Clinical trials: Tooth Caries
Vital Pulp Therapy
Diagnostic Biomarkers to Correlate Molecular Changes and Inflammatory Cascade in the Dental Pulp.
This study aimed to evaluate the molecular changes that occur within the pulp tissue during inflammation and its correlation with vital pulp therapy with its different treatment modalities (Direct pulp capping, Partial Pulpotomy…
- Trial name
- NCT05464797
- Testing
- Pulp therapy, Cytokines level in pulpal blood.
- Where
- Egypt
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Mansoura University
pH, Microbiome
Oral Changes With Caloric and no Caloric Sweeteners
The objective of this clinical trial is to compare the effect that the intake of beverages without sweeteners, added with non-caloric sweeteners (stevioside) and caloric sweeteners (sucrose) on oral pH and dental biofilm…
- Conditions
- pH, Microbiome, Dental Plaque
- Trial name
- NCT05852145
- Testing
- Stevioside, Sucrose, Natural water
- Where
- Mexico
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Hospital Infantil de Mexico Federico Gomez
High Caries Risk, Low Caries Risk
TAS1R1, TAS1R3, TLR2, TLR4, CA6 Gene Polymorphism on Dental Caries
The aim of this study is to examine the effects of TAS1R1, TAS1R3, TLR2, TLR4, CA6, gene polymorphism on caries risk in adults.
- Trial name
- NCT04066101
- Testing
- high caries risk, caries activity
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Recep Tayyip Erdogan University Training and Research Hospital
Obesity, Obesity, Childhood
Associations Between Obesity, Dental Caries, Erosive Tooth Wear and Periodontal Disease in Adolescents: A Case Control-study
Objectives To compare oral health (dental caries, periodontal status, and erosive tooth wear (ETW)), diet and oral hygiene habits between obese and normal weight adolescents, and to explore possible risk associations.
- Conditions
- Obesity, Obesity, Childhood, Tooth Wear, Tooth Erosion
- Trial name
- NCT05146557
- Testing
- Dental examination
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- University Ghent
Post-operative Pain, Dental Caries
The Effect of Different Lining Strategies on Amalgam Restorations
The aim of this research is to compare the clinical outcome of amalgam restorations placed in conjunction with three different lining protocols, each of which represents a different therapeutic concept.
- Trial name
- NCT02435459
- Testing
- No lining, Calcium Hydroxide cement, RMGI cement
- Where
- United Kingdom
- Volunteers
- 640 people, healthy volunteers welcome
- Sponsor
- University of Birmingham
Dental Caries
Effect of a Sugar-Free Chewing Gum Containing Magnolia Bark Extract on Caries Lesions in Healthy Adult Volunteers
The effect of chewing gums containing MBE and xylitol on different variables related to caries and gingivitis in a sample of adult volunteers with a high risk for caries will be evaluated.
- Trial name
- NCT02310308
- Testing
- Chewing gum administration
- Where
- 2 sites in Italy
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- Università degli Studi di Sassari
Caries, Dental
Management of Occlusal Dentinal Caries in Deciduous Molars
This study evaluated and compared the efficacy of no caries removal and sealing with a well-adapted and crimped stainless steel crown verses selective caries removal upto soft dentin and upto firm dentin in healing and/or…
- Trial name
- MOD (NCT03552835)
- Testing
- no caries removal, partial caries removal upto soft dentin, partial caries removal upto firm dentin
- Where
- India
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Sneha D. Suwarnkar
Caries,Dental
Comparative Evaluation of Bioflx Crowns vs Stainless Steel Crowns
Comparative Evaluation of Clinical Success,Parental and child Satisfaction of Bioflx Crowns Versus Stainless Steel Crowns as Restorations for Primary Molars: A Randomized Clinical Study
- Trial name
- NCT06396195
- Testing
- bioflx crown, stainless steel crown
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Cairo University
Primary Teeth, Dental Caries
Assessment of Stainless Stain Crowns Placed Using the Hall Technique and Traditional Technique
The purpose of this study is to evaluate and compare the clinical performance of Stainless Stain Crowns Placed Using the Hall Technique and Traditional Technique
- Conditions
- Primary Teeth, Dental Caries, Dentin, Carious
- Trial name
- NCT03433157
- Testing
- Hall technique, Traditional technique
- Where
- Turkey (Türkiye)
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Dental Caries
Arresting Active Dental Caries in Preschool Children by Topical Fluorides
This randomized clinical trial aims to compare the effectiveness of three topical fluoride application protocols, namely three applications of a 30% SDF solution at yearly or weekly interval and three applications of a 5% NaF…
- Trial name
- NCT02426619
- Testing
- SDF solution, NaF varnish
- Where
- China
- Volunteers
- 371 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
PreTerm Birth
Prevalence of Dental Caries in Preterm Birth Children Aged 2-5 Years in Primary Dentition
The purpose of the study is to determine the prevalence of dental caries in preterm birth children aged 2-5 years in primary dentition.
