Clinical trials: Tolerance
Metabolic Syndrome, Overweight
Effects of Lignan-rich Diet on Cardiometabolic Risk Factors
Diet plays an important role in relation to prevention of type 2 diabetes, cardiovascular disease and certain cancers. Studies have shown that diets with high whole-grain content could decrease the risk of these lifestyle related…
- Conditions
- Metabolic Syndrome, Overweight, Central Obesity, Impaired Glucose Tolerance
- Trial name
- NCT02987595
- Testing
- Whole-grain rye, high lignan, Whole-grain wheat, low lignan
- Where
- Sweden
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Swedish University of Agricultural Sciences
Digestion, Gut Microbiota
Feeding Tolerance and Gut Maturation of Infants Consuming a Formula Rich in Glycoprotein
This is a non-randomized, single-arm, open-label, prospective interventional study using a commercially available starter infant formula in healthy term formula-fed infants with a parallel group of healthy term breast-fed infants…
- Trial name
- NCT04880083
- Testing
- Commercially Available Starter Infant Formula
- Where
- China
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Healthy
Ascending Single-dose Study to Evaluate TVB-2640 in Chinese Healthy Subjects
Ascending oral single-dose study to evaluate the safety and pharmacokinetics of TVB- 2640 tablets in the Chinese healthy population.
- Trial name
- NCT04352361
- Testing
- TVB-2640
- Where
- China
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Ascletis Pharmaceuticals Co., Ltd.
Trypanosomiasis, African
Multiple Dose Study to Evaluate Security, Tolerance and Pharmacokinetic of Fexinidazole (Drug Candidate for Human African Trypanosomiasis) Administered With a Loading Dose and With Food
This trial will study the tolerability and pharmacokinetic of fexinidazole using two different dosage regimen of repeated administrations.
- Trial name
- NCT01483170
- Testing
- Tablets Fexinidazole
- Where
- France
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Drugs for Neglected Diseases
Obesity
Safety and Tolerance of a Nutritional Intervention Program- In.Form 1.2
The study evaluated and the safety, tolerance and acceptability of a lifestyle modification program with nutritional supplementation in generally healthy overweight subjects with cardiometabolic risk factors.
- Trial name
- NCT03098056
- Testing
- PROG2
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Nature's Sunshine Products, Inc.
Skin Flaccidity Inner Thighs Knees Arms
Aesthetic Performance of an Injective Treatment for the Inner Thighs, Knees and Arms
The objective of this study is to investigate the efficacy of the "SUNEKOS® Body" in woman aged 40-65 years with skin flaccidity of the inner thighs, knees and arms.
- Trial name
- NCT04113265
- Testing
- SUNEKOS ® Body
- Where
- Italy
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Derming SRL
Food Allergy, Early Allergen Introduction
Food Introduction for Risk Reduction, Support Tolerance: Behavioral Intervention for Toddler Eating Success
The goal of this clinical trial is to evaluate the feasibility, acceptability, perceived safety, and adherence outcomes of FIRST BITES (Food Introduction for Risk Reduction, Support Tolerance: Behavioral Intervention for Toddler…
- Trial name
- FIRST BITES (NCT07857057)
- Testing
- Education and Reminders/Supportive Communication, Education
- Where
- 3 sites in United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- University of Texas Southwestern Medical Center
Anesthesia, Perioperative/Postoperative Complications
Use of Heart-lung Interaction to Predict Haemodynamic Tolerance to the Open Lung Approach With Individualised PEEP
This is an observational, prospective, single-centre study that will focus on patients undergoing major non-cardiac surgery requiring invasive mechanical ventilation and invasive blood pressure monitoring Hypotheses: A positive…
- Conditions
- Anesthesia, Perioperative/Postoperative Complications, Hypovolemia, Haemodynamic Instability
- Trial name
- HiPEEP (NCT06123039)
- Testing
- Tidal Volume Challenge, Recruitment maneuver obtaining individualised PEEP
- Where
- Spain
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario La Fe
Metabolic Syndrome, Obesity
Dietary Modulation of Gene Expression and Metabolic Pathways in Glucose Metabolism
Professor Matti Uusitupa, University of Kuopio, Department of Clinical Nutrition (www.uku.fi) Docent Matej Oresic, VTT (www.vtt.fi) Ursula Schwab, PhD, Docent, Marjukka Kolehmainen, PhD, Docent, Leena Pulkkinen, PhD, Docent…
- Conditions
- Metabolic Syndrome, Obesity, Impaired Glucose Tolerance, Impaired Fasting Glucose
- Trial name
- Sysdimet (NCT00573781)
- Testing
- Diet with increased intake of rye bread, berries and fish, Increased intake of whole grain and rye bread, Control diet with decreased intake of rye bread, berries and fish
- Where
- Finland
- Volunteers
- 106 people, healthy volunteers welcome
- Sponsor
- Marjukka Kolehmainen
Glucose Tolerance
Dietary Fibre and Metabolic Benefits
The aim of the project is to study the connection between bacterial fermentation in the colon of prebiotic substrates and effects on systemic metabolism and appetite i healthy humans
- Trial name
- NCT03423381
- Testing
- Cereal product 1, Cereal product 2, Cereal product 3
- Where
- Sweden
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Lund University
Obesity & Overweight, Circadian Rhythm Disorders
Effects of Akkermansia Muciniphila and Berberine Supplementation on Insulin Sensitivity in Night-shift Workers
Night shift work is associated with an increased risk of obesity, insulin resistance, and cardiometabolic disorders, largely due to circadian misalignment, disrupted sleep, and altered eating patterns.
