Clinical trials: Tobacco Abuse
Nicotine Dependence
Effects of Varenicline on Brain Activity During Nicotine Abstinence
This project aims to define mechanisms through which varenicline might be an effective smoking cessation medication.
- Trial name
- NCT00602927
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Nicotine Dependence, Tobacco Smoking
tDCS Plus Varenicline for Smoking Cessation
The goal of this clinical trial is to determine if active transcranial direct current stimulation (tDCS) plus varenicline is an effective, safe and accessible treatment option for smoking cessation.
- Conditions
- Nicotine Dependence, Tobacco Smoking, Smoking Cessation, Nicotine Use Disorder
- Trial name
- NCT06798324
- Testing
- Active Transcranial Direct Current Stimulation (tDCS), Varenicline 1mg BID
- Where
- Canada
- Volunteers
- 160 people
- Sponsor
- Centre for Addiction and Mental Health
Nicotine Dependence
Abuse Liability and Appeal of Oral Nicotine Products
There has been a recent proliferation of novel oral nicotine products (ONPs) brought to market, including new nicotine gums and pouches.
- Trial name
- NCT06506162
- Testing
- Flavor, Nicotine concentration
- Where
- 2 sites in United States
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Hospitalized Smokers, Chronic Diseases
Enhancing Tobacco Abstinence Following Hospitalization
The primary aim of this study is to examine the efficacy of a 12-week nurse-delivered relapse management intervention designed with conceptual underpinnings from Self-efficacy Theory to enhance smoking abstinence of hospitalized…
- Conditions
- Hospitalized Smokers, Chronic Diseases, Tobacco Use Disorder
- Trial name
- NCT00222703
- Testing
- Smoking relapse prevention
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- University of Pittsburgh
Tobacco Use Disorder
Smartphone-based Financial Incentives
Cigarette smoking during pregnancy increases risk for catastrophic pregnancy complications, growth retardation, other adverse fetal and infant health problems, and later-in-life chronic conditions among exposed offspring.
- Trial name
- NCT03922360
- Testing
- Smartphone-based Financial Incentives, Best Practices
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Bladder Cancer, Cervical Cancer
Varenicline or Nicotine Patch and Nicotine Gum in Helping Smokers in a Methadone Treatment Program Stop Smoking
RATIONALE: Varenicline, the nicotine patch, and nicotine gum help people stop smoking. It is not yet known whether varenicline is more effective than the nicotine patch given together with nicotine gum in helping smokers quit…
- Conditions
- Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT00790569
- Testing
- nicotine, varenicline
- Where
- United States
- Volunteers
- 315 people
- Sponsor
- Butler Hospital
Tobacco Dependence
Testing C-Raven, a Virtual Tobacco Cessation Intervention, in the Community
To inform a future randomized trial of a virtual counselor led computer delivered intervention for tobacco cessation augmented with community health worker (CHW) support and navigation to lung cancer screening in low-income…
- Trial name
- NCT06289192
- Testing
- C-Raven Virtual Tobacco Cessation Counseling, Nicotine Replacement Product, Community Health Worker
- Where
- 3 sites in United States
- Volunteers
- 5 people
- Sponsor
- Johns Hopkins University
Severe Mental Illness, Nicotine Dependence
Electronic Decision Support Systems for Smokers With Severe Mental Illness
This randomized clinical trial among SMI smokers assessed whether the EDSS with carbon monoxide monitor and health-checklist feedback lead to higher rates of initiation of smoking cessation treatment, days of smoking abstinence…
- Conditions
- Severe Mental Illness, Nicotine Dependence, Schizophrenia, Tobacco Use Disorder
- Trial name
- NCT01412866
- Testing
- EDSS with CO feedback and health checklist, EDSS with health checklist feedback alon
- Where
- United States
- Volunteers
- 124 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Nicotine Dependence
Approach Bias Retraining to Augment Smoking Cessation
Tobacco use is the most preventable cause of disease, disability, and death in the United States. Standard smoking cessation care (cognitive behavioral therapy and nicotine replacement therapy), is effective in approximately 20%…
- Trial name
- NCT03325777
- Testing
- Approach Bias Retraining
- Where
- United States
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Jasper A. Smits
Cancer, Smoking
Improving Tobacco Treatment Rates for Outpatient Cancer Patients Who Smoke
The main purpose of this research study is to evaluate the effectiveness of "nudges" to clinicians, to patients, or to both in increasing Tobacco Use Treatment Service (TUTS) referral and engagement; and to explore clinician…
- Conditions
- Cancer, Smoking, Tobacco Use, Nicotine Dependence
- Trial name
- SPP1 (NCT04737031)
- Testing
- Clinician Nudge, Patient Nudge
- Where
- 3 sites in United States
- Volunteers
- 2,146 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Abuse Tobacco, Exposure
Perceptions of E-Cigarettes and Synthetic Cooling Agents, The ICE Study
This study evaluates how synthetic cooling additives like WS-3 and WS-23 impact e-cigarette perceptions, use behavior, and toxicant exposure.
