Clinical trials: Tooth Caries
Microbial Colonization
Microbiological Assessment After Chemo-Mechanical Caries Removal Using Papain-based Enzyme Versus Conventional Rotary Tools in Occlusal Carious Lesions
This study will be conducted to assess the efficacy of caries excavation using the papain-based chemo-mechanical method (Brix 3000) in comparison to conventional rotary tools in the reduction of the bacterial population in…
- Trial name
- NCT03408626
- Testing
- Papain-based Chemo-mechanical caries removal agent, conventional rotary
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Cairo University
Caries; Initial, Caries Active
Clinical Effectiveness of Bioactive Silica Based With Calcium Toothpaste
This study will be conducted to Clinically evaluate Bioactive Silica Based with calcium booster (Refix technology) toothpaste and Sodium Fluoride varnish versus conventional fluoride toothpastes in management of white spot…
- Trial name
- NCT07120243
- Testing
- Toothpaste Product, Varnishes, Fluoride
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Rawda Hesham Abd ElAziz
Dental Caries, Gingival Inflammation
DETERMINATION OF THE EFFECTS OF STAINLESS STEEL CROWNS CEMENTED WITH RESIN CEMENTS ON INTERLEUKIN-10, 12, 18 LEVELS IN GINGIVAL CREVICULAR FLUID
This split-mouth clinical study aimed to evaluate the early effects of stainless steel crowns cemented with self-adhesive resin cement and high-viscosity glass ionomer cement on clinical periodontal parameters and interleukin-10…
- Conditions
- Dental Caries, Gingival Inflammation, Periodontal Response to Dental Restorative Materials
- Trial name
- SSC-CYTO (NCT07421206)
- Testing
- Self-Adhesive Resin Cement Group, High-Viscosity Glass Ionomer Cement
- Where
- Turkey (Türkiye)
- Volunteers
- 45 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Dental Caries
Performance of Glass-ionomer Cements: 2-year Follow-up
The purpose of this randomized clinical trial was evaluate the performance of two conventional glass-ionomer cements in the pit and fissure sealing and atraumatic restorative treatment in high caries risk children.
- Trial name
- NCT02659917
- Testing
- Glass ionomer, Glass ionomer cement, -Glass ionomer-
- Volunteers
- 147 people, healthy volunteers welcome
- Sponsor
- Fernanda Miori Pascon
Post-operative Pain, Pulpitis - Irreversible
Outcomes of Pulpotomy and Root Canal Treatment in Teeth With Symptomatic Irreversible Pulpitis
The aim of this study is to evaluate the clinical effectiveness of total pulpotomy (TP), radicular pulpotomy (RP), and root canal treatment (RCT) in mandibular premolar and/or molar teeth diagnosed with symptomatic irreversible…
- Conditions
- Post-operative Pain, Pulpitis - Irreversible, Success Rate
- Trial name
- NCT07375576
- Testing
- Total Pulpotomy, Radicular pulpotomy, Root canal treatment
- Where
- Turkey (Türkiye)
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- Mustafa Kemal University
Dental Caries Class II
A 2-year Clinical Impact of Bulk-fill Low-viscosity Resin Composite Liners in Class II Restorations.
This randomized clinical trial evaluated the clinical performance of class II resin composite restorations using bulk-fill high-viscosity ormocer versus methacrylate-based with or without a thin layer of bulk-fill low-viscosity…
- Trial name
- NCT06032689
- Testing
- Xtra-fill, x-base, Admira fusion x-tra
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Mansoura University
Dental Caries, Infection, Bacterial
Evaluation of Gel and Solution of Chlorhexidine in Disinfection Root Canals of Primary Anterior Teeth.
The process of removing bacteria and their products from the root canals is an essential step that is achieved through the combination of mechanical preparation and irrigation with chemicals.
- Conditions
- Dental Caries, Infection, Bacterial, Tooth, Deciduous
- Trial name
- NCT05361278
- Testing
- Chlorhexidine solution, Activated chlorhexidine solution, Chlorhexidine gel
- Where
- Syria
- Volunteers
- 15 people
- Sponsor
- Damascus University
Dental Caries
Three-Year Clinical Evaluation of Class II Posterior Composite Restorations
The aim of this study was to investigate the clinical effectiveness of direct resin composite restorations placed with different placement techniques (incremental or bulk) and with different flowable linings (conventional or…
- Trial name
- NCT02858947
- Testing
- Aelite Flo, x-tra base
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- Ondokuz Mayıs University
Dental Caries, Primary Teeth
Non-Restorative Versus Conventional Caries Treatment in Primary Teeth: A Randomized Controlled Trial
Dental caries is common in young children, and treatment of cavities in primary teeth can be challenging. Conventional treatment usually involves removal of carious tooth tissue and placement of a restoration.
- Trial name
- NRCT (NCT07866755)
- Testing
- Non-restorative caries treatment (NRCT), CT
- Where
- Slovenia
- Volunteers
- 96 people
- Sponsor
- Lenka Likar Ostrc, DMD
Dental Caries
Ethanolic Extract of Aloe Vera Versus Chlorohexidine as Cavity Disinfectant.
