Clinical trials: Tolerance
Non-Diabetic Disorder of Endocrine Pancreas
MTNR1B SNP*Food Timing Interaction on Glucose Control
The purpose of this investigation is to assess the role of melatonin receptor 1B (MTNR1B) single nucleotide polymorphism (SNP)*food timing interaction on glucose control in the deleterious effect in a vulnerable population with…
- Trial name
- ONTIME-MT (NCT03036592)
- Testing
- Early OGTT, Late OGTT
- Where
- Spain
- Volunteers
- 889 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Healthy
Fiber Health Benefits
The investigators hypothesize that fiber supplementation will provide measurable differences in indices of children's health (fewer complaints of abdominal pain and constipation, lower body mass index) compared to placebo.
- Trial name
- NCT02177864
- Testing
- Fiber
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Warren Bishop
Non-Diabetic Disorder of Endocrine Pancreas
Glucose Tolerance, Meal Timing and MTNR1B
The purpose of this investigation is to assess in a community-based cohort of late-night eaters the effect of coincident food intake and endogenous melatonin on glycemic control, and the putative interaction effect of melatonin…
- Trial name
- ONTIME-DINE (NCT03003936)
- Testing
- Dinner timing
- Where
- Spain
- Volunteers
- 280 people, healthy volunteers welcome
- Sponsor
- Universidad de Murcia
Corneal Defect
Evaluate the Tolerance, Safety and Pharmacokinetics of Germinal Peptide Eye Drops in Healthy Volunteers
Phase I Clinical Trial to Evaluate the Tolerance, Safety and Pharmacokinetics of Germinal Peptide Eye Drops in Healthy Volunteers.
- Trial name
- NCT03662971
- Testing
- Germinal peptide eye drops
- Where
- China
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Zhaoke (Guangzhou) Ophthalmology Pharmaceutical Ltd.
Infant Development
Comparison of Growth and Tolerance of Healthy Term Infants Fed Iron-Fortified Infant Formulas
A 4 month growth monitoring study of healthy term infants fed iron fortified infant formula. Infants will be fed ad-libitum for 16 weeks and growth will be evaluated in terms of weight gain over the 16 weeks.
- Trial name
- NCT05947084
- Testing
- Infant Formula
- Where
- 29 sites in United States
- Volunteers
- 518 people, healthy volunteers welcome
- Sponsor
- Aussie Bubs, Inc.
Healthy Infants
Gastrointestinal Tolerance Study of a New Infant Formula
This study is initiated to investigate the gastrointestinal tolerance of a new infant formula in healthy, term, Asian infants.
- Trial name
- BOOGIE (NCT01681355)
- Testing
- Infant Formula
- Where
- 5 sites in Indonesia, Thailand
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Danone Asia Pacific Holdings Pte, Ltd.
Calorie Deficiency, Fasting
Effects of Calorie Restriction and Cold Stimuli on Health-related Indicators, Cognitive and Motor Functions
The goal of this clinical trial was to identify if duration of acute calorie restriction (CR)/fasting or combination CR with cold stimuli have any effects on mental and physical health-related markers, and to clarify if different…
- Conditions
- Calorie Deficiency, Fasting, Cold Exposure
- Trial name
- NCT05545943
- Testing
- 2-days of zero calorie restriction and whole-body cold-water immersion, 6-days of calorie restriction, 2-days of zero calorie restriction without whole-body cold-water immersion
- Where
- Lithuania
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Lithuanian Sports University
Colonoscopy
Comparison of Different Low Volume Solutions Prior to Colonoscopy
Study evaluates the head -to-head efficacy and tolerability of low volume preparations prior to colonoscopy
- Trial name
- NCT03698474
- Testing
- Natrium picosulfate / Magnesium citrate, Polyethylene glycol / Ascorbic acid, Natrium/ Kalium/ Magnesium sulfate
- Where
- Czechia
- Volunteers
- 612 people, healthy volunteers welcome
- Sponsor
- Tomas Bata Hospital, Czech Republic
Potential Abnormality of Glucose Tolerance, Appetite Disorders
Acute Effects of Juice Consumption With Biofunctional Compounds and Probiotics on Glucose Metabolism
This study investigated the short-term effects of fruit juice enriched with Vitamin D3 or n-3 PUFA or probiotics and the combination of the three ingredients on glucose metabolism.
- Trial name
- NCT05702359
- Testing
- Glucose as reference food, Control juice, Juice with vitamin D3
- Where
- Greece
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Agricultural University of Athens
Healthy Term Infants
Randomised, Controlled Study to Assess Safety and Tolerance of Infant Formula With Prebiotics and Postbiotics in Healthy Infants.
A randomised, controlled, double-blind, parallel group, multi-country study to investigate the safety and tolerance of infant formula with prebiotics and postbiotics in healthy term infants.
