Clinical trials: Tooth Caries
Deep Caries Lesion of Primary Teeth
Impact of Different Restorative Treatments for Deep Caries Lesion in Primary Teeth
In front of a lack of evidence to determine the best treatment for deep cavitated carious lesions, the search for an effective restorative technique, which results in a least possible discomfort to patients, and reduce the time…
- Trial name
- NCT02903979
- Testing
- HVGIC, Indirect pulp capping
- Where
- Brazil
- Volunteers
- 108 people, healthy volunteers welcome
- Sponsor
- Universidade Ibirapuera
Dental Caries
Pharmacokinetics of Advantage Anti-Caries Varnish
The study aim is to characterize the kinetics of iodine and fluoride following topical application of a combined PVP-I and NaF anti-dental caries varnish in healthy adults.
- Trial name
- NCT04183231
- Testing
- Anti-caries varnish
- Volunteers
- 16 people, healthy volunteers welcome
- Sponsor
- Advantage Silver Dental Arrest, LLC
Child Behavior, Dental Caries
Midazolam and Ketamine Effect Administered Through the Nose for Sedation of Children for Dental Treatment
Randomised clinical trial to test the efficacy, safety and cost-effectiveness of sedatives; masked, controlled, parallel design with three arms, phase 4.
- Trial name
- NASO (NCT02447289)
- Testing
- Intranasal ketamine, Oral ketamine, Intranasal midazolam
- Where
- Brazil
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Universidade Federal de Goias
Caries Arrested
Selective Versus Stepwise Removal of Deep Carious Lesions in Permanent Teeth Using Different Medicaments
The study involved 54 adult patients between the ages of 18 and 50 years who had a posterior permanent tooth with a deep occlusal (Class I) carious lesion that extended to the inner third of the dentin (D3) and divided them into…
- Trial name
- NCT06585436
- Testing
- partial caries removal
- Where
- Egypt
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Al-Azhar University
pH, Saliva
Carbonated Beverage Consumption in pH and Bacterial Proliferation
The objective of this research is to evaluate the oral modifications caused by different types of coke drinks (regular coke and diet coke).
- Conditions
- pH, Saliva, Dental Plaque
- Trial name
- pHSB (NCT05437874)
- Testing
- Natural Water
- Where
- Mexico
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Hospital Infantil de Mexico Federico Gomez
Root Canal Therapy
Clinical Applicability of PBSCIMMO as a Single Material in Endodontic Obturations
A randomized, interventional, prospective, unicentric clinical study, 86 patients will be submitted to endodontic treatment of necrotic teeth.
- Trial name
- PBSCIMMO (NCT03514264)
- Testing
- Gutta Percha and AHPLUS cement (group A), PBS CIMMO cement (group B)
- Where
- Brazil
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Universidade do Vale do Sapucai
Class II Dental Caries
Clinical Performance of Bulk-Fill Composite Using With Adhesives With or Without Chlorhexidine
This study aims to evaluate the clinical success of chlorhexidine-containing dentin bonding agent in primary molars with a 12-month follow-up.
- Trial name
- NCT06257108
- Testing
- Class II Cavity Restorations
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Uşak University
Dental Caries
Validation of Near-infrared Light Transillumination for Interproximal Enamel Caries Detection
The aim of this study is to validate a near-infrared light transillumination device (DIAGNOcam, KaVo, Biberach, Germany) for interproximal enamel caries detection and compare it with the established diagnostic methods (visual…
- Trial name
- NCT02657538
- Testing
- Non invasive caries treatment, Invasive caries treatment, Near-infrared light transillumination device (DIAGNOcam, KaVo, Biberach, Germany)
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- University of Bern
Dental Caries
Assessment of Digital Technologies for Detection of Dental Caries
This study aims to evaluate and compare different digital diagnostic technologies used for the detection of dental caries in clinical practice.
- Trial name
- NCT07560514
- Testing
- Diagnostic methods for dental caries
- Where
- Slovakia
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- University Hospital, Martin
Caries, Dental, Periodontal Diseases
The Effectiveness of an Oral Health Education Programme of Adolescents in Hong Kong
This project aims to evaluate the relative efficacy of a peer-led intervention based on the Social Cognitive Theory and Health Belief Model versus the control (only pamphlet delivery) on increasing the prevalence of healthy oral…
- Trial name
- NCT03694496
- Testing
- peer-led theory-based intervention group
- Where
- Hong Kong
- Volunteers
- 1,184 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Dental Caries
Fissure Caries Inhibition Study With Solea CO2-9.3μm Short-pulsed Laser
The objective of this clinical study is to evaluate whether the use of the new CO2 - 9.3μm short-pulsed laser increases the caries resistance of occlusal pit and fissure surfaces in patients in addition to fluoride therapy.
