Clinical trials: Topical Administration
Dermatitis, Contact, Dermatitis, Occupational
Efficacy of Glycerol, Two Topical Steroids, and a Topical Immune Modulator Against Skin Irritation
The purpose of this study is to compare the efficacy of glycerol ointment, triamcinolone acetonide ointment, clobetasol ointment and tacrolimus ointment on irritated skin in a cumulative skin irritation test model using healthy…
- Trial name
- WA+TR_1 (NCT00779792)
- Testing
- clobetasol, triamcinolone acetonide, tacrolimus
- Where
- Denmark
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- Odense University Hospital
Acne Vulgaris
A Safety, Tolerability, Efficacy and Exposure Study of XEN801 Topical Gel
Phase 1/2 study enrolling up to 60 healthy volunteers in Phase 1 followed by approximately 150 subjects with acne vulgaris in Phase 2.
- Trial name
- NCT02656043
- Testing
- XPF-005
- Where
- 20 sites in Canada
- Volunteers
- 213 people, healthy volunteers welcome
- Sponsor
- Xenon Pharmaceuticals Inc.
Lateral Canthal Lines
Safety and Efficacy Study of RT001 to Treat Moderate to Severe Lateral Canthal Lines
The purpose of this study is to determine the safety and efficacy of 2 sequential doses of RT001 compared to vehicle control following applications at Baseline (Day 0) and Week 2.
- Trial name
- NCT00884234
- Testing
- Vehicle Control, RT001 (Botulinum Toxin Type A Topical Gel)
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Revance Therapeutics, Inc.
Acne Vulgaris
TSN2898-201 Safety and Efficacy of TSN2898 in the Treatment of Acne Vulgaris
The purpose of this study is to determine the safety and effectiveness of TSN 2898 topical gel in the treatment of moderate to severe acne.
- Trial name
- NCT02796066
- Testing
- Vehicle, TSN2898
- Where
- 6 sites in United States, Dominican Republic and 1 more
- Volunteers
- healthy volunteers welcome
- Sponsor
- Thesan Pharmaceuticals, Inc.
Dry Eye Syndromes
ACCURATE Study for Subjects With Dry Eyes
To determine treatment and imaging outcomes in bilateral ocular surface disease management with an intracanalicular dexamethasone (0.4 mg) insert compared to standard topical over-the-counter artificial tears lubrication…
- Trial name
- ACCURATE (NCT04237012)
- Testing
- Dextenza 0.4Mg Intracanalicular Insert, Over the counter Artificial tears
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- The Eye Centers of Racine and Kenosha
To See the Safety and Efficacy of the Topical Latanoprost Compared With Topical Brimonidine in the Treatment of the Primary Open Angle Glaucoma Patients
The Effectiveness of Topical Latanoprost Compared With Topical Brimonidine in the Treatment of the Primary Open Angle Glaucoma
Outpatient department of cmch, ceitc,cimch POAG patients enrolled for the study.
- Trial name
- NCT04205201
- Testing
- Drugs, Investigational
- Where
- 2 sites in Bangladesh
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Chittagong Medical College
Photoaging
Efficacy in Daily Use of a Novel Skin Care Product for the Treatment of Photoaged Skin
Photoaged or chronically sun-exposed skin is characterised by a number of clinical features including fine and coarse wrinkles. The pathogenesis of wrinkle formation has yet to be determined fully but recent work suggests that…
- Trial name
- NCT03144193
- Testing
- Topical anti-aging cosmetic cream
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Manchester
Pediculosis Capitis
Efficacy and Safety of Topical 0.5% Ivermectin Lotion for the Treatment of Head Lice Infestation in Filipinos
This is a randomized, double-blind, placebo-controlled clinical study evaluating the efficacy and safety of a single application of 0.5% ivermectin lotion in Filipino subjects with head lice.
- Trial name
- NCT03286101
- Testing
- 0.5% Ivermectin lotion, Vehicle
- Where
- Philippines
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- United Laboratories
Healthy Subjects
Tofacitinib Citrate Topical Gel 3.2% FDA BA Bridging Study
This is a Phase 1, single center, open-label, fixed sequence, two-period pharmacokinetic (PK) study to evaluate the safety and relative systemic bioavailability of topical and oral tofacitinib formulations in approximately 14…
- Trial name
- NCT04468425
- Testing
- Tofacitinib Citrate
- Where
- Canada
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- TWi Biotechnology, Inc.