- Trial name
- WAVE (NCT04015050)
- Testing
- milk based infant formula
- Where
- Poland
- Volunteers
- 279 people, healthy volunteers welcome
- Sponsor
- Nutricia Research
Type 2 Diabetes
Study of Vitamin D and Omega-3 Supplementation for Preventing Diabetes
The VITamin D and OmegA-3 TriaL (VITAL; NCT 01169259) is an ongoing randomized clinical trial in 25,875 U.S. men and women investigating whether taking daily dietary supplements of vitamin D3 (2000 IU) or omega-3 fatty acids…
- Trial name
- NCT01633177
- Testing
- Vitamin D3, Omega-3 fatty acid (fish oil)
- Where
- United States
- Volunteers
- 22,220 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Growth and Tolerance
Growth of Infants Fed Hydrolysate Formulas
Effects on weight and weight gain will be monitored in healthy term infants fed assigned infant formulas.
- Trial name
- NCT02006992
- Testing
- RTF Infant Formula, Powder Infant Formula
- Where
- 8 sites in United States
- Volunteers
- 195 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Burn Out, Psychological Disturbance
A Specialized Nutraceutical for Pre-burnout
High demands, professional overload and emotional stress are well known negative influences on mental health. Chronic stress-related occupational diseases, especially Burnout, are becoming an important issue.
- Trial name
- WELBI (NCT04532892)
- Testing
- Meta 18.06 Day and Meta 18.06 Night
- Where
- France
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Institut Pasteur de Lille
Vision Correction
Acceptance & Tolerance Study of Multifocal Contact Lenses by Functional Emmetropes
The primary objective of this study is to determine the retention rate over a two month period of vision correction in emmetropic, presbyopes fitted with multifocal contact lenses.
- Trial name
- NCT02394925
- Testing
- Multifocal Test Contact lens
- Where
- 2 sites in United States, United Kingdom
- Volunteers
- 113 people, healthy volunteers welcome
- Sponsor
- Johnson & Johnson Vision Care, Inc.
Obesity, Insulin Resistance
Hypoxic Exercise and Glucose Metabolism
The obesity epidemic calls for new therapeutic opportunities to prevent and treat obesity and its comorbidities amongst which are insulin resistance and cardiovascular diseases.
- Conditions
- Obesity, Insulin Resistance, Impaired Glucose Tolerance in Obese
- Trial name
- HYTRIM (NCT04280991)
- Testing
- Moderate intensity exercise under mild normobaric hypoxia and normoxia
- Where
- Netherlands
- Volunteers
- 11 people, healthy volunteers welcome
- Sponsor
- Maastricht University Medical Center
Skin Care
To Investigate the Cutaneous and Ocular Local Tolerance of Two Cosmetic Facial Cleanser in Healthy Females With Sensitive Skin
The objective of this clinical study is to assess the cutaneous and ocular local tolerance of two cosmetic facial cleansers in healthy female participants with sensitive skin under normal conditions of use.
- Trial name
- NCT03172364
- Testing
- Micellar cleanser, Micellar foaming cleanser
- Where
- 2 sites in Brazil
- Volunteers
- 122 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Polycystic Ovary Syndrome, Obstructive Sleep Apnea
Polycystic Ovary Syndrome (PCOS) and Sleep Apnea
Polycystic ovary syndrome (PCOS) affects 5-10% of women in the United States. Its onset is usually at the time of puberty with manifestations of menstrual irregularity, hirsutism, and obesity.
- Trial name
- NCT00203996
- Testing
- continuous positive airway pressure (CPAP), depot leuprolide plus estrogen/progestin replacement, pioglitazone
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of Chicago
SARS-CoV2 Infection, Immunisation Reaction
Effect of Different SARS-CoV-2 Vaccine Schedules and Vaccination Intervals on Reactogenicity and Humoral Immunogenicity
Investigation of the reactogenicity and immunogenicity of homologous and heterologous vaccine combinations with regard to the formation of SARS-CoV-2 antispike antibodies in health care workers after basic immunization and boost…
- Conditions
- SARS-CoV2 Infection, Immunisation Reaction, Antibody Hypersensitivity, Tolerance
- Trial name
- NCT05076227
- Testing
- IM injection of vaccination (mRNA vaccination), IM injection of vaccination (vector based vaccination)
- Where
- Germany
- Volunteers
- 1,206 people, healthy volunteers welcome
- Sponsor
- Serge Thal
Antiplatelet Drug
Antiplatelet Thrombolysin (Anfibatide) Phase 1 Clinical Trial in Healthy Volunteers
This is a phase 1, dose-escalation, and multidose study, aiming to investigate the tolerability, safety and pharmacokinetics of Anfibatate in healthy subjects.
- Trial name
- NCT04404790
- Testing
- Anfibatide 5 IU/60kg, Anfibatide 5 IU/60kg +0.002 IU/kg/h, Anfibatide 5 IU/60kg +0.004 IU/kg/h
- Where
- China
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Lee's Pharmaceutical Limited
Insulin Sensitivity, Endothelial Dysfunction
Resistance Training and Cardiometabolic Health
This study will investigate the relationship between resistance training load and repetitions on cardiometabolic outcomes. The primary objective of this clinical trial is to determine whether high load or low load resistance…
- Conditions
- Insulin Sensitivity, Endothelial Dysfunction, Blood Pressure
- Trial name
- NCT03325933
- Testing
- High Load/Low Rep Resistance Training, Low Load/High Rep Resistance Training
- Where
- United States
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Arizona State University
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