- Trial name
- LaserFissure (NCT02357979)
- Testing
- Laser, Fluoride
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Oral Squamous Cell Carcinoma (OSCC), Periodontal Disease
Discovery and Validation of Biomarkers for Periodontitis, Dental Caries and Oral Squamous Cell Carcinoma
The goal of this observational study is to develop better ways to detect and predict major oral diseases, including oral cancer, gum disease, and tooth decay.
- Conditions
- Oral Squamous Cell Carcinoma (OSCC), Periodontal Disease, Dental Caries
- Trial name
- NCT07745803
- Testing
- Step 1 and 2 periodontal therapy according to the EFP clinical practice guidelines, Dental filling with or without root canal treatment, Oral cancer surgical resection including extension, dissection and reconstruction with adjunctive radiation, chemotherapy and/or biological treatments per international guidelines,
- Where
- China
- Volunteers
- 4,000 people, healthy volunteers welcome
- Sponsor
- Shanghai Ninth People's Hospital Affiliated to Shanghai Jiao Tong University
Demineralization, Tooth, White Spot Lesion of Tooth
Preventive Effects of Silver Diamine Fluoride on Early Enamel Caries
Fixed orthodontic patients are at risk of developing dental caries. Topical application of fluoride varnish (FV) around the orthodontic brackets and using fluoridated mouth rinses have been suggested to prevent the formation of…
- Conditions
- Demineralization, Tooth, White Spot Lesion of Tooth, Fixed Appliances, Early Caries Lesions
- Trial name
- NCT06797882
- Testing
- Silver diamine fluoride- potassium iodide, Fluoride varnish, 0.9 % saline
- Where
- Malaysia
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Caries, Caries,Dental
Extraction of the Compromised First Permanent Molars
Compromised first permanent molars (FPM), whether diagnosed with severe molar incisor hypomineralization (MIH), irreversible pulpities, or necrosis, require frequent re-treatment consequently entering the restorative cycle, which…
- Trial name
- FPM (NCT06231823)
- Testing
- Extraction
- Where
- Egypt
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Dental Caries, Quality of Life
Impact of Two Recall Intervals on Dental Caries Incidence, Anxiety and Quality of Life of Preschool Children
Objectives: To assess the effectiveness of two recall intervals on dental caries incidence (primary outcome) in preschool children with low and moderate caries risk.
- Conditions
- Dental Caries, Quality of Life, Anxiety
- Trial name
- NCT02263768
- Testing
- Oral clinical conditions
- Where
- Brazil
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Dental Caries
Bioactive Composite Versus Resin-Modified Glass Ionomer Liners: 2-Year Clinical Trial
compare 2-year clinical performance of recent bioactive ionic resin composite to resin-modified glass ionomer liner in indirect dental pulp treatment.
- Trial name
- BIRCRMGILYCT (NCT05470959)
- Testing
- ACTIVA bioactive, Riva LC
- Where
- Egypt
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Dental Cavity
Pathogenic Species and Genotypes of Bacterial Diversity in Relation to the Severity of Dental Caries
The primary objective of this study is to estimate the distribution of pathogenic species and genotypes of bacterial diversity in 7 stages ICDAS (International Caries Detection and Assessment System) corresponding to the severity…
- Trial name
- Caries Species (NCT02056262)
- Testing
- Dental cavity evaluation, Saliva sampling, Plaque sampling
- Where
- 3 sites in France
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Dental Caries Extending to Pulp
Color Stability of NeoMTA Pulpotomized Primary Teeth
This randomized control study will use 15 pediatric subjects selected from the patient population in the pediatric dental clinic at Children's Medical Center Dental Clinic (CMC Dental Clinic).
- Trial name
- NCT03254290
- Testing
- NeoMTA, Formocresol
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Texas A & M University Baylor College Of Dentistry
Dental Caries
CAMBRA - PBRN Caries Management By Risk Assessment In A Practice-Based Research Network
The goal of this project is to create a Practice Based Research Network with 30 researcher dentists calibrated on the administration of a caries risk assessment and the treatment modalities recommended based on the caries risk…
- Trial name
- CAMBRA-PBRN (NCT01176396)
- Testing
- Caries prevention active intervention, control treatment
- Where
- United States
- Volunteers
- 460 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Dental Caries Extending Into Dentin, Root Caries
Root Caries Excavation with Air Water/powder Prophylaxis Device for ART Restorations
The main objective of this RCT is to compare the efficacy of a powder/water jet prophylaxis device and conventional hand excavation in excavating root surface caries, with regard to restoration survival/success in older adults.
- Trial name
- ART-AIRFLOW (NCT04822246)
- Testing
- Control: Hand instrumentation for caries excavation, Intervention 1: EMS Airflow device for caries excavation, Intervention 2: Hand excavation + EMS Airflow device for caries excavation
- Where
- Switzerland
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Murali Srinivasan, Dr. med. dent., BDS, MDS, MBA, MAS