Clinical trials: Topical Anesthetic
Flexible Bronchoscopy
Effect of the Topical Application of Anaesthetics With EnkFiberoptic Atomizer During the Bronchoscopy
The aim of this prospective study is to examine the benefits and risks of administration of local anaesthetics with a special atomizing set (Enk Fiberoptic Atomizer, Cook Medical) during flexible bronchoscopy.
- Trial name
- EnkAtomizerII (NCT02262442)
- Testing
- Enk Fiberoptic Atomizer, bronchoscope
- Where
- Germany
- Volunteers
- 60 people
- Sponsor
- RWTH Aachen University
Oral Cavity Disease
Microneedle Pretreatment as a Strategy to Improve the Effectiveness of Topical Anesthetics Formulations
A randomized, crossover, double-blind, two-sessions clinical trial with 30 male volunteers was performed to access pain of local anesthesia after using a topical anesthetic associated or not with prior application of microneedles…
- Trial name
- NCT05267938
- Testing
- Topical Anesthetic, Local anesthetic
- Where
- Brazil
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- University of Campinas, Brazil
Pain, Anxiety
Randomized Control Trial of a Topical Anesthetic to Evaluate Pain and Anxiety During Venipuncture
The purpose of this study is to evaluate the amount of anxiety and pain felt by children during procedures that require a needle stick after using a topical anesthetic or placebo cream.
- Trial name
- NCT00676364
- Testing
- 4% lidocaine topical anesthetic cream
- Where
- United States
- Volunteers
- 114 people, healthy volunteers welcome
- Sponsor
- Jenny Boucher, PharmD
Adhesive Capsulitis of the Shoulder
Spray vs EMLA Cream on Pain During Intra-articular Injection
All participants are randomly allocated to the spray group, EMLA group and placebo group. In spray group, participants receive an application of placebo cream at the needle electrode insertion site 60 minutes before needle…
- Trial name
- NCT03484832
- Testing
- Walter Ritter Ethyl Chloride Spray, EMLA Cream
- Where
- South Korea
- Volunteers
- 63 people
- Sponsor
- Soonchunhyang University Hospital
Cataract
Combined Intracameral Lidocaine for Manual Small Incision Cataract Surgery Under Topical Anesthesia
The purpose of this study is to determine whether intraocular lidocaine increases patient comfort during the different stages of MSICS while under topical anesthesia.
- Trial name
- NCT01023334
- Testing
- MSICS under topical anesthesia with intracameral lidocaine, MSICS under topical anesthesia with intracameral balanced salt solution.
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Wenzhou Medical University
Lip Augmentation
A Multicenter, Double-blind, Randomized, Controlled, Roll-over Retreatment Study of the Safety and Pain Associated With Injections of PN40082, RV001 With Topical Anesthetic or RV001 for Lip Augmentation
The purpose of this study is to evaluate the safety of repeat injections and pain associated with injection of PN40082 and comparative pain associated with RV001 with a topical anesthetic and RV001 for lip augmentation.
- Trial name
- NCT04029545
- Testing
- PN40082
- Where
- 5 sites in United States
- Volunteers
- 5 people, healthy volunteers welcome
- Sponsor
- Prollenium Medical Technologies Inc.
Pain
Skin Refrigerant to Reduce the Pain Associated With IV Insertion
The purpose of this study is to determine whether or not the pain of IV catheter insertion in the Emergency Department can be reduced significantly with the use of a rapid acting topical anesthetic spray and to determine whether…
- Trial name
- NCT02499965
- Testing
- Ethyl Chloride Topical Aerosol Anesthetic, Nature's Tears Sterile Water
- Where
- United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- Brooke Army Medical Center
Diabetes (DM), Retinopathy, Diabetic
Comparison of 4 Methods of Eye Drops for Pupil Dilation in Diabetic Patients
Pupil dilation is required for many eye conditions. Diabetic patients may need more dilating eye drops to have pupil size large enough for eye exams.
- Conditions
- Diabetes (DM), Retinopathy, Diabetic, Pupil Dilation
- Trial name
- NCT07495670
- Testing
- 1 drop of a 0.8% tropicamide + 5% phenylephrine combination, 1 drop of 0.5% tetracaine and 1 drop of a 0.8% tropicamide + 5% phenylephrine combination, 3 drops of a 0.8% tropicamide + 5% phenylephrine combination
- Where
- Thailand
- Volunteers
- 84 people
- Sponsor
- Burapha University
Local Anesthetic Infiltration, Topical Anesthesia
Topical Cryoanesthesia Versus Benzocaine in Pediatric Dentistry
This clinical study tested and compared two ways (cold-base technique or "cryoanesthesia" and conventional benzocaine gel) to reduce pain from dental injections in children.
