Clinical trials: Topical Anaesthesia
Investigate the Efficacy of Sucrose During Eye Examination
Efficacy of Oral Sucrose and Topical Anesthetics to Reduce Pain During Eye Examination for Retinopathy of Prematurity
Oral sucrose reduces pain during heel sticks and venipunctures in preterm infants. The purpose of this study was to determine the effectiveness of local anesthetic eye drops and a pacifier, plus repeated doses of 24% sucrose, to…
- Trial name
- NCT01811979
- Testing
- Oral sucrose solution, Steril water
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Dr. Sami Ulus Children's Hospital
Local Anesthetics, Ultrasound Guidance
Duplex Guided Application of Local Anesthetic Before Femoral Artery Catheterization
The aim of this study is to evaluate the optimization of local anesthetic effect with duplex ultrasound-guided injection of lidocaine before femoral artery puncture during diagnostic or therapeutic interventional procedures.
- Conditions
- Local Anesthetics, Ultrasound Guidance, Catheterization
- Trial name
- NCT00903825
- Testing
- Ultrasound guided injection of femoral local anesthetic (lidocaine), Injection of femoral local anesthetic (lidocaine) with manual palpation
- Where
- Greece
- Volunteers
- 200 people
- Sponsor
- University of Patras
Dental Trauma, Local Anesthesia
Clinical Efficiency of Xanthan Hydrogels Containing Local Anesthetics Encapsulated in Nanostructured Lipid Carries
In a crossover, randomized, placebo-controlled, double-blind study, 40 volunteers will receive the following formulations: hydrogels containing LAs (local anesthetic) - lidocaine and prilocaine (both at 2.5%) encapsulated in CLN…
- Conditions
- Dental Trauma, Local Anesthesia, Oral Cavity Disease
- Trial name
- NCT05912335
- Testing
- Topical anesthetic
- Where
- Brazil
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Local Anaesthesia
Buzzy System Compared to Topical Anaesthesia During Infiltration Injection in Children.
Aim of the study is to test the effect of Buzzy System (vibrating device) compared to topical anaesthesia on pain reduction during injection of infiltration anaesthesia in children.
- Trial name
- NCT05083975
- Testing
- Buzzy System, Topical anesthetic, 1.8 ml of 4% articaine hydrochloride with epinephrine 1:100,000
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Cairo University
Diagnostic, Procedures and Surgeries on or Through Accessible Mucous Membranes
Topical Application of Cocaine HCl 4% and 10% on Safety and Efficacy in Local (Topical) Anesthesia
This study aims to evaluate topical application of Cocaine HCl 4% and 10% on safety and efficacy in local (topical) anesthesia for diagnostic procedures and surgeries on or through accessible mucous membranes of the nasal…
- Conditions
- Diagnostic, Procedures and Surgeries on or Through Accessible Mucous Membranes, of the Nasal Cavities
- Trial name
- NCT01746940
- Testing
- Cocaine HCl 4% Topical Solution, Cocaine HCl 10% Topical Solution
- Where
- 2 sites in United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- Lannett Company, Inc.
Flexible Bronchoscopy
Effect of the Topical Application of Anaesthetics With EnkFiberoptic Atomizer During the Bronchoscopy
The aim of this prospective study is to examine the benefits and risks of administration of local anaesthetics with a special atomizing set (Enk Fiberoptic Atomizer, Cook Medical) during flexible bronchoscopy.
- Trial name
- EnkAtomizerII (NCT02262442)
- Testing
- Enk Fiberoptic Atomizer, bronchoscope
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- RWTH Aachen University
Difficult Airway
Effects of Topical Anesthesia With Pressure Nebulized 2% Lidocaine During Awake Intubation
As reported, about 0.43% patients can not be intubated unevenly because of difficult airway and 30% of the total death of anesthesia due to failed intubation.
- Trial name
- NCT01185535
- Testing
- times of topical anesthesia for glottis
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Oral Cavity Disease
Microneedle Pretreatment as a Strategy to Improve the Effectiveness of Topical Anesthetics Formulations
A randomized, crossover, double-blind, two-sessions clinical trial with 30 male volunteers was performed to access pain of local anesthesia after using a topical anesthetic associated or not with prior application of microneedles…
- Trial name
- NCT05267938
- Testing
- Topical Anesthetic, Local anesthetic
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Bronchopulmonary Disease
Nebulized Lignocaine for Topical Airway Anesthesia During Flexible Bronchoscopy: A Randomized Controlled Trial
Flexible bronchoscopy is one of the most widely performed procedures for diagnosis of various bronchopulmonary diseases. Most patients tolerate the procedure well although cough is often reported as a distressing symptom.
- Trial name
- NEBULA (NCT03040193)
- Testing
- Lignocaine Nebulization, Saline Nebulization
- Where
- India
- Volunteers
- 200 people
- Sponsor
- All India Institute of Medical Sciences
Gag Reflex
US-guided Airway Nerve Block vs. Topical Lidocaine in Video Laryngoscopy for Difficult Bariatric Intubation.
