Clinical trials: Tomography
Healthy Subjects, Schizophrenia
Studies of Frontal Lobe Brain Functioning in Schizophrenia
The purpose of this study is to use brain imaging technology to investigate the role of the frontal lobe of the brain in the thinking of individuals with schizophrenia and other neuropsychiatric disorders and healthy volunteers.
- Conditions
- Healthy Subjects, Schizophrenia, Parkinson Disease
- Trial name
- NCT00001258
- Testing
- Oxygen-15 Water
- Where
- United States
- Volunteers
- 1,039 people
- Sponsor
- National Institute of Mental Health (NIMH)
Healthy Participants, Idiopathic Pulmonary Fibrosis (IPF)
A Study to Evaluate the Safety, Tolerability, Kinetics and Repeatability of 18F-BMS-986327
The purpose of this study is to assess the safety, tolerability, kinetics and test-retest repeatability of the novel LPA1 positron emission tomography (PET) ligand 18F-BMS-986327 in healthy participants and participants with…
- Trial name
- NCT04069143
- Testing
- 18F-BMS-986327
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Bristol-Myers Squibb
Lung Cancer, Blood Biomarkers
AI for Lung Cancer Risk Definition in Computed Tomography Screening Programs
Low-dose computed tomography (LDCT) lung cancer (LC) screening can reduce mortality among heavy smokers, but there is a critical need to better identify people at higher risk and to reduce harms related to management of benign…
- Trial name
- NCT06320184
- Testing
- Artificial Intelligence risk model
- Where
- Italy
- Volunteers
- 650 people, healthy volunteers welcome
- Sponsor
- Fondazione IRCCS Istituto Nazionale dei Tumori, Milano
Stroke Acute
EnDOvascular Therapy for Late WiNdow IschEmic Stroke Patients Selected bY AutoMatic Plain ComputErized Tomography
The DONE SYMPLE Investigator-initiated phase III prospective, randomized, open-label, blinded endpoint-controlled clinical trial.
- Trial name
- DONE SYMPLE (NCT07001852)
- Testing
- Endovascular Therapy (Mechanical Thrombectomy), Standard Medical Management
- Where
- 2 sites in United States, Armenia
- Volunteers
- 500 people
- Sponsor
- Santiago Ortega Gutierrez
Acute Mesenteric Ischemia
The Feasibility of a Radiological Score Based on CT Signs for Recognizing Salvageable Bowel in Acute Mesenteric Ischemia
Computed tomography (CT) is the standard modality for scanning patients with critical acute abdominal conditions, including suspected acute mesenteric ischemia (AMI).
- Trial name
- AMESIradiol (NCT06445660)
- Where
- Estonia
- Volunteers
- 200 people
- Sponsor
- University of Tartu
Coronary Microvascular Disease, Coronary Artery Disease
Multicenter Registry of Coronary Flow-Derived Indexes for Coronary Microvascular Disease (Multicenter FLOW-CMD Registry)
Multicenter FLOW-CMD registry is a prospective, multi-center, registry study. The aim of the study is to evaluate prognostic implications of coronary microvascular disease (CMD) in patients with ischemic heart disease (IHD)…
- Conditions
- Coronary Microvascular Disease, Coronary Artery Disease, Ischemic Heart Disease
- Trial name
- NCT05369182
- Testing
- Invasive physiologic assessment, Intravascular imaging
- Where
- 7 sites in South Korea
- Volunteers
- 1,003 people
- Sponsor
- Samsung Medical Center
Locally Advanced Breast Cancer
A Prospective Study to Evaluate FDG-PET, Breast MRI, and Breast Ultrasonography in Monitoring Tumour Responses in Patients With Locally Advanced Breast Cancer (LABC) Undergoing Neoadjuvant Chemotherapy
The overall goal of this study is to determine how FDG-PET, breast MRI and breast ultrasound can be incorporated into the assessment of treatment responses in women with LABC undergoing neoadjuvant chemotherapy.
- Trial name
- PETLAB (NCT00788489)
- Where
- Canada
- Volunteers
- 49 people
- Sponsor
- Ontario Clinical Oncology Group (OCOG)
Healthy Volunteers
A Study With [18F]MNI-1054 to Determine Lysine -Specific Demethylase 1A (LSD1) Brain Enzyme Occupancy of TAK-418 After Single-Dose Oral Administration in Healthy Participants
The purpose of this study is to determine brain LSD1 enzyme occupancy and the relationship of occupancy to TAK-418 dose and plasma exposure after single oral dosing of TAK-418 in healthy participants using [18F]MNI-1054 positron…
- Trial name
- NCT04202497
- Testing
- TAK-418, [18F]MNI-1054 (radiotracer)
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- Takeda
Therapy-Associated Cancer
Prognostic Value of 177Lutetium-PSMA Single Photon Emission Tomography and Timing of Response
177Lutetium-PSMA-617 is an established treatment for patients with metastatic castration-resistant prostate cancer (mCRPC). Early response assessment is critical for optimizing patient management.
