Clinical trials: Tobacco Smoking
Tobacco Prevention and Cessation
Incentive-based Intervention for Smoking Cessation and Prevention in High Schools
The purpose of this study is to design an incentive-based intervention to motivate a tobacco-free lifestyle among high school students and to pilot the intervention in the first academic year in two schools (CT and NY) and…
- Trial name
- Rise Above (NCT01173835)
- Testing
- Incentives for being tobacco free
- Where
- United States
- Volunteers
- 1,651 people, healthy volunteers welcome
- Sponsor
- Yale University
Tobacco Dependence
Bioequivalence Between Two New Oral Nicotine Replacement Therapy Products and Nicorette® Microtab
The purpose of this study is to assess the bioequivalence between two new oral nicotine replacement therapy products and Nicorette® microtab.
- Trial name
- NCT01238640
- Testing
- Code STD, Code STE, Nicorette Microtab
- Where
- Sweden
- Volunteers
- 84 people
- Sponsor
- McNeil AB
Lung Cancer
Genetic Epidemiology of Lung Cancer and Smoking
We will conduct an interdisciplinary case-control/sib-pair study of lung cancer designed to explore the genetic determinants both of lung cancer and of smoking.
- Trial name
- NCT00340340
- Where
- 18 sites in Italy
- Volunteers
- 4,429 people
- Sponsor
- National Cancer Institute (NCI)
Tobacco Cessation, Smoking Cessation
Effectiveness of Oral Nicotine Pouches as a Cessation Tool Among Adult Tobacco Users in Pakistan
Smoking remains a major public health challenge in Pakistan, where many adult smokers have limited access to effective smoking cessation support.
- Trial name
- NCT07785479
- Testing
- Velo 6 mg Oral Nicotine Pouches, Motivational Counselling
- Where
- Pakistan
- Volunteers
- 148 people
- Sponsor
- Cyntax Health Projects PVT LTD
Tobacco Use Disorder
Low Nicotine Content Cigarettes in Vulnerable Populations: Affective Disorders
While the prevalence of smoking in the United States general population has declined over the past 50 years, there has been little to no decline among people with mental health conditions.
- Trial name
- NCT04090879
- Testing
- Either normal nicotine content cigarettes (15.8mg/g) or reduced nicotine content cigarettes (0.4mg/g), E-Cigarettes
- Where
- 2 sites in United States
- Volunteers
- 326 people, healthy volunteers welcome
- Sponsor
- Brown University
Smoking Cessation
Using a General Health Promotion Approach to Help Smokers With Chronic Diseases Quit
This study aims to evaluate the effectiveness of a general health promotion (GHP) approach to motivate smokers with chronic diseases to quit smoking.
- Trial name
- NCT04037696
- Testing
- General Health Promotion Approach, Control
- Where
- Hong Kong
- Volunteers
- 720 people
- Sponsor
- The University of Hong Kong
Nicotine Vaping
Kick-Nic! Youth Quit Vaping App
High school and middle school students who want to quit vaping will be randomized to receive the Kick-Nic! app or a control NCI website to determine the efficacy of the app for vaping cessation.
- Trial name
- NCT06662305
- Testing
- Kick-Nic! mobile phone application, NCI Quit Vaping website
- Where
- United States
- Volunteers
- 306 people, healthy volunteers welcome
- Sponsor
- Yale University
Tobacco Dependence
Early Withdrawal Exposure and Negative Affect Withdrawal (NAW) Regulation Training for Smoking Cessation
Smoking remains the single most preventable cause of morbidity and mortality in the United States, accounting for approximately half a million deaths every year.
- Trial name
- NCT03912194
- Testing
- cognitive-behavioral withdrawal regulation strategies, relaxation strategies, early withdrawal exposure
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Cigarette Smoking Toxicity
Smoking Topography and Harm Exposure in Menthol Cigarettes
This study will examine how menthol affects smoking when menthol smokers switch to non-menthol cigarettes. Participants will smoke their preferred brand (control) or Camel Crush cigarettes, which have the ability to be menthol or…
- Trial name
- MQAT (NCT01329263)
- Testing
- Menthol to non-menthol
- Where
- United States
- Volunteers
- 87 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Cancer, Myocardial Infarction
Early Smoking Reduction or Cessation by Means of no Nicotine Electronic Cigarette Added to Standard Counselling.
The aim of this study is the evaluation of early smoking reduction or cessation by means of no nicotine electronic cigarette added to standard counselling.
