Clinical trials: Tobacco Abuse
Nicotine Dependence, Cigarettes
Epidemiology and Acute Oral Effects Electronic Cigarette
Electronic cigarettes are battery-powered vaporizers which have a similar feel to tobacco smoking. They do not produce cigarette smoke but rather an aerosol, which is frequently referred to as vapor.
- Trial name
- NCT03011710
- Testing
- ProVari v2.5 (E-cigarette), Marlboro Gold (Conventional cigarette), Cigarette tip
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Semmelweis University
Marijuana Use, Marijuana Dependence
Examining Effects of Domain Specific Episodic Future Thinking on Cannabis Use
The overarching goal of this online study is to compare the efficacy of six (weekly) sessions of Domain-Specific Episodic Future Thinking (DS-EFT) relative an active control condition on improving the ability to value future…
- Conditions
- Marijuana Use, Marijuana Dependence, Tobacco Use, Alcohol Use, Unspecified
- Trial name
- NCT05324813
- Testing
- Domain-Specific Episodic Future Thinking
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Michael Sofis
Tobacco Dependence
Testing C-Raven, a Virtual Tobacco Cessation Intervention, in the Community
To inform a future randomized trial of a virtual counselor led computer delivered intervention for tobacco cessation augmented with community health worker (CHW) support and navigation to lung cancer screening in low-income…
- Trial name
- NCT06289192
- Testing
- C-Raven Virtual Tobacco Cessation Counseling, Nicotine Replacement Product, Community Health Worker
- Where
- 3 sites in United States
- Volunteers
- 5 people
- Sponsor
- Johns Hopkins University
Smoking
Korean Youth Smoking Cessation Study
Cigarette smoking remains the leading preventable cause of morbidity and mortality in the United States. In Los Angeles, rates of morbidities due to cigarette smoking follow prevalence.
- Trial name
- NCT02021175
- Testing
- Tailored CBME Therapy via Technology, Standard of Care
- Where
- United States
- Sponsor
- University of California, Los Angeles
Nicotine Dependence, Tobacco Smoking
Project 2: Strategies for Reducing Nicotine Content in Cigarettes
The main goal of this project is to compare two different approaches to reducing levels of nicotine in cigarettes: an immediate reduction in nicotine content in cigarettes to non-addictive levels or a gradual reduction in…
- Trial name
- NCT02139930
- Testing
- Normal Nicotine Control Group, Immediate Nicotine Reduction Group, Gradual Nicotine Reduction Group
- Where
- 10 sites in United States
- Volunteers
- 1,250 people
- Sponsor
- Wake Forest University Health Sciences
COVID-19, Cancer
COVID EHR COHORT at the University of Wisconsin
This cohort study will obtain electronic health record (EHR) data (limited data set) from 21 health systems affiliated with the Cancer Center Cessation Initiative (C3I) network or health systems with large numbers of COVID-19…
- Conditions
- COVID-19, Cancer, Nicotine Dependence, Pulmonary Disease
- Trial name
- CEC-UW (NCT04506528)
- Where
- United States
- Volunteers
- 1,634,381 people
- Sponsor
- University of Wisconsin, Madison
Nicotine Vaping, Nicotine Dependence
Nicotine and Pavlovian Bias
Nicotine remains a major cause of health problems in the US and around the world. Insight into the behavioral changes induced by nicotine use may help advance the understanding of the mechanisms underlying the maintenance of…
- Trial name
- NCT06027723
- Testing
- Nicotine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Tobacco Dependence, Nicotine Dependence
Studying the Effects of Administration of Polyunsaturated Fatty Acids (PUFAS) of Omega-3 Series in Nicotine Dependence
Nicotine dependence may prolong the exposure to toxic substances that cause various diseases. The Central Nervous System (CNS) is consisted by a large amount of Polyunsaturated Fatty Acids (PUFAS) from omega-3 serie.