- Trial name
- NCT02999061
- Where
- Egypt
- Volunteers
- 383 people, healthy volunteers welcome
- Sponsor
- Cairo University
Clinical Trial, Dental Caries
Clinical Evaluation of Class I Direct and Indirect Restorations Over 10 Years
This clinical study aims to evaluate and compare the long-term clinical performance of direct and indirect restorations in Class I cavities of molar teeth over a 10-year period.
- Trial name
- NCT07081529
- Testing
- Direct Restoration with Microhybrid Composite, Indirect Restoration with Reinforced Microfill Composite
- Volunteers
- 27 people, healthy volunteers welcome
- Sponsor
- Kocaeli University
Caries, Dental, Fluorosis, Dental
Dental Fluorosis Risk by the Use of Acidulated Fluoride Dentifrice
This research aimed to evaluate the risk of dental fluorosis by using an experimental fluoridated acidulated dentifrice compared to conventional dentifrices in two-to-four-year-old children residing in a non fluoridated area by…
- Trial name
- NCT03761485
- Testing
- Use of Dentifrice Fluoride
- Volunteers
- 452 people, healthy volunteers welcome
- Sponsor
- Federal University of Paraíba
Dental Caries in Children
Impact of Oral Health Program on Al-Lith Children's KAP
Dental caries remains a significant global public health issue, particularly affecting children's health, development, and well-being, with inadequate knowledge, attitudes, and practices around oral health exacerbating these…
- Trial name
- NCT07009015
- Testing
- The oral health education intervention program
- Where
- Malaysia
- Volunteers
- 430 people, healthy volunteers welcome
- Sponsor
- Universiti Putra Malaysia
Vitamin D Deficiency, Dental Caries
Maternal Vitamin D Levels in Pregnancy and Dental Caries in Children
The main aim of this study is to investigate potential associations between maternal pre- and postnatal vitamin D level and oral health outcomes (caries and developmental defects of enamel) in their children at 7-9 years of age.
- Conditions
- Vitamin D Deficiency, Dental Caries, Dental Enamel Hypoplasia
- Trial name
- NCT03273725
- Testing
- Dental examination including taking a saliva sample.
- Volunteers
- 178 people, healthy volunteers welcome
- Sponsor
- Tannhelsetjenestens Kompetansesenter Midt-Norge
Periodontal Disease, Periapical Disease
Periodontal and Periapical Inflammation and Pregnancy
This is a retrospective chart review of patient records at the University of Mississippi Medical Center. We are not actively recruiting patients for this study.
- Conditions
- Periodontal Disease, Periapical Disease, Pregnancy, Diabetes
- Trial name
- NCT00490165
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Roger Johnson
Deep Carious Lesions
Radiographic Assessment of Calcific Bridge Formation by Light Activated Calcium Silicate Versus Calcium Hydroxide for Deep Caries
sixty participants will be divided in to two groups (n=30) of patient treated by partial caries removal according to the capping material (A),where (A1)represents calcium silicate group,(A2)represent calcium hydroxide group.Apply…
- Trial name
- NCT03233893
- Testing
- light activated calcium silicate
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Nutrition Disorders in Old Age, Caries,Dental
LifE Style, Nutrition and Oral Health in Care Givers (LENTO)
The LENTO study sample includes the caregivers and their clients living in eastern Finland. The aims of this study are 1. to study the nutritional status, oral health, coping, functional capacity and quality of life 2.
- Conditions
- Nutrition Disorders in Old Age, Caries,Dental, Dentures, Oral Mucositis
- Trial name
- NCT04003493
- Testing
- Nutrition and oral health intervention
- Where
- Finland
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Eastern Finland
Dental Caries, Periodontal Diseases
Xylitol Chewing-gums: Concentration in Saliva and Antibacterial Effect
a double-blind cross-over in vivo study was performed to measure the salivary concentration of Xylitol released from the two chewing gums containing different amount of the polyol.
- Trial name
- NCT03971981
- Testing
- 100% Xylitol Gum, 22% Xylitol Gum
- Where
- Italy
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Università degli Studi di Sassari
Dental Caries, White Spot Lesion
A Randomized Controlled Trial of Vitamin D Supplementation on Salivary Biomarkers and Cariogenic Oral Microbiome
The goal of this clinical trial is to compare the treatment effect of vitamin D supplementation and topical fluorides in the population having vitamin D deficiency and Initial Carious Lesions (ICL) on the progression of ICL in…
- Conditions
- Dental Caries, White Spot Lesion, Initial Caries, Incipient Enamel Caries
- Trial name
- Incipient (NCT06172764)
- Testing
- Vitamin D supplements along with behavioral modification, Topical fluoride application and Vitamin D supplements along with behavioral modification, Topical fluoride application along with behavioral modification
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Dow University of Health Sciences