- Conditions
- Obesity & Overweight, Circadian Rhythm Disorders, Gut Microbiota Modulation, Prediabetes (Insulin Resistance, Impaired Glucose Tolerance)
- Trial name
- Shift2Health (NCT07440147)
- Testing
- Verum (A)
- Where
- Austria
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- FH Joanneum Gesellschaft mbH
Gastrointestinal Tolerance
Tolerance of Healthy Term Infants Fed Infant Formulas #3
The primary objective of this study is to assess the comparative gastrointestinal (GI) tolerance of normal term infants to six experimental milk protein-based powdered infant formulas.
- Trial name
- NCT00977964
- Testing
- Experimental milk protein infant formula Process A, Experimental milk protein infant formula Process B, Experimental milk protein infant formula Process C
- Where
- 15 sites in United States
- Volunteers
- 270 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Inflammatory Bowel Diseases
Multiple-dose Escalation Clinical Study of VC005 Tablets in Healthy Subjects
This clinical trial is a randomized, double-blind, single-center, placebo-controlled and multiple-dose escalation Pharmacokinetics study
- Trial name
- NCT05354752
- Testing
- VC005 tablets
- Where
- China
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Jiangsu vcare pharmaceutical technology co., LTD
Healthy Volunteers
Clinical Investigation to Evaluate the Tolerance of T10070 on Healthy Volunteers
The goal of this clinical trial investigation is to evaluate the tolerance of the T10070 on healthy volunteers by clinical examination under ophthalmological control.
- Trial name
- NCT05622435
- Testing
- T10070, Plastic tube with a roll-on applicator filled with an ointment
- Where
- Poland
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Laboratoires Thea
Nutritional and Metabolic Diseases
Saskatoon Berry on Metabolism and Gut Microbiota in Healthy Subjects
Diabetes becomes epidemic in worldwide countries. Nine out of ten diabetic patients are type 2 diabetes (T2D). T2D is characterized by insulin resistance and obesity.
- Trial name
- NCT04809688
- Testing
- Saskatoon berry, Dried Saskatoon berry
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Healthy Volunteers
A Phase I Clinical Trial of Meplazumab in Healthy Volunteer
This is a single center, double-blinded, placebo-controlled phase I clinical trail in healthy volunteer of meplazumab for injection.
- Trial name
- NCT04369586
- Testing
- meplazumab for injection
- Where
- China
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Xijing Hospital
Diabetes, Prediabetes
The Usefulness of Postprandial Triglyceride for Assessment of Cardiovascular Risk
The hypertriglyceridemia at fasting status has been known to be an important risk factor for cardiovascular disease (CVD). Recently, postprandial triglyceride (TG) levels draw an attention as a superior predictor of CVD because…
- Trial name
- NCT01972542
- Testing
- Oral fat tolerance test
- Where
- South Korea
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Seoul National University Bundang Hospital
Glucose Tolerance Impaired
Dose Response Relationship Between Fat Ingestion and Metabolism
The goal of this clinical trial is to compare features of metabolism in healthy, young adults after they consume four meals of differing fat quantity.
- Trial name
- AFDR (NCT05906342)
- Testing
- 20% fat meal, 40% fat meal, 60% fat meal
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- McMaster University
Pulmonary Arteriovenous Malformations, Hereditary Hemorrhagic Telangiectasia
Cardiopulmonary Exercise Testing to Evaluate Pulmonary AVMs
Pulmonary arteriovenous malformations (PAVMs) are a rare vascular condition affecting the lungs. PAVMs lead to low blood oxygen levels, yet are very well tolerated by patients.
- Trial name
- NCT02436213
- Testing
- Cardiopulmonary exercise test, Blood test
- Where
- United Kingdom
- Volunteers
- 39 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Diabetes, Hyperglycemia
Insulin Secretion in Diabetes Before and After Glycemic Control
The objective of this project is to understand defects in insulin secretion that contribute to abnormal glucose metabolism in patients with diabetes.
- Trial name
- NCT00469833
- Testing
- insulin glargine
- Where
- United States
- Volunteers
- 17 people, healthy volunteers welcome
- Sponsor
- US Department of Veterans Affairs
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