Clinical trials: Tooth Disease
Dental Pain
Evaluation of the Efficacy and Safety of Diclofenac HPBCD 25, 50 mg/ml in the Treatment of Post-surgical Pain Following Dental Surgery
The present study is proposed to evaluate the efficacy and safety of single doses of Diclofenac HPBCD subcutaneous (s.c.) (25 mg/1 ml and 50 mg/1 ml) in the treatment of acute moderate-to-severe pain after dental impaction…
- Trial name
- NCT00942448
- Testing
- Diclofenac HPBCD
- Where
- 6 sites in Poland, United Kingdom
- Volunteers
- 306 people
- Sponsor
- IBSA Institut Biochimique SA
Dental Pain
Evaluation of EXPAREL for Prolonged Postsurgical Analgesia in Subjects Undergoing Third Molar Extraction
This is a Phase 3, randomized, double-blind, placebo-controlled study in subjects scheduled to undergo elective bilateral third molar extraction under local anesthesia.
- Trial name
- NCT02517905
- Testing
- Bupivacaine liposome
- Where
- United States
- Volunteers
- 166 people
- Sponsor
- Pacira Pharmaceuticals, Inc
Periapical Periodontitis, Bacterial Infections
Adjunctive Steps for Disinfection of Teeth With Primary Endodontic Infections
This study aims to evaluate an endodontic treatment protocol using adjunctive steps for disinfection of teeth with primary endodontic infections.
- Trial name
- NCT03537664
- Testing
- Root canal preparation, Intracanal medication
- Where
- Brazil
- Volunteers
- 45 people
- Sponsor
- University of Sao Paulo
Dental Caries
Pharmacokinetics of Advantage Arrest in Children
The purpose of this study is to characterize basic PK parameters (Cmax, t1/2, AUC) in healthy children to contribute to evidence for the safety of Advantage Arrest, consistent with Guidance for Industry--Exposure--Response…
- Trial name
- NCT04186663
- Testing
- Silver Diamine Fluoride
- Where
- United States
- Volunteers
- 59 people, healthy volunteers welcome
- Sponsor
- Advantage Silver Dental Arrest, LLC
Tooth Loss, Ceramic Implant
PMCF Study of CeraRoot Ceramic Implants One-piece: 3 Years Follow up
The main objective is to evaluate the success / failure rate of CeraRoot ceramic implants (one piece) during three year follow up.
- Trial name
- NCT04598776
- Where
- Spain
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- CeraRoot SL
Dental Caries
In Vivo Comparison of Salivary Fluoride Levels Following the Application of Different 5% NaF Varnishes
This study will be a cross-over single blinded clinical study to evaluate the in vitro fluoride release of three different brands of 5% NaF varnish.
- Trial name
- NCT01629290
- Testing
- Enamel Pro, Duraphat, Vanish
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Dental Plaque
Evaluate Dental Plaque Benefit of a Preventive Treatment Gel
The objective of the study is to evaluate anti-plaque efficacy of a preventive treatment gel in a modified 4-day plaque model.
- Trial name
- NCT03546491
- Testing
- Preventive Gel, Marketed Control
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Procter and Gamble
Irreversible Pulpitis, Apical Periodontitis
Success of Pulpotomy in Molars With Pulpitis With Periodontitis Detected Using AI and Those Without Periodontitis
Statement of problem: Although performing full pulpotomy in mature permanent molars with irreversible pulpitis showed success rates comparable to RCT, there is a growing need for further studies in order to determine the…
- Conditions
- Irreversible Pulpitis, Apical Periodontitis, Pulpitis
- Trial name
- NCT06767371
- Testing
- Patients with mature permanent molars diagnosed with severe pulpitis with apical periodontitis to be treated with full pulpotomy., Patients with mature permanent molars diagnosed with moderate pulpitis without apical periodontitis to be treated with full pulpotomy., Teeth with irreversible pulpitis
- Where
- Egypt
- Volunteers
- 57 people
- Sponsor
- Misr International University
Dental Pain
Phase 2 Study of Indomethacin Capsules to Treat Dental Pain
The purpose of this study is to determine whether Indomethacin Test Formulation Capsules are safe and effective for the treatment of dental pain.
- Trial name
- NCT00964431
- Testing
- Celecoxib 400 mg, Indomethacin Test (lower dose), Indomethacin Test (upper dose)
- Where
- United States
- Volunteers
- 203 people
- Sponsor
- Iroko Pharmaceuticals, LLC
Dental Plaque
Clinical Research Study Efficacy of a Prototype Oral Rinse
Evaluate the efficacy of an oral rinse on dental plaque and gingival inflammation
- Trial name
- Quigley (NCT01021007)
- Testing
- Iodine, water
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Colgate Palmolive
Dental Caries
Assessment of Caries Diagnosis and Caries Treatment in Dental PBRN Japan
The objective of this study is to examine what methods Dental PBRN Japan dentists adopt for diagnosis, treatment, and prevention of dental caries.
