Clinical trials: Total Hip Replacements
Thromboembolism, Arthroplasty, Replacement, Hip
Dabigatran Etexilate in Extended Venous Thromboembolism (VTE) Prevention After Hip Replacement Surgery
The objective of this study is to determine the comparative efficacy and safety of two oral regimens of dabigatran etexilate, compared to a standard subcutaneous regimen of enoxaparin, in prevention of venous thromboembolism in…
- Trial name
- NCT00168818
- Testing
- dabigatran etexilate, enoxaparin
- Where
- 116 sites in Australia, Austria and 14 more
- Volunteers
- 3,494 people
- Sponsor
- Boehringer Ingelheim
Total Hip Arthroplasty, Primary Total Hip Arthroplasty
Outcomes After Hypotensive Neuraxial Anesthesia in Total Hip Arthroplasty
This is a retrospective chart review to determine if neuraxial anesthesia is associated with worse outcomes after Primary Total Hip Arthroplasty.
- Conditions
- Total Hip Arthroplasty, Primary Total Hip Arthroplasty, Hypotension, Database
- Trial name
- NCT03973320
- Testing
- Chart Review
- Where
- United States
- Volunteers
- 11,292 people
- Sponsor
- Hospital for Special Surgery, New York
Arthritis, Degenerative
Pilot Study Evaluating the Safety and Efficacy of a New Hard-on-Hard Total Hip Replacement System
The purpose of this study is to assess the early and long term safety and efficacy of the hard-on-hard total hip replacement system (R3 ODH-ODH utilization) in patients with non-inflammatory arthritis.
- Trial name
- NCT02154516
- Testing
- ODH Hip System
- Where
- 2 sites in South Africa
- Volunteers
- 26 people
- Sponsor
- Smith & Nephew, Inc.
Venous Thromboembolism, Bleeding
Prospective Genotyping For Total Hip or Knee Replacement Patients Receiving Warfarin (Coumadin)
Several human genes affect how medications are metabolized by the body. It is believed that knowledge of variations of these genes can help health care providers better manage an anticoagulation medicine called warfarin…
- Trial name
- NCT00634907
- Testing
- Pharmacogenetic-based warfarin dosing, Usual care warfarin dosing
- Where
- United States
- Volunteers
- 263 people
- Sponsor
- Gwen McMillin
Avascular Necrosis, Osteoarthritis
PMCF Study on the Safety and Performance of the Alloclassic Variall Cup Ceramic Bearing System in Total Hip Arthroplasty
The study is a multicenter, prospective, non-randomized, non-controlled consecutive cohort post-market clinical follow-up study.
- Conditions
- Avascular Necrosis, Osteoarthritis, Inflammatory Arthritis, Posttraumatic Arthritis
- Trial name
- NCT03672370
- Where
- 2 sites in Austria
- Volunteers
- 100 people
- Sponsor
- Zimmer Biomet
Total Hip Arthroplasty
A Hemodynamic Comparison of Stationary and Portable Pneumatic Compression Devices
We are comparing two pneumatic compression devices, VenaFlow (stationary) and MCS (portable) in both the supine an standing position.
- Trial name
- NCT02345642
- Testing
- ActiveCare+SFT Supine, VenaFlow Elite Supine, ActiveCare+SFT Standing
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Osteoarthritis, Hip
Mini Stem DEXA (Dual Energy X-ray Absorptiometry)
The objective of this study is to evaluate the bone ingrowth after implantation of the study device. This study will also document any device-related surgical complications or adverse radiographic observations.
- Trial name
- MISDexa (NCT01066936)
- Where
- Australia
- Volunteers
- 20 people
- Sponsor
- Smith & Nephew, Inc.
Osteoarthritis, Acetaminophen
Intravenous Versus Oral Acetaminophen in Primary Total Hip Arthroplasty
The purpose of this study is to determine if intravenous acetaminophen is superior to oral acetaminophen when used as part of a multimodal pathway for primary total hip arthroplasty.
- Conditions
- Osteoarthritis, Acetaminophen, Arthroplasty, Hip Replacement
- Trial name
- NCT02839876
- Testing
- Intravenous acetaminophen, Oral acetaminophen
- Where
- United States
- Volunteers
- 81 people
- Sponsor
- Duke University
Arthroplasties, Hip Replacement, Arthroplasties, Knee Replacement
Self-adherent Absorbent Silver Dressing in Adults After Hip or Knee Arthroplasty
The overall rationale for this investigation is to evaluate the clinical performance potential for Mepilex Border Post-Op Ag in the ability to minimize the risk of skin related post-operative wound complications such as…
- Trial name
- NCT03016078
- Testing
- Mepilex Border Post-Op Ag
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Molnlycke Health Care AB
Orthostatic Hypotension
An Open Label Trial to Decrease Signs and Symptoms of Orthostatic Hypotension Using Midodrine or Intravenous Fluid Bolus in Patients Following Total Hip Arthroplasty
Orthostatic hypotension following total hip arthroplasty is known to limit the ability of patients to perform physical therapy (PT) and increase the length of hospital stay and costs.
