Clinical trials: Tolerance
Chronic Obstructive Pulmonary Disease
DETECT-Register DocumEnTation and Evaluation of a COPD Combination Therapy
Prospective, multi-centre, non-interventional study to collect findings about the effects of LABA/LAMA (Long Acting Beta2-Agonists / Long Acting Muscarinic Antagonists) combination preparations on COPD (Chronic obstructive…
- Trial name
- DETECT (NCT02552160)
- Where
- 180 sites in Germany
- Volunteers
- 3,732 people
- Sponsor
- AstraZeneca
Calcifying Tendinitis of Shoulder
Efficacy and Tolerance of Ultrasound-guided Needling and Lavage of Calcific Tendinitis of the Rotator Cuff Performed With or Without Subacromial Corticosteroid Injection
Calcific tendinitis of the rotator cuff is a common cause of chronic pain of the shoulder. Needling and lavage of the calcification is one of the therapeutic options after failure of conservative management with physiotherapy and…
- Trial name
- CALCECHO (NCT02403856)
- Testing
- Sodium Chloride 0.9%, Methylprednisolone acetate, Ultrasound-guided Needling and Lavage
- Where
- 3 sites in France
- Volunteers
- 136 people
- Sponsor
- Nantes University Hospital
Multiple Sclerosis, Heat Tolerance
Cooling During Inpatient Rehabilitation in Persons With MS
The goal of this clinical trial is to shed light on the use of cooling during intensive active training sessions during a three-week multidisciplinary inpatient rehabilitation stay in persons with Multiple Sclerosis.
- Conditions
- Multiple Sclerosis, Heat Tolerance, Fatigue Symptom
- Trial name
- CoolEx (NCT07852156)
- Testing
- Wearing a cooling vest during intensive, active training sessions, Control
- Where
- Switzerland
- Volunteers
- 42 people
- Sponsor
- Klinik Valens
Healthy
Oxytocin Effects on the Tolerance of Infidelity
To investigate whether intranasal oxytocin (40 IU) treatment can influence the tolerance of infidelity in males and females.
- Trial name
- NCT02733237
- Testing
- oxytocin treatment
- Where
- China
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- University of Electronic Science and Technology of China
Psoriasis
A Study to Evaluate the Switch From Etanercept to Infliximab in Subjects With Moderate-to-Severe Psoriasis (Study P05133)
This study will evaluate the efficacy, tolerability, and effect on the quality of life of infliximab in adults with moderate-to-severe psoriasis who are resistant to etanercept after 12 weeks of treatment or have failed 24 weeks…
- Trial name
- TANGO (NCT00686595)
- Testing
- Infliximab
- Volunteers
- 48 people
- Sponsor
- Merck Sharp & Dohme LLC
Radiation Tolerance
Radiation Dosimetry in Teeth
Irradiation of any tissue creates changes in that tissue. Ionizing radiation imparts charges to the tissue as it interacts with tissue components, changing the tissue structure.
- Trial name
- NCT00178347
- Testing
- Exposure to irradiation
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Rochester
Sarcoma
Efficacy of the Combination of Nivolumab and Ipilimumab as a Treatment in Patients With Sarcoma of Rare Subtype
This is a randomized open label study, with 2 arms treatments conducted in patients with metastatic or unresectable advanced sarcoma of rare subtype; previously treated by anthracycline-based regimen except for whom standard…
- Trial name
- RAR-Immune (NCT04741438)
- Testing
- Nivolumab and IPILIMUMAB, Pazopanib Oral Tablet [Votrient]
- Where
- 13 sites in France
- Volunteers
- 96 people
- Sponsor
- Centre Leon Berard
Gastrointestinal Tolerance
Gastrointestinal Tolerance of Infant Formula
The study objective is to evaluate the gastrointestinal tolerance of infant formula supplemented with prebiotics.
- Trial name
- NCT02322138
- Testing
- Experimental 1 Infant Formula, Experimental 2 Infant Formula, Reference Group
- Where
- 10 sites in United States
- Volunteers
- 131 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition
Healthy
A Tolerance Clinical Study on Aerosol Inhalation of Mesenchymal Stem Cells Exosomes In Healthy Volunteers
Exosomes are naturally occurring nanosized vesicles and comprised of natural lipid bilayers with the abundance of adhesive proteins that readily interact with cellular membranes.
- Trial name
- NCT04313647
- Testing
- 1X level of MSCs-Exo, 2X level of MSCs-Exo, 4X level of MSCs-Exo
- Where
- China
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Ruijin Hospital
Opioid-Related Disorders, Substance-Related Disorders
Effects of Dextromethorphan on Opioid Tolerance in Methadone Patients - 1
The purpose of this study is to determine if addition of dextromethorphan to a stable dose of methadone in opioid dependent subjects will significantly affect physical and psychological aspects of opioid tolerance.
