Clinical trials: Tooth Disease
Dentin Sensitivity
A Study of the Relief of Tooth Sensitivity of an Experimental Mouthrinse Device
This study is for people with sensitive teeth and involves going to the dentist for 4 visits over 6 weeks. During the first 2 weeks, you will just brush your teeth two times a day with the fluoride toothpaste provided.
- Trial name
- NCT01345292
- Testing
- Mouthwash, Potassium nitrate toothpaste, Sodium fluoride toothpaste
- Where
- United States
- Volunteers
- 226 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Dental Caries
Caries Lesion Activity in Orthodontic Patients - Calcivis System
This is a prospective, single-centre clinical study to monitor caries lesion activity in orthodontic patients with the Calcivis System over a 12 week period.
- Trial name
- NCT02771522
- Testing
- Calcivis System
- Where
- United Kingdom
- Volunteers
- 36 people
- Sponsor
- Calcivis Ltd
Decay
Clinical Evaluation of Lava Digital Veneer System (DVS) Crowns
Study aim is to compare Lava Computer Aided Design / Computer Aided Milling Computer Aided Machining (CAD/CAM)crowns that are veneered (covered) with porcelain that has been milled using CAD/CAM, with similar CAD/CAM Lava crowns…
- Trial name
- NCT01278862
- Testing
- DVS veneer, Conventional Veneer
- Where
- United States
- Volunteers
- 77 people
- Sponsor
- Solventum US LLC
Malocclusion
Class II Correction Study Using the Invisalign System
To demonstrate that growing teenagers which present up to full cusp Class II malocclusions can be treated using the Invisalign System.
- Trial name
- NCT02376829
- Testing
- Invisalign System
- Where
- 10 sites in United States, Canada
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Align Technology, Inc.
Demineralization, Remineralization
Clinical Study to Evaluate the Anti-cavity Efficacy of Three Dentifrices: An In Situ Model
Clinical study to evaluate the anti-cavity effectiveness of three dentrifices using an intra-oral enamel Demineralization and Remineralization In-Situ Model.
- Conditions
- Demineralization, Remineralization, Dental Cavity, Enamel Lesions
- Trial name
- NCT07134231
- Testing
- Fluoride free toothpaste in a chalk base, Fluoride Toothpaste, Fluoride free toothpaste in a PCC/RNCC base
- Where
- Brazil
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Pain, Postoperative, Tooth Diseases
Efficacy and Safety of Ibuprofen and Caffeine in Dental Pain
The primary objective of this study is to compare the efficacy of a combination product containing ibuprofen 400 mg and caffeine 100 mg versus either ingredient alone as well as placebo for the treatment of post-surgical dental…
- Trial name
- NCT01929031
- Testing
- ibuprofen + caffeine, ibuprofen, caffeine
- Where
- United States
- Volunteers
- 562 people
- Sponsor
- Boehringer Ingelheim
Gingivitis
A Study to Determine the Effects of Adding an Experimental Device With Mouthrinse to Oral Care Regimen
The study will determine the effects of adding mechanical plaque control to a person's oral care regimen. Participants who qualify to participate in the study will will have an equal chance of being assigned to one of three…
- Trial name
- NCT01419626
- Testing
- Interdental cleaning device with water, Interdental cleaning device with essential-oil mouthrinse
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Johnson & Johnson Consumer and Personal Products Worldwide
Jaw, Edentulous, Partially
Implant Retained Rehabilitation With Surgical and Prosthetic Digital Workflow
The aim of this study is to prospectively collect clinical data to confirm the safety and clinical performance of Neodent Titanium Base Abutment and Pro PEEK Abutment in daily dental practice setting, by means of a randomized…
- Trial name
- NCT04066309
- Testing
- Neodent GM Helix Implant, GM Customizable Healing Abutment, GM Pro PEEK Abutment
- Where
- Brazil
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Neodent
Dental Plaque
Effect of Enzymes on Dental Biofilm Accumulation
Double-blind, placebo-controlled, cross-over study investigating dental biofilm accumulation after 4-days in 28 subjects randomised to receive: Sequence 1: 5 active enzyme-containing lozenges per day for 4-days followed by a…
- Trial name
- NCT05579938
- Testing
- Enzyme-containing lozenge
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Novozymes A/S
Malocclusion
The Effect of OrthoPulse Photobiomodulation on the Rate of Tooth Movement During Alignment With Fixed Appliances
The aim of this study is to determine efficacy of OrthoPulse photobiomodulation on the rate of tooth movement during alignment for Subjects receiving fixed appliance orthodontic treatment.
- Trial name
- NCT03202355
- Testing
- Fixed Appliance Orthodontic Treatment, OrthoPulse™
- Where
- 3 sites in United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Biolux Research Holdings, Inc.
