Clinical trials: Tobacco-Related Disorders
Use; Tobacco, Harmful, Alcohol Abuse
Dental and Medical Office iMET to Reduce Teen Tobacco, Alcohol, and Drug Use
The purpose of the project is to improve adolescent behavioral counseling services in healthcare settings with a new Internet/Intranet-based Motivational Enhancement Therapy (iMET) intervention that targets the use of tobacco…
- Conditions
- Use; Tobacco, Harmful, Alcohol Abuse, Drug Abuse
- Trial name
- NCT00907309
- Testing
- iMET, iMET/TE
- Where
- United States
- Volunteers
- 121 people
- Sponsor
- Boston Children's Hospital
Nicotine Addiction
Effect of Product Characteristics on the Abuse Liability of Nicotine Pouches
The goal of this study is to assess the effects of nicotine concentration and its interplay with pH on sensory experience, product appeal, and abuse liability of NPs among young adults NP users.
- Trial name
- NCT07165808
- Testing
- Nicotine pouch: Low dose, Nicotine pouch: High dose, Low pH
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Emory University
Nicotine Dependence, Smoking
N-acetylcysteine for Tobacco Use Disorder
The purpose of this study is to assess the effects of administering N-Acetylcysteine (NAC) to assist in initial cessation and/or relapse prevention in adult cigarette smokers.
- Trial name
- NCT02737358
- Testing
- N-acetylcysteine (NAC)
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Medical University of South Carolina
Smoking Cessation, Tobacco Use Disorder
Effectiveness of Reducing Smoking in Facilitating Smoking Cessation in Adolescents - 2
Currently one in five high school students smoke. Smoking can harm adolescents well before they reach adulthood by causing a number of immediate, sometimes irreversible, health risks and problems.
- Trial name
- NCT00158158
- Testing
- Usual Care, Smoking Reduction
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Nicotine Dependence
Nicotine Delivery Rate and Its Abuse Potential: Impact of Menthol
A placebo-controlled study to enroll male and female tobacco smokers who will participate in five experimental sessions. subjects will be given an IV infusion of either saline or 1 mg nicotine at rapid, moderate or slow infusion…
- Trial name
- NCT03580525
- Testing
- Nicotine saline infusion 0.00mcg/kg/s, Nicotine infusion 0.24mcg/kg/s, Nicotine infusion 0.096mcg/kg/s
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Yale University
Tobacco Use
Comparing an Opt-out to an opt-in Approach for Smoking Cessation in VA Primary Care Clinics
The investigators propose a Type I hybrid effectiveness/implementation study to evaluate two population-based approaches for increasing use of Quitlines and text messaging at two VA sites.
- Trial name
- NCT03477435
- Testing
- Staff training and academic detailing
- Where
- United States
- Volunteers
- 1,365 people
- Sponsor
- VA Office of Research and Development
Nicotine Dependence, Vaping
Influence of the Consumption of Conventional and Electric Cigarettes on Skin Circulation
The survey participants are divided into a smoking and non-smoking group. The smoker group is further divided according to the quantity and quality of nicotine ("normal" smoking, vaping).
- Conditions
- Nicotine Dependence, Vaping, Smoking
- Trial name
- NCT04645914
- Testing
- Use of nicotine product (smoking/vaping)
- Where
- Germany
- Volunteers
- 198 people, healthy volunteers welcome
- Sponsor
- University Hospital Muenster
Tobacco Dependence
UW Quitting Using Intensive Treatment Study (QUITS)
This research will determine whether two highly promising modifications to varenicline treatment (i.e. use of a nicotine patch adjuvant and extended 24-week duration) produce superior smoking outcomes when they are either used…
- Trial name
- QUITS (NCT03176784)
- Testing
- Varenicline, Nicotine patch
- Where
- 2 sites in United States
- Volunteers
- 1,251 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Drug Abuse, Nicotine Dependence
Cognitive Task Development and Implementation for Functional MRI Studies
Background: Drugs of abuse have effects on mood, behavior, thinking, and decision making that may encourage people to continue using them and make it difficult for them to stop.
- Trial name
- NCT01036685
- Where
- United States
- Volunteers
- 525 people, healthy volunteers welcome
- Sponsor
- National Institute on Drug Abuse (NIDA)
Tobacco Use Disorder
Comparing Smoking Treatment Programs for Lighter Smokers - 1
The purpose of this study was to compare two different types of Food and Drug Administration (FDA) approved smoking cessation medications (nicotine patch or bupropion) used in conjunction with two levels of counseling.
