Clinical trials: Tooth Wear, active
Obesity, Dental Erosion
Salivary Function and Dental Changes During GLP-1 Therapy
People who use glucagon-like peptide-1 (GLP-1) receptor agonists, such as semaglutide and tirzepatide, may experience changes in their oral health.
- Conditions
- Obesity, Dental Erosion, Saliva Collection, Saliva Altered
- Trial name
- NCT07720466
- Testing
- Unstimulated Whole Saliva Collection, Salivary Analysis, Oral Examination and BEWE Assessment
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people
- Sponsor
- Bilecik Seyh Edebali Universitesi
Edentulism Complete, Edentulism
PRINTOW: Occlusal Wear of Denture Teeth in Digitally Fabricated Complete Dentures
This randomized controlled trial evaluates the occlusal wear of denture teeth fabricated using three digital workflows: 3D-printed denture teeth, CAD/CAM-milled double cross-linked denture teeth, and prefabricated denture teeth.
- Trial name
- Printow (NCT07585162)
- Testing
- CAD/CAM-Milled Denture Base with Milled Denture Teeth, CAD/CAM-Milled Denture Base with Prefabricated Denture Teeth, 3D-printed denture base and teeth
- Volunteers
- 45 people
- Sponsor
- Najla Chebib
Edentulous Mandible
"Comparative Study of Supra-Structure Materials in Full-Arch Implant Prosthetics: a Randomized Clinical Trial"
after the implants' osseointegration period (4 months), digital scans will be taken for the implant positions and the STL files will be stored and sent for the CAD software to design a full arch restoration.
- Trial name
- CSDSMDA (NCT06673355)
- Testing
- dental implant prosthesis
- Where
- Egypt
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Misr University for Science and Technology
Idiopathic Infertility, Infertility Unexplained
Biological Aging Hallmarks-Guided Integrative TCM and Conventional Medicine in Post-Treatment Unexplained Female Infertility
The goal of this clinical trial is to determine whether telomere profiling and other biological aging hallmarks can help identify underlying mechanisms of persistent infertility in women with post-treatment unexplained…
- Conditions
- Idiopathic Infertility, Infertility Unexplained, Infertility (IVF Patients), Infertility Assisted Reproductive Technology
- Trial name
- TECMI (NCT07404969)
- Testing
- 1. Aging Hallmarks Biomarker Profiling (Telomere-Based), 2. Integrative Botanical and Nutraceutical Intervention, 3. Natural Conception or Assisted Reproductive Technologies
- Where
- Switzerland
- Volunteers
- 15 people
- Sponsor
- BEYOND GENOMiX SA, AG, Ltd
Pediatric Obesity
Qualitative Evaluation of Pediatric Obesity Therapeutic Education Programs
Obesity concerns almost the entire planet and is considered in France as a major public health issue: 17% of children are overweight and 4% obese.
- Trial name
- QUALIPOP (NCT06488235)
- Volunteers
- 32 people
- Sponsor
- University Hospital, Angers
Implant Supported Overdenture, Wear, Occlusal
Clinical Evaluation of Conventional and 3D-printed Implant-supported Overdentures Retained With New Attachment Systems
Randomized Crossover Clinical Trial Comparing Two Denture Designs (A and B) Retained by Two Locator Systems (ST and EMI) in Implant Overdenture Patients
- Trial name
- IODs (NCT07580534)
- Testing
- Crossover Assignment
- Where
- Egypt
- Volunteers
- 20 people
- Sponsor
- Al-Azhar University
Edentulism
Assessment of Wear and Muscular Efficiency of 3D Printed Versus Conventional Denture Teeth: A Cross-Over In Vivo Study
This study aims to evaluate the wear resistance and muscular efficiency of denture teeth fabricated using two different methods: 3D printing and conventional techniques.
- Trial name
- 3D-DENTURE (NCT07035574)
- Testing
- Conventional Denture Teeth, 3D Printed Denture Teeth
- Volunteers
- 13 people
- Sponsor
- Cairo University
Wear, Occlusal
Evaluation of Wear Resistance of CAD/CAM Hybrid Ceramic and Nano-Hybrid Composite Overlays in Endodontically Treated Molars and Their Effect on Natural Antagonist Teeth
This randomized clinical trial aims to to evaluate and compare the 24-month surface wear of the restoration and the surface wear of the opposing natural tooth structure of CAD/CAM Hybrid Ceramic (SHOFU Hard blocks) versus…
- Trial name
- NCT07689032
- Testing
- SHOFU Hard blocks, BRILLIANT Crios
- Volunteers
- 24 people
- Sponsor
- Cairo University
Sjögren Syndrome
Dental and Periodontal Status of Patients With Sjögren's Syndrome.
