Clinical trials: Topical Anaesthesia
Cardiac Surgery
Effect of Topical Airway Block on Hemodynamic Stability Post Induction of Anaesthesia in Cardiac Surgeries
Opioids have always been the mainstay in management of patients during cardiac surgeries. Mega doses are often used to relieve stress of surgeries in highly labile patients with narrow hemodynamic threshold to keep the balance…
- Trial name
- hemodynamics (NCT06395727)
- Testing
- Fentanyl, Lidocain
- Where
- 2 sites in Egypt
- Volunteers
- 106 people
- Sponsor
- Ain Shams University
Skin Lacerations
Prospective Evaluation of Topical Anesthesia in Children
This study is designed to assess efficacy and comfort of LET solution vs. EMLA cream and topical infiltration of lidocaine.
- Trial name
- LET (NCT04378283)
- Testing
- LET gel (lidocaine 4%, epinephrine 0.1%, and tetracaine 0.5%), EMLA plus infiltration as anesthetic for wound repair.
- Where
- Germany
- Volunteers
- 99 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Unrecognized Condition
Topical Oral Anesthesia Adjuncts in Conventional Intubation on First-Pass Success Rate
This study aims to determine the first-pass success rate in video laryngoscopy and other parameters that topical anesthesia can affect during intubation.
- Trial name
- NCT06661967
- Testing
- Lidocaine spray
- Where
- Thailand
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Queen Savang Vadhana Memorial Hospital, Thailand
Thalassemia in Children
Efficacy of Transdermal Microneedle Patch for Topical Anesthesia Enhancement in Paediatric Thalassemia Patients
Microneedle (MN) is the mimic of a hypodermic needle, composed of hundreds of micron-sized, out-of-plane protrusions, typically arranged in arrays on a patch that can be applied onto the skin.
- Trial name
- NCT05078463
- Testing
- Microneedle, 1 Finger Tip Unit (FTU) EMLA Cream (30-minute application time), 1 Finger Tip Unit (FTU) EMLA (15-minute application time)
- Where
- Malaysia
- Volunteers
- 20 people
- Sponsor
- Universiti Kebangsaan Malaysia Medical Centre
Bronchopulmonary Diseases
1% vs. 2 % Lignocaine for Endobronchial Ultrasound Guided Transbronchial Needle Aspiration
Endobronchial Ultrasound Guided Transbronchial Needle Aspiration (EBUS -TBNA) is commonly performed for diagnosis of mediastinal pathologies.
- Trial name
- NCT02913300
- Testing
- Lignocaine 1% concentration solution, Lignocaine 2% concentration solution
- Where
- India
- Volunteers
- 100 people
- Sponsor
- All India Institute of Medical Sciences
Anesthesia, Pediatric ALL
Topical Analgesia Before Inhalational Anaesthesia
Peripheral venous cannulation (insertion of a drip line into a vein) is a fundamental component of anaesthesia for both children and adults alike.
- Trial name
- NCT04959409
- Testing
- Topical analgesia (EMLA or AMETOP)
- Where
- United Kingdom
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Nottingham University Hospitals NHS Trust
Diabetes (DM), Retinopathy, Diabetic
Comparison of 4 Methods of Eye Drops for Pupil Dilation in Diabetic Patients
Pupil dilation is required for many eye conditions. Diabetic patients may need more dilating eye drops to have pupil size large enough for eye exams.
- Conditions
- Diabetes (DM), Retinopathy, Diabetic, Pupil Dilation
- Trial name
- NCT07495670
- Testing
- 1 drop of a 0.8% tropicamide + 5% phenylephrine combination, 1 drop of 0.5% tetracaine and 1 drop of a 0.8% tropicamide + 5% phenylephrine combination, 3 drops of a 0.8% tropicamide + 5% phenylephrine combination
- Where
- Thailand
- Volunteers
- 84 people
- Sponsor
- Burapha University
Pain, Symptomatic Irreversible Pulpitis
Ethyl Chloride Versus 5% Lidocaine for Topical Anesthesia of Oral Mucosa
Local anesthesia in the oral cavity is a pain full experience for the patient. All means should be made to reduce the pain and anxiety of the patient for needle stick procedures.
- Trial name
- NCT05306470
- Testing
- Ethyl chloride, 5% lidocaine gel
- Where
- Pakistan
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Altamash Institute of Dental Medicine
Analgesia
Effectiveness of Pre-administered Natural Sweet-tasting Solution (Honey) for Decreasing Pain of Needle Insertion
This study aims to assess Effectiveness of Pre-administered Natural Sweet-tasting Solution (honey) for Decreasing Pain Associated with Dental Injections (infiltration) prior to dental extraction in 6-8 years old healthy Children…
- Trial name
- NCT06393777
- Testing
- honey
- Volunteers
- 14 people, healthy volunteers welcome
- Sponsor
- Cairo University
Local Anesthetic Infiltration, Topical Anesthesia
Topical Cryoanesthesia Versus Benzocaine in Pediatric Dentistry
This clinical study tested and compared two ways (cold-base technique or "cryoanesthesia" and conventional benzocaine gel) to reduce pain from dental injections in children.
