Clinical trials: Tobacco Abuse
Tobacco Dependence
Testing C-Raven, a Virtual Tobacco Cessation Intervention, in the Community
To inform a future randomized trial of a virtual counselor led computer delivered intervention for tobacco cessation augmented with community health worker (CHW) support and navigation to lung cancer screening in low-income…
- Trial name
- NCT06289192
- Testing
- C-Raven Virtual Tobacco Cessation Counseling, Nicotine Replacement Product, Community Health Worker
- Where
- 3 sites in United States
- Volunteers
- 5 people
- Sponsor
- Johns Hopkins University
Tobacco Dependence
Improving Health for Aboriginal People Through Tobacco Related Research
Aim: To identify barriers and facilitators in the uptake of smoking cessation pharmacotherapies, tobacco prevention, doctor visits, smoking amongst youth, community held health priorities and barriers to research in Aboriginal…
- Trial name
- NCT01735448
- Testing
- Focus group, One-on-one interviews, Survey
- Where
- 3 sites in Australia
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- The Queen Elizabeth Hospital
Cannabis Use Disorder, Tobacco Use Disorder
Clinical Trial Tobacco Marijuana
Approximately 50% of persons seeking treatment for cannabis-use disorders (CUDs) regularly smoke tobacco. Combining tobacco with cannabis has become a common method of smoking cannabis.
- Trial name
- RCTTM (NCT02277665)
- Testing
- CUD Treatment, Tobacco Treatment
- Where
- 3 sites in United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Dartmouth-Hitchcock Medical Center
Vaping, Adolescent
Nicotine and Cannabis Vape Labeling Experiment - Spring 2025
This study assesses how the ways in which nicotine and cannabis vaping devices are labeled impact use susceptibility, anticipated effects, and health harm.
- Conditions
- Vaping, Adolescent, Electronic Cigarette Use, Nicotine
- Trial name
- EPIC/ADVANCE (NCT06919276)
- Testing
- Vaping Device Labeling
- Where
- United States
- Volunteers
- 3,048 people, healthy volunteers welcome
- Sponsor
- University of Southern California
Smoking Cessation, Tobacco Use Disorder
Effectiveness of the Nicotine Patch in Suppressing Nicotine Withdrawal Symptoms in Women Versus Men - 1
Women typically have a more difficult time quitting smoking than men. Little research has been done to understand the differences between men and women that may cause this distinction.
- Trial name
- NCT00218140
- Testing
- nicotine transdermal system
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Lung Cancer, Tobacco Use Disorder
Green Tea Extract in Preventing Cancer in Former and Current Heavy Smokers With Abnormal Sputum
RATIONALE: Chemoprevention is the use of certain drugs to keep cancer from forming. Green tea extract may keep cancer from forming.
- Trial name
- NCT00573885
- Testing
- defined green tea catechin extract
- Where
- Canada
- Volunteers
- 53 people
- Sponsor
- British Columbia Cancer Agency
Marijuana Smoking
Nabilone & Marijuana Addiction
Safety of Nabilone in reducing marijuana craving
- Trial name
- NCT01025700
- Testing
- Cesemat
- Where
- Canada
- Volunteers
- 35 people
- Sponsor
- University of British Columbia
Smoking Cessation
Smoking Cessation Self-Help for Dual Users of Tobacco Cigarettes and E-Cigarettes
The purpose of this study is to develop and test a series of booklets designed to assist smokers of tobacco cigarettes who are also using e-cigarettes (dual users) in quitting smoking and remaining smoke-free.
- Trial name
- NCT02416011
- Testing
- GENERIC, eTARGET
- Where
- United States
- Volunteers
- 2,896 people, healthy volunteers welcome
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Nicotine Dependence, Pregnancy
Biomarker Feedback to Motivate Cessation in Pregnancy
Phase 3 Pilot Clinical Trial.
- Trial name
- MAW Phase 3 (NCT02431611)
- Testing
- Biomarker feedback (phone based smoking cessation counseling), Control condition (phone based smoking cessation counseling)
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Tobacco Dependence
Harm Reduction for Smokers With Mental Illness
To compare the efficacy of e-cigarette (e-cig) provision with or without behavioral support (SWITCH IT) delivered via telehealth to reduce harm among smokers with MI who cannot quit smoking and are not ready to pursue cessation…
- Trial name
- NCT06543407
- Testing
- SWITCH IT, E-cig Provision Only
- Where
- 2 sites in United States
- Volunteers
- 250 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Tobacco Use Disorder
Naltrexone Augmentation of Nicotine Patch Therapy - 1
Naltrexone Augmentation of Nicotine Patch Therapy
- Trial name
- NCT00218153
- Testing
- Naltrexone
- Where
- 2 sites in United States
- Volunteers
- 200 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Cigarette Smoking, Marijuana Abuse
Mobile Contingency Management for Marijuana and Tobacco Cessation
The purpose of this pilot project is to pilot-test a combined cannabis and smoking cessation treatment. The intervention combines mobile technology with behavioral strategies, counseling, and medications.
