Clinical trials: Tobacco Abuse
Nicotine Dependence, Bipolar Disorder
Targeted Intervention for Bipolar Smokers
The purpose of this research is to develop and test a new type of smoking cessation counseling for individuals with bipolar disorder.
- Trial name
- NCT01550029
- Testing
- Counseling/Healthy Lifestyle, Counseling/Managing Mood
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of Cincinnati
Nicotine Dependence, Cigarettes
Negotiating a Quit Date or Not in Online Interventions
The primary purpose of the current study is to test the effect of providing users of automated web-based smoking cessation interventions with the option of negotiating and re-negotiating the quit date.
- Trial name
- NCT03194919
- Testing
- Endre: a digital smoking cessation counsellor
- Where
- 2 sites in Czechia, Norway
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Tobacco Dependence
Reduced Nicotine Content Cigarettes in Smokers of Lower Socioeconomic Status
The overall goal of this study is to address the question of whether progressively lowering nicotine content in cigarettes can reduce or eliminate nicotine dependence in smokers of low socioeconomic status
- Trial name
- NCT01928719
- Testing
- Reduced Nicotine Content Cigarettes, Same Nicotine Content Cigarettes
- Where
- 2 sites in United States
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Tobacco Use Disorder, Cigarette Smoking
Pharmacokinetics of Nicotine Sublingual Tablets Versus Nicorette Lozenge in Healthy Smokers
The purpose of the study is to compare two different dosage forms from which nicotine is released and absorbed into the bloodstream.
- Trial name
- NCT02906995
- Testing
- Sublingual tablet 4 mg versus Nicorette Lozenge 4mg
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Friends Research Institute, Inc.
Tobacco Use Disorder
Tobacco Use Intervention Among Radiation Oncology Patients
Tobacco prevention and intervention strategies in the general population are ongoing and evolving. However, strategies to help cancer patients overcome tobacco dependence have been limited.
- Trial name
- NCT00587353
- Testing
- Behavioral and pharmacologic tobacco use intervention
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Mayo Clinic
Tobacco Dependence
Establishing the Effect of Flavor on the Addictive Potential of Electronic Cigarettes
The current study aims to establish proof-of-concept that neural cue-reactivity can serve as an early, objective marker of electronic cigarette (ECIG) addictive potential.
- Trial name
- NCT03905928
- Testing
- Nicotine Containing ECIG with tobacco flavor, Nicotine Containing ECIG with Strawberry Vanilla Flavor
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Smoking, Sleep Disturbance
Racial Differences in Circadian and Sleep Mechanisms for Nicotine Dependence, Craving, and Withdrawal
The number one preventable cause of death in the world is tobacco use. Cigarette smoking in particular, costs an estimated $300 billion due to expenses related to medical care and lost productivity.
- Conditions
- Smoking, Sleep Disturbance, Nicotine Dependence
- Trial name
- NCT03968900
- Testing
- Sleep restriction condition, Sleep extension condition
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Alabama at Birmingham
Smoking Cessation
Impact of a Gene Test for Susceptibility to Lung Cancer in Smokers
Professor RP Young (Associate Professor of Medicine and Molecular Medicine, School of Biological Sciences, University of Auckland) and his team have developed a reliable genetic test "Respiragene" based on 20 single nucleotide…
- Trial name
- NCT01176383
- Testing
- Respiragene test and risk score
- Where
- United Kingdom
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Sussex NHS Research Consortium
Smoking Cessation, Tobacco Use Disorder
Examining the Effects of Cytisinicline on Neural Substrates of Cigarette Cue-reactivity
This study will randomize 64 non-treatment seeking individuals who smoke cigarettes daily in a double-blind, placebo-controlled laboratory study testing the effects of cytisinicline on the neural substrates of cigarette cue…
- Trial name
- Cytisinicline (NCT06617312)
- Testing
- Cytisinicline
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- University of California, Los Angeles
Tobacco Dependence, Obesity
New Hampshire Medicaid Wellness Incentive Program
The New Hampshire Medicaid Wellness Incentive Program (WIP) will address both the health disparity and increased costs by providing incentivized health promotion programs to overweight or obese and/or tobacco-smoking Medicaid…
- Conditions
- Tobacco Dependence, Obesity, Mental Illness
- Trial name
- NHWIP (NCT02515981)
- Testing
- NH Medicaid Incentives Program
- Where
- 12 sites in United States
- Volunteers
- 2,800 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Tobacco Use Disorder
Interest in Smokeless Tobacco Product as a Substitution for Cigarettes in Current Smokers
This randomized clinical trial studies interest in smokeless tobacco product as a substitution for cigarettes in current smokers. Use of smokeless tobacco products may help people stop smoking.
