Clinical trials: Topical Anaesthesia
Anesthesia, Local
A Study of the Safety and Anesthetic Effect of AG-920 Topical Ophthalmic Solution
This is a Phase 3, randomized, placebo-controlled, double masked, parallel design study in healthy subjects performed in the US.
- Trial name
- NCT04513652
- Testing
- AG-920
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- American Genomics, LLC
Macular Degeneration
Pilot Study: A Randomized Trial Of Anesthetic Agents For Intravitreal Injection
This study is designed to compare four currently used types of anesthesia used prior to intravitreal injection in order to evaluate the most effective method of anesthesia in reducing pain and discomfort associated with…
- Trial name
- NCT00769392
- Testing
- Proparacaine Ophthalmic, Tetracaine Ophthalmic, Lidocaine 4%
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- Lahey Clinic
Ophthalmology, Cataract Surgery Anesthesia
An Extension Test of Whether to Use Oral Anti-anxiety Drugs (Alprazolam) When Patients Choose Second Eye Cataract Surgery After Unblinding, and Analyze Their Anxiety, Satisfaction and Pain Satisfaction
Phacoemulsification is one of the most used surgical methods for cataract surgery today, and the surgeries are under the anesthetic and sedative to make it comfortable and safe for patients.
- Conditions
- Ophthalmology, Cataract Surgery Anesthesia, Oral Anxiolytic, Satisfaction Survey
- Trial name
- NCT06874452
- Testing
- Alprazolam (Xanax)
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- National Taiwan University Hospital
Pain
The Effect of Microneedle Pretreatment on Topical Anesthesia
This study evaluates the role of microneedle pretreatment in the speed at which anesthesia develops after application of topical 4% lidocaine.
- Trial name
- NCT02596750
- Testing
- Microneedle Roller
- Where
- United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- University of California, Davis
Open Angle Glaucoma
Study on the Impact of Ocular Anesthetic Procedures in Ocular Blood Flow
Anaesthetic procedures in ophthalmology surgery have been a subject rapidly evolving in the past decades. When deciding for a retrobulbar block, the local injection of varying mixtures and volumes of fast-acting anesthetics (such…
- Trial name
- NCT01840215
- Where
- Belgium
- Volunteers
- 240 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Upper Gastrointestinal Endoscopy, Topical Anesthesia
Oropharyngeoesophageal Topical Anesthesia Versus Propofol - Ketamine Sedation for Upper Gastrointestinal Endoscopy
Esophagogastroduodenoscopy (EGD) is an essential and widely used diagnostic and therapeutic procedure in gastroenterology. EGD can be performed in association with topical anesthesia of the pharynx, intravenous anesthesia, or…
- Conditions
- Upper Gastrointestinal Endoscopy, Topical Anesthesia, Intravenous Sedation
- Trial name
- NCT06566326
- Testing
- Propofol and ketamine, Modified Oropharyngeo-esophygeal Topical Anesthesia by OPETA Prototype tool
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Zagazig University
Conscious Sedation
Conscious Sedation for Cataract Operations Under Topical Anaesthesia
Topical anaesthesia of the eye for ophthalmologic procedures avoids pain and discomfort of local anaesthetic injection in the peribulbar or retrobulbar block so that patient comfortability is achieved.
- Trial name
- NCT03933280
- Testing
- Nalbuphine, Propofol, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Menoufia University
Local Anesthesia of the Skin.
Fractional Laser Assisted Delivery of Anesthetics
The purpose of this study is to assess the efficacy of fractional CO2 laser assisted delivery of topically applied anesthetics (articaine hydrochloride 40 mg/ml and epinephrine 10 μg/ml solution and EMLA cream) regarding to…
- Trial name
- NCT02246179
- Testing
- AFXL, AHES, EMLA cream
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Netherlands Institute for Pigment Disorders
Metal Staple Removal After Total Knee Replacement
Topical Anesthesia for Removal of Stitches After Total Knee Arthroplasty
Lidocaine patch is a safe and effective topical anesthetic agent for removal of metal staples after total knee replacement
- Trial name
- NCT02812602
- Testing
- Lidocaine patch
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Local Anesthesia, Satisfaction
Evaluation of Deep Topical Fornix Nerve Block Versus Topical Anaesthesia Procedure
General anaesthesia now a days is not the first choice in phakic intra ocular lens surgery (Phakic IOL) , the short duration of the surgery, general anaesthesia complications, decrease the length of hospital stay and decreasing…
- Trial name
- NCT02196441
- Testing
- 2% tetracaine local anaesthetic drops, 0.5% bupivacaine
- Where
- Saudi Arabia
- Volunteers
- 102 people
- Sponsor
- Cairo University
Phacoemulsification
Phacoemulsification Under Topical Anesthesia and Its Complications
The purpose of this study is to determine if topical anesthesia is safe for phacoemulsification in eyes with comorbidities.
