Clinical trials: Topical Anesthetic
Conscious Sedation
Propofol Sedation During Upper Endoscopy With and Without Topical Pharyngeal Anesthesia
It is unclear whether a topical pharyngeal anesthesia adds any benefit to the upper gastrointestinal endoscopy under a propofol sedation.
- Trial name
- NCT01081002
- Testing
- Lidocaine 10%, Diluted gentian root solution
- Where
- 2 sites in Switzerland
- Volunteers
- 294 people
- Sponsor
- University Hospital, Basel, Switzerland
Anxiety
COMPARISON OF THE TOPICAL ANAESTHETIC EFFICACY OF VARIOUS AGENTS WITH ANAESTHETIC EFFECTS IN CHILDREN
The purpose of the study is to compare the effectiveness of natural methods-such as basil oil, chamomile oil, and ice-with synthetic topical anesthetics, such as topical anesthetic sprays and topical anesthetic creams, and to…
- Trial name
- NCT07849192
- Testing
- Vemcaine, Essences and Essential Oils, VISION
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Uşak University
Anesthesia
Effects of Benzocaine 20% Topical Anesthetic and no Topical Agent on Pain Perception During Intra-oral Injections
The aim of this randomized controlled trial. is to test the efficacy of topical anesthesia against the use of no topical agent during buccal infiltration in maxillary anterior teeth.
- Trial name
- NCT03261115
- Testing
- No topical anesthesia
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Nurain Rehman
Glaucoma, Intraocular Pressure
The Measurement of Intraocular Pressure in Normal Children Under General Anesthesia With and Without Nitrous Oxide and Anesthetic Eye Drops
Pediatric glaucoma is a rare but potentially blinding condition where the pressure in the eye is too high. Diagnosis is based on intraocular pressure (IOP) and assessment of the optic nerve, cornea and other structures.
- Conditions
- Glaucoma, Intraocular Pressure, Anesthesia
- Trial name
- IOP (NCT01925391)
- Testing
- Tono-pen XL Applanation tonometer + Ocu-film +
- Where
- 2 sites in United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- University of Miami
Anxiety Disorder, Allergic Skin Reaction
The Effect of Medical Clowns and Topical Anesthetic Cream on Pain and Anxiety in Children Undergoing Allergy Skin Tests
Allergy skin tests are occasionally associated with pain and anxiety in patients undergoing this procedure. The investigators intend to examine if medical clowns compared with local anesthetic cream can decrease these feelings in…
- Trial name
- NCT01425619
- Testing
- Cream of Macrogol cetostearyl ethers, Cream of Lidocaine 2.5 %.and Prilocaine 2.5 %, Care and treatment from a medical clown
- Where
- Israel
- Volunteers
- 160 people
- Sponsor
- Meir Medical Center
Epiphora, Dacryostenosis
Does Topical Ophthalmic Anesthetic Prior to Probing and Irrigation Decrease Pain?
Purpose: It is unknown whether instillation of a drop of anesthetic ophthalmic solution into the eye such as proparacaine hydrochloride 0.5% prior to probing and irrigation of the tear duct (lacrimal drainage) system improves…
- Conditions
- Epiphora, Dacryostenosis, Dacryocystitis
- Trial name
- NCT04229771
- Testing
- Proparacaine Hydrochloride ophthalmic solution, USP 0.5%, Balanced salt solution
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Corewell Health East
Anesthesia
Efficacy of Injected Local Anesthetic vs Topical Anesthetic in Cosmetic Injectable Fillers.
The purpose of the study is to compare two modalities of local anesthetic administration prior to the placement of cosmetic facial injectable fillers.
- Trial name
- NCT02379221
- Testing
- Injectable, Topical
- Where
- United States
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- David Grant U.S. Air Force Medical Center
Pain
Pre Injection Use of Cryoanesthesia Versus Topical Anesthetic Gel in Reducing Pain Perception During Palatal Injections
The goal of this interventional study is to assess the effectiveness of pre-injection use of topical ice application in decreasing pain perception when administering greater palatine nerve block injections as compared to that of…
- Trial name
- NCT06165432
- Testing
- Topical Benzocaine, Topical ice
- Where
- Nepal
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- B.P. Koirala Institute of Health Sciences
Pain
Comparison Study on Topical Anesthetic Agents (LMX4 and BLT) Prior to Fractional Skin Resurfacing
The purpose of this research study is to test which topical anesthesia: LMX4 (Lidocaine 4%) or BLT (Benzocaine 20%, Lidocaine 6%, and Tetracaine 4%) is more effective in reducing discomfort during treatment with the Fraxel DUAL…
- Trial name
- NCT01842373
- Testing
- LMX4, BLT
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Milton S. Hershey Medical Center
Dental Pain, Postoperative Pain
Comparative Efficacy of 20% Benzocaine Versus TAC Alternate Gel
The project is a study comparing the effectiveness of two topical anesthetics for control of pain associated with dental needle insertion in the palatal mucosa.