- Trial name
- NCT01800500
- Testing
- smoking cessation intervention, questionnaire administration, quality-of-life assessment
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- Roswell Park Cancer Institute
Tobacco Dependence
Quitline Use in Surgical Patients
Elective surgery represents a teachable moment to deliver tobacco interventions. The overall goal of this proposal is to increase the utilization of the QUITPLANSM Helpline by surgical patients who smoke.
- Trial name
- NCT00656500
- Testing
- Standard brief advice, Quitline intervention
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Mayo Clinic
Tobacco Use Disorder
Transcranial Magnetic Stimulation and Tobacco Use Disorder
The purpose of this study is to determine if brain stimulation using repetitive transcranial magnetic stimulation (rTMS) directed at different parts of the brain can decrease feelings of cigarette craving and symptoms of…
- Trial name
- NCT03827265
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of California, Los Angeles
Nicotine Dependence
Pharmacokinetics and Pharmacodynamics of Different Nicotine Salt Concentration Vape System Pods and Free-base Nicotine
Comparison of the pharmacokinetics and pharmacodynamics of two different nicotine salt concentrations and free-base nicotine using an open vape pod system
- Trial name
- NCT04170907
- Testing
- standardized vaping protocol
- Where
- Switzerland
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Nicotine Dependence, Pregnancy
Biomarker Feedback to Motivate Cessation in Pregnancy
Phase 3 Pilot Clinical Trial.
- Trial name
- MAW Phase 3 (NCT02431611)
- Testing
- Biomarker feedback (phone based smoking cessation counseling), Control condition (phone based smoking cessation counseling)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Nicotine Dependence
Smoking Cessation in Substance Abuse Treatment Patients: A Feasibility Study
The purpose of this study is to compare the effects of self-help materials for smoking cessation and self-help materials for smoking cessation plus prize-based contingency management (CM), in which prize incentives are available…
- Trial name
- NCT00408265
- Testing
- Contingency Management
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- UConn Health
Tobacco Dependence
Pharmacokinetics With Two New Oral Nicotine Replacement Products and Nicorette® Gum
Single-dose pharmacokinetics with two new oral nicotine replacement products and Nicorette® gum.
- Trial name
- NCT01152723
- Testing
- Nicotine
- Where
- Sweden
- Volunteers
- 28 people
- Sponsor
- McNeil AB
Healthy Volunteers, Nicotine Dependence
PET Imaging of Nicotinic Acetylcholine Receptors
Background: Central nicotinic acetylcholine receptors (nAChRs) are the primary target for the action of nicotine. In addition to being involved in tobacco dependence, they are also involved in a variety of brain disorders…
- Conditions
- Healthy Volunteers, Nicotine Dependence, Pharmacokinetics
- Trial name
- NCT01046513
- Where
- United States
- Volunteers
- 14 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smokeless Tobacco Use
Highdose Nicotine Patch Therapy for Smokeless Tobacco Use
Smokeless tobacco use ("chewing") is associated with negative health effects. To date, no medications have been shown to help chewers quit long-term.
- Trial name
- NCT00939029
- Testing
- nicotine replacement therapy (nicotine patches)
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Smoking, Smoking, Tobacco
Financial Incentives for Smoking Treatment
The investigators plan to compare the impact of two approaches for smoking cessation on smoking abstinence, use of evidenced-based therapy, and quality of life among a diverse population of patients at the Manhattan campus of the…
- Conditions
- Smoking, Smoking, Tobacco, Tobacco Use Disorder
- Trial name
- FIESTA (NCT02506829)
- Testing
- Smoking cessation counseling (Quitline), Smoking cessation pharmacotherapy (e.g, nicotine replacement therapy), Financial incentives
- Where
- United States
- Volunteers
- 182 people
- Sponsor
- NYU Langone Health
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