Clinical trials: Tobacco Smoking
Nicotine Addiction
Neural Mechanisms Associated With Risk of Smoking Relapse
This study will examine how abstinence-induced brain changes contribute to smoking cessation outcomes in treatment-seeking smokers.
- Trial name
- NCT02837510
- Testing
- Standard smoking cessation counseling
- Where
- United States
- Volunteers
- 119 people
- Sponsor
- University of Pennsylvania
Smoking Cessation
Internet-Based Smoking Cessation for Operations Enduring Freedom and Iraqi Freedom (OEF/OIF) Veterans
The overarching aim of the study is to evaluate in a randomized trial the impact of an internet intervention compared to a standard clinic-based control group to promote smoking cessation among Operation Enduring Freedom and…
- Trial name
- NCT01001546
- Testing
- Internet-based, Standard Clinic-Based
- Where
- United States
- Volunteers
- 413 people
- Sponsor
- US Department of Veterans Affairs
Nicotine Dependence, Nicotine Addiction
A Smartphone Application (ACT on Vaping) for Vaping Cessation in Young Adults
Almost one in ten young adults report current e-cigarette use, putting them at risk of developing nicotine addiction and long-term health effects of exposure to inhaled toxicants.
- Conditions
- Nicotine Dependence, Nicotine Addiction, Nicotine Use Disorder, Nicotine Vaping
- Trial name
- NCT05897242
- Testing
- Smartphone app, Text Message, Survey Administration
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Smoking, Nicotine Dependence
Placebo-controlled Trial of Bupropion for Smoking Cessation in Pregnant Women
Smoking during pregnancy adversely affects the health of the mother and her developing baby. Maternal smoking approximately doubles the risk of miscarriage, placental complications, preterm delivery, low birth weight and fetal…
- Trial name
- BIBS (NCT02188459)
- Testing
- Bupropion
- Where
- 3 sites in United States
- Volunteers
- 129 people
- Sponsor
- Henry Kranzler
Tobacco Use, Tobacco Smoking
Tobacco Cessation at FDNY
At the Fire Department of the City of New York (FDNY) World Trade Center Health Program, 36% of participants in the low dose computed tomography (LDCT) lung cancer screening program are current smokers, despite referral to the…
- Conditions
- Tobacco Use, Tobacco Smoking, Tobacco Use Cessation
- Trial name
- NCT05997225
- Testing
- opt out enrollment, tailored counseling, varenicline started prior to target quit date, opt in enrollment, non-tailored counseling, varenicline started prior to target quit date
- Where
- United States
- Volunteers
- 23 people, healthy volunteers welcome
- Sponsor
- Albert Einstein College of Medicine
Tobacco Use Disorder, Nicotine Addiction
Cognitive Training for Nicotine Dependence
This randomized clinical trial tested the effects of a computerized (web-based) cognitive training intervention on smoking cessation.
- Trial name
- NCT01252966
- Testing
- Cognitive Training, Control training
- Where
- United States
- Volunteers
- 213 people
- Sponsor
- University of Pennsylvania
Smoking
Modeling Stress-precipitated Smoking Behavior for Medication Development
The purpose of this study is to examine whether guanfacine will attenuate the ability of stress to precipitate smoking lapse behavior in treatment seeking and non-treatment seeking daily smokers.
- Trial name
- NCT00773357
- Testing
- guanfacine
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Yale University
Smoking Cessation
Smoking Cessation in Subjects With Mild-to-moderate Chronic Obstructive Pulmonary Disease (COPD).
This study is to be conducted in subjects with mild-to-moderate COPD who are cigarette smokers with the intent of demonstrating differences in smoking cessation between varenicline and placebo.
- Trial name
- NCT00285012
- Testing
- Varenicline Tartarate
- Where
- 32 sites in United States, France and 2 more
- Volunteers
- 504 people
- Sponsor
- Pfizer
Smoking Cessation
A Pharmacokinetic and Pharmacodynamic Evaluation of Cytisine in Healthy Smokers
The primary objectives of this study are: To evaluate the pharmacokinetic (PK) parameters during repeat dosing of 1.5 mg or 3.0 mg cytisine when administered as the commercial 25-day schedule.
- Trial name
- NCT03303911
- Testing
- Cytisine
- Where
- United Kingdom
- Volunteers
- 26 people
- Sponsor
- Achieve Life Sciences
Smoking
A Pharmacokinetic Evaluation of Two Nicotine Patches in Smokers
Bioequivalence study to confirm that a NTS with a polyisobutylene (PIB) adhesive from an alternative supplier delivers the same nicotine blood profile as that of the currently approved NTS with a polyisobutylene adhesive from the…
- Trial name
- NCT01702519
- Testing
- nicotine
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Smoking Cessation
Automated Mobile Contingency Management for Smoking Cessation: A Pilot RCT (SCC PREVAILgo)
The purpose of the proposed project is to pilot test an automated mobile phone-based contingency management (CM) approach to tobacco (smoking) cessation.
