Clinical trials: Tobacco Consumption
Nicotine Dependence, Electronic Cigarette Use
E-cigarette Nicotine Study
This is a pilot randomized controlled trial (RCT) with the overarching aim of testing the influence of reducing electronic nicotine delivery system (ENDS) use or nicotine on addiction and combustible cigarette (CC) smoking among…
- Conditions
- Nicotine Dependence, Electronic Cigarette Use, Cigarette Smoking
- Trial name
- NCT04709471
- Testing
- Nicotine, Juul e-cigarette, Reduction
- Where
- United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Tobacco Use Disorder/Cigarette Smoking
Smoking Cessation Intervention for Young Adults Using MTM: A Randomized Controlled Trial
The goal of this clinical trial is to evaluate whether a Multi-Theory Model (MTM)-based behavioral intervention can effectively promote smoking cessation and support behavior change in young adult cigarette smokers aged 18 to 29…
- Trial name
- NCT07104006
- Testing
- Multi-Theory Model (MTM)-Based Smoking Cessation Program
- Where
- United States
- Volunteers
- 144 people
- Sponsor
- University of Nevada, Las Vegas
Tobacco Use Disorder, Weight Gain
Lorcaserin for Preventing Weight Gain Among Smokers
This will be an open label clinical trial with all subjects receiving both lorcaserin and varenicline with a primary aim of reducing post cessation weight gain.
- Trial name
- NCT02393547
- Testing
- Varenicline, Lorcaserin
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Smoking, E-cigarette Use
Impact of New Product Standards for JUUL Among Dual JUUL/Combusted Cigarette Users
To date the majority of experimental tobacco regulatory science has focused specifically on the impact of possible tobacco product standards (e.g.
- Conditions
- Smoking, E-cigarette Use, Cigarette Smoking
- Trial name
- NCT04179617
- Testing
- 5% nicotine content JUUL pod, 3% nicotine content JUUL pod
- Sponsor
- Duke University
Tobacco Cessation
Pilot Testing a Digital Intervention to Improve Smoking Cessation in Persons With Serious Mental Illness
All patients with serious mental illness are abstinent while in the hospital for a psychiatric admission yet almost all return to smoking after discharge.
- Trial name
- NCT04367506
- Testing
- BecomeAnEX, Usual Care
- Where
- 2 sites in United States
- Volunteers
- 59 people
- Sponsor
- University of Maryland, Baltimore
Tobacco Use
Responses to Regulated E-Cigarette Advertisements
While conventional cigarette use continues to decline among youth and young adults, e-cigarette (EC) use is on the rise. Specifically, the investigators will conduct a randomized control trial (RCT) where young adults are…
- Trial name
- NCT05207033
- Testing
- Regulated ad condition, Unregulated ad condition
- Where
- United States
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Nicotine Dependence
Stress Neuroadaptation in Tobacco Dependence
The objective of the current study is to evaluate the validity of the No Shock, Predictable Shock, Unpredictable Shock (NPU) stressor task for use as a surrogate endpoint to predict short-term clinical outcomes among smokers…
- Trial name
- NCT03262233
- Testing
- nicotine
- Where
- United States
- Volunteers
- 226 people
- Sponsor
- University of Wisconsin, Madison
Cigarette Smoking Behavior
Impact of Cigarette Pack Constituent Disclosures
The purpose of this randomized controlled trial is to determine whether constituent disclosures on cigarette packs increase intentions to quit smoking.
- Trial name
- NCT02785484
- Testing
- Label with constituent disclosure message, Label with litter message
- Where
- United States
- Volunteers
- 784 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Cigarette Smoking
Effects of Narratives on Demand for Low and High Ventilated Cigarettes and Substitution for Alternative Products
This study will investigate the effects of narratives on demand for low and high ventilated cigarettes and substitution for alternative products in the Experimental Tobacco Marketplace.
- Trial name
- NCT05487625
- Testing
- High-ventilated cigarette alone, Low-ventilated cigarette alone, High- and low-ventilated cigarette with high-ventilated cigarettes increasing in price
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Virginia Polytechnic Institute and State University
Smoking, Tobacco Use
Project HEALS (Helping and Empowering pAtients for Living a Life Smoke-free
The purpose of the study is to pilot test a multi-modal smoking cessation and relapse prevention intervention with the lung cancer patient population and to obtain preliminary data on its feasibility.
- Conditions
- Smoking, Tobacco Use, Lung Cancer
- Trial name
- NCT05362318
- Testing
- Nicotine patch and lozenges, Telephone counseling sessions, Access to a web-based video
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- H. Lee Moffitt Cancer Center and Research Institute
Cigar Smoking, Tobacco Use
Cigar Legislation and Regulation in Tobacco for the Young (Project CLARITY)
This clinical trial will recruit young adults who currently use cigarillos and examine the smoking behavior and perceptions of different flavored cigarillos, product ingredients/additives impacting these perceptions, and…
- Trial name
- CLARITY (NCT07162935)
- Testing
- Cigarillo brand 1, Cigarillo brand 2, Cigarillo brand 3
- Where
- 2 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Substance Dependence
Relapse Prevention Study in Newly Abstinent Smokers
The purpose of this study is to determine the effect of GSK598809 as compared to placebo in preventing recently-quit smokers from going back to smoking.
