Clinical trials: Tolerance
Postprandial Glucose, GI Tolerance
A Crossover Study Evaluating the Postprandial Glycemic Response of Three Sweeteners in a Mixed Meal Setting
This study is using a double-blind, randomize crossover evaluating the impact of three different sweeteners on postprandial glycemic response in a mixed meal setting.
- Trial name
- NCT07895628
- Testing
- LOAM Fiber-based Sweetener, Sugar, Stevia
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- LOAM Science
Pediatric Obesity, Insulin Resistance
Metabolic Effect of Metformin in Obese Insulin Resistant Adolescents With Normal Glucose Tolerance
The primary objective of this randomized, parallel group, double-blind, placebo-controlled study is to determine whether treatment with metformin enhances insulin sensitivity in a group of ethnically diverse obese…
- Conditions
- Pediatric Obesity, Insulin Resistance, Hyperinsulinemia
- Trial name
- NCT00667498
- Testing
- Metformin
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Yale University
COVID-19
Safety and Efficacy of Intranasal Administration of Avacc 10 Vaccine Against COVID-19 in Healthy Volunteers
This study is a Phase I, first-in-human (FIH), double-blind, placebo- and OMV-controlled study of Avacc 10 in healthy adult male and female subjects to investigate the safety, tolerability, and immunogenicity of intranasally…
- Trial name
- ITV2002 (NCT05604690)
- Testing
- Avacc 10, Outer Membrane Vesicles (OMV) : OMV alone in vehicle
- Where
- Australia
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Intravacc B.V.
Fasting, Immune Function
The Impact of a 48-hour Fast with or Without Exercise on Immune Cell Metabolism and Glycemic Control in Healthy Active Adults
Many individuals engage in fasting for its purported health benefits but the effects of fasting on immune cell and whole body metabolism are not well understood in humans.
- Conditions
- Fasting, Immune Function, Glucose Tolerance
- Trial name
- FASTEX (NCT06737224)
- Testing
- Fasting + Exercise (FAST+EX): fasting + exercise condition, Fasting only (FAST): Non-exercise fasting condition
- Where
- Canada
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Gastrointestinal Disease, Flatulence
Evaluation of Gastrointestinal Symptoms Following Chilean Native Beans Consumption
The oligosaccharide content (raffinose, stachyose, and verbascose) in legumes would be responsible for gastrointestinal symptoms (bloating, pain, meteorism), associated with its consumption.
- Conditions
- Gastrointestinal Disease, Flatulence, Gastrointestinal Tolerance, Distension; Bowel
- Trial name
- NCT04243187
- Testing
- Chilean Native Beans
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Natalia Jara
Health Adult Subjects
Dose-response Effects of Dietary Nitrate on Running Time-to-exhaustion and Neuromuscular Fatigue: a Randomized Crossover Exploratory Pilot Study
Background: Dietary nitrate is a natural compound found in vegetables such as beetroot and leafy greens. Previous research suggests that consuming nitrate before exercise may improve endurance and physical performance.
- Trial name
- Nitrate TTE (NCT07735455)
- Testing
- Dietary Nitrate
- Where
- Spain
- Volunteers
- 9 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de Madrid
Healthy Volunteers
Analgesic Tolerance to Repeated Doses of Subcutaneous Morphine
30 healthy volunteers will be enrolled in this 6-session study. The first visit will be a screening/orientation session. The next 5 visits will be (full day) outpatient sessions taking place Monday through Friday during one week.
- Trial name
- NCT00256347
- Testing
- intramuscular injections of morphine
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Impaired Glucose Tolerance
Low Density Lipoprotein (LDL) Cholesterol Metabolism in Impaired Glucose Tolerance
Impaired glucose tolerance is associated with an increased risk of developing cardiovascular disease and atherosclerosis for reasons not yet totally understood.
- Trial name
- NCT01020578
- Testing
- Plasma kinetic study
- Where
- Brazil
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo General Hospital
Weight Management
Tolerance and Appetite Reduction of a Nutritional Solution With Intragastric Gelation Properties
The physical properties of a food product, such as its gelling properties in the stomach can influence how full a person may feel after its consumption.
- Trial name
- NCT07127198
- Testing
- Beverage Variant 1 (low gelation properties), Beverage Variant 2 (medium gelation properties), Beverage Variant 3 (high gelation properties)
- Where
- Switzerland
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
Ocular Hypertension, Glaucoma
Tolerance and Effect on Intraocular Pressure After Administration of SYL040012
The purpose of this study is to determine whether SYL040012 is safe for the treatment of ocular hypertension and glaucoma.
- Trial name
- NCT00990743
- Testing
- SYL040012
- Where
- Spain
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Sylentis, S.A.