- Conditions
- Local Anesthetic Infiltration, Topical Anesthesia, Pain Perception
- Trial name
- No acronym (NCT07351383)
- Testing
- Local Anesthesia (lidocaine hydrochloride)
- Where
- Mexico
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- Universidad Autonoma de San Luis Potosí
Multiple Sclerosis
Anesthetic Topical Adhesive (Synera™) to Reduce Injection Pain With Subcutaneous Multiple Sclerosis Medications
The purpose of this study is to see if applying an anesthetic topical adhesive, Synera®, will reduce the injection pain. Relieving injection site pain may improve the tolerability of Multiple Sclerosis medications.
- Trial name
- OUCH (NCT01834586)
- Testing
- Anesthetic Topical Adhesive Synera
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brown, Theodore R., M.D., MPH
Myopia
Preservative-free Topical Anesthetics for Post-PRK Pain
The goal of this interventional comparative study is to assess the efficacy and safety of a novel regimen of preservative-free unit-dose topical anesthetics for controlling early postoperative pain following single-step…
- Trial name
- NCT05733741
- Testing
- Preservative-free Benoxinate hydrochloride 0.4% (Benoxidia unit-dose vials [UD], Orchidia pharmaceutical Ind., Egypt), Preservative-free Sodium hyaluronate 0.2% (Polyfresh unit-dose vials [UD], Orchidia pharmaceutical Ind., Egypt).
- Where
- Egypt
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Assiut University
Cataract
Comparison Mydriasis by Mydrane With Topical Drop Application
The primary aim of the study is to compare the effectiveness of the intracameral application of Mydrane® (standardized combination of Tropicamide 0.02%, Phenylephrine 0.31% and Lidocaine 1%) with the preoperative topical…
- Trial name
- NCT04880928
- Testing
- Eye injection (Mydrane), eye drops (Phenylephrin), eye drops (Tropicamid)
- Where
- Austria
- Volunteers
- 42 people
- Sponsor
- Medical University of Graz
Anesthesia Intubation Complication, Intubation Complication
A Comparison Of Local Anesthetic Agents And Steroid On Tracheal Tube Cuff
This study aims to compare effects of two different agents on complications due to tracheal tube cuff in pediatric patients. Sore throat, hoarseness, laryngospasm, bronchospasm are the main complications.
- Conditions
- Anesthesia Intubation Complication, Intubation Complication, Sore Throat
- Trial name
- LA-STEROID (NCT04085744)
- Testing
- Lidocaine 10% Spray, Mometasone nasal spray
- Where
- Turkey (Türkiye)
- Volunteers
- 91 people
- Sponsor
- Derince Training and Research Hospital
Wounds, Local Anesthesia
To Evaluate Reduction of Pain in Wounds Treatment Previously Applying Lidocaine Topical Solution vs Placebo
The purpose of this study is to evaluate if applying a lidocaine topical solution before wounds treatment decreases the pain of the procedure in comparison with placebo solution.
- Trial name
- NCT02584335
- Testing
- Lidocaine solution ("A"), Saline solution ("B")
- Where
- Spain
- Volunteers
- 7 people
- Sponsor
- Hospital Universitari de Bellvitge
Pain
Efficacy of Ametop Cream in Reducing Pain of Local Anesthetic Infiltration
Ametop is a numbing cream used to ease the pain of having blood drawn or an IV inserted. It is safe and virtually none enters the blood stream.
- Trial name
- Ametop (NCT01864213)
- Testing
- Ametop cream
- Where
- Canada
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Premature Ejaculation
A Safety and Tolerability of PSD502 (a Topical Anesthetic) in the Treatment of Premature Ejaculation
A phase I, single-center, double-blind, randomized, placebo-controlled, safety and pharmacokinetic study to evaluate systemic and local vaginal exposure to lidocaine and prilocaine and the metabolites, 2,6-dimethylaniline…
- Trial name
- NCT01184105
- Testing
- Intervention A, Intervention B
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Plethora Solutions Ltd