Clinical trials: Tissue Transplantation
Chronic Myeloproliferative Disorders, Graft Versus Host Disease
Sirolimus, Tacrolimus, and Antithymocyte Globulin in Preventing Graft-Versus-Host Disease in Patients Undergoing a Donor Stem Cell Transplant For Hematological Cancer
RATIONALE: Giving chemotherapy and total-body irradiation before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells.
- Conditions
- Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Infection, Leukemia
- Trial name
- NCT00589563
- Testing
- anti-thymocyte globulin, cyclophosphamide, etoposide
- Where
- 2 sites in United States
- Volunteers
- 32 people
- Sponsor
- City of Hope Medical Center
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
Rituximab in Preventing Acute Graft-Versus-Host Disease in a Donor Stem Cell Transplant for Hematologic Cancer
This phase II trial is studying how well rituximab works in preventing acute graft-versus-host disease (GVHD) in patients undergoing a donor stem cell transplant for hematologic cancer.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Nasal Type Extranodal NK/T-cell Lymphoma
- Trial name
- NCT01044745
- Testing
- rituximab, mycophenolate mofetil, tacrolimus
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Nebraska
Leukemia, Lymphoma
A Phase I Study of NK Cell Infusion Following Allogeneic Peripheral Blood Stem Cell Transplantation From Related or Matched Unrelated Donors in Pediatric Patients With Solid Tumors and Leukemias
Background: Bone marrow stem cells, which are found in the bone marrow and blood stream, can be collected and transplanted to treat a variety of types of cancer in a process known as hematopoietic stem cell transplantation…
- Trial name
- NCT01287104
- Testing
- Natural Killer (NK) Cell Infusion, Stem Cell Infusion
- Where
- United States
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Normal Donors
Pilot Study of Educational Interventions in Pediatric Hematopoietic Stem Cell Donors to Increase Knowledge of Donation and Transplantation Procedures
Background: Hematopoietic Stem Cell Transplant (HSCT) represents the second most frequent major organ transplant in the United States.
- Trial name
- NCT01445158
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- National Cancer Institute (NCI)
RT II Gingival Recession
Hyaluronic Acid and Polynucleotides With Connective Tissue Graft and Coronally Advanced Flap for RT II Gingival Recession
This case series will evaluate the effectiveness of injectable hyaluronic acid combined with polynucleotides as an adjunct to coronally advanced flap and connective tissue graft in patients with RT II gingival recession.
- Trial name
- NCT07771244
- Testing
- Coronally Advanced Flap with Connective Tissue Graft and Hyaluronic Acid/Polynucleotides
- Where
- Egypt
- Volunteers
- 12 people
- Sponsor
- Cairo University
Soft Tissue Augmentation at Dental Implants, Marginal Bone Loss
Autogenous Soft Tissue Grafts for Primary Closure Over Immediately Placed Dental Implants
The aim of this interventional study is to evaluate the best method to place the autogenous soft tissue grafts for primary closure over immediately-placed dental implants.
- Trial name
- BFP - FGG (NCT07327047)
- Testing
- Free autogenous soft tissue grafts
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Mansoura University
Breast Cancer
Bone Marrow or Peripheral Stem Cell Transplantation in Treating Patients With Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with autologous bone marrow transplantation or peripheral stem cell transplantation…
- Trial name
- NCT00002942
- Testing
- autologous bone marrow transplantation, peripheral blood stem cell transplantation
- Where
- United States
- Volunteers
- 136 people
- Sponsor
- Wake Forest University Health Sciences
Vitiligo
Efficacy of Upadacitinib After NECS in Vitiligo
The goal of this clinical trial is to investigate the efficacy of upadacitinib after NECS in participants with vitiligo. The main question it aims to answer is: whether the short time use of upadacitinib after NECS will improve…
- Trial name
- NCT06454461
- Testing
- Upadacitinib 15 MG
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Jilin University
Organ or Tissue Transplant; Complications, Reiki
The Effect of Remote Reiki Treatment on Hopelessness, Fatigue and Pain in Patients Awaiting Organ Transplantation
The treatment and care of chronic kidney failure is a long-term process, and patients are significantly affected by this condition.
- Trial name
- NCT07394660
- Testing
- remote reiki
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Bozok University
Melanoma
Assessing the Tolerance and Clinical Benefit of feCAl tranSplantation in patientS With melanOma
Recent studies suggest that patients with metastatic melanoma whose gut microbiome is colonized by eubiotic bacteria have a stronger anti-cancer response to anti CTLA-4 and anti PD1.
- Trial name
- PICASSO (NCT04988841)
- Testing
- MaaT013, Ipilimumab, Nivolumab
- Where
- 5 sites in France
- Volunteers
- 70 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Neuroblastoma
Combination Chemotherapy in Treating Infants With Newly Diagnosed Neuroblastoma Who Are Undergoing Surgery With or Without Autologous Bone Marrow or Peripheral Stem Cell Transplant
RATIONALE: Drugs used in chemotherapy work in different ways to stop the growth of tumor cells, either by killing the cells or by stopping them from dividing.
