Clinical trials: Tolerance
Abdominal Obesity, Insulin Resistance
The Effect of Nordic Recommended Diet on the Features of Metabolic Syndrome - Multicentre Study
SYSDIET (Systems biology in controlled dietary interventions and cohort studies) is one of the three centres in the NCoE Food, Nutrition and Health, 2007-2011.
- Conditions
- Abdominal Obesity, Insulin Resistance, Impaired Glucose Tolerance, Type 2 Diabetes
- Trial name
- SYSDIET (NCT00992641)
- Testing
- Experimental diet, Control diet
- Where
- 8 sites in Denmark, Finland and 3 more
- Volunteers
- 167 people, healthy volunteers welcome
- Sponsor
- Marjukka Kolehmainen
Safety Issues, Tolerance
A Phase 1 Study in Healthy Volunteers to Evaluate the Safety, Tolerability and Pharmacokinetics of AVLX-144
This is a randomised, double-blind, placebo-controlled, single ascending dose study in healthy volunteer subjects. Each dose level will be investigated with eight 20-50-year-old male subjects (6 on active drug and 2 on placebo).
- Trial name
- NCT04689035
- Testing
- AVLX-144
- Where
- Finland
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Avilex Pharma
Hypothermia, Hypoxia
Pharmacologic Induction of Tolerance for Hypoxia & Hypothermia
Warfighter Performance Optimization in Extreme Environments remains an area of important and intense investigation, with the following goals: (1) Optimize, sustain and augment medical readiness and physiological/ psychological…
- Conditions
- Hypothermia, Hypoxia, Mountain Sickness
- Trial name
- PhITHy-Ho (NCT06129825)
- Testing
- Prospective
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Maryland, Baltimore
Hepatitis B, Chronic
Evaluation Freethiadine Tolerance in Healthy Subjects and Patients With Chronic Hepatitis B, Pharmacokinetics Characteristics and Antiviral Activity of Ⅰ Phase of Study
The Safety, Tolerability, Pharmacokinetics and antiviral activity Study of Anti hepatitis B virus treatment drug Freethiadine in Healthy subjects and in patients with chronic hepatitis B
- Trial name
- NCT05391360
- Testing
- Freethiadine tablets(part I), Freethiadine tablets (part II), entecavir tablets
- Where
- 2 sites in China
- Volunteers
- 128 people, healthy volunteers welcome
- Sponsor
- Sunshine Lake Pharma Co., Ltd.
Genetics, Metabolism
Study of Clinical Response to Acute Metformin By Leveraging Evaluations During a Mixed Meal Tolerance Test for Exploring Glycemia and GeneticS
The purpose of this research study is to examine whether specific genes (e.g. SLC16A11) affect how human beings respond to food and a medication that is commonly used to treat type 2 diabetes.
- Conditions
- Genetics, Metabolism, Type 2 Diabetes
- Trial name
- SCRAMBLED EGGS (NCT02087826)
- Testing
- Mixed Meal Tolerance Test, Metformin
- Where
- United States
- Volunteers
- 1,017 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Impaired Glucose Tolerance, Diabetes Mellitus, Type 2
The Interaction Between Metformin and Physical Training
Physical activity is a first line treatment for patients with type 2 diabetes (T2D), however, the vast majority of patients with T2D do not achieve satisfying glycemic control with physical activity alone, which is why…
- Trial name
- NCT03316690
- Testing
- Metformin treatment, Physical training
- Where
- Denmark
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Kristian Karstoft
Opioid Intoxication
The Evaluation of Safety and Tolerance of Commercially Available Naltrexone Administered Daily - Assessment for CBRN Operations
The objective of this study is to evaluate the tolerance and safety of naltrexone while performing military specific tasks, and to assess plasma concentrations following naltrexone, administered orally at 50 mg per day for 7…
- Trial name
- TEST CANADA (NCT03879460)
- Testing
- Naltrexone Hydrochloride
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Timothy Smith
Impaired Glucose Tolerance, Prediabetic State
Cardiovascular Disease (CVD) Risk and Prevention in Early Glucose Intolerance
The purpose of this study is to determine whether cardiovascular disease (CVD) risk markers, β-cell function, and insulin sensitivity can be improved by targeting mechanisms of both diabetes and CVD - using an antioxidant, an…
- Trial name
- NCT00122447
- Testing
- Aspirin, Alpha lipoic acid, Olmesartan
- Where
- 2 sites in United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Emory University
Human Volunteers
Nutrition Beverage Tolerance Study
To evaluate the sensations experienced by subjects consuming a nutritional beverage.
- Trial name
- NCT01464385
- Testing
- Nutritional Beverage
- Where
- United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Influenza
Evaluation the Safety and Tolerance of GP681 Tablets in Healthy Subjects
Influenza (influenza for short) is an acute respiratory infectious disease caused by influenza virus. The symptoms of the disease range from mild, moderate to severe, and severe cases require hospitalization and may die.