The investigators will test the effects of ultrasound guided airway nerve block vs lidocaine topical anesthesia and it's direct effect in decreasing incidence of gag and cough reflex in suspected difficult intubation patients…
- Trial name
- NCT07069686
- Testing
- Ultrasound guided airway nerve block for Endotracheal intubation, lidocaine topical anesthesia for Endotracheal intubation
- Where
- Egypt
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Ain Shams University
Coronary Artery Disease, Valvular Heart Disease
Effect of Topical Anesthesia on Hemodynamics During the Induction Period in Patients Undergo Cardiac Surgery.
The aim of the induction is to decrease stress response of endotracheal intubation. It is also important to keep hemodynamics stable during and after the induction period.
- Conditions
- Coronary Artery Disease, Valvular Heart Disease, Arrhythmia, Myocardial Disease
- Trial name
- NCT04744480
- Testing
- The combined topical anesthesia induction group
- Where
- China
- Volunteers
- 96 people
- Sponsor
- Qianfoshan Hospital
Cataract Surgery
Impact of Non-fasting on Anxiety in Cataract Surgery
The aim of this prospective study was to investigate whether non-fasting recommendation could reduce preoperative anxiety level, incidence of anesthetist interventions, and number of surgical complications in elective cataract…
- Trial name
- StarvAnx (NCT04769856)
- Testing
- State-Trait Anxiety Inventory (STAI) scale, Satisfaction scale
- Where
- France
- Volunteers
- 126 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Intubation, Intratracheal
Intubation Conditions During ERCP With Lidocaine Aerosol Plus Low-dose Cisatracurium or Conventional-dose Cisatracurium
This clinical study investigates the effects of lidocaine aerosol as an adjunct to low-dose cisatracurium for endotracheal intubation during ERCP (Endoscopic Retrograde Cholangiopancreatography) procedures.
- Trial name
- NCT07185074
- Testing
- Cisatracurium 0.05 mg/kg IV, Cisatracurium 0.15 mg/kg IV, Lidocaine aerosol 2.4% topical
- Where
- China
- Volunteers
- 186 people
- Sponsor
- Jiangang Song
Airway Complication of Anesthesia
Role of Airway Topicalization in Awake Fiberoptic Intubation
Airway management is an integral part of general anesthesia. Difficult airway management may lead to various adverse events such as airway trauma, up to cardiopulmonary arrest.
- Trial name
- NCT06720220
- Testing
- Dexmedetomidine Hydrochloride, Nebulization, Atomization
- Where
- Egypt
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Normal Pulp/ Pulpitis
Efficacy of Pressure Massage and Topical Gel on Pain During Intra Oral Injections
Eighty patients with inclusion criteria will participate in this studyEach patient will receive an injection in one of the following groups according to the random number table: 1.
- Trial name
- NCT02601924
- Testing
- 20% Benzocain (Master-Dent, Monroe, NC), Topical pressure massage
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Nahid Mohammadzadeh Akhlaghi
Anesthesia, Local
Soft Mist Nasal Administration Device for Topical Anaesthesia of the Nasal Cavity
Rationale: Effective and fast topical anesthesia of the nasal mucosa is of paramount importance for nasal instrumentation like nasal fiberoptic procedures, awake nasal fiberoptic intubation and placement of nasogastric tubes.
- Trial name
- NCT06205680
- Testing
- NAA for topical anaesthesia of the nasal cavity
- Where
- Netherlands
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Anesthesia, Local
Study of Two-step Anesthesia in Intravitreal Injection
A prospective, randomised, single-masked comparison of local anaesthetic approaches including topical anesthesia combined sub-conjunctival anesthesia (two-step anesthesia) for intravitreal injection #TAIVI# vs topical anesthesia
- Trial name
- TAIVI (NCT03871062)
- Testing
- Two step anesthesia, topical anesthesia
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Aier School of Ophthalmology, Central South University
Dental Anxiety, Dental Fear
The Effect of Rubber Dam on Objective and Subjective Parameters of Stress During Dental Treatment in Children
Although rubber dam application provides many advantages, several pediatric dentists avoid using it, arguing that it may increase stress for young patients.
- Conditions
- Dental Anxiety, Dental Fear, Rubberdam, Anesthesia, Dental
- Trial name
- NCT06779448
- Testing
- Evaluation of objective and subjective stress parameters caused by local anesthesia during treatments, Evaluation of objective and subjective stress parameters caused by topical anesthesia during treatments, Evaluation of objective and subjective stress parameters caused by the application of rubber dam during treatments in the patient and dentist
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Izmir Katip Celebi University
Cataract
Combined Intracameral Lidocaine for Manual Small Incision Cataract Surgery Under Topical Anesthesia
The purpose of this study is to determine whether intraocular lidocaine increases patient comfort during the different stages of MSICS while under topical anesthesia.
- Trial name
- NCT01023334
- Testing
- MSICS under topical anesthesia with intracameral lidocaine, MSICS under topical anesthesia with intracameral balanced salt solution.
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Wenzhou Medical University
Pain
Topical Amethocaine Gel for Intramuscular Injection in Term Neonates
This study will examine the efficacy of topical amethocaine gel (Ametop) in decreasing the pain response in term neonates subjected to intramuscular injection for administration of vitamin K.
- Trial name
- NCT00267111
- Testing
- Eucerin plus, Amethocaine gel 4%
- Where
- Canada
- Volunteers
- 110 people
- Sponsor
- Mount Sinai Hospital, Canada