Clinical trials: Tissue Transplantation
Wound Healing Disorder
Lipofilling for Healing of Chronic Wounds
Chronic wounds remain a therapeutic and financial challenge for physicians and the health care systems. Innovative, cheap and effective treatment methods would be of immense value.
- Trial name
- NCT05509673
- Testing
- Lipofilling (sublesional fat grafting)
- Volunteers
- 34 people
- Sponsor
- University of Witten/Herdecke
Gingival Recession, Surgery
Analysis of Root Coverage Stability.
One-hundred and one healthy participants (221 gingival recessions-GRs) were treated from 1987 to 1996. The probing depth (PD), keratinized tissue width (KTW), gingival recession depth (RD), gingival recession width (RW), gingival…
- Conditions
- Gingival Recession, Surgery, Oral Disease
- Trial name
- NCT05439382
- Testing
- Gingival recession regenerative surgery
- Where
- Italy
- Volunteers
- 101 people
- Sponsor
- Azienda Ospedaliero-Universitaria di Modena
Gingival Recessions
m-VISTA Technique vs. CAF in the Treatment of Class III Multiple Recessions
The main objective is to assess whether the percentage of root coverage (%RC) achieved in the treatment of multiples class III recessions using the technique we have called modified vestibular incision subperiosteal tunnel access…
- Trial name
- NCT03258996
- Testing
- Modified vestibular incision subperiosteal tunnel access, Coronally advanced flap
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Aitziber Fernandez Jimenez
Dental Pulp Regeneration
Dental Pulp Regeneration by Autologous Tissue Transplantation
The purpose of this study is to develop new improved therapy for teeth that require root canals due to tooth infection or tooth inflammation.
- Trial name
- NCT03833401
- Testing
- Autologous tissue transplantation, Root canal revascularization
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Actinic Keratoses
Imiquimod Versus Photodynamic Therapy of Actinic Keratoses in Organ Transplant Recipients
The purpose of this study is to compare two different therapies for actinic keratoses in organ transplant recipients with regard to efficacy and tolerability.
- Trial name
- AKtransplant (NCT01538901)
- Testing
- photodynamic therapy, imiquimod 5% cream
- Where
- 2 sites in Austria
- Volunteers
- 10 people
- Sponsor
- Medical University of Vienna
Neoplasms
Ovarian Tissue Cryopreservation and Subsequent Auto-Transplantation for Female Cancer Patients (HKCH)
Ovarian tissue freezing is an ideal option for these patients as it can be performed immediately and does not need any time for ovarian stimulation.
- Trial name
- NCT06505057
- Testing
- Ovarian Tissue Cryopreservation and Subsequent Auto-Transplantation
- Where
- Hong Kong
- Volunteers
- 100 people
- Sponsor
- Chinese University of Hong Kong
Lung Disease
Lung Diffusing Capacity for Nitric Oxide and Carbon Monoxide After Hematopoietic Stem-cell Transplantation
Early after allogeneic hematopoietic stem-cell transplantation (allo-HSCT), reductions of absolute lung volume and diffusing capacity for carbon monoxide (DLCO) are frequently detected even in the absence of overt idiopathic…
- Trial name
- DLNO/DLCO (NCT01735526)
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- IRCCS Azienda Ospedaliera Universitaria San Martino - IST Istituto Nazionale per la Ricerca sul Cancro, Genoa, Italy
Periodontal Diseases
Pinhole Surgical Technique Compared to Connective Tissue Graft in Treatment of Gingival Recession
This study compares the efficacy of root coverage achieved by the Pinhole Surgical Technique (PST) technique and the Connective Tissue Graft (CTG) technique in the treatment of Miller class I and II gingival recession defects.
- Trial name
- NCT04356391
- Testing
- Connective Tissue Graft Technique, Pinhole Surgical Technique
- Where
- United States
- Volunteers
- 43 people
- Sponsor
- State University of New York at Buffalo
Melanoma Stage III, Melanoma Stage IV
FMT to Convert Response to Immunotherapy
In this study the aim is to investigate whether transfer of the microbiota of either responder or non-responder patients via fecal microbiotica transplantation (FMT) can convert the response to immunotherapy in immune checkpoint…
- Trial name
- NCT05251389
- Testing
- Fecal microbiota transplantation
- Where
- Netherlands
- Volunteers
- 24 people
- Sponsor
- The Netherlands Cancer Institute
Rheumatoid Arthritis
Safety and Efficacy Study of Umbilical Cord-Derived Mesenchymal Stem Cells for Rheumatoid Arthritis
Rheumatoid arthritis is a chronic systemic disease, which is characterized by chronic inflammation in the synovial tissue. Rheumatoid arthritis will eventually result in the destruction of cartilage, bone and ligaments and joint…
- Trial name
- RA (NCT01547091)
- Testing
- Umbilical Cord-Derived Mesenchymal Stem Cells (UC-MSCs), Rheumatoid Arthritis With Disease-Modifying Drugs (DMARDs), UC-MSC+DMARDS
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Alliancells Bioscience Corporation Limited
Scleroderma, Cardiac Involvement
Autologous Stem Cell Transplantation for Progressive Systemic Sclerosis
Autologous stem cell therapy has been shown to be effective in patients with systemic sclerosis. Nevertheless treatment is associated with treatment related mortality and patients die during follow up despite successful…
- Conditions
- Scleroderma, Cardiac Involvement, Autologous Stem Cell Transplantation
- Trial name
- AST-MOMA (NCT01895244)
- Testing
- Autologous stemcell transplantation with CD (cluster of differentiation) 34 selected stem cells
- Where
- Germany
- Volunteers
- 44 people
- Sponsor
- University Hospital Tuebingen
Chronic Myeloproliferative Disorders, Graft Versus Host Disease
Sirolimus, Tacrolimus, Thymoglobulin and Rituximab as Graft-versus-Host-Disease Prophylaxis in Patients Undergoing Haploidentical and HLA Partially Matched Donor Hematopoietic Cell Transplantation
This Phase II clinical trial was designed for patients with hematologic malignancies in need of donor peripheral blood stem cell transplant, and have no HLA matched donor.