- Trial name
- NCT04729764
- Testing
- GP681 Tablet
- Where
- China
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Jiangxi Qingfeng Pharmaceutical Co. Ltd.
SEPP1 Levels in Differnet Glucose Tolerance Status
Human Selenoprotein P Concentration With Glucose Tolerance Status
Recently, seslenium(Se) has known as important regulator in metabolic status, lipid profile, atherosclerosis progression. SEPP1(selenoprotein P1)is a secreted protein from mainly liver.
- Trial name
- NCT01258426
- Volunteers
- healthy volunteers welcome
- Sponsor
- Korea University
Celiac Disease
A Population-based Study of Celiac Disease in South Europe in Children Between 1 to 5 Years of Age
Celiac disease (CD) was diagnosed for years almost exclusively in children. This is due to the fact that in adulthood it manifests in a much more attenuated form, while the classic form with severe diarrhea, malnutrition and…
- Trial name
- HNCEL (NCT05968404)
- Volunteers
- 3,659 people, healthy volunteers welcome
- Sponsor
- Hospital Mutua de Terrassa
Obesity, Metabolic Syndrome
Study to Determine the Effects of Human Growth Hormone and Pioglitazone in Overweight, Prediabetic Adults
The purpose of the study was to determine the effects of growth hormone and an insulin sensitizer drug in pre-diabetic adults with excessive amounts of abdominal fat.
- Conditions
- Obesity, Metabolic Syndrome, Impaired Glucose Tolerance
- Trial name
- NCT00352287
- Testing
- Recombinant human growth hormone; pioglitazone
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Stanford University
Heat Stress, Heat
Study of Biomarkers of Heat Tolerance and Recovery During Ultra-endurance Exercise
Military personnel are called upon to serve in hot, dry or humid climates, which places great demands on their ability to tolerate heat. Induced heat stress can impair performance and lead to pathologies.
- Trial name
- PENTHERE (NCT05921864)
- Testing
- Passive heat exposure, Active heat exposure
- Where
- France
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Direction Centrale du Service de Santé des Armées
T2DM (Type 2 Diabetes Mellitus)
Safety, Tolerance and Pharmacokinetics of THR-1442 in Chinese Healthy Subjects
The purpose of this study was to investigate Safety, tolerability and pharmacokinetics in Chinese healthy subjects.
- Trial name
- NCT05369078
- Testing
- THR-1442 20mg Single dose, THR-1442 20mg Multiple dose group
- Where
- China
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Newsoara Biopharma Co., Ltd.
Immune Tolerance, Liver Transplant; Complications
Immune Tolerance After Pediatric Liver Transplantation
Immunosuppressive (IS) agents are effective treatment to avoid acute or chronic rejection after pediatric liver transplantation.
- Trial name
- NCT05501301
- Testing
- IS weaning off
- Where
- China
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
COVID-19 Pneumonia
Phase I Clinical Trial of GEN2-Recombinant COVID-19 Vaccine (CHO Cells) in Healthy People Aged 18 and Above
phase I study will evaluate the safety and tolerability of GEN2-Recombinant COVID-19 Vaccine (CHO cells) in healthy people aged 18 years and older.
- Trial name
- NCT05408312
- Testing
- Experimental Vaccine 1, Experimental Vaccine 2, Experimental Vaccine 3
- Where
- China
- Volunteers
- 234 people, healthy volunteers welcome
- Sponsor
- National Vaccine and Serum Institute, China
Overweight, Pre Diabetes
DPP4 Activity, Microvascular Reactivity and Inflammation
Dipeptidyl peptidase 4 (DPP4) is a serine exopeptidase able to inactivate various oligopeptides involved in inflammation, immunity and vascular function.
- Conditions
- Overweight, Pre Diabetes, Diabetes Mellitus Type 2 Without Complication
- Trial name
- DPP4 (NCT03178019)
- Testing
- Laser-Doppler methods
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Rio de Janeiro State University
Gastrointestinal Tolerance, Healthy Population
Evaluating the Impact of Incremental Doses of a Sugar Replacer Blend on Gastrointestinal Tolerance in Chocolate
This study is a randomized, double-blind, crossover trial aiming at evaluating the gastrointestinal tolerance of sugar replacer ingredients and blends (maltitol, kestose (Oligofructose), kestose + cocoa and polydextrose premix at…
- Trial name
- NCT06479330
- Testing
- Milk Chocolate
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mondelēz International, Inc.
Exercise Induced Hypoalgesia, Circadian Rhythm
Pain Perception and Exercise-Induced Hypoalgesia Across Circadian Rhythms
The goal of this randomized crossover clinical trial is to investigate whether exercise-induced hypoalgesia (EIH) is influenced by circadian rhythm in healthy adults aged 18-40 years.
- Conditions
- Exercise Induced Hypoalgesia, Circadian Rhythm, Pain Perception, Healthy Participants
- Trial name
- NCT07290465
- Testing
- High-Intensity Functional Training (HIFT), Supervised Deep Breathing
- Where
- Turkey (Türkiye)
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Medipol University
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