- Trial name
- NCT01680848
- Volunteers
- 282 people, healthy volunteers welcome
- Sponsor
- Dental PBRN Japan
Dental Pulp Diseases, Dental Pulp Necrosis
Nanodiamond Modified Gutta Percha (NDGP) Composite for Non-surgical Root Canal Therapy (RCT) Filler Material
Non-surgical root canal therapy (RCT) represents a standard of treatment that addresses infected pulp tissue in teeth and protects against future infection while preserving the tooth for the patient for mainly cosmetic purposes.
- Conditions
- Dental Pulp Diseases, Dental Pulp Necrosis, Nerve Root Pain Nec
- Trial name
- NCT02698163
- Testing
- Nanodiamond reinforced Gutta Percha, Gutta Percha
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- University of California, Los Angeles
Dentin Sensitivity
Impact of Long Term Management of Dentine Hypersensitivity (DH) With a Daily Use Anti-sensitivity Toothpaste on the Quality of Life Related to Oral Health
This multicentre, non-comparative design study will monitor the impact of long term management of DH with daily use of a sensitivity toothpaste on the quality of life of a population of sensitivity sufferers.
- Trial name
- NCT02752958
- Testing
- stannous fluoride
- Where
- 2 sites in United Kingdom
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- GlaxoSmithKline
Toothache
Assessing the Analgesic Efficacy of Naproxen Sodium in Postsurgical Dental Pain.
To evaluate the analgesic efficacy of a single, oral dose of a naproxen sodium extended-release tablet, compared to placebo in postsurgical dental pain.
- Trial name
- NCT00720057
- Testing
- Naproxen Sodium ER (BAYH6689)
- Where
- 3 sites in United States
- Volunteers
- 312 people, healthy volunteers welcome
- Sponsor
- Bayer
Preterm Birth, Periodontal Disease
Saving Lives at Birth: Primary Prevention of Periodontal Disease in Relation to Preterm Birth in Malawi
The hypothesis of the investigators' project is that comprehensive primary preterm birth prevention, inclusive of maternal oral health with xylitol chewing gum (the intervention), will reduce the rate of periodontal disease and…
- Conditions
- Preterm Birth, Periodontal Disease, Caries, Dental
- Trial name
- PPaX (NCT02333227)
- Testing
- Xylitol gum
- Where
- United States
- Volunteers
- 10,069 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Caries, Dental Pulp Exposure
Calcium Hydroxide, Mineral Trioxide Aggregate and Biodentine (Trademark) as Direct Pulp Capping of Permanent Teeth
Background: Dental caries is considered an oral health problem worldwide. In Chile the last national epidemiological study (2007) showed a national prevalence of dental caries in children 6 years (70.3%) and 12 (62.5%).
- Trial name
- NCT02492841
- Testing
- Mineral trioxide aggregate, Calcium hydroxide, Biodentine
- Where
- Chile
- Volunteers
- 169 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Dental Caries, Unsatisfactory or Defective Restoration of Tooth
Clinical Evaluation of a Bulk Fill Resin Composite
The purpose of this clinical trial is to measure the clinical outcomes of Tetric PowerFill Class I and II restorations cured in 3 seconds with the Bluephase PowerCure curing unit.
- Trial name
- NCT04686422
- Testing
- Tetric PowerFill
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Ivoclar Vivadent AG
Partially Edentulous Jaw
Study on OsseoSpeed™ TX Short Implants in a Chinese Population
The purpose of this study is to investigate the clinical efficacy of OsseoSpeed™ TX 6 mm implants in a Chinese population by evaluation of marginal bone level alteration, implant stability and implant survival in the posterior…
- Trial name
- NCT01346696
- Testing
- OsseoSpeed™ TX implant (Ø 4.0 mm, length 6 mm)
- Where
- 3 sites in China
- Volunteers
- 45 people
- Sponsor
- Dentsply Sirona Implants and Consumables
Molar Incisor Hypomineralization, Dental Caries
Silver Diamine Fluoride and Papain-Based Gel for Management of MIH-affected Molar in Paediatric Patients
Molar incisor hypomineralization (MIH) is a developmental defect of enamel affecting the first permanent molar and frequently the incisors with a prevalence of 16-16.9% in Malaysia.
- Conditions
- Molar Incisor Hypomineralization, Dental Caries, Hypomineralization of Enamel
- Trial name
- NCT04710927
- Testing
- Silver Diamine Fluoride, Papain-Based Gel, High Viscosity Glass Ionomer Cement (HVGIC)
- Where
- Malaysia
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Alveolar Bone Loss, Loss of Teeth Due to Extraction
Evaluation of OSSIX-Plus Resorbable Collagen Membranes for Alveolar Ridge Preservation Following Exodontia
The purpose of this study is to evaluate clinically, histologically and radiographically the healing of extraction sockets covered with a resorbable collagen membrane (OSSIX-Plus) 12 weeks following exodontia.
- Conditions
- Alveolar Bone Loss, Loss of Teeth Due to Extraction, Edentulous Alveolar Ridge
- Trial name
- OSSIX (NCT00639860)
- Testing
- OSSIX-Plus
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- William Giannobile