- Trial name
- NCT00000352
- Testing
- Dextromethorphan
- Where
- United States
- Sponsor
- National Institute on Drug Abuse (NIDA)
Hepatectomy
Topical rhThrombin as an Adjunct to Hemostasis During Segmental Hepatectomy
rhThrombin is a serine protease from human.The study is to assess the Safety, Tolerability, Immunogenicity and efficacy of rhThrombin.
- Trial name
- NCT03611426
- Testing
- rhThrombin ( Topical )
- Where
- China
- Volunteers
- 84 people
- Sponsor
- Suzhou Zelgen Biopharmaceuticals Co.,Ltd
Gestational Diabetes
An Exercise Intervention to Prevent Gestational Diabetes
Women diagnosed with gestational diabetes mellitus (GDM) are at substantially increased risk of developing type 2 diabetes and obesity, currently at epidemic rates in the United States.
- Trial name
- NCT00728377
- Testing
- Physical activity, Heath & Wellness
- Where
- United States
- Volunteers
- 488 people
- Sponsor
- University of Massachusetts, Amherst
Diabetes, Sugar; Blood, High
The Efficacy of White Kidney Bean on Oral Glucose Tolerance Test
The goal of this randomized, double-blind, cross-over inverventional study is to evaluate the efficacy of white kidney bean on OGTT (oral glucose tolerance test).
- Trial name
- NCT05756712
- Testing
- Phase 1 Wonderlab Product, Phase 2 Wonderlab Product
- Where
- China
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- Shenzhen Precision Health Food Technology Co. Ltd.,
Safety Issues, Tolerance
Safety and Tolerability of Lactoferrin/FOS in Very Low Birth Weight Infants
This study will examine the safety and tolerability of supplementation with bovine lactoferrin with fructo-oligosaccharide a simple sugar in very low birth weight infants.
- Conditions
- Safety Issues, Tolerance, Very Low Birth Weight Infant
- Trial name
- NCT03163212
- Testing
- Lactoferrin/FOS
- Volunteers
- 20 people
- Sponsor
- University of Virginia
Elderly, Drug Therapy Syndrome
Stopping Benzodiazepines and Related Molecules Among Elderly Living in Residential Institutions
Intervention randomized controlled open study with 2 parallel arms . The objective of this study is to evaluate the feasibility of stopping the benzodiazepines treatment in elderly living in nursing homes.
- Conditions
- Elderly, Drug Therapy Syndrome, Substance-Related Disorders, Substance Withdrawal Syndrome
- Trial name
- BenzoFree (NCT02715440)
- Testing
- Immediate intervention
- Volunteers
- 116 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Chronic Obstructive Pulmonary Disease
Influence of the VitaBreath on Exercise Tolerance in COPD
People with COPD have more air in their lungs than other people (this problem with high lung volumes is called "hyperinflation").
- Trial name
- NCT03068026
- Testing
- VitaBreath, Pursed Lip Breathing technique
- Where
- United Kingdom
- Volunteers
- 24 people
- Sponsor
- North Tyneside General Hospital
Healthy Subjects, Diet Intervention
Effects of Plant-based Polar Lipids on Acute and Second Meal Glucose Tolerance and Appetite Sensations
The overall goal of the project is to increase knowledge which can be used for the development of food products with anti-diabetic properties, with the purpose to facilitate healthier food choices for people.
- Trial name
- NCT05844085
- Testing
- Non-polar lipids, No lipids, Polar lipids low
- Where
- Sweden
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Lund University
Obesity
Grape Polyphenols and Second-meal Effect
The aim of this is study is to evaluate the effects of a single intake of grapes (a polyphenol-rich food) in postprandial metabolism in subjects with obesity, including a first intake (high-fat breakfast) after overnight fasting…
- Trial name
- GRAPESECOND (NCT03741218)
- Where
- Spain
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- National Research Council, Spain
Advanced Hepatocellular Carcinoma
GPC3-targeting CART Cell in Treatment of Advanced Hepatocellular Carcinoma
A Phase I Clinical Trial for Evaluating the Safety, Tolerance and Efficacy of GPC3-targeting CART Cell in Treatment of Advanced Hepatocellular Carcinoma
- Trial name
- NCT05352542
- Testing
- GPC3 Targeting CART Cells
- Where
- 2 sites in China
- Volunteers
- 10 people
- Sponsor
- jianming xu
Infant Newborn
Growth and Tolerance of Young Infants Fed Infant Formulas
This is a randomized, multi-center, double blind, parallel study to compare growth and tolerance of healthy term infants fed either control or experimental infant formula.
- Trial name
- NCT01380886
- Testing
- experimental infant formula with alternate protein source, Infant formula powder
- Where
- 12 sites in United States
- Volunteers
- 209 people, healthy volunteers welcome
- Sponsor
- Abbott Nutrition