This Randomized Clinical Trial will be conducted to compare the efficacy of ethanolic extract of Aloe vera versus chlorhexidine cavity disinfectant in reducing total bacterial count of Streptococcus mutans (SM) and Lactobacilli…
- Trial name
- NCT04446364
- Testing
- Ethanolic extract of Aloe vera gel cavity disinfectant, Chlorohexadine
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dental Caries
Phase 2, Open-Label Study for Safety, Microbiology and PK of Single or Multiple Oral C16G2 Gel Doses
Part A: Open-label, multiple arm, safety, microbiology and pharmacokinetic (PK) study in healthy adult male and female subjects 18-75 years of age. All subjects will be assessed for safety and microbiology parameters.
- Trial name
- NCT02254993
- Testing
- C16G2
- Where
- 2 sites in United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Armata Pharmaceuticals, Inc.
Cervical Caries
Nobio Antimicrobial Particles Effect in a Split Mouth Model
The study purpose is to evaluate the antimicrobial effect of Nobio particles incorporated within Novidia Dental Bonding and Flowable Composite versus standard of care within a split mouth model.The study population will include…
- Trial name
- NCT03501784
- Testing
- Nobio particles incorporated within Novidia Dental Bonding, Filtek bond and flow composite
- Where
- Israel
- Volunteers
- 35 people
- Sponsor
- Nobio Ltd.
Dental Caries, Dental Restoration Failure
Effect on Placement Tecnique of Bulkfill Composite
The objective of this study was to evaluate the clinical performance of a bulk-fill composite resin (3M ESPE Filtek Bulk Fill, St Paul, MN, USA) in restorations placed in occlusal cavities by comparing different placement…
- Trial name
- NCT07673952
- Testing
- bulk tecnique, incrementally technique
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Dental Caries, Dental Plaque Index
Antimicrobial Effect of Curcumin Versus Chlorohexidine on Oral Microbiome
Dental caries, one of the world's most common infectious diseases, is a biofilm-mediated, sugar-driven, dynamic disease. It has an impact on physical, mental, and social health and is extremely costly to society.
- Conditions
- Dental Caries, Dental Plaque Index, Oral Microbiome
- Trial name
- NCT06847984
- Testing
- Curcumin, Chlorohexidine
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Cairo University
Dental Caries, Pulpitis
Pulpotomy Materials in Primary Molars
This randomized clinical trial aims to compare four different materials used in a dental procedure called pulpotomy. Pulpotomy is commonly performed on primary molars (back teeth in children) to treat deep cavities and preserve…
- Trial name
- NCT07120321
- Testing
- Mineral Trioxide Aggregate (MTA), Biodentine, Ferric Sulfate
- Where
- Turkey (Türkiye)
- Volunteers
- 22 people
- Sponsor
- Sacide Duman
Caries, Dental Pulp Exposure
Calcium Hydroxide, Mineral Trioxide Aggregate and Biodentine (Trademark) as Direct Pulp Capping of Permanent Teeth
Background: Dental caries is considered an oral health problem worldwide. In Chile the last national epidemiological study (2007) showed a national prevalence of dental caries in children 6 years (70.3%) and 12 (62.5%).
- Trial name
- NCT02492841
- Testing
- Mineral trioxide aggregate, Calcium hydroxide, Biodentine
- Where
- Chile
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Pulp Exposure, Dental, Deep Dental Caries
Effects of Total and Selective Caries Removal - Requiring or Avoiding Vital Pulp Therapy - on Pulp Vitality and Postoperative Pain in Deep Carious Mature Permanent Teeth: A Split-Mouth Clinical Study
The effect of selective caries cleaning and total caries cleaning on pulp health and post operative pain in teeth with deep caries will be investigated.
- Trial name
- NCT07041905
- Testing
- Total Caries Removal, Selective Caries Removal
- Where
- Turkey (Türkiye)
- Volunteers
- 15 people
- Sponsor
- Cukurova University
Composite Resins, Dental Caries Class II
Bulk-Fill Composite Restorations: Clinical Evaluation
This randomized controlled clinical study aims to evaluate the clinical performance of five different bulk-fill composite materials representing distinct technological approaches according to the World Dental Federation (FDI)…
- Trial name
- NCT07518537
- Testing
- Thermoviscous bulk-fill composite restoration, Sonic-activated bulk-fill composite restoration, Flowable bulk-fill composite restoration
- Where
- Turkey (Türkiye)
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Caries, Dental
Partial Caries Removal in Permanent Molars Restored Using Giomer
Dental manufacturers\' constant tweaks and improvements to composite compositions have resulted in a wider spectrum of restorative materials with positive long-term clinical performance.
- Trial name
- NCT06601972
- Testing
- Beautifil II LS (Low-Shrinkage), Nanohybrid resin composite
- Volunteers
- 122 people
- Sponsor
- NewGiza University
Dental Caries
Indirect Pulp Treatment in Primary Molars
This study was conducted to evaluate the clinical and the radiographic success of Dycal and Vitrebond as indirect pulp treatment materials in primary molars.
- Trial name
- RCT (NCT03770871)
- Testing
- Indirect pulp treatment using Dycal (TM), Indirect pulp treatment using Vitrebond (TM )
- Where
- Egypt
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Cairo University
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