Clinical trials: Tobacco Smoking
Substance Withdrawal Syndrome, Nicotine Dependence
Electronic Cigarettes in Daily Dependent Smokers
The aim of this study is to measure nicotine cue- and withdrawal-induced craving in current smokers under four distinct conditions: after smoking a conventional cigarette, an electronic cigarette (e-Cigarette) containing…
- Trial name
- NCT02108626
- Testing
- Nicotine
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- Centre for Addiction and Mental Health
Smoking, Smoking Cessation
Centralized Telephone Outreach to Assist Smoking Cessation Among Veterans
Smoking cessation interventions including behavioral and pharmacological components have been demonstrated to be both effective and cost-effective.
- Trial name
- NCT00012948
- Testing
- Telephone Care
- Where
- United States
- Volunteers
- 800 people
- Sponsor
- US Department of Veterans Affairs
Smoking Cessation
A Smoking Cessation Intervention for Yale Dining Employees
The purpose of this study is to evaluate a smoking cessation program for employees at the Yale University dining hall. Two pilot dining halls and six paired dining halls (3 test and 3 control sites) will be offered a contingency…
- Trial name
- NCT02562521
- Testing
- Contingency management, Nicotine replacement therapy, Varenicline
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Yale University
Nicotine Dependence, Major Depressive Disorder
Behavioral Activation and Varenicline for Smoking Cessation in Depressed Smokers
Persons who struggle with depression smoke at high rates and experience low quit rates in treatment. The best way to improve cessation treatment for this underserved population remains unknown.
- Trial name
- NCT02378714
- Testing
- Varenicline, BASC, Standard treatment
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Northwestern University
Smoking
Metabolism Informed Smoking Treatment: The MIST RCT
This phase 3 randomized controlled trial will test Metabolism-Informed Smoking Treatment (MIST), a precision approach to smoking treatment that biologically tailors medication selection to nicotine metabolism.
- Trial name
- NCT04590404
- Testing
- Post-discharge automated phone calls (IVR) with option to connect with a tobacco coach., Nicotine Replacement Therapy, Varenicline
- Where
- United States
- Volunteers
- 606 people
- Sponsor
- Vanderbilt-Ingram Cancer Center
Subjects at High Risk of Lung Cancer Due to Smoking
Continuous Observation of Smoking Subject
The purpose of this study is to offer annual low-dose spiral CT radiological examination for 5 years to 5000 volunteers from the general population who are considered to be at high risk of developing lung cancer.
- Trial name
- COSMOS (NCT01248806)
- Testing
- Low dose CT scan
- Where
- Italy
- Volunteers
- 5,203 people
- Sponsor
- European Institute of Oncology
Smoking
Nicotine Pharmacokinetic Profile and Safety of the Tobacco Heating System 2.2 Menthol (THS 2.2 Menthol).
The primary objective of this clinical study is to evaluate the pharmacokinetic (PK) profile (rate and amount of nicotine absorbed) following a single use of the THS 2.2 Menthol (mTHS), a candidate Modified Risk Tobacco Product…
- Trial name
- NCT01967706
- Testing
- mTHS, mCC, NRT
- Where
- Japan
- Volunteers
- 73 people, healthy volunteers welcome
- Sponsor
- Philip Morris Products S.A.
Tobacco Use
Address Tobacco Use Among Adolescents in Hong Kong
This study will examine the effectiveness of a social norms campaign in correcting smoking misperceptions, reducing smoking susceptibility and changing smoking-related behaviours in Hong Kong adolescents.
- Trial name
- NCT03264144
- Testing
- Social norms campaign
- Where
- Hong Kong
- Volunteers
- 12,868 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Tobacco Use and Smoking Behavior
Controlled Trial to Reduce Secondhand Smoke Exposure at Homes in Armenia
This study was designed to test the hypothesis whether a novel intervention that uses motivational interviewing along with immediate feedback and follow-up counseling calls is effective in educating the household members about…
- Trial name
- NCT01630356
- Testing
- in-person counseling, Demonstration of PM2.5 Pollution, Follow-up Counseling Calls
- Where
- Armenia
- Volunteers
- 250 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Cigarette Smoking, Marijuana Abuse
Mobile Contingency Management for Marijuana and Tobacco Cessation
The purpose of this pilot project is to pilot-test a combined cannabis and smoking cessation treatment. The intervention combines mobile technology with behavioral strategies, counseling, and medications.
