Clinical trials: Tolerance
Healthy Population, Glucose Tolerance
Effects of Low/No Calorie Sweeteners on Glucose Tolerance
This study aims to determine the effects of chronic exposure to some low/no calorie sweeteners (LNCS) on glucose tolerance and glucagon like peptide 1 (GLP-1) release in healthy individuals.
- Trial name
- NCT04904133
- Testing
- Low/No Calorie Sweeteners
- Where
- Turkey (Türkiye)
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Hypoglycemia, Reactive
Relevance of Reactive Hypoglycemia During an OGTT in Everyday Life Using Continuous Glucose Measurement
This research project aims to investigate the everyday relevance of reactive hypoglycemia (hypoglycemia after a glucose load) in the oral glucose tolerance test (OGTT).
- Trial name
- HypoCGM (NCT06182527)
- Testing
- Free Style Libre Pro IQ
- Where
- Germany
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of Ulm
Healthy Adults
Comparative Study on Tolerance and Pharmacokinetics of Voriconazole for Injection in Healthy Subjects
A single intravenous drip of voriconazole for injection developed by Qilu Pharmaceutical (Hainan) Co., Ltd. and the original product "vfend" was given to healthy subjects ， The pharmacokinetic differences and tolerance of the two…
- Trial name
- NCT05330000
- Testing
- 4 mg/kg Voriconazole, 6 mg/kg Voriconazole
- Where
- China
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- The Affiliated Hospital of Qingdao University
Diabetes, Healthy
Systemic Effects of Epidural Methylprednisolone Injection on Glucose Tolerance in Diabetic Patients
Several studies have shown that in diabetic patients, the glycemic profile was disturbed after intra-articular injection of corticosteroids. Little is known about the impact of epidural injection in such patients.
- Trial name
- NCT01420497
- Testing
- intra-articular infiltration, epidural infiltration
- Where
- Switzerland
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Vaudois
Healthy
Safety, Tolerance, and Pharmacokinetics of Single Oral Doses of BI 201335 NA and Bioavailability in Healthy Male Subjects
The objective of this study was to investigate the safety, tolerability, and pharmacokinetics of BI 201335 NA following administration of single rising doses from 4 mg to 1200 mg.
- Trial name
- NCT02182323
- Testing
- BI 201335 NA
- Volunteers
- 74 people, healthy volunteers welcome
- Sponsor
- Boehringer Ingelheim
Life Style
Effect of Physical Activity Pattern on Cardiometabolic Health
The goal of this study is to understand the interaction between the circadian system and physical activity. Participants will: complete 2 inpatient stays perform moderate exercise be provided with identical meals have frequent…
- Trial name
- PACE (NCT05838508)
- Testing
- Exercise intervention
- Where
- United States
- Volunteers
- 26 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Under-eyes Dark Circles
Efficacy and Tolerance Evaluation of an Injective Treatment for the Area Around the Eyes
Efficacy and tolerance evaluation of an intradermal injective HA and aminoacids based treatment for the area around the eyes
- Trial name
- NCT03881189
- Testing
- SUNEKOS® 200
- Where
- Italy
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Derming SRL
Immune Tolerance
Vitamin D Supplementation and Regulatory FoxP3+ T Cells in the GUT
In this pilot study the investigators aim to investigate the effects of vitamin D supplementation on regulatory FoxP3+ T cells in the gastrointestinal mucosa in healthy women and men.
- Trial name
- NCT01538485
- Testing
- Cholecalciferol
- Where
- Austria
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Medical University of Graz
Diabetes After Total Pancreatectomy
The Impact of Lixisenatide on Postprandial Glucose Tolerance in Pancreatectomised Subjects
Postprandial glucose (PPG) excursions are not only determined by insulin-mediated glucose disposal and endogenous glucose production (regulated by insulin and glucagon); also the rate of gastric emptying constitutes an important…
- Trial name
- Px-Lixi (NCT02640118)
- Testing
- Lixisenatide, Standardized liquid meal
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Growth, Infections
Effects of an Infant Formula and follow-on Formula Containing Bio-active Ingredients on Growth, Tolerance and Infections
In this clinical trial, the growth (weight for age), product tolerance (product intake, comfort) and infection-related symptoms of healthy infants consuming an IF and FOF containing bio-active ingredients will be evaluated and…
- Trial name
- NCT06137235
- Testing
- cows milk infant formula and follow-on formula with bioactive ingredients, standard cows milk infant formula and follow-on formula
- Where
- 3 sites in Greece
- Volunteers
- 456 people, healthy volunteers welcome
- Sponsor
- FrieslandCampina
Breastfeeding, Post Partum
Acceptability & Tolerance of Immediate Versus Delayed Postpartum Contraceptive Implant
To study and compare acceptability and tolerance between breast-feeding post-partum woman, who receive contraceptive implant 48-72 hours after giving birth or at 5-7 weeks after giving birth, using either Levonorgestrel or…
- Trial name
- NCT03353012
- Testing
- Etonogestrel Drug Implant, Levonorgestrel Drug Implant
- Where
- Thailand
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Chulalongkorn University
Acromegaly
Oral Glucose Tolerance Testing (OGTT) on Patients Taking Somatostatin Analogs
The purpose of this study is to test the effect of long-acting somatostatin analog medications, taken by patients with acromegaly or carcinoid syndrome, on growth hormone in comparison to healthy controls who are not receiving…
- Trial name
- NCT01371045
- Testing
- Oral Glucose Tolerance Test (OGTT)
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Cedars-Sinai Medical Center
Healthy
New Infant Formula Trial in Healthy Term Subjects on Growth, Body Composition, Tolerance and Safety
This study is initiated to investigate the effect of a new infant formula in healthy term subjects on growth, body composition, tolerance and safety.
