Clinical trials: Tobacco Use Disorder
Tobacco Dependence
Tobacco Intervention in Buprenorphine Treatment
Drug addiction treatment patients, including those in treatment for opioid dependence, have a high rate of tobacco dependence, especially cigarette smoking.
- Trial name
- IBIS (NCT01350011)
- Testing
- Innovative System, Standard Treatment Control (STC)
- Where
- United States
- Volunteers
- 175 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Smoking
Genetic Differences in Limbic Activation Associated With Nicotine Withdrawal
Objectives: To evaluate neural correlates associated with emotional processing during nicotine withdrawal preferentially involving the amygdala and associated areas within the corticolimbic and mesolimbic circuitry.
- Trial name
- NCT00664404
- Testing
- Functional Magnetic Resonance Imaging (fMRI)
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center
Periodontitis (Stage 3), Smoking ( Cigarette)
Salivary TNF-α, FoxO-1, and SIRT-1 Levels in Periodontitis and Smoking
This study examines whether smoking and gum disease (periodontitis) are linked to changes in three biological markers found in saliva: TNF-α, FoxO-1, and SIRT-1.
- Trial name
- NCT07764549
- Testing
- Salivary Biomarker Analysis (ELISA)
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Zehra Hasgül
Tobacco Use Disorder
Smoking Cessation Behavioral Treatment Study
The purpose of this study is to evaluate the effectiveness of two behavioral interventions on smoking behavior - Mindfulness-Oriented Recovery Enhancement (MORE) and Cognitive Behavioral Therapy (CBT).
- Trial name
- NCT03948893
- Testing
- Mindfulness-Oriented Recovery Enhancement (MORE), Cognitive Behavioral Therapy (CBT)
- Where
- 2 sites in United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Missouri-Columbia
Smoking, Tobacco, Vaping
Investigating Exposure to Toxicants From Smoking and Vaping
Background: Many people who smoke use vaping products to help them quit. Levels of toxicants in urine samples are substantially lower in those who exclusively vape compared to those who smoke, suggesting that vaping poses only a…
- Conditions
- Smoking, Tobacco, Vaping, Mental Health Disorder
- Trial name
- NCT05953220
- Testing
- Exclusive tobacco smoking, Exclusive e-cigarette use, Dual use of e-cigarettes and tobacco smoking
- Where
- United Kingdom
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- King's College London
Marijuana Smoking, Cannabis
Study on Regulated Cannabis Sales in Pharmacies
Though regulated cannabis sales are increasing, little is known about the individual health effects of cannabis regulation. Data from countries with a regulated market can be used to test the effect of regulation on the price of…
- Conditions
- Marijuana Smoking, Cannabis, Cannabis Use
- Trial name
- SCRIPT (NCT06120855)
- Testing
- Regulated cannabis from authorized pharmacies, Cannabis from the illicit market
- Where
- 2 sites in Switzerland
- Volunteers
- 1,177 people, healthy volunteers welcome
- Sponsor
- University of Bern
Cardiovascular Health, Self-management
MECA Clinical Intervention ( MECA Health360x)
The purpose of this research is to test whether a technology application(Health360x) that lets participants set goals for better health and track health can help participants reduce their heart disease risk.
- Trial name
- MECAH360x (NCT04791618)
- Testing
- Health360x plus health coach, Health360x only (High tech)
- Where
- 2 sites in United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Morehouse School of Medicine
Nicotine Dependence, E-Cig Use
Research and Innovation to Stop E-cigarette/Vaping in Young Adults
The aim of this study is to test intervention components to help young adults quit vaping. A 2x2 factorial design will be used where all participants receive quitline-delivered behavioral phone counseling, and components to be…
- Trial name
- (RISE) (NCT04974580)
- Testing
- Nicotine patch, Phone Counseling, Digital Coaching
- Where
- United States
- Volunteers
- 508 people, healthy volunteers welcome
- Sponsor
- Ohio State University
Smoking, Cigarette
Smoking and Peptidoglycan Recognition Protein-1 and Initial Periodontal Therapy
A total of 40 patients with CP (20 smokers (S+CP) and 20 nonsmokers (S-CP)) and 40 periodontally healthy subjects (20 smokers (S+PH) and 20 nonsmokers (S-PH)), comprising 80 subjects, were included in this study.
- Trial name
- NCT03915730
- Testing
- Initial periodontal therapy
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Kırıkkale University
Nicotine Dependence
Do Flavors Increase the Addiction Potential of Nicotine?
The FDA has concluded that flavors (e.g. menthol) are associated with greater addiction potential in tobacco cigarettes (Gottlieb March 13, 2019).
