation disorders are often seen in critically ill patients e.g. with severe infection or following extensive injury, that can lead to life threatening events as a result of excessive blood clot formation leading to…
- Trial name
- FORTITUDE (NCT06680180)
- Testing
- Viscoelastometric assessment of fibrinolysis
- Where
- 4 sites in Australia
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Anders Aneman
Intracerebral Hemorrhage
Minimally Invasive Surgery Plus Rt-PA for ICH Evacuation Phase III
A phase III, randomized, case-controlled, open-label, 500-subject clinical trial of minimally invasive surgery plus rt-PA in the treatment of intracerebral hemorrhage (ICH).
- Trial name
- MISTIE-III (NCT01827046)
- Testing
- rt-PA
- Where
- 84 sites in United States, Australia and 7 more
- Volunteers
- 499 people
- Sponsor
- Johns Hopkins University
Intravenous, Thrombosis
Intravenous TNK vs TPA for AIS Treatment on MSU,a Prospective Multicenter RCT
Acute ischemic stroke is one of the devastating diseases that increase hospitalization, disabilities, and deaths worldwide. Current treatment with intravenous thrombolytic agent can help reduce disabilities and improve quality of…
- Conditions
- Intravenous, Thrombosis, Acute Ischemic Stroke
- Trial name
- NCT06498323
- Testing
- tenecteplase
- Where
- Thailand
- Volunteers
- 160 people
- Sponsor
- Mahidol University