Clinical trials: Tooth Caries
Dental Caries
A Study to Evaluate the Microbiology, Safety and Tolerability of C16G2 Dental Strip Application
Single-blind study to evaluate whether C16G2 Strip administered in multiple doses can effectively kill the bacteria in the oral cavity that cause dental caries..
- Trial name
- NCT03052842
- Testing
- C16G2 Strip
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Armata Pharmaceuticals, Inc.
Amelogenesis Imperfecta, Dental Caries
Clinical Performance of Composites in Patients With Amelogenesis Imperfecta
In AI patients, adhesion still remains the first option in order to achieve an early, minimally invasive intervention, and the altered enamel still represents an acceptable substrate for bonding in some AI variants.
- Conditions
- Amelogenesis Imperfecta, Dental Caries, Dental Composite
- Trial name
- NCT04897724
- Testing
- dental composite
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Neslihan Tekçe
Incipient Caries
Clinical and Cost-Effectiveness of Silver Diamine Fluoride and Silver Fluoride, With or Without Application of LED, in Arresting Incipient Permament Molar Caries
The study aims to compare the effect of international brand ammonia based 38% SDF, water based silver fluoride solution (AgF), an aqueous silver fluoride solution, and local brand ammonia based SDF with and without LED light…
- Trial name
- SDF and AgF (NCT07366645)
- Testing
- International Sliver Diamine Fluoride, Local brand Egyptian Silver Diamine Fluoride, Silver Fluoride
- Volunteers
- 366 people
- Sponsor
- Cairo University
Tooth Diseases
Clinical Evaluation of a Self-Adhering Flowable Composite in Class I Cavities
The aim of this study is to evaluate long-term clinical performance of a self-adhering flowable resin composite in comparison with a conventional flowable resin composite used with an etch\&rinse adhesive system in minimally…
- Trial name
- NCT03556553
- Testing
- Vertise Flow, LuxaFlow, Teco Adhesive
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Hacettepe University
Caries, Dental
Prevention of Adult Caries Study (PACS)
Adult tooth decay is an infectious disease that afflicts the majority of Americans aged 55 and older and is the most common chronic disease at midlife with an ever growing economic toll.
- Trial name
- NCT00357877
- Testing
- 10% w/v chlorhexidine acetate coating FDA IND #45466
- Where
- 4 sites in United States
- Volunteers
- 983 people
- Sponsor
- Tufts University
Dental Caries
Effect of Calcium Glycerophosphate (CaGP) - Fluoride Dentifrice on Dental Biofilm pH
The aim of this study was to investigate the buffering effect of a calcium glycerophosphate-fluoride (CaGP-F) dentifrice on in vivo dental biofilm after a cariogenic challenge and evaluate its probable 12-hour protective effect.
- Trial name
- CAGP-F (NCT00875212)
- Testing
- calcium glycerophosphate, no active ingredient, fluoride
- Where
- Brazil
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Federal University of Paraíba
Dental Caries
Evaluation of a Brief Tailored Motivational Intervention to Prevent Early Childhood Caries
The Detroit Dental Health Project (DDHP)aims to promote oral health and reduce disparities within the community of low-income African-American children (0-5 years) and their main caregivers (14+ years), living in the City of…
- Trial name
- NCT01123330
- Testing
- Motivational Interviewing
- Where
- United States
- Volunteers
- 2,042 people, healthy volunteers welcome
- Sponsor
- Temple University
Dental Cervical Non-carious Lesion
Glass Hybrid Versus Composite Restorations of Non-carious Cervical Lesions
A glass hybrid restorative system (EQUIA forte) clinically compared to a composite resin based material (Clearfil SE Bond, Filtek Supreme XT) for the treatment of dental non-carious cervical lesions.
- Trial name
- NCT02631161
- Testing
- Equia Forte, Filtek Supreme XT/Clearfil SE Bond
- Where
- Germany
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Dental Caries in Children, Autistic Disorder
Dietary Impacts on Oral Health in Autistic Children: A Cross-Sectional Analysis
The study aims to explore how dietary habits affect oral health in children with autism. By examining a cross-section of the autistic paediatric population, the research seeks to identify patterns or specific dietary preferences…
- Conditions
- Dental Caries in Children, Autistic Disorder, Dietary Habits
- Trial name
- OHIDPAP-CS (NCT06280651)
- Testing
- dietary preferences and their implications for oral health in children with Autism Spectrum Disorder
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- King Khalid University
Dental Caries
Clinical Trial of the Effect of Different Categories of Adhesive System
This study aims to evaluate the clinical effectiveness of contemporary resin-based adhesive systems by retention rate of resin restorations placed in non carious cervical lesions with four different adhesive strategies: 3 and 2…
- Trial name
- NCT02751970
- Testing
- Dental restoration, 3 step ER, 2 step ER
- Where
- Chile
- Volunteers
- 185 people, healthy volunteers welcome
- Sponsor
- Universidad de Valparaiso
Dental Caries (Diagnosis), Dental Plaque (Diagnosis)
Intra Oral Scan and CBCT Aided Diagnosis of Dental Plaque and Caries
In this prospective controlled trial, patients will be enrolled at the University Hospital Ghent. Inclusion criteria are: age between 18 and 70 years old, presence of 20 or more teeth, and have a minimum one carious tooth…
- Trial name
- NCT06945354
- Where
- Belgium
- Volunteers
- 50 people
- Sponsor
- University Ghent
Ballet Dancers, Caries, Cervical
PICN Versus Bioactive Composite for Cervical Restorations in Ballet Dancers
Background and Objectives: Professional ballet dancers endure high occlusal loads, increasing cervical defect prevalence. Conventional composites fail frequently under such conditions.