- Trial name
- NCT03739437
- Testing
- Mobile Contingency Management, Standard Care
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Oklahoma
Nicotine Dependence
Smoking While on Transdermal Nicotine Replacement Therapy: Effects on Craving and Cessation
Smoking while on nicotine patches will help subjects to reduce their expired carbon monoxide levels from the levels they were before they started using the patch. Subjects will also decrease their daily consumption of cigarettes.
- Trial name
- NCT00289653
- Testing
- Nicoderm
- Where
- Canada
- Volunteers
- 23 people
- Sponsor
- Centre for Addiction and Mental Health
Diabetes Mellitus, Cigarette Smoking
The Effectiveness of Smoking Cessation in Prediabetic Smokers
Existing literature investigating the impact of smoking cessation on new-onset diabetes mellitus (DM) risk is conflicting. Combing the need for smoking cessation and body weight self-management to prevent the progression of…
- Conditions
- Diabetes Mellitus, Cigarette Smoking, Prediabetes
- Trial name
- NCT01926041
- Testing
- Varenicline for tobacco smoking cessation, Individualized counseling about both smoking cessation and weight control techniques
- Where
- Taiwan
- Volunteers
- 589 people
- Sponsor
- National Taiwan University Hospital
Cardiovascular Disease (CVD), Hypertension
Veteran Peer Coaches Optimizing and Advancing Cardiac Health
The purpose of this study is to test if having a Veteran peer health coach will improve blood pressure control among Veterans with high blood pressure and at least one other Cardiovascular disease (CVD) risk factor.
- Conditions
- Cardiovascular Disease (CVD), Hypertension, Hyperlipemia, Obesity
- Trial name
- Vet-COACH (NCT02697422)
- Testing
- Community-based peer health coach intervention
- Where
- United States
- Volunteers
- 264 people
- Sponsor
- VA Office of Research and Development
Smoking Cessation, Nicotine Dependence
Varenicline and Motivational Advice for Smokers With Substance Use Disorders
The purpose of this study is to evaluate the effects of 12 weeks of varenicline as compared to nicotine replacement therapy for smoking cessation among outpatients in treatment for substance use disorders.
- Trial name
- VARSUD (NCT00756275)
- Testing
- Nicotine Replacement Treatment (NRT), varenicline, Behavioral counseling for smoking cessation
- Where
- United States
- Volunteers
- 158 people
- Sponsor
- Brown University
Chronic Pancreatitis, Genetic Mutation
An Observational Study on the Natural Course of Chronic Pancreatitis
To explore the impact on genetic and environmental factors for clinical manifestation, and the progression of chronic pancreatitis, including development of pancreatic insufficiency and other complications.
- Conditions
- Chronic Pancreatitis, Genetic Mutation, Smoking, Tobacco, Drinking, Alcohol
- Trial name
- NCT04574297
- Testing
- smoking and alcohol assumption, genetic sequencing
- Volunteers
- 798 people
- Sponsor
- Changhai Hospital
Behavior
Effects of Smoking State on Decision Making
Adult smokers will be tested using behavioral and neuroimaging measures after smoking as usual and after overnight abstinence.
- Trial name
- Effort (NCT04826276)
- Testing
- smoking abstinence, smoking satiety
- Where
- United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Smoking Cessation
Smartband Mindfulness Study
To determine treatment fidelity for a smartband/smartphone-based smoking monitoring, notification and brief mindfulness intervention.
- Trial name
- NCT03995225
- Testing
- Smartband automatic smoking detection combined with brief mindfulness interventions
- Where
- United States
- Volunteers
- 155 people, healthy volunteers welcome
- Sponsor
- Yale University
Smoking Cessation
Informing Tobacco Treatment Guidelines for African American Non-Daily Smokers
The researchers are testing if counseling alone or counseling plus over-the-counter nicotine replacement therapies (NRT), like the patch,gum, or lozenge, helps African American non-daily smokers quit smoking.
- Trial name
- NCT02244918
- Testing
- Nicotine Replacement Therapy, Smoking Cessation Counseling
- Where
- 2 sites in United States
- Volunteers
- 278 people, healthy volunteers welcome
- Sponsor
- University of Kansas Medical Center
Smoking Cessation
PATH Partnering to Achieve Tobacco-free Health
The overall aim of this 5-year project is to capitalize on the strong theoretical and promising empirical evidence for Acceptance \& Commitment Therapy (ACT) as an intervention for smoking cessation by comparing the effectiveness…
- Trial name
- PATH (NCT01533974)
- Testing
- Acceptance & Commitment Therapy (ACT), Cognitive Behavioral Therapy (CBT)
- Where
- United States
- Volunteers
- 450 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center