Clinical trials: Tobacco Cigarette Smoking
Tobacco Use Disorder
Nicotine Regulation for Dual Users of E-cigarettes and Cigarettes
Cigarette smoking remains the leading cause of preventable morbidity and mortality in the US. Use of multiple tobacco products is becoming increasingly prevalent, with dual use of e-cigarettes and cigarettes representing the most…
- Trial name
- RDEC (NCT06614504)
- Testing
- Varying the nicotine content of cigarettes, Varying the nicotine content of e-cigarettes
- Where
- 2 sites in United States
- Volunteers
- 308 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Cigarette Smoking, Alcohol Use Disorders
Varenicline + Prazosin for Heavy Drinking Smokers
The purpose of this study is to examine the effect of varenicline and prazosin on smoking, drinking, and sleep among cigarette smokers who report heavy alcohol use. Varenicline is an FDA approved smoking cessation medication.
- Trial name
- NCT02193256
- Testing
- Varenicline, Prazosin
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Yale University
Cigarette Smoking, Addiction Nicotine
Investigation of Cigarette Cravings in Smokers
Interventions to disrupt memory reconsolidation have held promise for the treatment of stress- and anxiety-related disorders. In the present study, the investigators will examine whether an intervention based on these principles…
- Conditions
- Cigarette Smoking, Addiction Nicotine, Tobacco Use
- Trial name
- NCT04843969
- Testing
- Stress induction, Control stress exposure, Cue induction
- Where
- Canada
- Volunteers
- 76 people
- Sponsor
- Marco Leyton
Smoking, Cigarette
Tobacco Use Treatment in Cancer Patients
Tobacco use among cancer survivors reduces the effectiveness of cancer treatments, increases the risk for additional primary cancers, and increases mortality.
- Trial name
- NCT03482583
- Testing
- Nicotine Replacement Therapy, Referral to AHEC/Quitline
- Where
- 5 sites in United States
- Volunteers
- 90 people
- Sponsor
- University of Florida
Pulmonary Disease, Chronic Obstructive, Tobacco Smoking
COPD E-cigarette Topography Training
This study is for people with chronic obstructive pulmonary disease (COPD) and who smoke. Investigators are trying to find out if training on e-cigarette use will help smokers switch to e-cigarettes.
- Trial name
- NCT05510154
- Testing
- Brief advice, Single Training, Training to Competency
- Where
- United States
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Cigarette Smoking
Health-Kit Enabled Mobile App for Tobacco Cessation
Tobacco use is the leading preventable cause of death in the US, contributing to more than 480,000 premature deaths each year. The Tobacco Treatment Guidelines underscore the need to offer patients who use tobacco products brief…
- Trial name
- NCT06292130
- Testing
- refresh
- Where
- United States
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- Pro-Change Behavior Systems
Oxidative Stress, Inflammation
PsP Ganoderma Lucidum Supplementation and Biomarker Changes in Smokers
The goal of this randomized controlled clinical trial is to evaluate whether polysaccharide peptide (PsP) supplementation from Ganoderma lucidum can modulate biomarkers of oxidative stress, inflammation, nicotine exposure, and…
- Conditions
- Oxidative Stress, Inflammation, Cigarette Smoking
- Trial name
- PSPGL (NCT07316400)
- Testing
- PsP
- Where
- Indonesia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Brawijaya
Tobacco Use Disorder
The Study of AZD8529 for Smoking Cessation in Female Smokers
To evaluate the efficacy and safety of AZD8529 for smoking cessation in female smokers.
- Trial name
- NCT02401022
- Testing
- AZD8529
- Where
- 9 sites in United States
- Volunteers
- 214 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoking, Pain
Pain and Smoking Study
This purpose of this study is to test the telephone delivery of a cognitive behavioral intervention (CBI), for smoking cessation among Veteran smokers with chronic pain
- Conditions
- Smoking, Pain, Smoking Cessation
- Trial name
- PASS (NCT02971137)
- Testing
- Smoking Cessation plus CBI, Smoking Cessation Standard
- Where
- 2 sites in United States
- Volunteers
- 371 people
- Sponsor
- VA Office of Research and Development
Cigarette Smoking
Culturally Targeted & Individually Tailored Smoking Cessation Study: LGBT Smokers
For the approximately 4.6 million LGBT persons in the U.S., smoking rates among those living in urban areas are roughly twice that of heterosexuals.
- Trial name
- NCT01633567
- Testing
- Culturally Targeted Cessation Program, Non-Targeted Cessation Program
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Illinois Chicago
Tobacco Use Disorder, Cigarette Smoking
Pharmacokinetics of Nicotine Sublingual Tablets Versus Nicorette Lozenge in Healthy Smokers
The purpose of the study is to compare two different dosage forms from which nicotine is released and absorbed into the bloodstream.
