Clinical trials: Tobacco-Related Disorders
Tobacco Use, Substance Use Disorders
STEPS: Substance Use Trial of E-cigarettes or Pharmacotherapy for Smoking
The purpose of this study is to investigate whether non-cigarette tobacco products, namely e-cigarettes (nicotine vapes), can help people who smoke and are in treatment for substance use disorder quit smoking by switching…
- Trial name
- STEPS (NCT06922617)
- Testing
- Switching to E-Cigarette, Quitting using Medication, Counseling
- Where
- 4 sites in United States
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Drug Abuse, Nicotine Dependence
Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging
Background: Functional and structural magnetic resonance imaging (MRI) techniques have allowed researchers to map and study how the brain works when at rest and when engaged in specific tasks.
- Trial name
- NCT01036581
- Testing
- MagPro X100 Magnetic Stimulator, Transcranial Rotating Magnetic Stimulator, Magnetom Prisma Fit 3T Scanner
- Where
- United States
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Drug Abuse, Nicotine Dependence
Cognitive Task Development and Implementation for Functional MRI Studies
Background: Drugs of abuse have effects on mood, behavior, thinking, and decision making that may encourage people to continue using them and make it difficult for them to stop.
- Trial name
- NCT01036685
- Where
- United States
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Smoking Cessation, Depression
Adapting and Pilot Testing a Skills-based Smoking Cessation Intervention to Address Developmental and Health-related Stress Among Adults Who Smoke
Smoking remains the leading preventable cause of death in the United States, and there are persistent and significant disparities in tobacco use among transgender and gender diverse (TGD) individuals.
- Conditions
- Smoking Cessation, Depression, Anxiety, Nicotine Dependence
- Trial name
- NCT06654414
- Testing
- PRIDE QUIT, Enhanced Treatment As Usual (ETAU)
- Where
- 3 sites in United States
- Volunteers
- 100 people
- Sponsor
- Massachusetts General Hospital
Well Being, Drug Addiction
Evaluation of Effectiveness of the LifeSkills Training - Lombardia - Primary Shool Program ( Val3P-LST )
Life Skills Training is a school-based prevention program aiming at promoting wellbeing and at preventig use of substances. It has a version for middle school and another for primary school students.
- Conditions
- Well Being, Drug Addiction, Tobacco Use, Alcohol Abuse
- Trial name
- Val3P-LST (NCT07858513)
- Testing
- life skills primary prevention
- Where
- Italy
- Volunteers
- 3,927 people, healthy volunteers welcome
- Sponsor
- Agenzia di Tutela della Salute della Città Metropolitana di Milano
Tobacco Use Disorder, Substance Use Disorder
Smoking Cessation CM for Veterans With or at Risk for Cancer
Tobacco use among US Veterans poses significant health problems and challenges to their overall well-being. The aim of this project is to evaluate the effectiveness of a program called Contingency Management (CM) in helping…
- Trial name
- CM_TUD_Cancer (NCT06432985)
- Testing
- Focus Group, Contingency Management (CM), TUD Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Substance Use Disorder (SUD), Alcohol Use Disorder (AUD)
Metabolome and Gut Microbiome Changes During Smoking Cessation in Long-term Drug Therapy in a Therapeutic Community
Theoretical Framework: Cigarette smoking is the leading preventable cause of death worldwide, with nicotine dependence notably common among individuals with Substance Use Disorders (SUD).
- Conditions
- Substance Use Disorder (SUD), Alcohol Use Disorder (AUD), Nicotine Addiction, Healthy Adult Participants
- Trial name
- NCT06803706
- Testing
- 6-weeks CBT smoking cessation programme, Long-term drug therapy within a therapeutic community
- Where
- 3 sites in Austria
- Volunteers
- 97 people, healthy volunteers welcome
- Sponsor
- Sigmund Freud PrivatUniversitat
Substance Use (Drugs, Alcohol), Tobacco Use
The ICEC Cluster Trial: Integrated Community Engagement Collaborative for Youth Substance Use Prevention in Rural America
This study will evaluate whether the Integrated Community Engagement (ICE) Collaborative can help prevent alcohol, tobacco, and other drug use among youth living in rural communities.
- Conditions
- Substance Use (Drugs, Alcohol), Tobacco Use, Adolescent Substance Use
- Trial name
- NCT07843576
- Testing
- Integrated Community Engagement Collaborative, School-Based Data Collection and Reporting without Network Coordinator Support
- Where
- United States
- Volunteers
- 25,000 people, healthy volunteers welcome
- Sponsor
- West Virginia University
Asperger's Disorder, Asperger Disorder
QAIAx (AIhealth4U) - AI Smart Health Cities: Microcity Enclave Program (Quantum AI/AGI Agency a/k/a AI City Hall Project - UPSTO App Nos. 64/074,526, 64/063,557, 64/105,164, 63/903,181, 63/729,428, 64/125,360)
BRIEF SUMMARY A. "What is the purpose of this study?" BACKGROUND. The QAIAx clinical trial (Quantum AI/AGI Public Health Agency), known operationally as the "AI City Hall Project," represents a landmark intergovernmental research…
- Conditions
- Asperger's Disorder, Asperger Disorder, Autism Disorder, Autism
- Trial name
- QAIAx (NCT07661823)
- Testing
- AI City Hall Project (AIhealth4u - Public Health Central), AI City Hall Project (QAIAx Microcity A - AI Public Health Central)
- Where
- United States
- Volunteers
- 1,000,000 people, healthy volunteers welcome
- Sponsor
- Veterans Recovery Network Inc.
