Clinical trials: Tooth Lesions
Necrotic Pulp, Postoperative Pain
Evaluation of Postoperative Pain After Using 3MIX-TATIN Versus Calcium Hydroxide Iodoform Paste In Necrotic Primary Molars Treated by Lesion Sterilization and Tissue Repair Therapy
The aim of the current study is to compare a newly introduced material which is a combination of triple mix antibiotics paste and anti-hyperlipidemia drug simvastatin, the new material is named 3MIX-TATIN \& will be compared to…
- Trial name
- 3-mixtatin (NCT03084601)
- Testing
- Calcium Hydroxide, Iodoform, paste, 3-mixtatin
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Mahmoud M Saadoon
Dental Fluorosis
Resin Infiltration Versus Microabrasion With CPP-ACP for Fluorotic White Spot Lesions
Dental fluorosis can cause visible chalky-white spots on the front teeth. These white spot lesions may affect dental appearance even when the tooth surface is intact.
- Trial name
- NCT07704983
- Testing
- Resin infiltration, Enamel Microabrasion Plus CPP-ACP
- Where
- Vietnam
- Volunteers
- 42 people
- Sponsor
- Hue University of Medicine and Pharmacy
Dental Caries
Evaluation of the Antibacterial Effect of Laser Diode and Zinc Oxide Nano Particles in Cavity Disinfection
this is a randomized controlled clinical trial, evaluating the antibacterial effect of laser diode and zinc oxide nano-particles when used as cavity disinfectants.Two groups, including 15 patients each, will be randomly allocated…
- Trial name
- NCT03478150
- Testing
- zinc oxide nano-particles, laser diode
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University
Dentin Hypersensitivity, Active Dental Caries
Fluoride Therapies on Hypersensitive Carious Lesions in Primary Teeth
This observational cohort study aims to evaluate the short-term (3 months) efficacy of the standard fluoride therapy in the German National Health System for managing hypersensitive carious lesions in primary teeth (fluoride…
- Trial name
- NCT04804423
- Testing
- 38% Silver Fluoride and Potassium Iodide solution (generic name; Riva Star®), Sodium fluoride varnish (generic name; Duraphat®)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- University Medicine Greifswald
Non-Carious Cervical Lesions (NCCLs), Dentin Hypersensitivity
Evaluation of Different Non-Invasive Methods in the Treatment of Dentin Hypersensitivity Associated With Non-Carious Cervical Lesions: A Split-Mouth Clinical Study
The aim of this split-mouth clinical study is to compare the effectiveness of D Blue diode laser application and ProSylc bioactive glass powder application in reducing dentin hypersensitivity in patients with non-carious cervical…
- Trial name
- NCCL-DH (NCT07648147)
- Testing
- D Blue Diode Laser, ProSylc Bioactive Glass Powder
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Cukurova University
Reduction in DMFT Index and Plaque Index in Patients at the Treatment Completion, an Average of 4 Years, DMFT Index, ICDAS Score, Dental Plaque Index, Communication, Prevention, Dentist, Orthodontist
A New Digital Communication Tool Between Dentist and Orthodontist to Improve Dental Prevention
Dentists and orthodontists of the oral medicine department of Reims University Hospital noted that many children presented white spots around orthodontic brackets, or decays at the end of their multi-brackets orthodontic…
- Trial name
- ComDentODFPrev (NCT06517238)
- Testing
- There is no intervention
- Where
- France
- Volunteers
- 30 people
- Sponsor
- CHU de Reims
Periodontal Pocket, Tooth,Non Vital
Chlorhexidine Intracanal Medicament in Periodontal Healing in Concomitant Endo Perio Lesion With Communication
The aim of this prospective randomized controlled clinical trial is to evaluate the effectiveness of chlorhexidine intracanal medicament along with periodontal treatment in concomitant endodontic periodontal lesions with…
- Trial name
- NCT02627326
- Testing
- open flap debridement
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Dental Caries
Elmex Gel Efficacy in Preventing White Spot Lesions
the objective of this phase IV study: to establish the efficacy of elmex gel with a fluoride concentration of 1.25% compared with placebo by determining prevention of white spot lesions in patients wearing fixed orthodontic…
- Trial name
- NCT00268138
- Testing
- elmex gel
- Where
- 2 sites in Germany, Israel
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Asymptomatic Molar Teeth With Periapical Lesions
Postoperative Pain After Root Canal Preparation Using Different Engine-driven Systems
A hundred twenty patients who had an asymptomatic mandibular molar teeth with periapical lesion were included. For each patient, teeth were prepared with Reciproc Blue or Protaper Universal instruments.
- Trial name
- NCT04454814
- Testing
- Protaper Universal instruments, Reciproc Blue instruments
- Where
- Turkey (Türkiye)
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Ege University
Dental Caries in Children
SDF Effectiveness on Arresting Caries in Children
Purpose: To assess the clinical effectiveness of silver diamine fluoride (SDF) to control asymptomatic cavitated carious lesions compared to conventional glass ionomer restoration in preschool children.