- Trial name
- NCT02869451
- Testing
- bupropion, transdermal nicotine patch, Nicotine polacrilex
- Where
- United States
- Volunteers
- 7 people
- Sponsor
- Duke University
Acute Coronary Syndrome, Cardiovascular Diseases
Aggressive Smoking Cessation Trial (ASAP)
The ASAP Trial is a 5-year, multi-centre, randomized controlled trial that will assess the efficacy, safety, and tolerability of aggressive smoking cessation therapy among people at elevated cardiovascular risk.
- Trial name
- ASAP (NCT05257629)
- Testing
- Combination Therapy Arm (Varenicline and Nicotine E-Cigarettes Plus Counseling), Varenicline Plus Counseling
- Where
- 13 sites in Canada
- Volunteers
- 798 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital
Smoking Cessation
Simple Physical Exercise With Instant Messaging Support for Smoking Via "Quit to Win" Contest 2022 (QTW2022)
This project aims to test the effectiveness of an integrated intervention of brief cessation advice (AWARD) and simple physical exercise with Instant Messaging (IM) support compared with control participants among current smokers…
- Trial name
- NCT05430451
- Testing
- AWARD advice, Referral card, Self-help smoking cessation booklet
- Where
- China
- Volunteers
- 1,031 people
- Sponsor
- The University of Hong Kong
Tobacco Use Cessation, Tobacco Use Disorder
Effectiveness of Bupropion for Treating Nicotine Dependence in Young People
Little is known about the best ways to help young people stop smoking. Bupropion (a medication marketed as Wellbutrin or Zyban) has proved helpful in treating adult smokers.
- Trial name
- NCT00129272
- Testing
- Bupropion-SR
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoking Cessation, Lifestyle, Healthy
Community-Centered eHealth Smoking Cessation Intervention(CCeSCI)
Recent findings regarding why Chinese male smokers are reluctant to quit have offered insight for a possible new solution. Consistent with the Cognitive Dissonance Theory, "smoking rationalization beliefs" are a set of beliefs by…
- Trial name
- NCT05508672
- Testing
- Community-Centered eHealth Smoking Cessation Intervention (CCeSCI), Traditional "smoking is harmful" education
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Duke Kunshan University
Underage Alcohol Use, Smoking, Non-Tobacco Products
Culturally Enhancing a Motivational Interviewing Intervention For Latinx Adolescents
The purpose of this study is to compare two versions of an intervention focused on teaching 10-14-year-old Latina/o adolescent's skills that will decrease the likelihood that they will use tobacco, alcohol, and other drugs.
- Trial name
- NCT03947177
- Testing
- GMIT, GMIT+
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Schizophrenia, Tobacco Use Disorder
Effect of Bupropion on Smoking Behavior in Smokers With Schizophrenia
Many individuals with schizophrenia smoke cigarettes but little is known about the factors that control smoking in people with schizophrenia.
- Trial name
- NCT00218231
- Testing
- 300 mg/day bupropion-sr, 0 mg/day bupropion-sr
- Where
- 2 sites in United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoking
Researching the Youth Smoking Experience
The primary hypothesis of this pilot study is that dependence can be prevented in adolescents who smoke, but who are not yet dependent.
- Trial name
- NCT00156702
- Testing
- Feedback and Motivational Interviewing, Smoking Prevention Video
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Virginia Commonwealth University
Cigarette Smoking
Analysis of Lipid Biomarkers of Exposure and Host Response
The purpose of this prospective, open-label, clinical trial is to establish the feasibility and validity of exhaled breath condensate (EBC) biomarkers for use in studies designed to evaluate harm reduction strategies of smoking.
- Trial name
- NCT00493831
- Testing
- nicotine polacrilex, transdermal system or inhaler
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Nebraska
Obesity, Smoking Cessation
Addressing Post Cessation Weight Gain
Some individuals smoke with the perception that smoking helps control body weight. Smokers gain an average of as much as 10 pounds in the months following smoking abstinence, with heavier and more-dependent smokers gaining more…
- Trial name
- NCT02412631
- Testing
- lorcaserin, Varenicline
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Sex, Cigarette Smoking
Mapping Brain Glutamate in Humans: Sex Differences in Cigarette Smokers
The proposed study evaluated sex differences in glutamate (Glu), with a focus on the dorsal anterior cingulate cortex (dACC), anterior insula, and thalamus, as well as how it is influenced by sex (males vs.
- Trial name
- NCT05279053
- Testing
- Abstinence and Smoking
- Where
- United States
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
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