- Trial name
- NCT02906995
- Testing
- Sublingual tablet 4 mg versus Nicorette Lozenge 4mg
- Where
- United States
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Friends Research Institute, Inc.
Nicotine Dependence, Cigarette Smoking
New Approaches to Smoking Cessation in Heavy Drinkers
The purpose of this study is to develop and test an integrated cognitive-behavioral intervention for smoking and alcohol among heavy drinking smokers.
- Conditions
- Nicotine Dependence, Cigarette Smoking, Alcohol Consumption, Heavy Drinking
- Trial name
- NCT02151591
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 26 people
- Sponsor
- Yale University
Second Hand Tobacco Smoke
Impact of Secondhand Exposure to E-cigarettes Aerosols on the Respiratory System
Limited studies have evaluated potential exposure to secondhand e-cigarette aerosol, an indication of impact on indoor air quality.
- Trial name
- TackSHSWP6 (NCT03102684)
- Testing
- Secondhand exposure to e-cigarette aerosols (low), Secondhand exposure to e-cigarette aerosols (high)
- Where
- Greece
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Institut Català d'Oncologia
Tobacco Smoking, Vaping
Vaping Cessation Using the Ottawa Model for Smoking Cessation Among E-Cigarette Users
This study aims to determine if a standardized approach including counselling and Nicotine Replacement Therapy (NRT) can help e-cigarette users quit vaping.
- Trial name
- VC-OMSC (NCT06164678)
- Testing
- OMSC
- Where
- Canada
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Ottawa Heart Institute Research Corporation
Smoking
Assessment of HPHC Exposure in Smokers Switching to THS/TP18 With Different Device Variants
This is a randomized, controlled, open-label, 6 parallel arms study to assess reduced exposure of biomarkers of exposure (BoE) of selected HPHC in smokers switching to TP18 (a prototype heated tobacco device) or THS relative to…
- Trial name
- NCT07443631
- Testing
- THS1 (TP18 variant 1), THS2 (TP18 variant 2), THS3 (TP18 variant 3)
- Where
- United Kingdom
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Tobacco Use, Smoking
An Extended Facebook Intervention for Young Sexual and Gender Minority Smokers
The 2-year research plan will test the Extended Put It Out Project (POP-6) in a pilot randomized trial (N=168) compared to TSP-6, as well as comparing POP-6 and TSP-6 to the POP-3 and TSP-3 interventions from a…
- Conditions
- Tobacco Use, Smoking, Tobacco Dependence, Tobacco Use Disorder
- Trial name
- POP-6 (NCT03553992)
- Testing
- POP-6:, TSP-6:
- Where
- United States
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Smoking ( Cigarette)
Ecological Momentary Assessment of Smoking Triggers, Needs, and Cigarette Forgoing
This study will evaluate a smartphone-based program designed to support adults who smoke cigarettes. Participants will use the spark app to complete brief surveys during the day and a daily evening survey about their smoking…
- Trial name
- spark Forgo (NCT07852845)
- Testing
- Non-Adaptive Motivational EMI, Adaptive Motivational EMI
- Volunteers
- 45 people
- Sponsor
- University of South Carolina
Periodontal Diseases, Dysbiosis
Effect of Aerosol From THS and Cigarette Smoke on Periodontal Tissues and Its Microbiome
Cigarette smoke has an adverse effect on the entire body as well as on the supporting apparatus of the teeth. THS (tobacco heating system) are new products on the market in which tobacco is heated and not burned like in classic…
- Trial name
- NCT06480877
- Testing
- Taking a swab from periodontal pockets or gingival sulci
- Where
- Croatia
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Clinical Hospital Center Rijeka
Smoking, Smoking Habit
PRogetto Salute Parma
This project from the University Hospital of Parma (AOUPR) aims to verify the feasibility of a prevention program in our district, relying on advanced technological resources and highly experienced team in lung cancer early…
- Conditions
- Smoking, Smoking Habit, Smoking, Tobacco, Smoking, Cigarette
- Trial name
- PSP (NCT04282694)
- Testing
- Low-dose computed tomography (LDCT)
- Where
- Italy
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- University of Parma
Tobacco Cessation, Electronic Nicotine Delivery Systems
Flavored Electronic Nicotine Delivery Systems to Lower Smoking and Exposure to Tobacco Toxicants Among Cigarette Smokers Interested in Quitting, REFLECT Trial
This clinical trial studies whether different flavored electronic nicotine delivery systems (ENDS) help lower smoking and exposure to tobacco toxicants among cigarette smokers interested in reducing their smoking.
- Trial name
- REFLECT (NCT07896330)
- Testing
- Vaping - Fruit flavored ENDS, Biospecimen Collection, Vaping - tobacco flavored ENDS
- Where
- United States
- Volunteers
- 286 people, healthy volunteers welcome
- Sponsor
- Roswell Park Cancer Institute