- Conditions
- Chronic Myeloproliferative Disorders, Graft Versus Host Disease, Leukemia, Lymphoma
- Trial name
- NCT01116232
- Testing
- anti-thymocyte globulin, rituximab, sirolimus
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Barbara Ann Karmanos Cancer Institute
Skin Cancer, Kidney Transplantation
TUMORAPA 1: Efficacy of Rapamycin in Secondary Prevention of Skin Cancers in Kidney Transplant Recipients
In a population of kidney transplant recipients having developed a first squamous cell carcinoma, the aim of the study is to assess the incidence of subsequent skin cancers over 2 years in patients who are switched to rapamycin…
- Trial name
- NCT00133887
- Testing
- rapamycin, ciclosporine, tacrolimus
- Where
- France
- Volunteers
- 77 people
- Sponsor
- Hospices Civils de Lyon
Gingival Recession
Connective Tissue Graft From Tuberosity Area and L-PRF Associated With Coronally Advanced Flap for Root Coverage
The aim of the present randomized controlled clinical study is to compare the efficacy of subepithelial connective tissue graft harvested from the maxillary retromolar tubeosity area and L-PRF membranes in the treatment of RT1…
- Trial name
- NCT05783258
- Testing
- Periodontal surgery with CAF+tSCTG, Periodontal surgery with CAF+L-PRF
- Where
- Italy
- Volunteers
- 30 people
- Sponsor
- G. d'Annunzio University
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
Palifermin in Preventing Chronic Graft-Versus-Host Disease in Patients Who Have Undergone Donor Stem Cell Transplant for Hematologic Cancer
RATIONALE: Growth factors, such as palifermin, may prevent chronic graft-versus-host disease caused by donor stem cell transplant.
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
- Trial name
- NCT01233921
- Testing
- palifermin, flow cytometry, laboratory biomarker analysis
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Martin, Paul
Androgenetic Alopecia, Cicatricial Alopecia
Evidence-Based Integrated Protocol to Maximize Hair Follicle Survival in Follicular Unit Extraction (FUE)
Follicular unit extraction (FUE) is a widely used surgical technique for hair restoration, yet hair follicle survival rates vary depending on surgical instrumentation, graft handling, and perioperative care.
- Trial name
- NCT07850011
- Testing
- Integrated Evidence-Based FUE Protocol, Standard FUE Practice
- Volunteers
- 30 people
- Sponsor
- Assiut University
Chronic Myeloproliferative Disorders, Leukemia
Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating Patients With Refractory Cancer
RATIONALE: Drugs used in chemotherapy use different ways to stop tumor cells from dividing so they stop growing or die. Combining chemotherapy with peripheral stem cell transplantation may allow the doctor to give higher doses of…
- Conditions
- Chronic Myeloproliferative Disorders, Leukemia, Lymphoma, Multiple Myeloma and Plasma Cell Neoplasm
- Trial name
- NCT00003406
- Testing
- carboplatin, docetaxel, ifosfamide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Cancer Treatment Centers of America
Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission
Haploidentical Donor Bone Marrow Transplant in Treating Patients With High-Risk Hematologic Cancer
This phase II trial studies how well giving fludarabine phosphate, cyclophosphamide, tacrolimus, mycophenolate mofetil and total-body irradiation together with a donor bone marrow transplant works in treating patients with…
- Conditions
- Accelerated Phase Chronic Myelogenous Leukemia, Adult Acute Lymphoblastic Leukemia in Remission, Adult Acute Myeloid Leukemia in Remission, Adult Acute Myeloid Leukemia With 11q23 (MLL) Abnormalities
- Trial name
- NCT00049504
- Testing
- cyclophosphamide, fludarabine phosphate, tacrolimus
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Fred Hutchinson Cancer Center
Defect of Articular Cartilage, Osteochondral Lesion of Talus
DeNovo NT Ankle LDC Study
The purpose of this post-market clinical study is to collect long-term outcomes for DeNovo NT Graft treatment of articular cartilage lesions in the ankle in a standard clinical setting.
- Conditions
- Defect of Articular Cartilage, Osteochondral Lesion of Talus, Osteochondritis Dissecans
- Trial name
- NCT01347892
- Testing
- DeNovo NT Natural Tissue Graft
- Where
- 8 sites in United States
- Volunteers
- 205 people
- Sponsor
- Zimmer Orthobiologics, Inc.
Adult Langerhans Cell Histiocytosis, Childhood Langerhans Cell Histiocytosis
Blood Stem Cell Transplant in Treating Patients With Hematologic Cancer
RATIONALE: Giving chemotherapy drugs and total-body irradiation before a donor peripheral blood stem cell transplant helps stop the growth of cancer cells.
- Conditions
- Adult Langerhans Cell Histiocytosis, Childhood Langerhans Cell Histiocytosis, Leukemia, Lymphoma
- Trial name
- NCT00008216
- Testing
- Peripheral Blood Stem Cell Transplantation
- Where
- United States
- Volunteers
- 48 people
- Sponsor
- Columbia University
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