Clinical trials: Topical Administration
Vitiligo
Effectiveness of Micro-needling With 5 Fluorouracil Versus Potent Topical Steroids in the Treatment of Limited Vitiligo
The goal of this clinical trial is to learn how well 5 fluorouracil (5FU) with micro-needling works to treat limited vitiligo as compared to strong steroid applied on skin.
- Trial name
- NCT07398807
- Testing
- Microneedling with 5-fluorouracil, Topical application of 0.05% Clobetasol propionate
- Where
- Pakistan
- Volunteers
- 40 people
- Sponsor
- Combined Military Hospital (CMH) institute of Medical Sciences Bahawalpur Pakistan
Vascular Malformations, Lymphatic Malformation
Topical Sirolimus in Cutaneous Lymphatic Malformations
Cutaneous microcystic lymphatic malformations (CMLMs) are rare conditions of children and adults resulting from abnormal embryologic development of lymphatic vessels.
- Trial name
- TOPICAL (NCT03972592)
- Testing
- Topical 0.1% Sirolimus, Topical Vehicle
- Where
- 17 sites in France
- Volunteers
- 55 people
- Sponsor
- University Hospital, Tours
Pleural Effusion
Efficacy of Topical Lidocaine/Prilocaine in Pain Management in Pleurocentesis
The research aims to compare the efficacy of topical Pridocaine cream (lidocaine 2.5% and prilocaine 2.5%) and the standardized local lidocaine infiltration in pain management before pleurocentesis.
- Trial name
- NCT05984264
- Testing
- lidocaine 2.5% and prilocaine 2.5% cream in pain management before pleurocentesis.
- Where
- Egypt
- Volunteers
- 118 people
- Sponsor
- Assiut University
Cystinosis
New Cysteamine Eye Drops Formulation to Treat Corneal Crystals in Cystinosis
This study will evaluate the safety and effectiveness of a new formulation of eye drops used to treat cystine crystals that form in the corneas of patients with cystinosis.
- Trial name
- NCT00001736
- Testing
- Cysteamine
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- National Eye Institute (NEI)
Atopic Dermatitis (AD)
EFFICACY AND TOLERANCE OF AN EYELID BALM IN COMBINATION WITH TACROLIMUS 0.1% IN PATIENTS WITH EYELID ATOPIC DERMATITIS
The aim of this study is to evaluate the tolerance and efficacy of a new emollient cream specifically dedicated to the eyelid area when applied in association with tacrolimus 0.1% in subjects suffering from eyelid Atopic…
- Trial name
- NCT07819071
- Testing
- Tested Emollient RV5258A, tacrolimus 0.1%
- Where
- Poland
- Volunteers
- 33 people
- Sponsor
- Pierre Fabre Dermo Cosmetique
Oral Leukoplakia
Evaluation of Effect of Topical Melatonin in Treatment of Oral Leukoplakia
Oral leukoplakia is the most commonly occurring oral premalignant disorder. It has an overall prevalence rate of 1-4% with highest prevalence rate of 10.54% in Asian countries.
- Trial name
- NCT04251845
- Testing
- topical melatonin
- Where
- India
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Postgraduate Institute of Dental Sciences Rohtak
Acne Rosacea
DMT210 Topical Gel in the Treatment of Acne Rosacea
The study evaluates the safety, tolerability, and efficacy of DMT210 Gel, 5% when applied twice daily for 12 weeks in adult patients with moderate to severe acne rosacea.
- Trial name
- NCT03003104
- Testing
- DMT210 Topical Gel 5%, Vehicle Control
- Where
- 9 sites in United States
- Volunteers
- 107 people
- Sponsor
- Dermata Therapeutics
Sturge Weber Syndrome, Port-wine Mark
Treatment of Port-wine Mark in Sturge-Weber Syndrome Using Topical Timolol
Primary Objective: To assess the possible utility of topical timolol in the management of port-wine mark (PWM) in Sturge-Weber syndrome in children.
- Trial name
- NCT01533376
- Testing
- Timolol, Preservative free artificial tear gel.
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- Wills Eye
Hypothalamus-Pituitary-Adrenal Axis Assessement, Topical Steroid Therapy in Chronic Skin Diseases
Does Topical Steroid Treatment Impair the Adrenal Function?
The purpose of this study is to determine if topical steroids treatment for different skin diseases suppress the adrenal cortisol production.
- Trial name
- NCT00476489
- Where
- Israel
- Volunteers
- 50 people
- Sponsor
- HaEmek Medical Center, Israel
Cutaneous Leishmaniasis
Phase 3 Study of Walter Reed (WR) 279,396 and Paromomycin Alone for the Treatment of Cutaneous Leishmaniasis in Panama
This study is a pivotal Phase 3, randomized, double-blind, 3-site, two-group trial assessing the efficacy and safety of WR 279,396 Topical Cream and Paromomycin Alone Topical Cream in subjects with CL in Panama.
