Clinical trials: Tooth Caries
Orthodontics, White Spot Lesions [Initial Caries] on Smooth Surface of Tooth
Orthodontic Treatment on Oral Microbiota and Salivary Proteins
Study on the changes in oral microbiota during orthodontic treatment in patients aged 8-18 years. Orthodontic patients treated at Stomatology Hospital of Xi'an Jiaotong University from March 2025 to March 2027 will be recruited.
- Conditions
- Orthodontics, White Spot Lesions [Initial Caries] on Smooth Surface of Tooth, Caries, Dental
- Trial name
- NCT06824493
- Testing
- no interventions, No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Xi'an Jiaotong University
Dental Caries in Children
3D-printed Crowns Versus Zirconia Crowns for Primary Molars
The aim of the present study is to compare between 3D-printed crowns and prefabricated zirconia crowns for restoring pulpally-treated primary molars regarding the following aspects: 1.
- Trial name
- NCT06068244
- Testing
- 3D printed crowns, Zirconia crowns
- Where
- Egypt
- Volunteers
- 46 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Dental Caries, Minimally Invasive
Sealing Defective Margins of Composite Restorations With Fluid Composite Resin Nanofiller Reinforced
the patient (n=60), with at least 3 composite resins with marginal defects , randomized into 3 groups A=Sealed with flow composite reinforced with nanofiller , B= Sealed with resin sealant , and C=Control, without intervention …
- Conditions
- Dental Caries, Minimally Invasive, Repair
- Trial name
- SEAL2 (NCT03214445)
- Testing
- Sealing margins with flow composite, Sealing margins with seal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Chile
Dental Caries, Oral Disease
Fluoride Varnish Community Trial
This cluster-randomized controlled community trial aimed to assess the efficacy and costs of fluoride varnish application for caries prevention in a high-risk population in South Africa.
- Conditions
- Dental Caries, Oral Disease, Costs
- Trial name
- NCT03429829
- Testing
- Flairesse varnish
- Where
- 2 sites in South Africa
- Volunteers
- 513 people, healthy volunteers welcome
- Sponsor
- DMG Dental Material Gesellschaft mbH
Anxiety Disorders, Oral Disease
Effect of Trait Anxiety in Women on Oral Health Status and Oral Health Care-Seeking Behavior
Trait anxiety is the tendency of an individual to perceive environmental stimuli such as different events and situations as threatening; it's stable and reflects how an individual generally feels.
- Conditions
- Anxiety Disorders, Oral Disease, Periodontal Diseases, Periodontal Attachment Loss
- Trial name
- NCT04274855
- Where
- Egypt
- Volunteers
- 451 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Early Childhood Dental Caries
Development and Evaluation of a Medical Intervention for Early Childhood Caries
This study aimed to evaluate the effect of three forms of continuing medical education (CME) on provision of preventive dental services to Medicaid-enrolled children by medical personnel in primary care physician offices.
- Trial name
- IMB-RCT (NCT00464009)
- Testing
- Continuing medical education
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of North Carolina, Chapel Hill
Oral Health Related Quality of Life (OHRQoL), Early Childhood Caries (ECC)
Assessment of Oral Health-Related Quality of Life in Preschool-Aged Children in Alto Alentejo
The observational study aims to improve understanding of Oral Health-Related Quality of Life (OHRQoL) among preschool children in the District of Portalegre, Portugal, by examining the roles of sociodemographic, behavioral, and…
- Conditions
- Oral Health Related Quality of Life (OHRQoL), Early Childhood Caries (ECC), Traumatic Dental Injuries, Gingivitis
- Trial name
- NCT07648121
- Where
- Portugal
- Volunteers
- 454 people, healthy volunteers welcome
- Sponsor
- University of Lisbon
Dental Caries
In Vivo Evaluation of an Experimental Fluoride-containing Dentifrice With Hydrocolloid
The literature recognizes that fluoride is the most widely used and studied means for dental remineralization. The use of fluoride toothpaste in brushing is considered more rational method for the prevention of caries.
- Trial name
- FdentifriceT (NCT02809014)
- Testing
- Dentifrice F-Complex, Dentifrice F-Complex + NaF, Dentifrice standard
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Fabio Correia Sampaio
Dental Caries
Prevention of Enamel Demineralization by Use of K18-smooth Surface Sealant
This study will evaluate effectiveness of a urethane dimethacrylate (UDMA)-quaternary ammonium methacrylate (K18) resin (UDMA-K18) smooth surface sealant to prevent biofilm attachment to tooth surfaces thereby eliminating the…
- Trial name
- K18 (NCT03306433)
- Testing
- UDMA-K18 smooth surface sealant
- Where
- United States
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Pulpitis, Caries Active
Hydraulic Cements in Partial Pulpotomy
This study is a randomized clinical trial that compares two types of hydraulic cements used in partial pulpotomy procedures for permanent teeth affected by deep decay and pulp inflammation.