- Trial name
- ICE (NCT06208202)
- Testing
- Behavioral Intervention, Biospecimen Collection, Survey Administration
- Where
- United States
- Volunteers
- 158 people, healthy volunteers welcome
- Sponsor
- Ohio State University Comprehensive Cancer Center
Marijuana Dependence
Vaping THC From Electronic Cigarettes
This study aims to understand THC pharmacology and the safety of cannabis vaping, including the pharmacology and safety of co-administration of nicotine and THC.
- Trial name
- V-PAX (NCT02955329)
- Testing
- Nicotine, Cannabis, PAX Loose Leaf Vaporizer
- Where
- United States
- Volunteers
- 8 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Tobacco Abuse Cigarette
Effect of a Mobile-Based Anti-Smoking Nursing Intervention on Nursing Students (HDDN)
This clinical trial aims to understand whether a mobile-based anti-smoking nursing intervention can help nursing students change their smoking-related intentions, attitudes, and decision-making.
- Trial name
- HDDN (NCT07429825)
- Testing
- HDDN Mobile Application
- Where
- Turkey (Türkiye)
- Volunteers
- 43 people
- Sponsor
- LÜTFİYE GÖKÇE
Alcohol Drinking, Smoking
An Effectiveness Trial of Project ALERT
The purpose of this study is to replicate a longitudinal evaluation of Project ALERT, a substance abuse prevention program that targets middle school students.
- Conditions
- Alcohol Drinking, Smoking, Marijuana Smoking
- Trial name
- NCT00650585
- Testing
- Project ALERT
- Where
- United States
- Volunteers
- 8,338 people, healthy volunteers welcome
- Sponsor
- Pacific Institute for Research and Evaluation
Tobacco, Tobacco Abstinence
Quitting Matters Human Immunodeficiency Virus Hybrid Trial
The purpose of this study is to compare the advantages and disadvantages of two approaches for quitting smoking among people living with HIV (PWH).
- Conditions
- Tobacco, Tobacco Abstinence, Smoking Cessation, Smoking Cessation; Tobacco Dependence
- Trial name
- QMH (NCT06883097)
- Testing
- Learn to Quit-HIV (LTQ-H) App, QuitStart
- Where
- United States
- Volunteers
- 314 people
- Sponsor
- Wake Forest University Health Sciences
Tobacco Use Disorder
Role of Metabolites in Nicotine Dependence (4) - 13
The purpose of this study is to determine the effects of cotinine with or without a transdermal nicotine replacement on tobacco withdrawal symptoms.
- Trial name
- NCT00000296
- Testing
- Cotinine fumarate
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Vaping, Nicotine Dependence
Nicotine and Pavlovian Bias
Nicotine remains a major cause of health problems in the US and around the world. Insight into the behavioral changes induced by nicotine use may help advance the understanding of the mechanisms underlying the maintenance of…
- Trial name
- NCT06027723
- Testing
- Nicotine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Nicotine Dependence, Tobacco Use Disorder
A Survey on Consumer Use of Over-the-Counter (OTC) Nicotine Patches
Since 1996, the nicotine patch has been re-classified from prescription to over-the-counter (OTC) status in the United States. Little is known about how the public uses the OTC nicotine patch due to lack of monitoring.
- Trial name
- NCT00134927
- Where
- United States
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Tobacco Dependence
Tobacco Cessation Interventions With Ohio Appalachian Smokers
Tobacco use remains a significant public health problem and is increasingly prevalent among vulnerable groups. Appalachians have a high prevalence of tobacco use and are at increased risk for tobacco-attributable diseases.
- Trial name
- NCT02695225
- Testing
- Lay-led tobacco abstinence, Lay-led promotion of Ohio Quit Line
- Volunteers
- 707 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Tobacco Dependence
S-Adenosyl-L-Methionine (SAMe) for Smoking Abstinence
Cigarette smoking is of great public health importance and is the single most important preventable cause of morbidity, mortality and excess health care costs in the United States.
- Trial name
- NCT00722124
- Testing
- S-Adenosyl-L-Methionine
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
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