- Trial name
- NCT00846690
- Testing
- benzocaine, TAC alternate gel
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- The University of Texas Health Science Center, Houston
Cataract
Efficacy and Safety Assessment of Intracameral Injection of T2380 in Cataract Surgery
The purpose of this study is to determine the efficacy and safety assessment of T2380 for mydriasis and anaesthesia in phacoemulsification cataract surgery versus reference group (topical mydriatics and anaesthetic) 2X246…
- Trial name
- NCT02101359
- Testing
- T2380, Mydriatics, Tetracaine
- Where
- France
- Volunteers
- 609 people
- Sponsor
- Laboratoires Thea
Anesthesia, Local, Photodamaged Skin
Comparative Study of Two Topical Anesthetics Prior to Fractional Nonablative Laser Treatment of the Face
The purpose of this study is to determine the efficacy of lidocaine 2.5%/prilocaine 2.5% cream versus lidocaine 23%/tetracaine 7% ointment for topical anesthesia prior to a nonablative laser procedure.
- Conditions
- Anesthesia, Local, Photodamaged Skin, Topical and Infiltration Anesthetic Toxicity
- Trial name
- NCT04523961
- Testing
- 2.5 g of lidocaine 23% / tetracaine 7% ointment without occlusion, 7.5 g lidocaine 2.5%/ prilocaine 2.5% cream with occlusion
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Mayo Clinic
Episiotomy Wound
Comparison Between Lidocaine Prilocaine Cream and Lidocaine Injection on Pain Control During Episiotomy.
The present study aims to compare the effects of lidocaine-prilocaine cream and lidocaine injection on the reduction of pain while doing and repairing episiotomy, controlling the pain in the post-partum period, and reduction the…
- Trial name
- NCT05891132
- Testing
- 10 ml of lidocaine 2%, lidocaine prilocaine cream 15gm
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Cairo University
Topical Anesthesia
Pharmacokinetic Study of Nanoencapsulated Gel of Lidocaine, Prilocaine and Combination of Lidocaine and Prilocaine
This trial evaluated the pharmacokinetic interaction between fixed doses of lidocaine (2.5%), prilocaine (2.5%) or the association of both (Nanorap®) in healthy volunteers. The drug safety and tolerability was also evaluated.
- Trial name
- NCT03441841
- Testing
- Lidocaine + Prilocaine, Lidocaine, Prilocaine
- Where
- Brazil
- Volunteers
- 48 people, healthy volunteers welcome
- Sponsor
- Galeno Desenvolvimento de Pesquisas Clínicas
Local Anesthesia, Pain, Postoperative
EMLA Topical Anesthetic During Scaling and Root Planing
Injectable anesthesics previous to subgingival scaling and root planing (SRP) presents some disadvantages like fear of the needle insertion, long-lasting effect and prolonged dampening of adjacent tissues.
- Conditions
- Local Anesthesia, Pain, Postoperative, Self-Perception
- Trial name
- NCT01860235
- Testing
- EMLA, Injectable anesthesia, 2% Benzocaine
- Volunteers
- 32 people
- Sponsor
- Franciscan University Center
Corneal Abrasions
Proparacaine vs Placebo for Corneal Injuries
Introduction: Traumatic injuries to the outer covering of the eye (the cornea) are a common emergency department complaint. They cause significant patient distress including pain, loss of sleep and missed work days.
- Trial name
- Dogma (NCT00620997)
- Testing
- Proparacaine drops 0.05%, saline drops
- Where
- Canada
- Volunteers
- 43 people
- Sponsor
- London Health Sciences Centre
Spray, Pain
Safety of Gebauer's Pain Ease and Gebauer's Ethyl Chloride
This study aims to determine if Gebauer's Pain Ease or Gebauer's Ethyl Chloride topical anesthetic sprays are safe for use as numbing agents prior to placing epidurals and arterial lines, based on whether they introduce increased…
- Conditions
- Spray, Pain, Safety Issues
- Trial name
- NCT04207710
- Testing
- Gebauer's Pain Ease Top Aerosol Mist Spray, Gebauer's Ethyl Chloride
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Henry Ford Health System
Flexible Nasendoscopy
Nasal Prep for Nasendoscopy in Children
Flexible nasendoscopy involves passing a soft, thin, endoscope through the nose. This diagnostic procedure is often essential for assessment of a child by an Otolaryngologist in outpatients.
- Trial name
- NCT01351298
- Testing
- 0.05% xylometazoline hydrochloride with 1% lidocaine hydrochloride, 0.05% xylometazoline hydrochloride, Isotonic normal saline
- Where
- Canada
- Volunteers
- 69 people
- Sponsor
- Children's & Women's Health Centre of British Columbia
Healthy
Radial Artery Dilation Study: The Effect of Topical Administration of Nitroglycerin and Lidocaine Versus Lidocaine Alone of the Radial Artery Diameter
The radial artery, which is located on the outer side of the forearm, can be used in interventional procedures, such as cardiac catheterization, to provide access to the arterial blood supply.
- Trial name
- NCT00686231
- Testing
- Nitroglycerin 15mg, Nitroglycerin 30mg, Lidocaine 20mg
- Where
- United States
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Wound, Anesthesia, Local
To Evaluate Reduction of Pain in Wounds Treatment Previously Applying Lidocaine Topical Solution vs Placebo.
The purpose of this study is to evaluate if applying a lidocaine topical solution before wounds treatment decreases the pain of the procedure in comparison with placebo solution.
- Trial name
- NCT03676556
- Testing
- Lidocaine, Saline Solution
- Where
- 2 sites in Spain
- Volunteers
- 46 people
- Sponsor
- Hospital Universitari de Bellvitge