- Trial name
- NCT01733706
- Testing
- No nicotine electronic cigarette, Standard counseling
- Where
- 2 sites in Italy
- Volunteers
- 75 people
- Sponsor
- European Institute of Oncology
Obesity, Smoking Cessation
Gut Hormones in Obesity, Nicotine and Alcohol Dependence
The "Gut Hormones in Addiction" study is a proof-of-concept experimental medicine human study to answer the following questions: 1.
- Conditions
- Obesity, Smoking Cessation, Alcoholism
- Trial name
- GHADD (NCT02690987)
- Testing
- Exenatide, Desacyl ghrelin, Saline
- Where
- United Kingdom
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Smoking, Lung Cancer
Centralized Lung Cancer EARly Detection Among Smokers (CLEAR Study)
This trial studies how well a centralized care strategy works in improving the quality of smoking cessation and shared decision making among patients who smoke and are considering lung cancer screening.
- Trial name
- NCT04200534
- Testing
- Best Practice, Nicotine Patch, Quality-of-Life Assessment
- Where
- 3 sites in United States
- Volunteers
- 358 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Healthy Smokers
Pilot Pharmacokinetic Study of New Nicotine Lozenge Formulations
The purpose of this study is to determine the pharmacokinetic profile of nicotine following a single oral administration of three new nicotine lozenge formulations (V0474) in comparison with two reference products.
- Trial name
- NCT01574898
- Testing
- V0474 - A mg, V0474 - B mg, V0474 - C mg
- Where
- France
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- Pierre Fabre Medicament
Smoking Cessation
Cumulative Skin Irritation Potential of a New 15 mg Nicotine Patch
An investigation on the cumulative skin irritation potential of a newly developed 15 mg nicotine patch. Evaluation of skin irritation of a newly developed 15 mg nicotine transdermal patch.
- Trial name
- NCT00965913
- Testing
- Nicotine Patch, Nicotine Patch Comparator
- Where
- Germany
- Volunteers
- 42 people
- Sponsor
- McNeil AB
Smoking Cessation, Smoking Behaviors
Varenicline Light Smoking Pilot
The goal of this study is to assess varenicline vs. placebo for its effect on decreasing cue reactivity in light and intermittent smokers.
- Conditions
- Smoking Cessation, Smoking Behaviors, Smoking
- Trial name
- NCT04089982
- Testing
- Varenicline
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Duke University
Vaping
Responses to E-cigarette Message Source and Presentation
The goal of this clinical trial is to use crowdsourcing to test the effects of a message source (expert and peer) and message presentation types (one-sided and two-sided) to identify the optimal message type for young adults who…
- Trial name
- NCT06274723
- Testing
- Expert, one-sided, Expert, two-sided, Peer, one-sided
- Where
- United States
- Volunteers
- 848 people, healthy volunteers welcome
- Sponsor
- University of Massachusetts, Worcester
Smoking, Overweight
Pilot-Testing a Family-Based Intervention to Improve Child Outcomes and Increase Family Activity
The purpose of this study is to examine the feasibility and acceptability of a family-based program to improve physical activity and tobacco outcomes in a small pilot of middle school students and their families.
- Conditions
- Smoking, Overweight, Obesity
- Trial name
- HFDC (NCT01969760)
- Testing
- Healthy Families DC Program
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Cassandra Stanton, PhD
Chronic Obstructive Pulmonary Disease, Chronic Bronchitis
Pulmonary and Cardiac Effects of E-Cigarette Use in Pulmonary Patients Who Smoke Cigarettes
The purpose of this study is to compare the effects of e-cigarettes and continued smoking on pulmonary and cardiac outcomes in a population with established pulmonary disease.
- Conditions
- Chronic Obstructive Pulmonary Disease, Chronic Bronchitis, Emphysema, Asthma-COPD Overlap Syndrome
- Trial name
- NCT05610514
- Testing
- E-Cigarette, Financial Incentives
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- University of Vermont
Sexual Behavior, Alcohol Drinking
Adolescent Safer Sex Social Network Intervention
Social networks are thought to hold the potential for shaping behavior on the grounds that social and situational factors more strongly influence behavior than do personality variables.
- Conditions
- Sexual Behavior, Alcohol Drinking, Marijuana Smoking
- Trial name
- NCT00107562
- Testing
- Adolescent Safer Sex Social Network Intervention
- Where
- 2 sites in United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Smoking Cessation, Vaping
Concentration Impact Nicotine Salt
Double-blind (for the two active arms), randomized, three-arm (two active and one control) clinical trial investigating factors (e.g.
- Trial name
- CINS (NCT04725656)
- Testing
- Smoking cessation counseling, Open system vape device and nicotine salt e-liquids
- Where
- Switzerland
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
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