- Trial name
- NCT07598305
- Testing
- Polymer-infiltrated ceramic network (PICN) - carious, Polymer-infiltrated ceramic network (PICN) - abfraction, Self-curing bioactive bulk-fill composite - carious
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- I.M. Sechenov First Moscow State Medical University
Oral Health in Children With Inflammatory Bowel Disease
Oral Health in Children With Inflammatory Bowel Disease
In adults with inflammatory bowel disease (IBD), a higher prevalence of dental caries and periodontal disease has been reported compared with healthy control subjects, but similar data on children are missing in the literature.We…
- Trial name
- NCT05538923
- Testing
- No intervention was given to the patients
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- Marmara University
Posterior Ceramic Onlays, Badly Decayed Teeth Need to be Restored , Teeth Restored With Large Filling Restorations
Functional Evaluation of Ceramic Onlay Restorations With Different Preparation Designs
Tooth preparation designs for posterior ceramic restorations have been based on traditional cast metal restoration designs, but with more occlusal tooth reduction and with a slightly increased taper.
- Trial name
- NCT04274959
- Testing
- ceramic onlay with shoulder preparation design., ,ceramic onlay with butt joint preparation design
- Volunteers
- 39 people
- Sponsor
- Cairo University
Bacterial Infections, Dental Caries
Hydrogen Peroxide Fumigation in Dental Office Environment
The study's null hypothesis posits no significant difference in bacterial levels in the dental office environment before and after implementing hydrogen peroxide (H₂O₂) fumigation.
- Conditions
- Bacterial Infections, Dental Caries, Aerosol Disease
- Trial name
- NCT06100848
- Testing
- Microbiological analysis after Caries treatment, Microbiological analysis after Caries treatment and fumigation
- Where
- Poland
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Osteoporosis, Dental Caries
Salivary Cytokines, MMP-8 and Dental Caries in Osteoporosis Patients
This study examines saliva samples from patients with osteoporosis. The levels of cytokines and Matrix Metalloproteinase-8 (MMP-8) enzyme in saliva will be measured.
- Conditions
- Osteoporosis, Dental Caries, Biomarkers, Matrix Metalloproteinase 8
- Trial name
- NCT07709247
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Afyonkarahisar Health Sciences University
Head and Neck Cancer
Chlorhexidine Gel Therapy for Cariogenic Oral Microflora
The goal of this clinical research study is to find out if 1% chlorhexidine gluconate gel will decrease the amount of bacteria that causes tooth decay. Whether the gel is acceptable to patients will also be studied.
- Trial name
- NCT01036412
- Testing
- 1% Chlorhexidine Gluconate Gel, Surveys
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- M.D. Anderson Cancer Center
Dental Caries
Comparison of Clinical and Radiographic Outcomes of SMART Technique vs ART in Primary Molars
This study conducted on thirty children aged 3-6 years old of both genders, have bilateral carious lower first primary molars. Pre-operative periapical x- ray were taken for both sides.
- Trial name
- NCT05438381
- Testing
- Atraumatic Restorative Technique (ART), SMART Technique
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Mansoura University
Dental Caries
Comparison of the Effect of Fluoride Remineralizer Gel and Foam
Compare the remineralizing effect of acidulated fluoride gel Flugel (1.23% FFA, DFL) and acidulated Fluoride Foam Flúor Care (1.23% FFA, FGM) in maxillary anterior permanent teeth of 58 children aged 7 to 12 years of age.
- Trial name
- NCT02490592
- Testing
- Fluoride Foam, Fluoride gel
- Volunteers
- 58 people, healthy volunteers welcome
- Sponsor
- University Center of João Pessoa
Decay, Dental
General Dentists' Knowledge, Attitudes and Clinical Usage of SDF
This study will look at how dentists in the UK are using Silver Diamine Fluoride (SDF) in their everyday practice. SDF is a liquid treatment that helps stop tooth decay.
- Trial name
- GDPKAUSDF (NCT07405437)
- Where
- United Kingdom
- Volunteers
- 34 people, healthy volunteers welcome
- Sponsor
- University of Edinburgh
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