Nicotine Dependence
Orexin s Role in the Neurobiology of Substance Use Disorder
Study Description: Despite the availability of pharmacotherapy for some substance use disorders, relapse vulnerability is still a significant issue.
- Trial name
- NCT05630781
- Testing
- Belsomra, Methylphenidate
- Where
- United States
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Use Disorder, Substance Use Disorders
Temporal Interference Methods for Addiction Treatment
This clinical study is testing whether a new non-invasive brain stimulation method, called temporal interference (TI), can reduce nicotine cravings and usage in people who vape.
- Trial name
- NCT07210268
- Testing
- TI-NDBS
- Where
- 2 sites in United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Indiana University
Smoking Cessation, Tobacco Smoking
Trauma-Informed Care for Smoking Cessation for Pregnancy
Trauma-informed approaches have been shown to support recovery from other substance use disorders and involve four key elements: (1) Realizing the prevalence of trauma and pathways to recovery, (2) Recognizing symptoms of trauma…
- Conditions
- Smoking Cessation, Tobacco Smoking, Tobacco Use Cessation, Smoking Reduction
- Trial name
- NCT07129590
- Testing
- Expired carbon monoxide (CO), Interviews, Questionnaires
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Nicotine Dependence, Tobacco-Related Carcinoma
A Digital Intervention (ACT on Vaping App) for Vaping Cessation in Young Adult E-Cigarette Users
This clinical trial evaluates a smartphone application (app) called Acceptance and Commitment Therapy (ACT) on Vaping for helping young adults quit using electronic cigarettes (e-cigarettes).
- Trial name
- NCT06909500
- Testing
- Smartphone app, Text Message, Survey Administration
- Where
- United States
- Volunteers
- 1,178 people, healthy volunteers welcome
- Sponsor
- Fred Hutchinson Cancer Center
Opioid Use Disorder, Tobacco Use Disorder
Deep Transcranial Magnetic Stimulation for Tobacco Cessation in Adults With Opioid Use Disorder
This pilot study will evaluate the use of deep transcranial magnetic stimulation (Deep TMS) to help adults with opioid use disorder (OUD) who are receiving medications for opioid use disorder (MOUD) such as buprenorphine or…
- Trial name
- NCT07770555
- Testing
- Deep TMS System With H4 Coil
- Where
- 2 sites in United States
- Volunteers
- 12 people
- Sponsor
- Payel Roy
Cannabis Use, Tobacco Use Disorder
N-Acetylcysteine for Smoking Cessation in Tobacco and Cannabis Co-Use
Tobacco and cannabis co-use is a common and growing public health problem, especially in states that have legalized cannabis. There are no pharmacologic treatments for co-occurring tobacco and cannabis use.
- Conditions
- Cannabis Use, Tobacco Use Disorder, Drug Use Disorder
- Trial name
- NAC_CUD-TUD (NCT04627922)
- Testing
- N-Acetyl cysteine, Cognitive behavioral therapy (CBT)
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- Ellen Herbst
Tobacco Use Disorder, Substance Use Disorder (SUD)
Contingency Management for Veteran Smokers Undergoing Major Elective Surgery
The goal of this study is to design and test the first mobile contingency management (CM) smoking cessation intervention for military Veterans undergoing major elective surgery.
- Trial name
- CM_Surgery (NCT06678672)
- Testing
- Contingency Management (CM), Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 36 people
- Sponsor
- University of California, San Francisco
Tobacco Use, Opioid Use Disorder
E-cigarette Switching Older Adults
The goal of this clinical trial is to learn if adults 50 years and older who currently smoke tobacco and are in treatment for opioid use disorder will switch to using e-cigarettes instead of continued smoking.
- Conditions
- Tobacco Use, Opioid Use Disorder, Tobacco-Related Disorders
- Trial name
- NCT06534905
- Testing
- E-cigarette, Control/Standard Advice
- Where
- United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
OCD, Major Depressive Disorder (MDD)
Computer Game, Qualitative, and MEG/EEG Assessment of Serotonergic Psychedelics
This is an observational study which does NOT directly administer a psychedelic substance but rather recruits participants who are already participating in another clinical trial in which they may receive a serotonergic…
- Conditions
- OCD, Major Depressive Disorder (MDD), Alcohol Use Disorder (AUD), Healthy Volunteer
- Trial name
- NCT06624137
- Testing
- Serotonergic Psychedelic
- Where
- 2 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Yale University
Nicotine Dependence
Smart Olfaction App to Reduce Relapse
The proposed project aims to refine and test a novel biobehavioral smoking cessation intervention that integrates the strategic application of olfactory stimulation to reduce cigarette craving with an established smartphone-based…
- Trial name
- SOARR (NCT07007195)
- Testing
- Ad Libitum Use followed by Instructed Use of the Inspire Device, Instructed Use followed by Ad Libitum Use of the Inspire Device, Smart-T Smoking Cessation App with the Inspire Device Condition
- Where
- United States
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- University of Houston
Nicotine Use Disorder, Smoking Cessation
Implementation of Tobacco Cessation Programming at Community Behavioral Health Sites
The goal of this study is to: partner with Respiratory Health Association and determine barriers and unmet smoking cessation treatment needs from leaders in behavioral health organizations, treatment programs and adults who smoke…
- Conditions
- Nicotine Use Disorder, Smoking Cessation, Smoking Cessation Intervention
- Trial name
- NCT06837220
- Testing
- Enhanced Courage to Quit
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- University of Chicago