- Trial name
- NCT02869451
- Testing
- bupropion, transdermal nicotine patch, Nicotine polacrilex
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Duke University
Nicotine Dependence
Atomoxetine's Effects On Nicotine Response And Stress Response In Smokers
The purpose of this study is to evaluate atomoxetine's effects on the rewarding and reinforcing effects of nicotine in a controlled human laboratory study with 24 otherwise healthy nicotine dependent subjects.
- Trial name
- NCT02046551
- Testing
- Atomoxetine
- Where
- United States
- Sponsor
- Yale University
Tobacco Use
Evaluation of the Abuse Liability of Very Low Nicotine (VLN) Cigarettes
This study is designed to evaluate the abuse liability of very low nicotine cigarettes compared to nicotine gum and usual brand cigarettes
- Trial name
- NCT03559751
- Testing
- VLN cigarettes (A), Usual Brand Cigarettes (B), Nicotine gum (C)
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- 22nd Century Group, Inc.
Tobacco Use Disorder
Smartphone-based Financial Incentives
Cigarette smoking during pregnancy increases risk for catastrophic pregnancy complications, growth retardation, other adverse fetal and infant health problems, and later-in-life chronic conditions among exposed offspring.
- Trial name
- NCT03922360
- Testing
- Smartphone-based Financial Incentives, Best Practices
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Smoking Cessation, Tobacco Use Disorder
Comparative Effectiveness of Two Tobacco Cessation Interventions for Employees of Partners HealthCare, Inc.
Specific Aim: To conduct a randomized controlled trial among permanent employees of Partners HealthCare, Inc., and their adult dependents, who are current tobacco smokers.
- Trial name
- PiHQ (NCT02601521)
- Testing
- Internal tobacco coach, External tobacco coach
- Where
- United States
- Volunteers
- 106 people
- Sponsor
- Massachusetts General Hospital
Tobacco Abuse Smoke
Effect of the Transcranial Direct Current Stimulation (tDCS) on Dependent Smoking People
The purpose of this study is to evaluate the effect of 10 sessions of anodal transcranial Direct Current Stimulation (tDCS - 1 mA) applied to left vs right CDLPF of tobacco-dependent subjects compared to the application of a…
- Trial name
- TabaSCo (NCT02867514)
- Testing
- transcranial Direct Current Stimulation (tDCS)
- Where
- 2 sites in France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Besancon
Healthy, no Evidence of Disease, Tobacco Use Disorder
Phase II A Trial of Curcumin Among Patients With Prevalent Subclinical Neoplastic Lesions (Aberrant Crypt Foci)
Chemoprevention is the use of certain substances to keep cancer from forming, growing, or coming back. Curcumin is a compound found in plants that may prevent colon cancer from forming.
- Trial name
- NCT00365209
- Testing
- laboratory biomarker analysis, pharmacological study, curcumin
- Where
- United States
- Volunteers
- 44 people, healthy volunteers welcome
- Sponsor
- National Cancer Institute (NCI)
Nicotine Dependence, Cigarettes
Evaluation of LLLT/Music for Smoking Cessation
The purpose of this research is to study the preliminary effectiveness of a light therapy and music device for at-home use to aid the seasoned cigarette smoker in his/her attempt to stop smoking.
- Trial name
- NCT04830384
- Testing
- Fully Active, LLLT Only, Music Only
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Freedom Laser, Inc.
Anxiety Disorders, Anxiety
Personalized Feedback for Smokers With Elevated Anxiety Sensitivity
This project will develop and refine a computer-delivered integrated Personalized Feedback Intervention (PFI) that directly addresses smoking and anxiety sensitivity (AS).
- Conditions
- Anxiety Disorders, Anxiety, Tobacco Dependence, Smoking, Cigarette
- Trial name
- NCT03382093
- Testing
- Personalized Feedback Intervention, Smoking Information Control
- Where
- United States
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of Houston
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