- Trial name
- Venus (NCT01609634)
- Testing
- Test Product, Control Product 1, Control Product 2
- Where
- 2 sites in Singapore
- Volunteers
- 541 people, healthy volunteers welcome
- Sponsor
- Danone Asia Pacific Holdings Pte, Ltd.
Idiopathic Ketotic Hypoglycemia
A Glucometabolic Evaluation of Patients With Idiopathic Ketotic Hypoglycemia
The project will evaluate 1) the postprandial metabolism and 2) continuous glucose levels in subjects diagnosed with Idiopathic Ketotic Hypoglycemia (IKH)) and healthy control subjects.
- Trial name
- IKH_MetEx (NCT05310292)
- Testing
- Oral glucose tolerance test, Mixed meal test
- Where
- Denmark
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University Hospital, Gentofte, Copenhagen
Cardiovascular Disease (CVD), Chronic Obstructive Pulmonary Disease (COPD)
Towards Personalized Nutrition With SCAPIS2-HOME
The Swedish CardioPulmonary bioImage Study (SCAPIS) is a nationwide, open-access, population-based cohort in Sweden designed to study cardiovascular disease and chronic obstructive pulmonary disease.
- Trial name
- NCT06992921
- Testing
- Dietary intervention
- Where
- 2 sites in Sweden
- Volunteers
- 1,641 people, healthy volunteers welcome
- Sponsor
- Chalmers University of Technology
Infant Term Birth
Happy Smooth Study
The purpose of this study is to evaluate the stool composition and GI tolerance of an experimental formula with a new fat blend plus L. reuteri vs control formula.
- Trial name
- NCT03710551
- Testing
- Experimental Infant Formula, Standard Infant Formula
- Where
- Philippines
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Pain, Acute
Duration of Music Interventions and Pain Tolerance (DOMINANT)
This study will investigate the effect of different durations of music interventions (1, 5 and 20 minutes of music) on pain tolerance.
- Trial name
- DOMINANT (NCT06286137)
- Testing
- Listening to music for 1 minute, Listening to music for 5 minutes, Listening to music for 20 minutes
- Where
- Netherlands
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Erasmus Medical Center
Tolerance
Impact of OCT1 on Metformin Tolerance
Metformin is the first-line treatment for medical management of Type 2 Diabetes. Up to 25% of patients experience significant gastrointestinal symptoms and in approximate 5%, side-effects result in the discontinuation of…
- Trial name
- ImpOCT (NCT02586636)
- Testing
- Metformin, Omeprazole
- Where
- United Kingdom
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- NHS Tayside
Bacterium; Agent
Colonization and Persistence of Bifidobacterium Longum
Healthy adults referred to as the absence of intestinal disorders, liver and kidney problems, lactose intolerance, and no use of ongoing medication for chronic diseases will be recruited.
- Trial name
- NCT01650753
- Testing
- Probiotic Powder
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- University of Nebraska Lincoln
Unilateral Amputation of the Lower Limb
Virtual Reality Applied to the Evaluation and Rehabilitation of Locomotion - Study of Tolerance in the Lower Limb Amputee
The adaptability of the locomotor activity allows to face all the modifications of the immediate environment met in the daily activities.
- Trial name
- REVA (NCT05635799)
- Testing
- Analysis of walking on flat ground, Hospital Anxiety Disorder Questionnaire, Analysis of walking on slopes
- Where
- France
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire Dijon
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