- Trial name
- NCT02154243
- Testing
- Midodrine, Intravenous fluid bolus
- Where
- United States
- Volunteers
- 13 people
- Sponsor
- Hospital for Special Surgery, New York
Anesthesia, Conduction, Osteoarthritis, Hip
Pain and Sensation After Regional Anesthesia - Pilot Study
This study aims to determine spinal resolution and pain levels after the placement of a lumbar plexus block (LPB) and spinal for total hip replacement procedure.
- Trial name
- NCT03623035
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Wake Forest University Health Sciences
Pain, Total Knee Replacement
Predicting, Understanding and Speeding Recovery After TKA
The objective of this research study is to better understand patterns of recovery after Total Knee Arthroplasty (TKA) amd Total Hip Replacement (THA).
- Conditions
- Pain, Total Knee Replacement, Total Hip Replacement
- Trial name
- NCT02685735
- Testing
- Gabapentin
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Wake Forest University Health Sciences
Knee Arthropathy, Hip Arthropathy
Preoperative Acupuncture for Total Knee or Hip Arthroplasty
Open-label, randomized controlled trial to determine the effect of preoperative acupuncture on preoperative anxiety and postoperative pain for high-anxiety patients undergoing total hip or knee arthroplasty.
- Conditions
- Knee Arthropathy, Hip Arthropathy, Anxiety
- Trial name
- (Acupuncture) (NCT06099223)
- Testing
- Acupuncture needles
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Hartford Hospital
Metabolic Profiling Muscle
HIP: Hip Imaging Protocol
Objective measures of skeletal muscle features have previously been used to assess skeletal muscle quality. In certain clinical populations, such as intensive care (ICU) patients, specific features of the psoas muscle measured by…
- Trial name
- NCT04126161
- Testing
- CT, Ultrasound
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Duke University
Anticoagulation
Multi-center Study to Evaluate the Safety of Apixaban (BMS-562247) in Indian Subjects Undergoing Elective Total Knee Replacement or Total Hip Replacement Surgery
The primary purpose of this protocol is to evaluate the safety of Apixaban in prophylaxis of Venous Thromboembolism (VTE) in Indian patients undergoing elective total knee or hip replacement
- Trial name
- NCT01884337
- Testing
- Apixaban
- Where
- 20 sites in India
- Volunteers
- 557 people
- Sponsor
- Bristol-Myers Squibb
Primary Total Hip Arthroplasty, Primary Total Knee Arthroplasty
Total Joint Arthroplasty and Sleep
To compare non-prescription sleep aids (low-dose diphenhydramine and melatonin) to sleep hygiene education for improving postoperative sleep quality after total joint arthroplasty.
- Trial name
- NCT03968939
- Testing
- Diphenhydramine (Benadryl), Melatonin, Sleep Hygiene Education
- Where
- United States
- Volunteers
- 55 people
- Sponsor
- James A. Keeney
Osteoarthritis
Analgesia After Total Hip Arthroplasty: Peri-Articular Injection Versus Epidural Patient Controlled Analgesia (PCA)
The best way to provide analgesia after total hip arthroplasty is hotly debated. There are two protocols in use at Hospital for Special Surgery(HSS).
- Trial name
- PAI Hip (NCT01658072)
- Testing
- Peri-Articular Injection, Epidural Patient Controlled Analgesia (Epidural PCA)
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Hospital for Special Surgery, New York
Joint Diseases
28 mm Ceramic-on-Ceramic Acetabular Cup Total Hip Replacement Study
The study is designed to evaluate artificial hips with a 28 mm ceramic head and a ceramic liner to determine whether they perform as well as artificial hips with a 28 mm ceramic head and a polyethylene liner.
- Trial name
- NCT00208507
- Testing
- 28 mm ceramic head on ceramic acetabular liner., 28 mm ceramic head on polyethylene liner
- Where
- 2 sites in United States
- Volunteers
- 264 people
- Sponsor
- DePuy Orthopaedics
Wound Complication
Closed Incision Negative Pressure Therapy vs Standard of Care
High risk patients who receive direct anterior approach total hip arthroplasty are more likely to experience wound complications.
- Trial name
- Prevena (NCT03061903)
- Testing
- Prevena, Aquacel
- Where
- 3 sites in United States, Canada
- Volunteers
- 122 people
- Sponsor
- Columbia University
Total Knee Replacement, Total Hip Replacement
Meloxicam for Pain Management After Total Joint Arthroplasty (TJA)
The purpose of this project is to determine if a change in patient reported pain, nausea and vomiting after total knee and hip arthroplasty could be observed with the substitution of Intravenous meloxicam for ketorolac in the…
- Trial name
- NCT05291598
- Testing
- IV meloxicam, Ketorolac
- Where
- United States
- Volunteers
- 223 people
- Sponsor
- University of Miami