Sjögren's syndrome (SS) is a rare chronic systemic autoimmune disease characterized by destruction of the exocrine glands, including the salivary glands.The lack of saliva exposes the patient to dental caries, and dental wear…
- Trial name
- CB-SJO (NCT04848870)
- Testing
- Salivary samples
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Eating Disorders, Oral Health
Oral Indicators for ED Screening
The main objective of this research project is to explore the capability of a standardized, evidence-based study tool (the OHEDs Checklist) in the early identification of oro-dental manifestations potentially indicative of an…
- Conditions
- Eating Disorders, Oral Health, Eating Disorders Symptoms
- Trial name
- OHEDS (NCT07295197)
- Where
- Italy
- Volunteers
- 461 people, healthy volunteers welcome
- Sponsor
- University of Bologna
Esophagogastric Cancer
A Study of Tooth Erosion in People With Esophagogastric Cancer
The researchers are doing this study to find out more about what may lead to the loss of tooth enamel (the thin outer covering of the tooth) and how often it happens in people with esophagogastric cancer, colorectal cancer…
- Trial name
- NCT05612048
- Testing
- Survey, Intra-oral camera, Optional Salvia sample
- Where
- United States
- Volunteers
- 174 people, healthy volunteers welcome
- Sponsor
- Memorial Sloan Kettering Cancer Center
Dentin Hypersensitivity, Erosive Tooth Wear
Multi-site Study to Look at Tooth Wear and Tooth Sensitivity and the Risk Factors Associated.
The goal of this observational study is to learn about tooth wear and tooth sensistivity and reasons for these conditions in five locations throughout the United States.
- Trial name
- NCT07195357
- Testing
- epidemiological
- Where
- United States
- Volunteers
- 2,500 people
- Sponsor
- Indiana University
Child Obesity
Attrition in Pediatric Obesity Management
Our feasibility study will assess the feasibility and acceptability of Family Navigation (FN) to address attrition (dropout) in pediatric obesity management.
- Trial name
- NCT05403658
- Testing
- Family Navigation, Usual Care
- Where
- Canada
- Volunteers
- 108 people
- Sponsor
- University of Alberta
Dental Caries, Class II Dental Caries
Clinical Evaluation of Wear Resistance and Bioactivity of Self Cured Bioactive Resin Composite
Introduction: Resin-based composites (RBCs) have become the gold standard in restorative dentistry due to their superior aesthetics, adhesion, and minimally invasive application.
- Trial name
- NCT07262086
- Testing
- Resins, Composite nanohybrid, Resins, Composite bioactive
- Where
- Egypt
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- Suez Canal University
Mixed Dentition Using Sequential Dental Aligners
This Study Will Examine Shortened Treatment Wear Time for Patients With Mixed Dentition Using AirFlex Aligner, Sequential Dental Aligners.
This study will examine shortened treatment wear time for patients with mixed dentition using sequential dental aligners. Using the existing AirFlex aligner design that patients with permanent dentition use, it may be possible to…
- Trial name
- NCT07220317
- Testing
- Sequential Aligners
- Volunteers
- 45 people
- Sponsor
- OrthoFX
Prediction of Tooth Wear
Predict Tooth Wear
Tooth wear, resulting from gradual loss of dental hard tissue due to mechanical and chemical factors, impacts tooth structure, texture, and function.
- Trial name
- PREDITOOTH (NCT06681844)
- Testing
- Tooth Shape assessed using an intraoral scanner one after avulsion
- Where
- 5 sites in United States, Belgium and 3 more
- Volunteers
- 1,000 people
- Sponsor
- Hospices Civils de Lyon
Caries, Erosive Tooth Wear
New In Situ Model Design for Caries and Erosion
This study will test simultaneously and independently two novel in situ models, one for caries and one for erosive tooth wear (ETW), based on the simulation of these dental conditions on enamel specimens placed on 3D-printed…
- Trial name
- NCT07849270
- Testing
- 0 ppm fluoride toothpaste, 250 ppm fluoride toothpaste (dose-response control), 1150 ppm fluoride toothpaste
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Indiana University
Enamel Hypomineralization, Tooth Erosion
Hydroxyapatite Toothpastes and Enamel Remineralization:
This randomized controlled clinical trial aims to evaluate the efficacy of two commercially available toothpastes containing hydroxyapatite in the remineralization of early enamel lesions.
- Trial name
- HEREMI (NCT07069218)
- Testing
- Biorepair® Total Protection Plus Toothpaste, Bioniq® Toothpaste
- Where
- Italy
- Volunteers
- 40 people
- Sponsor
- University of Pavia
Occlusal Wear of Teeth
Clinical Evaluation of Hybrid Ceramic Occlusal Veneers Bonded With Two Self Adhesive Resin Cements
This randomized clinical trial aims to evaluate the clinical performance of hybrid ceramic occlusal veneers cemented with two different bonding protocols: a self-adhesive bonding protocol with adhesive enhancement (BeautiLink SA…
- Trial name
- NCT07017062
- Testing
- hybrid ceramic occlusal veneers
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Cairo University
Carious Primary Molars
Occlusal Wear Of Bioflx Crowns Compared To Zirconia Crowns On Primary Molars
The goal of this clinical trial is to evaluate the occlusal wear of Bioflx crowns compared to zirconia crowns in the restoration of primary molars.
- Trial name
- NCT06890949
- Testing
- (Group A: Preformed Bioflx Crown), (Group B: Preformed Zirconia crown)
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University