Superficial Skin and Soft Tissue Infections Caused by Gram-positive Bacteria
A Phase I Clinical Trial to Evaluate CMS-F021 Following Single and Multiple Doses in Healthy Participants
"This study is a first-in-human (FIH) trial of CMS-F021 conducted in healthy Chinese adult participants, consisting of two parts: Part 1-a single ascending dose (SAD) study (referred to as Part 1 SAD), and Part 2-a multiple…
- Trial name
- NCT07790770
- Testing
- CMS-F021 Gel, Drug: CMS-F021 Gel healthy participant
- Where
- China
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Dermavon Holdings Limited
Corneal Abrasion
Short Term Topical Tetracaine is Safe and Highly Efficacious for the Treatment of Pain Caused by Corneal Abrasions
The objective of this study was to show that patients with corneal abrasions would experience more pain relief with short term topical tetracaine than placebo, have similar complication rates, and take less hydrocodone for…
- Trial name
- NCT04187417
- Testing
- topical tetracaine hydrochloride 1%
- Volunteers
- 118 people, healthy volunteers welcome
- Sponsor
- INTEGRIS Southwest Medical Center
Vitiligo
Enhanced Transcutaneous Delivery of Betamethasone for the Treatment of Vitiligo
Vitiligo is the commonest acquired depigmenting disorder characterized by loss of melanocytes from the basal layer of skin causing white patches which leads to great psychological distress in many patients.
- Trial name
- NCT05233735
- Testing
- Enhanced Transcutaneous Delivery of Topical Betamethasone after the treatment with Tixel, Topical treatment
- Where
- Israel
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Tel-Aviv Sourasky Medical Center
Androgenetic Alopecia
Microarray Analysis of Scalp Biopsies After Minoxidil Treatment
The purpose of this study is to determine whether Minoxidil treatment affects hair growth in patients with male pattern baldness or androgenetic alopecia.
- Trial name
- NCT01309191
- Testing
- Minoxidil
- Where
- United States
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- University Hospitals Cleveland Medical Center
MGD-Meibomian Gland Dysfunction
Single Lipiflow Treatment to Reduce Pharmacologic Burden in DED
Purpose: To evaluate the efficacy of vectored thermal pulsation treatment in subjects with a history of dry eye disease currently using a topical immunomodulator medication.
- Trial name
- Reduce (NCT06542276)
- Testing
- Thermal Vectored Pulsation
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Dunes Eye Consultants
Healthy
Adhesion of Lidocaine Topical System 1.8%
The objective of this study is to evaluate the adhesion performance of ZTlido (lidocaine topical system) 1.8% in normal, healthy volunteers.
- Trial name
- NCT04312750
- Testing
- Lidocaine topical system 1.8%
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Scilex Pharmaceuticals, Inc.
Raynaud's Disease, Scleroderma
Phase III Study of a Topical Gel Formulation for Treatment and Prevention of Raynaud's Phenomenon
The purpose of this research study is to test the safety, tolerability, and effectiveness of Topical AmphiMatrix with Nitroglycerin (MQX-503) to relieve Raynaud's symptoms and increase blood flow to the fingers.
- Conditions
- Raynaud's Disease, Scleroderma, Autoimmune Diseases
- Trial name
- NCT00419419
- Testing
- Topical AmphiMatrix with nitroglycerin (MQX-503)
- Where
- 12 sites in United States, Sweden and 1 more
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- MediQuest Therapeutics
Healthy Volunteers
Analysis of Diphenylcyclopropenone (DPCP) in Normals
The drug diphenylcyclopropenone, or DPCP, modifies the immune system and has been shown to be effective in treating certain kinds of cancer.
- Trial name
- NCT01452594
- Testing
- Diphenylcyclopropenone
- Where
- United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Rockefeller University
Glaucoma, Open-Angle, Chronic Wounds
Absorption and Safety of Topical Timolol to Treat Chronic Wounds
Topical timolol has been used primarily as eye drops to treat glaucoma for many years. Recent clinical experience has broadened its off-label use for a number of skin conditions, including slow-healing wounds.
- Trial name
- NCT04903366
- Testing
- Timolol Maleate
- Where
- United States
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- VA Northern California Health Care System
Androgenetic Alopecia
Efficacy Study of Topical NEOSH101 to Treat Male Pattern Hair Loss
The purpose of this study is to measure the hair growth response to topical NEOSH101 when applied twice daily to the balding scalp for 16 weeks.
- Trial name
- NCT00418730
- Testing
- tetrapeptide aldehyde proteasome inhibitor (NEOSH101)
- Where
- Germany
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- Neosil, Inc.
Plaque Type Psorisis
Study Comparing Tapinarof Cream 1% To VTAMA ® (Tapinarof Cream 1%) In the Treatment of Plaque Psoriasis
To compare the safety and efficacy of the test (Tapinarof Cream 1%), placebo (vehicle cream) and reference VTAMA® (Tapinarof Cream 1%) treatments to demonstrate clinical equivalence in patients with plaque psoriasis.
- Trial name
- NCT06742957
- Testing
- Tapinarof Cream 1%, VTAMA®
- Where
- 26 sites in United States
- Volunteers
- 560 people, healthy volunteers welcome
- Sponsor
- Teva Pharmaceuticals USA