Clinical trials: Tonsils Hypertrophy
Adenoid Hypertrophy, Tonsillar Hypertrophy
Full-wrap Versus Conventional Suspension for Reducing Soft Palate Injury Rate in Transoral Surgery
This study aims to evaluate whether the use of full-wrap suspension, compared with the traditional double-strap suspension, can effectively reduce the risk of intraoperative and postoperative soft palate injury in…
- Conditions
- Adenoid Hypertrophy, Tonsillar Hypertrophy, Nasopharyngeal Diseases, Nasopharyngeal Tumors
- Trial name
- NCT07552545
- Testing
- Intraoperative soft palate suspension using the double-strap method., Intraoperative soft palate suspension using the full-wrap method.
- Where
- China
- Volunteers
- 138 people
- Sponsor
- Sun Yat-sen University
Tonsillar Hypertrophy, Sleep Apnea, Obstructive
Intracapsular Tonsillectomy in the Treatment of Obstructive Sleep Apnea in Adults
Treating sleep apnea in adults caused by tonsillar hypertrophy with intracapsular tonsillectomy by coblation
- Trial name
- NCT04314492
- Testing
- Tonsillectomy
- Where
- 2 sites in Finland
- Volunteers
- 25 people
- Sponsor
- Turku University Hospital
Tonsillar Hypertrophy
Efficacy and Safety of Irreversible Electroporation for Chronic Symptomatic Tonsillar Hypertrophy Treatment
The purpose of the IRE System is to address the clinical need for reducing the volume of chronic symptomatic hypertrophic tonsil(s) while minimizing side effects and complications. Procedure time will also be reduced.
- Trial name
- NCT06187194
- Testing
- IRE System
- Where
- Romania
- Volunteers
- 24 people
- Sponsor
- ENTire Medical Ltd.
Covid19, Immune Deficiency
The Relationship Between Covid-19 Infection in Pediatric Patients and Secondary Lymphoid Organs
We aimed to find out whether the tonsils and nasal tissues of pediatric patients are the main factors that protects the children's immune system against COVID-19 infection.
- Conditions
- Covid19, Immune Deficiency, Tonsillitis, Tonsil Hypertrophy
- Trial name
- NCT04646525
- Testing
- Physical examination
- Where
- Turkey (Türkiye)
- Volunteers
- 300 people
- Sponsor
- Selcuk University
Obstructive Sleep Apnea of Child
Single Cell Sequencing of Tonsillar Tissue in Children With OSA
Obstructive sleep apnoea (OSA) in children is a prevalent sleep disorder, and is characterised by repetitive complete or partial upper airway obstruction during sleep.
- Trial name
- NCT05115968
- Testing
- Tonsillectomy
- Where
- Hong Kong
- Volunteers
- 16 people
- Sponsor
- Chinese University of Hong Kong
Tonsillar Hypertrophy, Upper Airway Obstruction
Safety and Efficacy of the Irreversible Electroporation (IRE) System for Adenotonsillar Hypertrophy in Children
This is a multi-center, prospective, open-label, traditional feasibility study with a before-after study design. The study is designed to evaluate the safety and efficacy of an Irreversible Electroporation (IRE) System for the…
- Trial name
- NCT06960239
- Testing
- IRE System
- Where
- 2 sites in Romania, Uzbekistan
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- ENTire Medical Ltd.
Tonsillar Hypertrophy
Tulobuterol Patch in Pediatric Patients Undergoing Tonsillectomy
Tonsillectomy is a common pediatric procedure for the treatment of sleep-disordered breathing and chronic tonsillitis. Up to half of children having this procedure experience a perioperative respiratory adverse event.
- Trial name
- NCT04057469
- Testing
- Tulobuterol Hydrochloride
- Where
- 4 sites in South Korea
- Volunteers
- 182 people
- Sponsor
- Seoul National University Hospital
Pain, Postoperative, Tonsillar Hypertrophy
Management of Post-Tonsillectomy Pain in Pediatric Patients
Single-center, randomized, open-label, non-inferiority treatment pilot study to evaluate the effectiveness of a combined acetaminophen and ibuprofen regimen for treatment of post-operative tonsillectomy pain in the pediatric…
- Conditions
- Pain, Postoperative, Tonsillar Hypertrophy, Tonsillitis
- Trial name
- NCT04551196
- Testing
- Alternating Acetaminophen and Ibuprofen, Combined Acetaminophen and Ibuprofen
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Washington University School of Medicine
Chronic Tonsillitis, Tonsillectomy
Comparison of Cold Dissection Technique and Needle Monopolar Electrocautery Tonsillectomy
Patients 13-years-or older who undergo tonsillectomy operation (without another additional surgery) will be enrolled in the study.
- Conditions
- Chronic Tonsillitis, Tonsillectomy, Tonsillar Hypertrophy
- Trial name
- TONSIL (NCT02818647)
- Testing
- Tonsillectomy
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Pain, Postoperative, Tonsillar Hypertrophy
Optimization of Pediatric Tonsillectomy to IMprove AnaLgesia
The purpose of this study is to compare the use of short acting opioids (fentanyl/hydromorphone) with long acting opioids (methadone) for pain control following tonsillectomy surgery in children and adolescents.