- Trial name
- NCT00793468
- Testing
- GSK598809, Nicotine Replacement Transdermal Patch
- Where
- 10 sites in United States
- Sponsor
- GlaxoSmithKline
Smoking Cessation, Smoking, Cigarette
Pictorial Warning Labels and Memory for Cigarette Health-risk Information Over Time
Pictorial cigarette warning labels (PWLs) are thought to increase risk knowledge, but experimental research has not examined PWLs' longer term effects on memory for health risks.
- Trial name
- NCT03375840
- Testing
- Text-only PWL, Low-emot PWL, High-emot PWL
- Volunteers
- 4,424 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Nicotine Use Disorder, Smoking Cessation
Implementation of Tobacco Cessation Programming at Community Behavioral Health Sites
The goal of this study is to: partner with Respiratory Health Association and determine barriers and unmet smoking cessation treatment needs from leaders in behavioral health organizations, treatment programs and adults who smoke…
- Conditions
- Nicotine Use Disorder, Smoking Cessation, Smoking Cessation Intervention
- Trial name
- NCT06837220
- Testing
- Enhanced Courage to Quit
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Chicago
Cardiovascular Diseases, Smoking
Effect of Switching From Cigarette Smoking to THS on Systemic Endothelial Function in Subjects With Established Atherosclerotic Disease
The purpose of this study is to demonstrate improvement in flow mediated dilation (FMD), a functional endpoint associated with the progression of atherosclerosis, when switching from cigarettes to the Tobacco Heating System (THS)…
- Conditions
- Cardiovascular Diseases, Smoking, Tobacco Use, Peripheral Arterial Disease
- Trial name
- NCT05566678
- Testing
- Cigarette, THS, Smoking Abstinence
- Sponsor
- Philip Morris Products S.A.
Cigarette Smoking
Text Messaging-Based Smoking Cessation Program for Homeless Youth
Unaccompanied homeless youth smoke at much higher rates than non-homeless adolescents and young adults. Many homeless youth smokers are motivated to quit; yet, strategies specifically developed for this vulnerable population are…
- Trial name
- NCT03874585
- Testing
- Group counseling and nicotine replacement, Group counseling, nicotine replacement, and text messaging support
- Where
- 3 sites in United States
- Volunteers
- 77 people, healthy volunteers welcome
- Sponsor
- RAND
Cigarette Smoking
Project 1, Study 2: The Combined Impact of Nicotine Replacement and Spectrum Cigarettes
Project 1, Study 2 will evaluate the impact of very low nicotine content cigarettes with and without transdermal nicotine on cigarettes smoked per day, nicotine exposure, discomfort/dysfunction, other health-related behaviors…
- Trial name
- NCT02301325
- Testing
- Smoking research cigarettes with or without NRT
- Where
- United States
- Volunteers
- 240 people
- Sponsor
- Wake Forest University Health Sciences
Smoking, Tobacco Use
CSD201202: A Study to Assess Nicotine Uptake From Electronic Nicotine Delivery System P12
This is an open-label, randomized, 8-way crossover study designed to evaluate plasma nicotine pharmacokinetic (PK) parameters following an ad libitum use of Electronic Nicotine Delivery System (ENDS) investigational products…
- Trial name
- NCT05239884
- Testing
- ENDS Product A with 1.5% nicotine, ENDS Product B with 1.5% nicotine, ENDS Product C with 1.5% nicotine
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- RAI Services Company
Bladder Cancer, Cervical Cancer
Counseling and Nicotine Replacement Therapy in Helping Adult Smokers Quit Smoking
RATIONALE: Stop-smoking plans, including counseling and nicotine replacement therapy, may help smokers quit smoking. It is not yet known whether counseling and the nicotine lozenge is more effective than counseling and the…
- Conditions
- Bladder Cancer, Cervical Cancer, Esophageal Cancer, Gastric Cancer
- Trial name
- NCT00365508
- Testing
- nicotine lozenge, nicotine patch
- Where
- 10 sites in United States
- Volunteers
- 642 people
- Sponsor
- Fox Chase Cancer Center
COPD, Respiratory Symptoms
Expansion of the COPD At-risk Module in 4 States BRFSS Telephone Health Surveys
This cross-sectional survey study is intended to describe the characteristics of adults in 4 US states with regards to respiratory symptoms and tobacco exposure, utilizing an existing state-administered, CDC overseen Behavioral…
- Conditions
- COPD, Respiratory Symptoms, Tobacco Use, Asthma
- Trial name
- NCT02991391
- Testing
- None, use of a questionnaire
- Volunteers
- 40,690 people, healthy volunteers welcome
- Sponsor
- Duke University
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