Clinical trials: Tolerance
Food Hypersensitivity
Study on the Induction of Food Tolerance in Babies
This general population based, randomized controled trial aims at answering two major hypotheses: First, systematic early introduction of solid foods decreases the incidence of food allergy and dietary restrictions by the age of…
- Trial name
- INTO (NCT02825069)
- Testing
- Early introduction of solid foods
- Where
- Finland
- Volunteers
- 1,214 people, healthy volunteers welcome
- Sponsor
- University of Oulu
Maternal Hypoglycemia
Maternal Hypoglycemia and Placental Pathology
The purpose of this retrospective pilot study is to assess the association of maternal hypoglycemia during the one hour glucose tolerance test with decreased placental weight and identifiable placental pathology.
- Trial name
- NCT00614094
- Where
- United States
- Volunteers
- 350 people, healthy volunteers welcome
- Sponsor
- Oklahoma State University Center for Health Sciences
Healthy
Increased Salt Intake in Healthy Men
To study the effects of an increased salt intake on metabolic, cardiovascular and immunoregulatory functions in healthy men.
- Trial name
- BSALT (NCT02509962)
- Testing
- Slow sodium tablets
- Where
- Germany
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Type 2 Diabetic
Pilot Study of the Effect of Purple Rice on Glucose Tolerance, Serum Lipids and Inflammation
This is a pilot study to demonstrate the effect of purple rice on post-prandial glucose and insulin. The purple color is due, like red wine grapes, mainly to the anthocyanins.
- Trial name
- NCT01720511
- Testing
- Purple Rice, Brown Rice
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Pennington Biomedical Research Center
Type 2 Diabetes Mellitus, Obesity
Effect of Dietary Oils as G-protein-coupled Receptor Agonists on Glucose Tolerance
Agonistic activation of fat metabolite responsive G-protein-coupled receptors (GPCR) has been linked to improved glucose metabolism through increased glucose-stimulated-insulin-secreting (GSIS) and incretin release, improved…
- Trial name
- NCT03774095
- Testing
- Hydrolyzed pine nut oil, Hydrolyzed pine nut oil and olive oil
- Where
- Denmark
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Karina Vejrum Sørensen
Healthy
the Dietary Effects of VitaSugar/VitaFiber-IMO in Healthy Adults
The purpose of this study is to re-confirm the already established health effects and dose tolerance of Isomalto-oligosaccharide or IMO, which is a general health/functional food ingredient.
- Trial name
- NCT01462331
- Testing
- Isomaltooligosaccharide (digestion-resistant carbohydrates), Sucrose
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- BioNeutra Inc.
No Disease State or Condition
Pain Study to Assess Local Anesthetic Efficacy and Safety of CTY-5339 on Gingival Mucosal Tissue in Normal Volunteers
The purpose of this study is to determine if the topical application to gingival tissue of the combination of benzocaine and tetracaine has a longer duration of local anesthetic activity than benzocaine alone.
- Trial name
- NCT03233737
- Testing
- One spray CTY-5339-A, One spray CTY-5339-CB, One spray CTY-5339-P
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Cetylite Industries
Frozen Shoulder, Impairment Glucose Tolerance
Prevalence of Impaired Glucose Tolerance (IGT) in Patients With Frozen Shoulder
Idiopathic Adhesive Capsulitis, Frozen Shoulder is a condition in which there is a limitation and significant pain at the shoulder and it is increases with shoulder movements. The causes are not clear.
- Trial name
- NCT00926094
- Where
- Israel
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Tolerance, Capsaicin
Intranasal Capsaicinoid Spray
Rhinitis is inflammation of the inside of the nose. Symptoms of rhinitis include itchiness, sneezing, and a "runny" nose (rhinorrhea).
- Conditions
- Tolerance, Capsaicin, Rhinitis
- Trial name
- NCT03952845
- Testing
- Capsaicinoid
- Where
- Canada
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Nova Scotia Health Authority
Hyperlactatemia, Metabolic Syndrome (MetS)
Role of Elevated Lactate Levels on Lipid and Carbohydrate Metabolism.
The purpose of this study is to investigate whether the elevated circulating lactate levels of individuals with metabolic syndrome are responsible for their reduced lipolysis and glucose tolerance.
