Clinical trials: Topical Anesthetic
Anesthesia, Local
A Study of the Safety and Anesthetic Effect of AG-920 Topical Ophthalmic Solution
This is a Phase 3, randomized, placebo-controlled, double masked, parallel design study in healthy subjects performed in the US.
- Trial name
- NCT04513652
- Testing
- AG-920
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- American Genomics, LLC
Macular Degeneration
Pilot Study: A Randomized Trial Of Anesthetic Agents For Intravitreal Injection
This study is designed to compare four currently used types of anesthesia used prior to intravitreal injection in order to evaluate the most effective method of anesthesia in reducing pain and discomfort associated with…
- Trial name
- NCT00769392
- Testing
- Proparacaine Ophthalmic, Tetracaine Ophthalmic, Lidocaine 4%
- Where
- 3 sites in United States
- Volunteers
- 28 people
- Sponsor
- Lahey Clinic
Ophthalmology, Cataract Surgery Anesthesia
An Extension Test of Whether to Use Oral Anti-anxiety Drugs (Alprazolam) When Patients Choose Second Eye Cataract Surgery After Unblinding, and Analyze Their Anxiety, Satisfaction and Pain Satisfaction
Phacoemulsification is one of the most used surgical methods for cataract surgery today, and the surgeries are under the anesthetic and sedative to make it comfortable and safe for patients.
- Conditions
- Ophthalmology, Cataract Surgery Anesthesia, Oral Anxiolytic, Satisfaction Survey
- Trial name
- NCT06874452
- Testing
- Alprazolam (Xanax)
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- National Taiwan University Hospital
Open Angle Glaucoma
Study on the Impact of Ocular Anesthetic Procedures in Ocular Blood Flow
Anaesthetic procedures in ophthalmology surgery have been a subject rapidly evolving in the past decades. When deciding for a retrobulbar block, the local injection of varying mixtures and volumes of fast-acting anesthetics (such…
- Trial name
- NCT01840215
- Where
- Belgium
- Volunteers
- 240 people
- Sponsor
- Universitaire Ziekenhuizen KU Leuven
Local Anesthesia of the Skin.
Fractional Laser Assisted Delivery of Anesthetics
The purpose of this study is to assess the efficacy of fractional CO2 laser assisted delivery of topically applied anesthetics (articaine hydrochloride 40 mg/ml and epinephrine 10 μg/ml solution and EMLA cream) regarding to…
- Trial name
- NCT02246179
- Testing
- AFXL, AHES, EMLA cream
- Where
- Netherlands
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Netherlands Institute for Pigment Disorders
Anesthesia, Local
A Study of the Safety and Anesthetic Effect of AG-920 Topical Ophthalmic Solution
This is a Phase 3, randomized, placebo-controlled, double masked, parallel design study in healthy subjects performed in the US.
- Trial name
- NCT04829344
- Testing
- AG-920
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- American Genomics, LLC
Pain
Comparison of Patient Comfort After Two Anesthetic Protocols for Injections Into the Eye
Patient comfort during and after eye injections will be compared after two numbing (anesthetic) protocols, an eye preparation utilizing three cotton swabs soaked in 4% lidocaine drops versus a preparation using 3.5% lidocaine…
- Trial name
- NCT01087489
- Testing
- 4% lidocaine, 3.5% ophthalmic lidocaine gel
- Where
- United States
- Volunteers
- 53 people
- Sponsor
- Miami VA Healthcare System
Pain Management
Evaluation of the Efficacy and Onset of Action of a Topical Anesthetic Marker
The goal of this clinical trial is to to demonstrate the efficacy of a topical anesthetic in reducing pain during the performance of a painful test on the participant's arm.
- Trial name
- NCT07273916
- Testing
- Cutaneous marker (Transcutol P+ 20%, Tetracaine 7%, Lidocaine 23%, and dye q.s.),
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hexsel Dermatology Clinic
Clubfoot
Clubfoot Tenotomy Trial
Infants undergoing Ponseti treatment for idiopathic clubfoot often require percutaneous tendoachilles lengthening (TAL) after serial casting.
- Trial name
- ClubTT (NCT04766684)
- Testing
- Jet injection of 1% lidocaine, 4% liposomal lidocaine cream
- Where
- United States
- Volunteers
- 107 people
- Sponsor
- Vanderbilt University Medical Center
Electrodiagnosis
Comparison of the Effects of Vapocoolant Spray and EMLA Cream on Pain During Needle Electromyography
The purpose of this study is to compare the effects of vapocoolant spray and topical lidocaine 2.5% + prilocaine 2.5% cream (EMLA) on reducing pain during needle electromyography.
- Trial name
- NCT01606046
- Testing
- vapocoolant spray, topical anesthetic cream
- Where
- South Korea
- Volunteers
- 99 people
- Sponsor
- The Catholic University of Korea
Topical Anesthetic Applied With Sonophoresis
The Effect of Sonophoresis on Topical Anesthesia: A Pilot Study
The Dental Anesthesia Sonophoresis Device (DASD) is a novel device that is intended to reduce the discomfort associated with puncturing the oral mucosa.