- Conditions
- Local Anesthetic Infiltration, Topical Anesthesia, Pain Perception
- Trial name
- No acronym (NCT07351383)
- Testing
- Local Anesthesia (lidocaine hydrochloride)
- Where
- Mexico
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí
Analgesia, Recovery, Psychological
Enhanced Recovery After Uvulopalatoplasty
Obstructive sleep apnea is a prevalent condition often treated surgically with palatoplasty, which improves airway patency and reduces apneic events.
- Trial name
- NCT07246694
- Testing
- Glossopharyngeal nerve block, Standard multimodal analgesia
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Zagazig University
Dental Caries in Children
Different Methods for Reducing Buccal Infiltration Local Anesthesia Injection Pain
Local anesthetic injection is considered one of the most annoying dental procedures. The use of topical anesthesia is considered a routine procedure in the dental clinic especially for children.
- Trial name
- NCT06290531
- Testing
- Buzzy device (cold and vibration), Buzzy device (vibration only), precooling
- Where
- Egypt
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Cairo University
Phacoemulsification, Cataract
Sedation Methods During Cataract Surgery
Background: Phacoemulsification is the most common surgical procedure performed in the United States and European Union and sedation is commonly used during phacoemulsification to help alleviate patient anxiety and prevent the…
- Trial name
- NCT03054103
- Testing
- Midazolam + Ketamine 10 MG/ML: 0.5 ML, Midazolam + Ketamine 10 MG/ML: 1 ML, Midazolam + Normal saline
- Volunteers
- 105 people
- Sponsor
- Wake Forest University Health Sciences
Awake Fiberoptic Intubation
Dexmedetomidine Versus Ketamine-midazolam Sedation in Awake Fiberoptic Intubation in Suspected Difficult Airway
The goal of this clinical trial is to obtain the optimal patient's comfort and cooperation during awake fiberoptic intubation with prototype device.
- Trial name
- NCT06946212
- Testing
- Dexmedetomidine, Ketamine plus Midazolam
- Where
- Egypt
- Volunteers
- 34 people
- Sponsor
- Zagazig University
Nasopharyngeal Sampling, Local Anesthesia
Topical Lidocaine Anesthesia for Nasopharyngeal Sampling
Introduction: Nasopharyngeal sampling is widely used in the diagnosis of the Coronavirus Disease 2019 (COVID-19). The aim of this study is to evaluate the effects of topical lidocaine application for nasopharyngeal sampling, on…
- Trial name
- NCT04885777
- Testing
- Lidocaine
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Pain
Evaluate the Depth and Duration of Anesthesia
The purpose of the study is to determine the depth (mm) of anesthesia provided by the Synera topical patch (using sensory depth and pain depth evaluations), and to determine the duration (minutes) of anesthesia provided by the…
- Trial name
- NCT00891163
- Testing
- Synera™ Topical Patch (70 mg lidocaine/70 mg tetracaine)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- ZARS Pharma Inc.
Esophagogastroduodenoscopy
Usefulness of Lidocaine as Topical Pharyngeal Anaesthesia in Esophagogastroduodenoscopy Under Sedation With Propofol
The purpose of this study is to determine the efficacy of application of the anaesthesia topical pharyngeal with lidocaine in esophagogastroduodenoscopy under propofol´s sedation, in therms of dosage and side effect´s reduction…
- Trial name
- NCT01489891
- Testing
- Lidocaine
- Where
- Spain
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Hospital Universitario Infanta Cristina
Ankle Sprain
Topical Treatments for Ankle Sprains
Our aim was to evaluate the effects of topical analgesic drugs on rapid recovery of joint functions and pain relief in acute ankle injuries.
- Trial name
- NCT06623929
- Testing
- Etofenamat, Diclofenac
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Ankara City Hospital Bilkent
Hemodynamic Instability
Topical Anesthesia and Intra-arterial Chemotherapy for Retinoblastoma
The objective of this study is to use local topical anesthesia to numb the sensory input, captured by branches of the Trigeminal nerve found on the skin in and around the eye, to decrease a hemodynamic reflex seen during…
- Trial name
- TOPIAC (NCT02955524)
- Testing
- Tetracaine 0.5%, Lidocaine hydrochloride ophthalmic gel 3.5%
- Sponsor
- University of Miami
Myopia
Preservative-free Topical Anesthetics for Post-PRK Pain
The goal of this interventional comparative study is to assess the efficacy and safety of a novel regimen of preservative-free unit-dose topical anesthetics for controlling early postoperative pain following single-step…
- Trial name
- NCT05733741
- Testing
- Preservative-free Benoxinate hydrochloride 0.4% (Benoxidia unit-dose vials [UD], Orchidia pharmaceutical Ind., Egypt), Preservative-free Sodium hyaluronate 0.2% (Polyfresh unit-dose vials [UD], Orchidia pharmaceutical Ind., Egypt).
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Assiut University