- Conditions
- Hyperlactatemia, Metabolic Syndrome (MetS), Lipolysis, Exercise
- Trial name
- LACTMET (NCT07426172)
- Testing
- hyperlactacidemia, Saline (0.9%, sterile, for infusion)
- Where
- Spain
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ricardo Mora
Glucose Metabolism Disorders, Diabetes
Effects of Insulin Sensitizers in Subjects With Impaired Glucose Tolerance
Subjects with impaired glucose tolerance will be randomized to receive pioglitazone or metformin for 10 weeks. Measurements of insulin sensitivity, body composition, glucose tolerance, and muscle lipid accumulation will be…
- Trial name
- NCT00108615
- Testing
- Metformin, Pioglitazone, CT scans
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
Healthy
Effects of Plant Polar Lipids on Glucose Tolerance
In this randomized controlled trial, two different plant polar lipids are investigated with respect to their potential to affect acute and second meal glucose tolerance and appetite sensations.
- Trial name
- NCT06148974
- Testing
- Polar lipid 1, Polar lipid 2, Non-polar lipids
- Where
- Sweden
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- Anne Nilsson
Chronic Hepatitis B
Clinical Study to Evaluate the Safety, Tolerance and Pharmacokinetic Characteristics of Single Administration of HRS-5635 Injection in Chinese Healthy Subjects and the Safety, Tolerance, Pharmacokinetics and Antiviral Effect of Multiple Administration in Patients With Chronic Hepatitis B
The study is being conducted to evaluate the safety, tolerability, pharmacokinetics and pharmacodynamics of HRS-5635 in healthy adults and chronic hepatitis B. To explore the reasonable dosage of HRS-5635.
- Trial name
- NCT05808374
- Testing
- HRS-5635
- Where
- China
- Volunteers
- 85 people, healthy volunteers welcome
- Sponsor
- Fujian Shengdi Pharmaceutical Co., Ltd.
Hypoxemia, Altitude Hypoxia
Effects of Continuous Positive Airway Pressure on Peripheral Oxygen Saturation, Work of Breathing, and Exercise Tolerance at Altitude
Dyspnea and exercise intolerance are well known to travelers who have experienced time at high elevations, greater than 2500 meters (8200 feet).
- Trial name
- NCT05971290
- Testing
- Continuous positive airway pressure, Ambient air
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Atopic Dermatitis / Eczema
To Evaluate the in Use Tolerance of E45 Eczema Repair Emollient in Babies and Children With (Very(Dry/Atopic Skin
The investigation will evaluate, under dermatological control, the cutaneous in-use tolerance of E45 Eczema Repair Emollient with two or three times daily application, over a period of two weeks on children and babies with…
- Trial name
- NCT02857062
- Testing
- E45 Eczema Repair Emollient
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Reckitt Benckiser Healthcare (UK) Limited
Morbid Obesity, Weight Loss
Intragastric Balloon, Air Versus Fluid Filled: Randomized Prospective Study
Gastric balloons are an evolving way of reducing weight. There are two types on the market, up to date. Air filled balloons seem to be more safe, and more tolerable.
- Conditions
- Morbid Obesity, Weight Loss, Tolerance
- Trial name
- NCT02129296
- Testing
- Air filled balloon, Bioenteric BIB® balloon
- Where
- Egypt
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Xerophthalmia
Clinical Study for the Evaluation of Safety and Tolerability of NCP112 Eye Drops
The objective is to evaluate the safety, local tolerability, and pharmacokinetics of NCP112 eye drops through single and multiple dose-escalation ocular administrations in healthy adults.
- Trial name
- NCT06263998
- Testing
- NCP112
- Where
- South Korea
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Huons Co., Ltd.
Healthy Population
Evaluation of the Tolerance of Three Masks Under Dermatological Control.
This is a monocentric, open and randomized study. The purpose is to evaluate the cutaneous tolerance of three medical masks (class I medical device) after 3 consecutive days of use on a population with normal or sensitive skin.
- Trial name
- NCT05193799
- Testing
- Investigational devices must be used 8 hours per day
- Where
- France
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Groupe Kolmi Hopen
Gastrointestinal Tolerance, Liver Function
A Clinical Trial to Evaluate the Chronic Safety and Tolerance of Turmipure Gold™ in Healthy Subjects
The aim of this study is to evaluate the safety and tolerance of Turmipure Gold™ product during a chronic consumption of 5 weeks in healthy subjects.
- Conditions
- Gastrointestinal Tolerance, Liver Function, Kidney Function
- Trial name
- TURBIO-GOLD (NCT03945149)
- Testing
- Turmipure Gold™
- Where
- France
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Givaudan France Naturals
Healthy Volunteers, Brain Lesion
Pharmacokinetics, Pharmacodynamics Profile and Tolerance of P03277 in Healthy Subjects and Patients With Brain Lesions
The primary objective of this study was to evaluate the safety (clinical and biological) and pharmacokinetics (plasma and urine) profile of P03277 following single administration at ascending dose levels in healthy subjects.
- Trial name
- NCT03603106
- Testing
- P03277
- Where
- Belgium
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- Guerbet
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