- Trial name
- NCT05872542
- Testing
- Silver Diamine Fluoride (SDF), Glass Ionomer Restoration (GI), Sodium fluoride varnish with nano-sliver particles (NaF-AgNP)
- Where
- Saudi Arabia
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Umm Al-Qura University
Dental Caries
The Prevalence of White Spot Lesions During Orthodontic Treatment With Fixed Appliances
This study investigates how often cavities develop on the permanent teeth of patients with braces (orthodontic treatment). The hypothesis is that there is no difference in the number of cavities on the permanent teeth of patients…
- Trial name
- WSLs (NCT04186065)
- Where
- United States
- Volunteers
- 111 people, healthy volunteers welcome
- Sponsor
- Hiroko Nagaoka
White Spot Lesion of Tooth, Gingival Inflammation
EFFECTIVENESS of WATER FLOSS in PLAQUE REMOVAL and PREVENTION of WHITE SPOT LESIONS in ORTHODONTIC PATIENTS: a RANDOMISED CONTROLLED CLINICAL TRIAL
This clinical trial aims to learn if water floss is as efficient as other interdental cleaning tools and can prevent plaque accumulation and white spot lesions (WSLs) in orthodontic patients.
- Conditions
- White Spot Lesion of Tooth, Gingival Inflammation, Gingival Bleeding, Dental Plaque
- Trial name
- WATER FLOSS (NCT06752291)
- Testing
- water flosser
- Where
- Malaysia
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Malaya
Non-carious Cervical Lesions
Evaluation of Double Layer Application Using a Universal Adhesive in the Quality of Cervical Lesions Restorations
The aim of this study will be to evaluate the effect of a double layer application of a universal adhesive system used as etch-and-rinse application mode in non-carious cervical lesions (NCCLs), on the 6- and 12-months clinical…
- Trial name
- NCT06474494
- Testing
- Application of one layer, Application of double layer, Etch-and-rinse application mode
- Where
- Chile
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Universidad de los Andes, Chile
Pulpitis - Irreversible, Pulp Necrosis
Professional Practices Regarding Treatment of Non-vital Primary Teeth Among Dental Surgeons in France
When faced with primary teeth affected by irreversible pulpitis or pulp necrosis, extraction is often the preferred option for practitioners, although validated alternatives exist, notably pulpectomy, which has high success rates…
- Conditions
- Pulpitis - Irreversible, Pulp Necrosis, Apical Periodontitis
- Trial name
- DTNV (NCT07297836)
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Strasbourg, France
Dental Caries
In Situ Remineralisation Response of Different Artificial Caries-like Enamel Lesions to Home-care and Professional Fluoride Treatments
This study mainly compared the response of the artificial carious enamel lesions to remineralisation in situ. The tested in vitro demineralising protocols were: MC gel, PA gel, MHDP and Buffer solutions.
- Trial name
- NCT02637830
- Testing
- Application of fluoride varnish (22600 ppm F, Duraphat) at the begining of the study, Application of fluoride toothpaste (1500 ppm F, Crest) twice a day for 3 days of the study
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Dental Caries
DPBRN Longitudinal Study of Questionable Occlusal Caries Lesions
The purpose of this study will allow us to observe and follow the subjects' treatment from DPBRN Prevalence of Questionable Occlusal Caries Lesions Study over a 24 month period.
- Trial name
- NCT01309971
- Where
- 7 sites in United States, Denmark
- Volunteers
- 2,624 people, healthy volunteers welcome
- Sponsor
- Dental Practice-Based Research Network
Sjögren Syndrome
Dental and Periodontal Status of Patients With Sjögren's Syndrome.
Sjögren's syndrome (SS) is a rare chronic systemic autoimmune disease characterized by destruction of the exocrine glands, including the salivary glands.The lack of saliva exposes the patient to dental caries, and dental wear…
- Trial name
- CB-SJO (NCT04848870)
- Testing
- Salivary samples
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Healthy, Inflammation
Using a Narcotic to Enhance the Numbing Effect of the Local Anesthetic Lidocaine on Inflamed Molar Teeth
The effectiveness of local anesthetics is reduced if inflammation is present, making it difficult to control pain during such procedures as root canals and wisdom teeth removal.
- Conditions
- Healthy, Inflammation, Mouth Disease, Pain
- Trial name
- NCT00001952
- Where
- United States
- Volunteers
- 275 people
- Sponsor
- National Institute of Dental and Craniofacial Research (NIDCR)
Fissure Sealants, Oral Hygiene Orientation
Efficacy of Sealants in Cavitated Enamel Lesions on Occlusal Surfaces in Children
The aim of this study is to evaluate the efficacy of oral hygiene orientation singly, compared to resin-based sealants in controlling occlusal cavitated enamel lesions on primary and permanent molars.
- Trial name
- SLM1661 (NCT02617940)
- Testing
- fissure sealant, oral hygiene orientation
- Where
- Brazil
- Volunteers
- 546 people
- Sponsor
- Faculty Sao Leopoldo Mandic Campinas
Dentin Desensitizing Agents, Dentin Hypersensitivity, Non-carious Cervical Lesions
Clinical Efficacy of Using Bioactive Desensitizer Gel
To evaluate and compare the clinical effectiveness of a Bioactive Desensitizer Gel (which releases calcium and phosphate to form hydroxyapatite) versus a standard 5% Sodium Fluoride (NaF) Varnish in reducing cervical dentin…
- Conditions
- Dentin Desensitizing Agents, Dentin Hypersensitivity, Non-carious Cervical Lesions, Dentin Hypersensitivity
- Trial name
- NCT07323693
- Testing
- Treatment
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Cairo University