- Trial name
- NCT06881615
- Testing
- MTA PLACEMENT FOR PP, PUTTY PLACEMENT FOR PP
- Where
- Spain
- Volunteers
- 71 people, healthy volunteers welcome
- Sponsor
- Universidad Europea de Madrid
Dental Caries
DPBRN Prevalence of Questionable Occlusal Caries Lesions
The purpose of this study was to investigate the process involved when making decisions about the diagnosis and treatment of questionable lesions, as well as determine if there is any association between lesions progression (or…
- Trial name
- NCT01201447
- Where
- 7 sites in United States, Denmark
- Volunteers
- 2,624 people, healthy volunteers welcome
- Sponsor
- Dental Practice-Based Research Network
Dental Caries
Reminerlization Potential of GSE Gel versusCPP-ACP in Carious White Spot Lesions in Post Orthodontic Patients
Assess the effectiveness of applying grape seed extract (GSE) gel versus casein phosphopeptide-amorphous calcium phosphate (MI) paste on remineralization of white spot lesion (WSLs) in post orthodontic patients.
- Trial name
- NCT03966378
- Testing
- Grape seeds extract, Casein-phosphopeptide/amorphous-calcium phosphate
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Cairo University
Deep Caries
Evaluation of Three Different Pulp Capping Materials in Indirect Pulp Treatment of Primary Teeth
The aim of this randomized, controlled, three-arm parallel-group, double-blinded clinical trial was to evaluate the clinical, radiographic, and histopathological success of three different pulp-capping materials in one-stage…
- Trial name
- NCT04265833
- Testing
- Biodentine, TheraCal LC, Calcium hydroxide
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Caries, Tooth Decay
Improving Oral Health With Serious Games
This study investigated if computer games can be effective at changing the way children take care of their teeth. We a museum exhibit with 3D virtual reality games called "Attack of the S.
- Conditions
- Caries, Tooth Decay, Cavities, Gingivitis
- Trial name
- AOTSM (NCT02027597)
- Testing
- Attack of the S. Mutans, Follow-up, SnowWorld
- Where
- United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- University of Washington
Dental Caries, Dental Caries in Children
Technology-enabled Anticipatory Guidance and Peer Support in Empowering Parents to Prevent Early Childhood Caries
Early Childhood Caries (ECC) is a significant clinical and public health challenge that the world and the Singapore population are facing.
- Conditions
- Dental Caries, Dental Caries in Children, Diet Habit
- Trial name
- NCT06558955
- Testing
- Technology-enabled anticipatory guidance and peer support, Conventional health education
- Where
- Singapore
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- National University of Singapore
Caries, Dental
Atraumatic Restorative Treatment Sealants in First Permanent Molars
The aim of this bi-center study was to evaluate the retention and caries-preventive effect of Atraumatioc Restorative Treatment (ART) sealants, using two glass ionomer cement (GIC) versus non-sealant on first permanent molars of…
- Trial name
- NCT03667768
- Testing
- Glass ionomer sealant, Non-sealant (toothbrushing)
- Volunteers
- 437 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Caries,Dental, Pit and Fissure Caries
Retention of a Flowable Resin-based Sealant With Two Types of Adhesives
The aim of the present study is to compare the use of two adhesives for the placement of occlusal sealants, evaluating their retention on the occlusal surfaces.
- Conditions
- Caries,Dental, Pit and Fissure Caries, Sealant Dental
- Trial name
- NCT04945382
- Testing
- Scotchbond Universal 3M, Single Bond 3M
- Where
- Peru
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- National University of San Marcos, Peru
Dental Caries in Children
A Comparative Clinical Study of Different Caries Removal Techniques in Pediatric Patients
The aim of this study is to evaluate the acceptance of pediatric patiens using Er: YAG laser in comparison with the conventional techniques for caries removal.
- Trial name
- NCT04591418
- Testing
- Rotary handpieces, Er:YAG laser
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Cukurova University
Dental Caries
Effectiveness of Fissure Sealant and Topical Fluoride Application in Preventing Dental Caries
Nearly half of the 12-year-old children in China have dental caries (tooth decay) and most of the lesions are in the fissures of the first permanent molars.
- Trial name
- NCT01446107
- Testing
- placement of fissure sealant, fluoride varnish, silver fluoride
- Where
- China
- Volunteers
- 502 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Caries; Initial, Occlusal Caries
Early Treatments for Preventing Occlusal Caries Lesions
Sealants effectively arrest non-cavitated caries lesions on the fully erupted occlusal surface of permanent teeth. However, the clinical effectiveness of sealants is uncertain in preventing occlusal caries lesions in partially…
- Conditions
- Caries; Initial, Occlusal Caries, Caries,Dental
- Trial name
- NCT05969756
- Testing
- Fluoride varnish, Conventional etch and rinse sealant, Self-etch sealant
- Where
- 2 sites in Vietnam
- Volunteers
- 132 people, healthy volunteers welcome
- Sponsor
- Hue University of Medicine and Pharmacy