Clinical trials: Topical Anaesthesia
Periodontitis
Acceptance and Preference of Lidocaine Gel Compared to Injection Anesthesia After Non Surgical Periodontal Treatment
This project is a national, open label, multicenter, randomized split-mouth study in patients from 18 to 70 years of age to compare the efficacy and acceptability of lidocaine gel compared to injection anesthesia with articaine…
- Trial name
- NCT03354312
- Testing
- Lidocaine Hydrochloride 1% Gel, Articaine hydrochloride/epinephrine (adrenaline) hydrochloride
- Where
- 5 sites in Germany
- Volunteers
- 94 people
- Sponsor
- Chemische Fabrik Kreussler & CO GmbH
Itch
Inhibition of Non-histaminergic Pruritus Applied Using 3 Different Pruritogens
With this experiment, we want to use to investigate whether repeated application of EMLA cream as a tool to modulate non-histaminergic itching, which is produced using small needles from the plant mucuna pruriens (it is known…
- Trial name
- NCT04858360
- Testing
- Emla 1 hour, EMLA 3 hours, Vehicle cream for 1 hour
- Where
- Denmark
- Volunteers
- 22 people, healthy volunteers welcome
- Sponsor
- Aalborg University
Effect of Benzocaine on Pain
Effect of Benzocaine 20% Topical Anesthesia on Pain Levels When Placing Separators in Children Receiving Hall Technique Crowns
The goal of this RCT is to investigate the immediate effect of benzocaine 20% topical anesthesia on initial pain and discomfort levels associated with the placement of elastomeric orthodontic separators in children who are…
- Trial name
- NCT06272903
- Testing
- 20% benzocaine, topical anesthetic, Children's Toothpaste
- Where
- United Arab Emirates
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Mohammed Bin Rashid University of Medicine and Health Sciences
Topical Anaesthesia, General Anesthetic Drug Adverse Reaction
Evaluation of Postoperative Pain in Cases Undergoing Cataract Surgery Under Topical Versus General Anesthesia
Comparison between cataract surgery under local versus general anesthesia regarding postoperative pain, complications and patient satisfaction and need for rescue analgesic intake after surgery The results will be followed up at…
- Conditions
- Topical Anaesthesia, General Anesthetic Drug Adverse Reaction, Cataract
- Trial name
- NCT07287683
- Testing
- Topical Anaesthesia group, General Anaesthesia group
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Alexandria University
Corneal Opacity, Keratitis, Herpetic
Topical Anesthesia for Closed PKP vs Retrobulbar Anesthesia for Open-sky PKP
Penetrating keratoplasty (PKP) is an open-sky surgery that fundamentally has not changed for more than 100 years. Because conventional PKP is associated with the potential for the development of devastating complications such as…
- Conditions
- Corneal Opacity, Keratitis, Herpetic, Corneal Ulcer, Corneal Dystrophies, Hereditary
- Trial name
- NCT02826174
- Testing
- closed PKP under topical anesthesia, open-sky PKP under retrobulbar anesthesia, Anti-Rejection Agents
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Wenzhou Medical University
Esotropia
Surgery for Esotropia Under Topical Anesthesia
Adult patients requiring surgery for esotropia will be randomized to surgery under topical anesthesia or sub-Tenon's anesthesia. Amount of surgery required with the two anesthetic procedures will be compared.
- Trial name
- SETTA (NCT00993174)
- Testing
- Topical strabismus surgery, Sub-Tenon's strabismus surgery
- Where
- Spain
- Volunteers
- 60 people
- Sponsor
- Hospital Universitario Ramon y Cajal
Lacerations, Wound Repair
Pain Experience Using Lidocaine Adrenaline Tetracaine (LAT) Gel Versus Lidocaine Infiltration for Laceration Repair in Adults
This prospective comparative study evaluates pain experience in adult patients undergoing laceration repair in the emergency department using either topical lidocaine-adrenaline-tetracaine (LAT) gel or lidocaine infiltration as…
- Conditions
- Lacerations, Wound Repair, Acute Traumatic Wounds, Pain Management
- Trial name
- NCT07480135
- Testing
- Lidocaine-Adrenaline-Tetracaine (LAT) Gel, Lidocaine infiltration
- Where
- Belgium
- Volunteers
- 70 people
- Sponsor
- Vrije Universiteit Brussel
Arterial Catheterization
Rapydan Topical Anaesthesia for Arterial Cannulation
Arterial catheterization is painful and is associated with patient stress and anxiety. Analgesia is usually provided by subcutaneous injection of local anesthetic.
- Trial name
- NCT01494311
- Testing
- Lidocaine/tetracaine patch, Subcutaneous injection of 0.5 ml Lidocain 1%, Subcutaneous injection of saline
- Where
- 3 sites in United States, Austria and 1 more
- Volunteers
- 90 people
- Sponsor
- Medical University of Vienna
Primary Open Angle Glaucoma, Pseudoexfoliation Glaucoma
Uddevalla Skövde Transscleral Micropulse Study
Micro pulse transscleral laser treatment (MP-TLT) is a relatively new method to reduce the intraocular pressure (IOP) in glaucoma.
- Trial name
- USTMS (NCT05557721)
- Testing
- Topical lidocaine, MP-TLT
- Where
- 2 sites in Sweden
- Volunteers
- 40 people
- Sponsor
- Vastra Gotaland Region
Lidocaine Spray, Nebulized Lidocaine
Comparison Between Different Ways for Using Lidocaine During FB
compare the efficacy and safety of nebulized lidocaine, oropharyngeal lidocaine spray, or their combination for better outcome of topical anesthesia in subjects undergoing diagnostic FB; severity of cough , pain during procedure…
- Conditions
- Lidocaine Spray, Nebulized Lidocaine, Lung Diseases, Lung Cancer
- Trial name
- NCT06563050
- Testing
- Nebulized lidocaine, Lidocaine spray, Combination of nebulized lidocaine and lidocaine spray
- Volunteers
- 240 people
- Sponsor
- Assiut University
Pain
"Lidocaine 4% Cream (LMX4) vs Placebo for Pain Due to Lumbar Puncture in Infants 0-60 Days of Age."