Dentin Sensitivity
Effectiveness of Two Water-Based Potassium Oxalate Desensitizers on Dental Hypersensitivity
This study will compare the safety and effectiveness of two water-based potassium oxalate desensitizers on existing dentinal hypersensitivity.
- Trial name
- NCT02152826
- Testing
- Potassium oxalate
- Where
- United States
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Plaque, Dental
Single Brushing Plaque Removal Efficacy of a Battery-powered Toothbrush and a Manual Toothbrush
To evaluate and compare the plaque removal efficacy of a battery-powered toothbrush and a manual toothbrush following a single brushing.
- Trial name
- NCT06126445
- Testing
- Battery operated toothbrush, Manual toothbrush
- Where
- Canada
- Volunteers
- 62 people, healthy volunteers welcome
- Sponsor
- Church & Dwight Company, Inc.
Mouth, Edentulous
Study to Evaluate Bone and Gum Dimension Changes Around Dental Implants Placed in Different Positions in Bone.
The purpose of this study is to test two standard of care techniques of placing dental implants, and to compare how people's bones and gums respond to two different depths at which implants are placed.
- Trial name
- NCT01759537
- Testing
- Ankylos dental endosseous implants-Sub-crestal, Ankylos dental endosseous implants-Epi-crestal
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Dentsply International
Jaw, Edentulous, Partially
Study of Bone Preservation When OsseoSpeed™ Implants Are Placed Immediately Following Tooth Extraction
The purpose of this study is to evaluate the clinical performance of implants placed in individuals who are about to loose one or more of their upper teeth.
- Trial name
- NCT00711282
- Testing
- OsseoSpeed™
- Where
- 3 sites in Italy, Spain and 1 more
- Volunteers
- 104 people
- Sponsor
- Dentsply Sirona Implants and Consumables
Malocclusion
The Effects of Extraoral Photobiomodulation on the Rate of Orthodontic Alignment
The aim of this study is to determine if extraoral OrthoPulse®, which emits extraoral LED (Light Emitting Diode) photobiomodulation (PBM), reduces the time it takes to complete orthodontic alignment.
- Trial name
- NCT02267824
- Testing
- Extraoral OrthoPulse® PBM, Fixed Orthodontic Appliance Treatment
- Where
- 4 sites in United States, Canada and 1 more
- Volunteers
- 101 people
- Sponsor
- Biolux Research Holdings, Inc.
Calculus, Dental
Efficacy of Toothpaste Containing 0.454% Stannous Fluoride as Compared to a Regular Fluoride Toothpaste Containing 0.76% Sodium Monofluorophosphate in Controlling Supragingival Calculus Formation Over a 12-week Period.
To evaluate the comparative clinical efficacy of a test toothpaste containing 0.454% stannous fluoride as compared to a regular fluoride toothpaste containing 0.76% sodium monofluorophosphate in controlling supragingival calculus…
- Trial name
- NCT07223060
- Testing
- 0.454% stannous fluoride, 0.76% sodium monofluorophosphate
- Where
- Thailand
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Bruxism, Sleep-Related
A Sensor-enhanced Mouth Guard to Quantitatively Measure Bite Compression Forces.
The goal of this study is to determine if the Otis Brux-Sensor Night Guard (OBSNG) can record the bite compression forces of participants with Bruxism. The main questions it aims to answer is: 1.
- Trial name
- NCT06688474
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Otis Dental, LLC
Plaque, Dental, Gingivitis
Clinical Investigation to Assess the Efficacy of Manual Toothbrushes in the Reduction of Plaque and Gingivitis.
Qualified subjects will be enrolled and randomized to one of the two study groups based on their initial Plaque and Gingivitis scores. Subjects will be instructed to use the products according to the instructions provided.
- Trial name
- NCT06565897
- Testing
- Test regimen, Control regimen
- Where
- United States
- Volunteers
- 84 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dental Plaque Accumulation
4-day Plaque Accumulation Model Evaluating Compound Containing Gum
This will be a single-blind, single-center, 3-way crossover, randomized controlled clinical trial with 3 treatment periods utilizing 32 subjects.
- Trial name
- NCT06984744
- Testing
- MIIP-E2 containing gum
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Lactea Therapeutics, LLC
Postmenopausal Osteoporosis, Osteopenia
Study Evaluating ASTRA TECH Implant System, OsseoSpeed™ Implants in the Upper Jaw in Women With Osteoporosis
The overall objective of the study is to compare treatment with the ASTRA TECH Implant System, OsseoSpeed™ implant in the maxilla of postmenopausal women with and without systemic osteoporosis.
- Conditions
- Postmenopausal Osteoporosis, Osteopenia, Jaw, Edentulous, Partially
- Trial name
- NCT00745121
- Testing
- OsseoSpeed™
- Where
- 4 sites in Belgium, Germany and 1 more
- Volunteers
- 103 people
- Sponsor
- Dentsply Sirona Implants and Consumables