Healthy Pregnant Women
Milk Free From A1-Type β-Casein on Inflammation, Gastrointestinal Tolerance, and Pregnancy Outcomes
The aim of the study is to compare the effects of conventional Ultra High Temperature (UHT) milk containing both A1 and A2 type β-caseins (CON) with a2 UHT Milk containing A2 type β-casein only (A1PF) on inflammation, tolerance…
- Trial name
- NCT06980376
- Testing
- a2 UHT milk, Conventional UHT Milk
- Where
- 6 sites in China
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- a2 Milk Company Ltd.
Gastrointestinal Tolerance, Healthy Population
Evaluating the Impact of Incremental Doses of a Sugar Replacer Blend on Gastrointestinal Tolerance in Candies
This study is a randomized, single-blind, crossover trial aiming at evaluating the gastrointestinal tolerance of a sugar replacer blend (inulin + soluble corn fiber + erythritol) at 3 different doses
- Trial name
- NCT05827198
- Testing
- Low-sugar candies compared to regular sugar candies
- Where
- Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Mondelēz International, Inc.
Diabetes, Impaired Glucose Tolerance (IGT)
A Survey on the Rate of Glucose Intolerance in Hong Kong Chinese
Hypothesis: There is a high rate of glucose intolerance among Hong Kong Chinese. The investigators plan to screen Hong Kong Chinese from the community with oral glucose tolerance test (OGTT).
- Conditions
- Diabetes, Impaired Glucose Tolerance (IGT), Impaired Fasting Glucose (IFG), Glucose Intolerance
- Trial name
- NCT00787215
- Testing
- observational: no treatment involved
- Where
- China
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
General Health and Wellness, Energy and Vitality
M4C Nutraceutical Intervention Human Health Effects Pilot
This 3 month pilot study will be an unblinded, convenience sampling, nutraceutical intervention trial. Twenty fasted subjects will undergo a baseline health assessment via a questionnaire, baseline clinical chemistries, blood…
- Conditions
- General Health and Wellness, Energy and Vitality, Cognitive Function and Mental Health, Weight Management
- Trial name
- M4C Pilot (NCT06476236)
- Testing
- M4C
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Concordia University Wisconsin
Diabetic Macular Edema
Intra-individual Variability and Circadian Rhythm of VEGF Levels and Interaction With Biomarkers
The study evaluates the intra-individual variability of VEGF levels over a period of 6 months as well as the circadian variation of VEGF levels, both under standardized conditions in patients with type 2 diabetes without DME and…
- Trial name
- NCT02325271
- Testing
- Frequent blood and urine sampling and blood pressure measurement
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- GWT-TUD GmbH
Healthy Infants
To Investigate Effects of a New Infant Formula in Healthy Term Chinese Infants
This study investigates the effects of a new infant formula on growth, safety, and tolerance in healthy term Chinese infants. Screening starts after the informed consent is obtained.
- Trial name
- NCT03520764
- Testing
- New infant formula with synbiotics, Standard infant formula with prebiotics
- Where
- 6 sites in China
- Volunteers
- 284 people, healthy volunteers welcome
- Sponsor
- Danone Nutricia
Infant Nutrition Sciences
Acceptability, Tolerance, Satiety and Prebiotic Effect of a New Infant Cereal
This study evaluates a new infant cereals on acceptability, tolerance, satiety and prebiotic effect in infants.
- Trial name
- ACER (NCT02781298)
- Testing
- New Infant Cereal, Multicereals Infant Cereal
- Where
- 4 sites in Spain
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Hero Institute for Infant Nutrition
Ischemic Stress, Transient Non-Lethal Ischemia
The Role of Nitrite in Preconditioning Mediated Tolerance to Ischemic Stress
Many studies have shown that if the human body is stressed by a lack of blood flow for a short period of time, the body develops defenses to make the body more resistant to a future stress from lack of blood flow.
- Trial name
- NCT00250185
- Testing
- Sodium Nitrate, Acetylcholine
- Where
- United States
- Volunteers
- 135 people, healthy volunteers welcome
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Safety Issues
Tolerance of a Probiotic Formula
Evaluate the tolerance of a probiotic formula in infants
- Trial name
- NCT03925558
- Testing
- Probiotics
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Probi AB
Infant Nutrition
Digestive Tolerance of Slightly Hydrolyzed Starter Infant Formula With Probiotics
To demonstrate that infants have improved gut comfort when fed a slightly hydrolyzed starter formula containing probiotics compared to infants fed a control hydrolyzed and referenced non-hydrolyzed formula.
- Trial name
- NCT01036243
- Testing
- test formula 1, test formula 2, test formula 3
- Where
- Thailand
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Société des Produits Nestlé (SPN)
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