The study's hypothesis is LMX4 cream, a topical anesthetic cream, will reduce the pain of infants undergoing Lumbar Puncture (spinal tap).
- Trial name
- NCT00533468
- Testing
- Lidocaine Cream 4%
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- State University of New York at Buffalo
Hemodynamics After Endotracheal Intubation
Preoperative Topical Lidocaine Versus Intravenous Fentanyl to Obtund the Stress of Intubation Under Anesthesia.
To compare the effectiveness of preoperative combined topical airway anesthesia consisting of nebulised, mouth rinsing and gargling with lidocaine versus intravenous fentanyl to prevent the stress of endotracheal intubation by…
- Trial name
- NCT07533643
- Testing
- topical lidocaine, Fentanyl (Low Dose)
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Kasr El Aini Hospital
Lignocaine, Anesthesia, Local
Comparison of Pre-procedure Lignocaine Spray Versus Spray-as-you-go for Topical Airway Anesthesia in Flexible Bronchoscopy
Title: Comparing Two Methods of Topical Anesthesia for Fiberoptic Bronchoscopy Purpose: To compare the effectiveness of two methods of anesthesia, pre-procedure lignocaine spray (PPL) and spray-as-you-go (SAYG), in reducing…
- Conditions
- Lignocaine, Anesthesia, Local, Trachea, Airway Disease
- Trial name
- NCT07084623
- Testing
- Pre-procedure lignocaine spray (PPL), Lignocaine Spray (Spray-as-you-go)
- Where
- Pakistan
- Volunteers
- 50 people
- Sponsor
- Sheikh Zayed Federal Postgraduate Medical Institute
Pain, Acute
Bupivacaine vs Oxybuprocaine Topical Anesthesia in IVI
comparing two local anaesthetic agents, Bupivacaine 0.5% versus Oxybuprocaine used topically to provide surface anaesthesia before IVI procedures.
- Trial name
- NCT05069350
- Testing
- bupivacaine 0.5% and oxubuprocaine
- Where
- Egypt
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Research Institute of Ophthalmology, Egypt
Cataract
Comfort Operative Ocular Light Study
Digital 3D microscopes require less light and may be more comfortable for patients requiring cataract surgery under topical anesthesia compared to conventional microscopes.
- Trial name
- COOL (NCT05085314)
- Testing
- Ngenuity digital 3D microscope, Conventional microscope
- Where
- 2 sites in France
- Volunteers
- 134 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Perioperative Pain Experiences
Comparison the Topical Anesthesia and Retrobulbar Anesthesia for 27-gauge Vitrectomy for Vitreous Floaters
Routine anesthesia methods for vitrectomy surgery include retrobulbar and peribulbar anesthesia. However, both methods have potential complications that can vary from minor to severe.
- Trial name
- NCT03049163
- Testing
- vitrectomy under topical anesthesia [Proparacaine HCL (Alcaine®)]
- Where
- China
- Volunteers
- 30 people
- Sponsor
- Lin Zhong
Thyroid Diseases
Topical Bupivacaine Effect On The Response To Awake Extubation During Emergence From General Anesthesia
Emergence from general anesthesia is often complicated by the ETT-induced emergence phenomena (EP), which include coughing, sympathetic stimulation, sore throat, increased bleeding from the surgical site, and increased…
- Trial name
- NCT04471597
- Testing
- normal saline 0.9%, Bupivacaine Hydrochloride
- Where
- Egypt
- Volunteers
- 48 people
- Sponsor
- Zagazig University
Pain, Abortion, Spontaneous
Topic Cervical Anesthesia Plus Paracervical Blockade for Pain Control During Endouterine Manual Aspiration
To compare the effectiveness of lidocaine gel plus paracervical blockade vs. lidocaine gel alone in the management of pain during endouterine manual aspiration.
- Trial name
- NCT04791020
- Testing
- Lidocain topical + paracervical blockade, Lidocaine topical
- Where
- Panama
- Volunteers
- 100 people
- Sponsor
- Saint Thomas Hospital, Panama
Nebulization, Spray-as-You-Go
Nebulization Versus Spray-as-You-Go Airway Topical Anesthesia Using Dexmedetomidine and Lidocaine Mixture During Awake Flexible Fiberoptic Intubation in Temporomandibular Ankylosis
The aim of this study is to compare the efficacy of airway topical anesthesia with nebulization to the spray-as-you-go technique using dexmedetomidine and lidocaine mixture to achieve upper airway anesthesia in TMJ ankylosis…
- Conditions
- Nebulization, Spray-as-You-Go, Dexmedetomidine, Lidocaine
- Trial name
- NCT06088875
- Testing
- Nebulization, Spray-as-you-go
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Tanta University
All Adult Patients Undergoing an Otolaryngology Procedure With Inhaled Methoxyflurane as an Adjunct to Topical or Local Anesthesia
Penthrox in Otolaryngology
Our objective is to explore the use of methoxyflurane anesthesia as an adjunct analgesic to local anesthesia during in-office otolaryngology procedures in a prospective pilot study.
- Trial name
- PenthroxOTL (NCT07003880)
- Testing
- Methoxyflurane anesthesia
- Volunteers
- 50 people
- Sponsor
- Sir Mortimer B. Davis - Jewish General Hospital