Clinical trials: Tobacco-Related Disorders
Smoking Cessation, Marijuana Use
Project CheckUP: A Brief Behavioral Intervention for Quitline Callers Who Use Marijuana (MJ) and Tobacco
Smoking cigarettes remains the number one preventable cause of death and disease in the US. Smokers who call tobacco quitlines and use marijuana struggle to quit tobacco due to the interactive effects of nicotine and marijuana.
- Trial name
- NCT04737772
- Testing
- Behavioral: Quitline treatment as usual, QL Marijuana Check-Up intervention (QL-MJCU)
- Where
- United States
- Volunteers
- 107 people, healthy volunteers welcome
- Sponsor
- Consumer Wellness Solutions
Tobacco Dependence
Pharmacokinetics With Two New Oral Nicotine Replacement Products and Nicorette® Gum
Single-dose pharmacokinetics with two new oral nicotine replacement products and Nicorette® gum.
- Trial name
- NCT01152723
- Testing
- Nicotine
- Where
- Sweden
- Volunteers
- 28 people
- Sponsor
- McNeil AB
Tobacco Dependence
Pharmacokinetics With a New Oral Nicotine Replacement Product and Nicorette® Gum
Single-dose pharmacokinetics with a new oral nicotine replacement product and Nicorette® gum.
- Trial name
- NCT01152736
- Testing
- Nicotine
- Where
- Sweden
- Volunteers
- 19 people
- Sponsor
- McNeil AB
Tobacco Use Disorder
A Bioequivalence Study of Two Nicotine Lozenges in Fasting Conditions in Healthy Smokers
This study will assess the bioequivalence of the test product (Nicotine Prototype Mini lozenge 2 milligrams [mg]) to a commercial reference product (nicotine polacrilex mini lozenge 2 mg) in healthy smokers under fasting…
- Trial name
- NCT03541044
- Testing
- Nicotine Prototype Mini lozenge, Nicorette Mini Lozenge
- Where
- United States
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Nicotine Dependence, Overweight
A Study of Naltrexone SR/ Bupropion SR in Overweight and Obese Subjects Who Are Nicotine-Dependent
The purpose of this study is to determine whether a combination of naltrexone SR and bupropion SR is safe and effective in the treatment of nicotine-dependence in overweight and obese subjects.
- Conditions
- Nicotine Dependence, Overweight, Obesity
- Trial name
- NCT00563563
- Testing
- NB32, Ancillary therapy
- Where
- 3 sites in United States
- Volunteers
- 30 people
- Sponsor
- Orexigen Therapeutics, Inc
Prescription Drug Abuse, Substance Abuse
A High School Program for Preventing Prescription Drug Misuse
This project will develop and evaluate a program to prevent prescription drug misuse in high school students
- Conditions
- Prescription Drug Abuse, Substance Abuse, Substance Use (Drugs, Alcohol)
- Trial name
- NCT03219190
- Testing
- LST High School Hybrid
- Where
- United States
- Volunteers
- 1,804 people, healthy volunteers welcome
- Sponsor
- National Health Promotion Associates, Inc.
Tobacco Dependence
Evaluation of the Safety Profile, Quit and Reduction Rate After Nicorette® Gum and Patch Treatment
To evaluate the safety, smoking cessation and reduction rate during 3 months of active nicotine replacement therapy (NRT) and a follow-up period of 3 months in smoking hospital physicians and staff who are motivated to quit
- Trial name
- NCT00749463
- Testing
- Nicotine Gum, Nicotine Patch
- Where
- 6 sites in China
- Volunteers
- 300 people
- Sponsor
- McNeil AB
Smoking Cessation, Tobacco Use Disorder
Efficacy and Safety of Combination EMB-001 as a Potential Smoking Cessation Treatment
This open-label study will evaluate EMB-001, comprised of metyrapone, a cortisol synthesis inhibitor marketed as a diagnostic drug for testing hypothalamic-pituitary-adrenal (HPA) axis function, combined with oxazepam, an…
- Trial name
- NCT04868253
- Testing
- EMB-01
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Rose Research Center, LLC
Tobacco Dependence
Study to Determine the Efficacy and Safety of a Novel Nicotine Replacement Therapy
The purpose of this study is to assess the efficacy and safety of a novel nicotine product for continuous abstinence from smoking.
- Trial name
- NCT02355665
- Testing
- Nicotine Spray
- Where
- 8 sites in United States
- Volunteers
- 1,198 people
- Sponsor
- McNeil Consumer Healthcare Division of McNEIL-PPC, Inc.
Tobacco Dependence
A Study on the Effects of Two Nicotine Replacement Products on Tooth Staining
Participants will be smokers who want to quit, and have visible nicotine stains on their teeth. They will be given toothpaste and a toothbrush to use during the study, and will have an equal chance of being assigned to use either…
- Trial name
- NCT01440985
- Testing
- Nicotine
- Where
- Ireland
- Volunteers
- 200 people
- Sponsor
- McNeil AB
Thromboangiitis Obliterans (Buerger's Disease)
A First in Human Single Ascending Dose (SAD) Study of ATI-1013 in Healthy Smokers
This study is a first-in-human clinical trial of drug ATI-1013, in healthy adult cigarette smokers. The main questions it aims to answer are to learn about the safety of drug ATI-1013, how long drug ATI-1013 remains within the…
- Trial name
- NCT07215923
- Testing
- ATI-1013 (0.2 g), ATI-1013 (0.8 g), ATI-1013 (3.2 g)
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Antidote Therapeutics, Inc
Tobacco Dependence
Single-dose Nicotine Pharmacokinetics With Four Oral Nicotine Replacement Products
Single-dose nicotine pharmacokinetics with four oral nicotine replacement products. A study in healthy smokers.
- Trial name
- NCT01234896
- Testing
- Nicotine Medicated Gum, 4 mg Nicotine Gum, 2 mg Nicotine Gum
- Where
- Sweden
- Volunteers
- 44 people
- Sponsor
- McNeil AB