- Conditions
- Pain, Postoperative, Tonsillar Hypertrophy, Tonsillitis, Pediatric Sleep Apnea
- Trial name
- OPTIMAL (NCT06576830)
- Testing
- Methadone, Fentanyl/Hydromorphone
- Where
- United States
- Volunteers
- 440 people, healthy volunteers welcome
- Sponsor
- Duke University
Obstructive Sleep Disorder, Obstructive Sleep Apnea
Topical Microporous Polysaccharide Hemospheres Versus Electrocautery for Control of Pediatric Post-Tonsillectomy Bleeding
The ultimate goal of this work is to establish a method for control bleeding after tonsillectomy in awake children. Treatment of post-tonsillectomy bleeding in children typically requires general anesthesia with currently used…
- Conditions
- Obstructive Sleep Disorder, Obstructive Sleep Apnea, Tonsillar Hypertrophy
- Trial name
- NCT00945412
- Testing
- Micropolysaccharide Hemospheres (Arista), Electrocautery (Monopolar suction cautery)
- Where
- United States
- Sponsor
- Massachusetts Eye and Ear Infirmary
Adenoid Hypertrophy, Tonsillar Hypertrophy
Metabolomic Profiling of Racial Disparity
Tonsillectomy ± adenoidectomy (T\&A) is one of the most common surgical operations with over 500,000 pediatric T\&As performed annually in the United States.
- Conditions
- Adenoid Hypertrophy, Tonsillar Hypertrophy, Surgery
- Trial name
- NCT06266429
- Testing
- Blood collection
- Where
- United States
- Volunteers
- 84 people
- Sponsor
- Nationwide Children's Hospital
Tonsillar Hypertrophy, Eustachian Tube Dysfunction
Evaluation of Eustachian Tube Function With 226 and 1000 Hz Probes in Children Undergoing Tonsillectomy ± Adenoidectomy
In children undergoing tonsillectomy ± adenoidectomy without eustachian dysfunction, the objective is to control tubal functions with tympanometry utilising probes at 226 Hz and 1000 Hz, as well as measuring the ipsilateral and…
- Conditions
- Tonsillar Hypertrophy, Eustachian Tube Dysfunction, Tympanic Membrane Disorder, Eustachian Tube Dysfunction of Both Ears
- Trial name
- NCT06577051
- Testing
- Eustachian tube function test with 226 and 1000 Hz probes
- Where
- Turkey (Türkiye)
- Volunteers
- 128 people
- Sponsor
- Sumeyra DOLUOGLU
Laryngopharyngeal Reflux, Hypertrophy of Lingual Tonsil
Dexlansoprazole to Treat Laryngopharyngeal Reflux and Lingual Tonsil Hypertrophy
Main Hypothesis: The investigators hypothesize that measurements of lingual tonsil tissue (LTT) thickness will decrease following treatment with once daily oral dexlansoprazole 60 mg in patients diagnosed with laryngopharyngeal…
- Trial name
- NCT01328652
- Testing
- dexlansoprazole
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Advanced Center for Specialty Care
Obstructive Sleep Apnea, Tonsillar Hypertrophy
Tonsillectomy vs. Tonsillotomy in Adults With Obstructive Sleep Apnea
The primary purpose of this randomized controlled trial s to investigate whether surgical reduction of palatine tonsils (tonsillotomy) is a superior treatment compared to complete surgical removal of palatine tonsils…
- Trial name
- NCT06376383
- Testing
- Tonsillectomy, Tonsillotomy
- Volunteers
- 464 people
- Sponsor
- University of Aarhus
Adenoid Hypertrophy, Tonsillar Hypertrophy
Evaluation of the Effects of Adenoidectomy and Adenotonsillectomy on Voice in Children
This prospective study aims to evaluate the effects of adenoidectomy and adenotonsillectomy on voice and speech functions in children.
- Conditions
- Adenoid Hypertrophy, Tonsillar Hypertrophy, Voice Disorders in Children
- Trial name
- NCT07399041
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Gaziosmanpasa Research and Education Hospital
Obstructive Sleep Apnea, Tonsillar Hypertrophy
Long-term Results of Tonsillectomy in the Treatment of Obstructive Sleep Apnea in Adults
Long-term results of tonsillectomy in the treatment of obstructive sleep apnea in adults
- Conditions
- Obstructive Sleep Apnea, Tonsillar Hypertrophy, Sleep Apnea Syndromes
- Trial name
- NCT05049369
- Testing
- Polysomnography
- Where
- Finland
- Volunteers
- 17 people
- Sponsor
- Turku University Hospital
Obstructive Sleep Apnea, Enlargement of Tonsil or Adenoid
Caffeine in Children With Obstructive Sleep Apnea, Dose Response Study
The aim of this study is to evaluate whether a smaller dose of caffeine sodium benzoate 10 mg/kg IV is as effective as 20 mg/kg IV in decreasing the number of children who develop post extubation adverse upper airway respiratory…
- Trial name
- NCT01349205
- Testing
- Caffeine and sodium Benzoate 10 mg/kg IV, Caffeine and Sodium Benzoate 20 mg/kg IV, 0.9 NS Saline
- Where
- United States
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Oropharynx Cancer, Oropharynx Neoplasm
Outpatient Ultrasound for the Diagnostic Work-up of Oropharynx Cancer
The aim of the study was to examine the detection rate and tumor size evaluation in patients with suspected oropharynx cancer using a new technique with transoral ultrasound of the oropharynx.
- Conditions
- Oropharynx Cancer, Oropharynx Neoplasm, Tonsil Cancer, Tonsil Neoplasm
- Trial name
- NCT05698667
- Testing
- Transoral ultrasound, Transcervical ultrasound
- Where
- Denmark
- Volunteers
- 26 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Obstructive Tonsillar Hypertrophy, Tonsillitis
Randomized Controlled Study of Plasmaknife Tonsillectomy Versus Monopolar Tonsillectomy
Study objective is to provide prospective randomized controlled data on pediatric pain levels found in PlasmaKnife tonsillectomy and monopolar tonsillectomy.
- Trial name
- jPK (NCT00466544)
- Testing
- Plasmaknife, Monopolar
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Children's Hospital of Michigan