- Trial name
- NCT04696380
- Testing
- Nicotine, JUUL e-cigarette
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of Vermont
Tobacco Use Disorder
Acute Effects of Smoking on Airway Dendritic Cells
Airway dendritic cells control pulmonary immune responses to inhaled particles. It is the aim of the present study to investigate the acute effects of smoking on the number and surface molecule expression of human airway…
- Trial name
- NCT00740896
- Testing
- Smoking
- Where
- Germany
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Rostock
Tobacco Dependence
Use of Nicotine Pouches Among Daily Smokers
The purpose of this clinical trial is to understand the health effects of a new oral nicotine pouch, and also to understand if this product can help reduce traditional cigarette smoking. The main aims are: 1.
- Trial name
- NCT06043362
- Testing
- 0 mg nicotine pouch, 3 mg nicotine pouch, 6 mg nicotine pouch
- Where
- 2 sites in United States
- Volunteers
- 375 people, healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Tobacco Use Disorder
Social and Monetary Incentives for Smoking Cessation at Large Employers
The investigators will conduct a cluster randomized controlled trial of several behavioral interventions for smoking cessation among a sample of employees at large workplaces in the Bangkok metropolitan area.
- Trial name
- SMILE (NCT02421224)
- Testing
- Usual Care, Deposits, Small Individual Bonus
- Where
- Thailand
- Volunteers
- 4,190 people, healthy volunteers welcome
- Sponsor
- University of California, Berkeley
Tobacco Use Disorder, Schizophrenia
Nicotine and Sensorimotor Replacement for Smoking in Smokers With Schizophrenia
The objective of this study is to investigate the relative contributions of nicotine replacement and sensorimotor replacement (i.e., smoking denicotinized cigarettes) on abstinence-induced smoking urges, withdrawal-related…
- Trial name
- NCT01213524
- Testing
- sensorimotor replacement, 42 mg transdermal nicotine replacement, usual brand smoking
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Brown University
Nicotine Dependence, Cigarette Smoking
Lemongrass (Cymbopogon Citratus) on Nicotine Dependence, Cotinine Levels, and Related Biomarkers in Adult Smokers
The goal of this clinical trial is to learn whether lemongrass (Cymbopogon citratus) inhaler and liquid vapor interventions affect nicotine dependence and related biological and behavioral outcomes in adult smokers.
- Conditions
- Nicotine Dependence, Cigarette Smoking, Tobacco Use Disorder, Psychological Stress
- Trial name
- CCIVS (NCT07366294)
- Testing
- Lemongrass Inhaler, Lemongrass Liquid Vapor, Lemongrass Inhaler and Liquid Vapor
- Where
- Indonesia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Titin Andri Wihastuti
Tobacco Use, Periodontitis
Snuff Use, Smoking, Periodontitis and Mortality: 30-year Cohort Study From Sweden
Smoking and dual using associated with poor periodontal health.
- Trial name
- NCT03918902
- Testing
- Qestinnaires
- Volunteers
- 1,080 people, healthy volunteers welcome
- Sponsor
- University of Helsinki
Smoking Cessation
Enhancing Relapse Prevention for Smoking Cessation With Repetitive Transcranial Magnetic Stimulation
Tobacco use is one of the most significant cancer control and public health challenges in the US today. Half of all smokers in the US will attempt to quit tobacco each year, but fully 95% of those who attempt to quit will reverse…
- Trial name
- rTMS (NCT02822703)
- Testing
- rTMS Active 20Hz
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- The City College of New York
Smoking Cessation, Tobacco Use Disorder
Efficacy and Safety of Combination EMB-001 as a Potential Smoking Cessation Treatment
This open-label study will evaluate EMB-001, comprised of metyrapone, a cortisol synthesis inhibitor marketed as a diagnostic drug for testing hypothalamic-pituitary-adrenal (HPA) axis function, combined with oxazepam, an…
- Trial name
- NCT04868253
- Testing
- EMB-01
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Tobacco Use Cessation
Low-Cost Contingency Management for Smoking Cessation
An innovative low-cost form of contingency management has been developed in which participants receive the chance to draw vouchers from a fish bowl depending on whether or not their abstinence from tobacco is confirmed by…
- Trial name
- NCT01040260
- Testing
- Counseling, Contingency management, Nicotine patches
- Where
- United States
- Volunteers
- 103 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Lung Cancer, Smoking Cessation
PCORI-CER-1306-03385 Informed Decisions About Lung Cancer Screening
Educational research study where goal is to test educational materials that help people make informed decisions about lung cancer screening.
- Conditions
- Lung Cancer, Smoking Cessation, Tobacco Use Cessation
- Trial name
- NCT02286713
- Testing
- Patient Decision Aid, Standard Educational Information, Follow-Up Assessments: Questionnaires
- Where
- United States
- Volunteers
- 516 people, healthy volunteers welcome
- Sponsor
- M.D. Anderson Cancer Center