- Trial name
- RECIP (NCT07643935)
- Volunteers
- 280 people
- Sponsor
- Central Hospital, Nancy, France
Positron-Emission Tomography, Immunization Reaction
A Pilot Clinical Study of PET Scanning in Evaluation of Vaccine Reactogenicity
This study forms part of an integrated, multi-study effort to identify potential biomarkers of reactogenicity to vaccines. We have selected PET-CT as it is in routine clinical use and has been serendipitously shown to image lymph…
- Trial name
- PETVACC (NCT04515368)
- Testing
- Immunization
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Imperial College London
Pulmonary Disease, Chronic Obstructive, COPD
Study to Assess the Effect of the Aerobika Device in Addition to Standard of Care Treatment in Sputum Producing COPD Patients Using FRI
Primary: The primary objective of this study is to evaluate the effect of the Aerobika® device on the aerosol deposition pattern of concomitant inhalation medication using FRI.
- Trial name
- NCT02936817
- Testing
- Aerobika® Device, HRCT scans
- Where
- Belgium
- Volunteers
- 10 people
- Sponsor
- FLUIDDA nv
Prostate Cancer
Choline-PET for Evaluating the Incidence of Nodal Metastases Among Newly Diagnosed Patients of Prostate Cancer
Nodal involvement among patients with prostate cancer is known to be a poor prognostic factor. Traditionally, the presence or absence of nodal disease in patients with prostate cancer is ascertained with the use of anatomical…
- Trial name
- ChoPEN (NCT01769950)
- Testing
- Choline-PET
- Where
- India
- Volunteers
- 120 people
- Sponsor
- Bangalore Institute of Oncology
Root Canal Infection
Radicular Dentin Remaining, Risk of Perforation and Canal Transportation in Manual Versus Rotary Instrumentation in Primary Molars
Background: Root canal preparation techniques using manual instruments have found to be time-consuming and may lead to iatrogenic errors such as ledging, zipping, canal transportation, and apical blockage.
- Trial name
- NCT04793308
- Testing
- Endodontic files
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Cairo University
Coronary Artery Disease
Efficiency of AI Reporting (EAIR).
While there are features on a CCTA that are correlated with plaque vulnerability and can be reported on, this is not always done.
- Trial name
- EAIR (NCT05583968)
- Where
- United Kingdom
- Sponsor
- London North West Healthcare NHS Trust
Coronary Artery Disease
Very Early veRsus Deferred Invasive Evaluation Using Computerized Tomography in Patients With Acute Coronary Syndromes
The aim of this study is to evaluate if acute invasive coronary evaluation and treatment conducted within 12 hours of diagnosis improves clinical outcome compared to a deferred, subacute strategy in patients with unstable angina…
- Trial name
- VERDICT-EDI (NCT02061891)
- Testing
- Invasive coronary evaluation (Deferred), Invasive coronary evaluation (Acute)
- Where
- Denmark
- Volunteers
- 2,500 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Glioblastoma
Evaluation of FLT PET and MRI as Imaging Biomarkers of Early Treatment Response in Patients With Glioblastoma
Glioblastoma is the most common primary malignant neoplasm of the adult brain. Even after multimodal therapy, outcomes remain poor, with a median survival of one year.
- Trial name
- NCT01880008
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- Washington University School of Medicine
Cancer Prostate
Prospective Validation of PSMA-RADS
This is a prospective, multicenter study aimed at evaluating the diagnostic accuracy and reliability of the Prostate-Specific Membrane Antigen Reporting and Data System (PSMA-RADS) version 1.0 in detecting prostate cancer using…
- Trial name
- PSMA-RADS (NCT06359717)
- Where
- Egypt
- Volunteers
- 477 people
- Sponsor
- Zagazig University
Glioma, Low-grade Glioma
Evaluation of 18F-Fluciclovine Positron Emission Tomography - Magnetic Resonance Imaging (PET-MRI) in LGG
The purpose of this study is to see if 18F-Fluciclovine (Axumin®) is useful and safe in the management of children with Low Grade Gliomas (LGG).
- Conditions
- Glioma, Low-grade Glioma, Low Grade Glioma of Brain, Glioma, Malignant
- Trial name
- NCT05555550
- Testing
- 18F-Fluciclovine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Children's Hospital of Philadelphia
Lung Collapse
The Effect of Lateral Tilt on Ventilation Distribution in Lungs Assessed by Electrical Impedance Tomography
Prevention of lung inhomogeneity is an essential part of preventive strategy in neurocritical care, reducing the risks of secondary brain damage from hypoxemia, hypo/hypercapnia or pneumonia.
- Trial name
- N-LAT-EIT (NCT04235231)
- Testing
- Bed tilting, Body positioning
- Where
- Czechia
- Volunteers
- 250 people
- Sponsor
- Regional Hospital Liberec
Osteoporosis, Low-energy Trauma Fracture
3D Imaging of the Hip Using DXA
The study aims to determine the efficacy and best methods for predicting hip fractures and diagnosing post-menopausal osteoporosis using three dimensional structural engineering models (SEMs) of proximal femoral bone produced…
- Trial name
- 3DScans (NCT00666640)
- Testing
- DXA scan of hip, CT scan of hip
- Where
- United Kingdom
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sheffield Teaching Hospitals NHS Foundation Trust