- Trial name
- NCT00086411
- Testing
- nicotine transdermal system, bupropion, Medication Management
- Where
- United States
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Nicotine Dependence, Cigarettes, With Withdrawal
A Dietary Supplement for Early Cigarette Withdrawal
The purpose of this study is to determine whether a dietary supplement (DS) is effective in protecting against sad mood during early cigarette withdrawal.
- Trial name
- CIGAR (NCT02042521)
- Testing
- Dietary Supplement
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- Centre for Addiction and Mental Health
Smoking Cessation, Substance-Related Disorders
Easy Access to Smoking Cessation for People Receiving Opioid Agonist Therapy Who Are Smoking Tobacco
Background: About 85% of those receiving opioid agonist therapy (OAT) for opioid dependence are smoking tobacco. Cigarette smoke lead to lunge diseases and cause illness and death within this group.
- Trial name
- BAReNikotin (NCT05290025)
- Testing
- Nicotine patch, Nicotine gum, Nicotine lozenge
- Where
- 2 sites in Norway
- Volunteers
- 266 people
- Sponsor
- Haukeland University Hospital
Nicotine Dependence
Testing an Organizational Change Model to Address Smoking in Mental Healthcare
Despite an overall reduction in US smoking rates from >50% in the 1960s to about 20% by 2000, the rate of smoking among persons with a serious mental illness (SMI) remains 2-3 times greater than in the general population.
- Trial name
- NCT02849652
- Testing
- ATTOC Intervention, UC Intervention
- Where
- United States
- Volunteers
- 832 people
- Sponsor
- University of Pennsylvania
Nicotine Dependence
The Effect of Varenicline on D2/D3 Receptor Binding in Smokers
This study will evaluate effects of treatment with varenicline, a smoking cessation drug, on the dopaminergic system by using Positron Emission Tomography (PET) imaging with new radioligand, [11C]-(+)-PHNO.
- Trial name
- NCT01632189
- Testing
- Varenicline
- Where
- Canada
- Volunteers
- 8 people
- Sponsor
- Centre for Addiction and Mental Health
Covid19
Tobacco Use and the Risk of COVID-19
Contrasting hypotheses, including that of a protective role of nicotine, have been generated concerning the association between smoking and the occurrence of COVID-19 infection.
- Trial name
- NCT04896918
- Testing
- Tobacco use
- Volunteers
- 450,000 people
- Sponsor
- Karolinska Institutet
Tobacco Use Disorder
Smoking Cessation Treatment for Substance Use Dependents
The present research project aims to develop an innovative and empirically validated intervention protocol for smoking cessation among patients with substance use disorders (SUDs).
- Trial name
- NCT03551704
- Testing
- CBT + EFT, CBT + EFT + CM
- Where
- Spain
- Volunteers
- 120 people
- Sponsor
- University of Oviedo
Nicotine Dependence
Tobacco Use in Opioid Agonist Treated Pregnant Women
The primary objective of the proposed study is to evaluate the efficacy of tobacco abstinence-contingent voucher incentives versus non-tobacco abstinence-contingent incentives for reducing or eliminating tobacco use during…
- Trial name
- ROSE (NCT00497068)
- Testing
- tobacco abstinent contingent, non-contingent, control
- Where
- United States
- Volunteers
- 210 people
- Sponsor
- Johns Hopkins University
Tobacco Use Disorder, Substance Use Disorder
Smoking Cessation CM for Veterans With or at Risk for Cancer
Tobacco use among US Veterans poses significant health problems and challenges to their overall well-being. The aim of this project is to evaluate the effectiveness of a program called Contingency Management (CM) in helping…
- Trial name
- CM_TUD_Cancer (NCT06432985)
- Testing
- Focus Group, Contingency Management (CM), TUD Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- VA Office of Research and Development
Nicotine Dependence
Flavors and E-cigarette Effects in Adolescent Smokers- STUDY 2
This study is to examine if inhaled doses of an e-cigarette flavor, alone and in combination with menthol, changes the appeal of e-cigarettes containing low and high doses of nicotine.
- Trial name
- NCT03168191
- Testing
- Nicotine, Experimental Flavor, Menthol Flavor
- Where
- United States
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Yale University
Tobacco Use Disorder, Repetitive Transcranial Magnetic Stimulation
fMRI Study of the Neural Mechanism of rTMS in the Treatment of Nicotine Dependence
The goal of this clinical trial is to investigate the efficacy of treatment and the efficacy-related neural network mechanisms by stimulating the left dorsolateral prefrontal lobe with rTMS to nicotine dependent.
- Trial name
- NCT06762535
- Testing
- repetitive transcranial magnetic stimulation
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Tang-Du Hospital