- Trial name
- NCT01381783
- Testing
- Phacoemulsification
- Volunteers
- 111 people
- Sponsor
- Instituto de Oftalmologia Ivo Correa-Meyer
Thyroid Neoplasm, Parathyroid Neoplasms
Lidocaine And Neuromonitoring in Thyroid Surgery
The aim of this study is to test the hypothesis that the quality of recovery with topical lidocaine is better than placebo.
- Conditions
- Thyroid Neoplasm, Parathyroid Neoplasms, Anesthesia
- Trial name
- NCT04574947
- Testing
- Intravenous lidocaine, Intra-cuff lidocaine
- Where
- Russia
- Volunteers
- 110 people
- Sponsor
- Saint Petersburg State University, Russia
Pulmonary Disease
Washing Pipe with a Spray Nozzle for Topical Anesthesia During Bronchoscopy
The goal of this randomized control trial is to evaluate the effectiveness and safety of using a spray nozzle, compared to the conventional method, for topical anesthesia by the spray-as-you-go technique in reducing cough…
- Trial name
- NCT05970848
- Testing
- Washing Pipe With a Spray Nozzle
- Where
- Taiwan
- Volunteers
- 126 people
- Sponsor
- National Taiwan University Hospital
Anesthesia, Local
A Study of the Safety and Anesthetic Effect of AG-920 Topical Ophthalmic Solution
This is a Phase 3, randomized, placebo-controlled, double masked, parallel design study in healthy subjects performed in the US.
- Trial name
- NCT04829344
- Testing
- AG-920
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- American Genomics, LLC
Biliary Colic
Sedation for Patients Undergoing Endoscopic Retrograde Cholangiopancreatography
This study was performed to evaluate the role of BIS monitored sedation in reducing the dose of propofol and to know the effectiveness of pre-procedure administration of intravenous diclofenac sodium along with topical pharyngeal…
- Trial name
- NCT04860167
- Testing
- Propofol, Diclofenac Sodium and Lignocaine 10 % spray
- Where
- India
- Volunteers
- 90 people
- Sponsor
- Institute of Liver and Biliary Sciences, India
Pain
Comparison Between the Analgesic Effectiveness of Virtual Reality and Topical Anesthesia: A Clinical Study
A split-mouth, controlled trial aimed to clinically compare and evaluate the effectiveness of virtual reality versus topical anesthesia gel prior to administration of dental anesthesia injection in reducing the perceived pain and…
- Trial name
- NCT04919421
- Testing
- Dental injection and topical gel application, Dental injection and virtual reality device
- Where
- Saudi Arabia
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Riyadh Elm University
Gastroscopy
Topical Pharyngeal Anesthesia With Articaine for Gastroscopy
Topical Pharyngeal anesthesia (TPA) is widely used during upper endoscopy. Articaine is local anaesthetic that have not been previously evaluated in pharyngeal anesthesia for upper endoscopy.
- Trial name
- NCT01350050
- Testing
- articaine, 9% Sodium Chloride solution for injection
- Where
- Finland
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- Helsinki University Central Hospital
Clubfoot
Clubfoot Tenotomy Trial
Infants undergoing Ponseti treatment for idiopathic clubfoot often require percutaneous tendoachilles lengthening (TAL) after serial casting.
- Trial name
- ClubTT (NCT04766684)
- Testing
- Jet injection of 1% lidocaine, 4% liposomal lidocaine cream
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Vanderbilt University Medical Center
Healthy, Anesthesia
A Study to Compare the Efficacy of Rapydan Versus Tetracaine Gel
Tetracaine gel 4% is a topical anaesthetic gel commonly used in the UK that contains 40 mg of tetracaine base per gram. Adequate anaesthesia can usually be achieved following a 30 minute application time for venopuncture and a 45…
- Trial name
- NCT00670696
- Testing
- Rapydan, tetracaine gel
- Where
- United Kingdom
- Volunteers
- healthy volunteers welcome
- Sponsor
- Jazz Pharmaceuticals
Topical Anesthetic Applied With Sonophoresis
The Effect of Sonophoresis on Topical Anesthesia: A Pilot Study
The Dental Anesthesia Sonophoresis Device (DASD) is a novel device that is intended to reduce the discomfort associated with puncturing the oral mucosa.
- Trial name
- NCT01283490
- Testing
- DASD Group, Sonic Vibration (SV)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Loma Linda University