- Trial name
- NCT01735279
- Testing
- Omega 3
- Where
- Brazil
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Tobacco Dependence
Emergency Department Telephone Quitline
The purpose of this preliminary study was to evaluate the intervention completion rate among cigarette smokers enrolled through the Emergency Department (ED) in a tobacco quitline (QL) and to assess the feasibility of a…
- Trial name
- NCT00394420
- Testing
- Telephone Quitline
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Tobacco Use Disorder
Switching to Very Low Nicotine Content Cigarettes vs Reducing Cigarettes Per Day
The FDA recently gained the authority to regulate the nicotine content of cigarettes. Prior research suggests that smokers who switch to very low nicotine content (VLNC) cigarettes experience reduced addiction to nicotine and are…
- Trial name
- NCT03060083
- Testing
- Very low nicotine content (VLNC) cigarettes and nicotine replacement therapy (NRT), Reduce cigarettes per day (CPD) with nicotine replacement therapy (NRT)
- Where
- United States
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Schizophrenia
Value of Voxel-Based Morphometry in Schizophrenia
This cross-sectional observational study investigates structural brain abnormalities in schizophrenia and nicotine use disorder (NUD), with a focus on understanding how these abnormalities correlate with behavioral traits such as…
- Trial name
- NCT07108673
- Testing
- MRI
- Volunteers
- 96 people
- Sponsor
- Assiut University
Substance-related Disorders, Depression
Primary Care iSBIRT to Reduce Serious Teen Health Risks
The goal of the project is to develop and test an internet/intranet-based Screening, Brief Intervention, and Referral to Treatment (iSBIRT) system for adolescents that targets a broad range of serious health-risks and problem…
- Conditions
- Substance-related Disorders, Depression, High-risk Sex
- Trial name
- NCT00891631
- Testing
- iSBIRT, iSBIRT/TE
- Where
- United States
- Sponsor
- Boston Children's Hospital
HIV/AIDS and Infections, Drug Abuse
A Community-University Approach to Preventing HIV
Examine the feasibility and acceptability of delivering the S4E intervention to 20 African-American youths between the ages 16-21 in Flint, Michigan.
- Conditions
- HIV/AIDS and Infections, Drug Abuse, Adolescent Behavior, Drug Usage
- Trial name
- NCT03938077
- Testing
- Storytelling 4 Empowerment
- Where
- 2 sites in United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Michigan
Tobacco Dependence
Reduced Nicotine Content Cigarettes in Smokers of Lower Socioeconomic Status
The overall goal of this study is to address the question of whether progressively lowering nicotine content in cigarettes can reduce or eliminate nicotine dependence in smokers of low socioeconomic status
- Trial name
- NCT01928719
- Testing
- Reduced Nicotine Content Cigarettes, Same Nicotine Content Cigarettes
- Where
- 2 sites in United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Smoking Cessation
Smoking Cessation With the Nicotine Patch: A Pilot Study of Patch Messaging
The primary purpose of this study is to test the feasibility of sending pre-cessation nicotine patches and to examine the effects associated with the pre-cessation treatment phase. Specifically, this study aims to: 1.
- Trial name
- NCT01287377
- Testing
- Telephone Counseling, Nicotine Patches
- Where
- United States
- Volunteers
- 243 people
- Sponsor
- University of California, San Diego
Anxiety Disorders, Depression
Personalized Feedback for Distress Intolerant Smokers
This project will develop and refine a computer-delivered integrated Personalized Feedback Intervention (PFI) that directly addresses smoking and distress tolerance.
- Conditions
- Anxiety Disorders, Depression, Psychological Distress, Tobacco Dependence
- Trial name
- NCT03918031
- Testing
- PFI for Smoking & Distress Tolerance, PFI for Smoking Only
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of Houston
Smoking, Nicotine Dependence
A Trial of E-cigarettes in Current Cigarette Smokers
The purpose of this study is to examine cigarette smokers' use of electronic cigarettes (e-cigarettes), and how use of e-cigarettes affects short term smoking behavior.
- Conditions
- Smoking, Nicotine Dependence, Nicotine Dependence, Other Tobacco Product
- Trial name
- NCT02357173
- Testing
- electronic cigarette, cigarette group
- Where
- United States
- Volunteers
- 68 people
- Sponsor
- Medical University of South Carolina
Smoking Cessation, Nicotine Dependence
Engaging Sexual and Gender Minority Cigarette Smokers Into Social Media-based Treatment
This research study will evaluate the preliminary efficacy of Pride Posts Plus, a social media-based smoking cessation treatment.
- Conditions
- Smoking Cessation, Nicotine Dependence, Tobacco Use, Cigarette Smoking
- Trial name
- NCT04461288
- Testing
- Social media-based education, counseling, and support, Nicotine replacement therapies (NRT), Gamification
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Tobacco Dependence
Comparisons of Nicotine-free Cigarettes, Extra Low Nicotine Cigarettes vs. Medicinal Nicotine
In this study, smokers will be randomly assigned to one of three conditions for six weeks: 1) nicotine-free cigarettes (0.05mg); 2) extra low nicotine cigarettes (0.3 mg); or 3) medicinal 4 mg nicotine lozenge.
- Trial name
- NCT00777569
- Testing
- Nicotine free cigarettes, Extra-low nicotine cigarettes, Nicotine Lozenge
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Moderate or Severe Tobacco Use Disorder
Analysis and Evaluation of Smoking Treatment With Cytisine
The lack of clinical studies on the use of Cytisine in the treatment of the cessation of smoking, the need to find effective therapeutic alternatives and the opportunity to reduce costs related to the complications of cigarette…
- Trial name
- NCT06439303
- Testing
- Cytisine 1,5 mg
- Where
- Italy
- Volunteers
- 65 people
- Sponsor
- Regina Elena Cancer Institute
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