- Trial name
- NCT01283490
- Testing
- DASD Group, Sonic Vibration (SV)
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Loma Linda University
Local Anesthesia of the Skin
Fractional Laser Assisted Delivery of Anesthetics III
The purpose of this study is to compare the effect of pretreatment with two different ablative laser modalities, a CO2 laser and an Er:YAG laser, and to assess the role of laser density in fractional laser assisted topical…
- Trial name
- NCT02938286
- Testing
- Fractional CO2 laser, 2.5 mJ, 5% density, Fractional CO2 laser, 2.5 mJ, 15% density, Fractional Er:YAG laser, 9 mJ, 5% density
- Where
- Netherlands
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Netherlands Institute for Pigment Disorders
Premature Ejaculation
Efficacy, Safety and Tolerability of PSD502 (a Topical Anesthetic) in the Treatment Premature Ejaculation
The purpose of this study is to evaluate the effectiveness, safety and tolerability of the investigational drug, PSD502 in subjects with premature ejaculation (PE) The study drug, PSD02, is a metered dose (measured dose), topical…
- Trial name
- NCT00556478
- Testing
- PSD502, contains a mixture of lidocaine and prilocaine
- Where
- United States
- Volunteers
- 256 people
- Sponsor
- Plethora Solutions Ltd
Lentigo
The Effect of Topical Anesthetics on Patients' Pain and Operative Experience During Treatment With QSwitched Laser
This study will conduct a split-face and -body randomized control trial to compare lidocaine 2.5%/prilocaine 2.5% topical anesthetic (LPTA), lidocaine 7%/tetracaine 7% topical anesthetic (LTTA), and placebo vechicle (PV) on…
- Trial name
- NCT02427724
- Testing
- lidocaine 2.5%/prilocaine 2.5% topical anesthetic, lidocaine 7%/tetracaine 7% topical anesthetic, Q-switched 532nm Laser
- Where
- United States
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Northwestern University
Local Anesthesia of the Skin
Fractional Laser Assisted Delivery of Anesthetics IIIb
The purpose of this study are to compare the efficacy of two different commercially available local anesthetics on AFXL pretreated skin and to assess the role of the application time in this technique.
- Trial name
- NCT03279757
- Testing
- AHES 5 minutes, AHES 15 minutes, AHES 25 minutes
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Netherlands Institute for Pigment Disorders
Analgesia, Topical Anesthetic
Ametop Compared to Ametop With Pain Ease Spray
The investigators propose to examine if Pain Ease spray, used as an adjunct to the topical anesthetic Ametop Gel, can improve the percentage of pain-free IV starts.
- Trial name
- NCT03749915
- Testing
- Pain Ease Cold Spray, Ametop
- Where
- Canada
- Volunteers
- 240 people
- Sponsor
- University of British Columbia
Procedural Pain
Comparison of Virtual Reality, EMLA Cream, and Standard Care for Pain During Blood Draws in Children
This randomized controlled trial evaluates methods to reduce pain during venipuncture in children aged 3 to 15 years. The study compares three approaches: virtual reality distraction using a VR headset, topical anesthesia with…
- Trial name
- NCT07763132
- Testing
- Virtual Reality Distraction, Lidocaine-Prilocaine Cream
- Where
- Czechia
- Volunteers
- 450 people
- Sponsor
- Marie Lulková
Anesthesia of Mucous Membrane
Comparison of Two Topical Anesthetics: Benzocaine Versus Pliaglis
The efficacy of the topical anesthetics will be determined by how much pain the patient felt (using a Heft-Parker pain analog scale) upon needle penetration.
- Trial name
- NCT01951820
- Testing
- Pliaglis, Benzocaine, Articaine
- Where
- United States
- Volunteers
- 64 people, healthy volunteers welcome
- Sponsor
- University of Michigan
Pain
Reduction of Topical Anesthetic Onset Time Using Ultrasound
Children ages 3-7 who are undergoing blood drawing receive either standard care, topical medicine for numbing (LMX4), or the study intervention which utilizes ultrasound to speed the onset of LMX4 from 30 minutes to 5 minutes.
- Trial name
- NCT00126932
- Testing
- SonoPrep
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Connecticut Children's Medical Center
Child, Pain Due to Certain Specified Procedures
External Cold and Vibration Stimulation (Buzzy®) for Procedural Pain Management in Children Undergoing Needle-Related Procedures
Since the late 1980s, several studies focused on pediatric procedural pain and show that it still underevaluated and undertreated, especially in the Emergency Department (ED).
- Trial name
- NCT02616419
- Testing
- Buzzy® device, Maxilene® (Lidocaine liposomal 4%)
- Where
- Canada
- Volunteers
- 354 people
- Sponsor
- St. Justine's Hospital