- Trial name
- NCT01790659
- Testing
- WR 279,396, Paromomycin
- Where
- Panama
- Volunteers
- 399 people
- Sponsor
- U.S. Army Medical Research and Development Command
Acne Vulgaris
BPX-01 Minocycline Topical Gel in the Treatment of Acne Vulgaris
This is a 12-week, multi-center, double-blind, randomized, three-arm, vehicle-controlled study. Subjects will be randomized (1:1:1) to 1% or 2 % BPX-01 gel, or vehicle.
- Trial name
- OPAL (NCT02815332)
- Testing
- BPX-01 1% Minocycline Topical Gel, BPX-01 2% Minocycline Topical Gel, BPX-01 Vehicle Topical Gel
- Where
- 15 sites in United States
- Volunteers
- 225 people
- Sponsor
- BioPharmX, Inc.
Acne Vulgaris
Silymarin Cream Versus Salicylic Acid in Treatment of Acne Vulgaris
Acne vulgaris is a disease of the pilosebaceous unit that causes noninflammatory lesions (open and closed comedones), inflammatory lesions (papules, pustules, and nodules), and varying degrees of scarring.
- Trial name
- NCT04490967
- Testing
- Silymarin, Salicylic acid
- Volunteers
- 30 people
- Sponsor
- Assiut University
Neurofibromatosis Type 1, Cutaneous Neurofibromas
Topical Imiquimod 5% Cream for Treatment of Cutaneous Neurofibromas in Adults With Neurofibromatosis 1
The purpose of this study is to determine if imiquimod cream can reverse the growth of neurofibromas. Imiquimod is a skin cream that works by stimulating the body's immune system to respond to tumors.
- Trial name
- NCT00865644
- Testing
- Imiquimod 5% Cream
- Where
- United States
- Volunteers
- 11 people
- Sponsor
- Massachusetts General Hospital
Chronic Rhinosinusitis (Diagnosis)
Botulium Toxin Type A In Non Infectious Chronic Rhinosinusitis
The present work aims to assess the effectiveness and safety of topical application of BTX - A compared with its intra turbinate injection in controlling the symptoms in non infectious chronic rhinosinusitis patients
- Trial name
- NCT04572516
- Testing
- BTX A Topical, BTX A Injection
- Where
- Egypt
- Volunteers
- 30 people
- Sponsor
- Benha University
Gingivitis
Treatment of Human Gingivitis With Amnion-derived Cellular Cytokine Solution (ACCS)
The purpose of this study is to evaluate the safety of oral topical application of Amnion-derived Cellular Cytokine Solution (ACCS) in subjects with gingivitis
- Trial name
- NCT02071199
- Testing
- 1X ACCS (Amnion-derived Cellular Cytokine Solution), Normal saline, 0.3X ACCS
- Where
- United States
- Volunteers
- 54 people
- Sponsor
- Noveome Biotherapeutics, formerly Stemnion
Nonexudative Age-related Macular Degeneration
Safety Study of a Topical Treatment for Dry Age Related Macular Degeneration
Study to evaluate the safety and tolerability of MC-1101, a potential topical treatment for non-edxudative age Related Macular Degeneration (AMD) in medically stable individuals.
- Trial name
- NCT01922128
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- MacuCLEAR, Inc.
Atopic Keratoconjunctivitis
Long-term Topical Cyclosporine for Atopic Keratoconjunctivitis
Atopic keratoconjunctivitis (AKC) is a rare type of ocular allergy that is often associated with eczema. Over time, the complications from this disease process lead to loss of vision due to continual scarring of the corneal…
- Trial name
- NCT00987467
- Testing
- Cyclosporin 0.05% ophthalmic
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- Johns Hopkins University
Meatal Stenosis
Steroid Treatment for Meatal Stenosis
The goal of this observational study is to learn about the efficacy of topical steroid treatment for meatal stenosis. The main question it aims to answer is: Is steroid therapy effective for treatment of meatal stenosis?…
- Trial name
- NCT06834698
- Testing
- Betamethasone Cream, meatotomy
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people
- Sponsor
- Sehit Prof. Dr. Ilhan Varank Sancaktepe Training and Research Hospital
Eosinophilic Esophagitis
Dupilumab Versus Topical Corticosteroid Effectiveness - Comparison in the Treatment of Stenotic EoE
The goal of this clinical trial is to [primary purpose: e.g., learn if intervention or health behavior can treat, prevent, diagnose etc.] in [describe participant population/primary condition; could include any of the following…
- Trial name
- DeTECTS (NCT06705387)
- Testing
- Dupilumab, Fluticasone
- Where
- United States
- Volunteers
- 72 people
- Sponsor
- University of Colorado, Denver
Anosmia
NAC Trial for Anosmia
The purpose of this research study is to evaluate the use of NAC in the treatment of anosmia (a loss of the sense of smell). This drug is already approved by the Food and Drug Administration (FDA) for oral or pulmonary (lung)…
- Trial name
- NCT02481609
- Testing
- N-acetyl cysteine (NAC)
- Where
- United States
- Volunteers
- 29 people
- Sponsor
- University of Miami