- Trial name
- NCT00417053
- Testing
- filgrastim, busulfan, carboplatin
- Sponsor
- Children's Cancer and Leukaemia Group
Breast Cancer
Interleukin-12 in Treating Women With Metastatic Breast Cancer Who Have Received High-Dose Chemotherapy and Peripheral Stem Cell Transplantation
RATIONALE: Interleukin-12 may kill tumor cells by stopping blood flow to the tumor and by stimulating a person's white blood cells to kill breast cancer cells.
- Trial name
- NCT00003412
- Testing
- recombinant interleukin-12
- Where
- United States
- Volunteers
- 35 people
- Sponsor
- Beth Israel Deaconess Medical Center
Clinical Efficacy
Implant Placement and Simultaneous Soft Tissue Grafting With Single or Double Layers of Acellular Dermal Matrix
The purpose of this study is to compare the effect on soft tissue thickness of placing either a single or double layer of acellular dermal matrix simultaneous with dental implant placement.
- Trial name
- NCT01902056
- Testing
- One layer allograft, Two layer allograft
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- University of Louisville
Hair Loss/Baldness, Alopecia
Autologous Adipose-Derived Adult Stromal Vascular Cell Transplantation for Alopecia
Most common forms of hair loss (alopecia) are caused by aberrant hair follicle cycling and changes in hair follicle morphology. However, current treatments for alopecia do not specifically target these processes.
- Trial name
- A-ADSVC-CT-A (NCT03427905)
- Testing
- Lipoaspiration, Transplantation
- Where
- Lebanon
- Volunteers
- 20 people
- Sponsor
- Lebanese University
Breast Cancer
High Dose Chemotherapy Plus Peripheral Stem Cell Transplantation Compared With Standard Therapy in Treating Women With Locally Recurrent or Metastatic Breast Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Trial name
- NCT00002870
- Testing
- filgrastim, cyclophosphamide, epirubicin hydrochloride
- Where
- 32 sites in France
- Volunteers
- 180 people
- Sponsor
- UNICANCER
Brain and Central Nervous System Tumors, Neuroblastoma
Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Children With Newly Diagnosed Brain Tumor
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Conditions
- Brain and Central Nervous System Tumors, Neuroblastoma, Retinoblastoma, Sarcoma
- Trial name
- NCT00003273
- Testing
- filgrastim, carboplatin, cisplatin
- Where
- 19 sites in United States, Argentina and 1 more
- Sponsor
- NYU Langone Health
Breast Cancer, Chronic Myeloproliferative Disorders
Study of the Emotional Needs of Caregivers of Stem Cell Transplantation Patients
RATIONALE: Understanding the emotional needs of spouses or others who are living with and caring for patients who have undergone stem cell transplantation may help improve the quality of life of both the caregivers and the…
- Conditions
- Breast Cancer, Chronic Myeloproliferative Disorders, Gestational Trophoblastic Tumor, Leukemia
- Trial name
- NCT00082654
- Testing
- psychosocial assessment and care
- Where
- United States
- Sponsor
- Fred Hutchinson Cancer Center
Gingival Recession
Coronally Advanced Flap With Connective Tissue Graft and PRF for Recession Coverage
Over the years, numerous surgical techniques such as free autografts and pedicle grafts have been introduced to correct gingival recession defects.
- Trial name
- NCT03023995
- Testing
- CAF with Platelet rich fibrin, CAF with connective tissue graft
- Volunteers
- 10 people
- Sponsor
- Dr. D. Y. Patil Dental College & Hospital
Traumatic Articular Cartilage Defects in the Knee Joint
Phase III Study to Evaluate Safety and Effectiveness of NOVOCART 3D Plus vs. Microfracture in Knee Cartilage Defects
In this phase 3 clinical trial, a second generation ACI (autologous chondrocyte implantation technique) is compared to standard of care therapy (microfracture) to treat traumatic cartilage defects of the knee for efficacy and…
- Trial name
- N3D (NCT01656902)
- Testing
- NOVOCART® 3D plus, Microfracture
- Where
- 35 sites in Austria, Czechia and 8 more
- Volunteers
- 263 people
- Sponsor
- Tetec AG
Gingival Recession, Localized, Gingival Recession
Root Coverage With Tunneling Technique With Connective Tissue Versus Coronal Advancement Flap Technique.
This is a randomized triple-blind clinical trial. This comparative clinical study investigates the efficacy of root coverage using two periodontal techniques: the tunneling technique and the coronal advancement technique.
- Trial name
- NCT06228534
- Testing
- Root coverage with tunneling technique
- Where
- Ecuador
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Luis Alberto Chauca Bajaña
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