Clinical trials: Total Knee Anthroplasty
Total Knee Anthroplasty
Comparison of Ultrasound-Guided Lumbar ESPB and ACB for Knee Arthroplasty
Total knee arthroplasty (TKA) is a surgical procedure frequently associated with moderate-to-severe postoperative pain. While Adductor Canal Block (ACB) has demonstrated analgesic efficacy in TKA, the Erector Spinae Plane Block…
- Trial name
- NCT07115771
- Testing
- Postoperative analgesia management
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Bursa City Hospital
Osteo Arthritis of the Knee, Total Knee Anthroplasty
Dinalbuphine Sebacate in Postoperative Pain Control After TKA
To evaluate the effectiveness of Dinalbuphine Sebacate for controlling subacute pain after total knee arthroplasty
- Trial name
- Naldebain (NCT07140510)
- Testing
- Dinalbuphine Sebacate, Normal Saline
- Where
- Thailand
- Volunteers
- 100 people
- Sponsor
- Thammasat University
Total Knee Anthroplasty, Cryotherapy
Monocentric Randomised Controlled Trial Assessing Cryocompression Following Total Knee Replacement
Immediately following surgery, icepacks are commonly used to decrease inflammation and reduce pain and have demonstrated to decrease post-operative opioid consumption.
- Conditions
- Total Knee Anthroplasty, Cryotherapy, Compression
- Trial name
- CryoTKR (NCT07366736)
- Testing
- Cryotherapy, Game Ready
- Where
- France
- Volunteers
- 138 people
- Sponsor
- Clinique des Cèdres
Total Knee Anthroplasty, Nerve Block
Liposomal Bupivacaine Versus Ropivacaine With Perineural Dexamethasone or Dexmedetomidine as Adjuncts for Adductor Canal Block Combined With IPACK Block in Total Knee Arthroplasty
Effective postoperative pain management remains a cornerstone of enhanced recovery protocols following total knee arthroplasty (TKA).
- Conditions
- Total Knee Anthroplasty, Nerve Block, Ropivacaine, Liposomal Bupivacaine
- Trial name
- NCT07509866
- Testing
- Liposomal bupivacaine (LB), Ropivacaine with Perineural Dexamethasone, Ropivacaine with Perineural Dexmedetomidine
- Where
- China
- Volunteers
- 90 people
- Sponsor
- Huazhong University of Science and Technology
Total Knee Anthroplasty, Regional Anesthesia
The Sacral Erector Spinae Plane Block in Total Knee Arthroplasty
The goal of this observational study is to learn about the analgesic efficacy and postoperative recovery of two locoregional anesthesia combinations in patients > 18 years (ASA I-III), scheduled for unilateral TKA under spinal…
- Trial name
- sacral ESP (NCT07017400)
- Testing
- Local Anesthetic Injection
- Where
- Italy
- Volunteers
- 126 people
- Sponsor
- San Giovanni di Dio Hospital
Total Knee Anthroplasty
Assessment of the Nutritional Status of Patients Undergoing Prosthetic Orthopedic Surgery: An Exploratory Study
The aim of this study is to evaluate the impact of prosthetic orthopedic surgery on the nutritional status of patients undergoing total knee arthroplasty in adult patients scheduled.
- Trial name
- ORTHONUTRI (NCT07782502)
- Testing
- Blood and physical performance tests
- Where
- France
- Volunteers
- 60 people
- Sponsor
- GCS Ramsay Santé pour l'Enseignement et la Recherche
Total Knee Anthroplasty, Venous Insufficiency (Chronic)(Peripheral)
Impact of Chronic Venous Insufficiency on Outcomes After Total Knee Arthroplasty
Total knee arthroplasty (TKA) is an effective treatment for end-stage knee osteoarthritis; however, postoperative complications-particularly wound healing problems-remain a significant concern.
- Conditions
- Total Knee Anthroplasty, Venous Insufficiency (Chronic)(Peripheral), Doppler Ultrasound Diagnosis
- Trial name
- VENOUS-TKA (NCT07577141)
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- SB Istanbul Education and Research Hospital
Total Knee Anthroplasty, Osteoarthritis(Primary)
COntralateral CorticoSTeroid Injection in Total Knee Arthroplasty
Through a triple-blinded randomized control trial, the primary purpose of this pilot study is to assess the efficacy of administering peri-operative contralateral corticosteroid injection in patients undergoing TKA.
- Conditions
- Total Knee Anthroplasty, Osteoarthritis(Primary), Osteoarthritis (OA) of the Knee, Bilateral Knee Osteoarthritis
- Trial name
- COSTI (NCT06809998)
- Testing
- Corticosteroid Injection - 80mg methylprednisolone (total volume 2ml) with 6 mL of 1% Bupivacaine without epinephrine (Total Volume 8 mL)., Band-Aid
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Unity Health Toronto
Total Knee Anthroplasty
Using a Smart Implantable Device to Compare Early Recovery in Two Different Knee Arthroplasty Approaches
This is a single-institution, prospective, randomized study comparing the medial parapatellar and subvastus approaches in primary total knee arthroplasty using continuous, implant-based gait monitoring.
- Trial name
- NCT07348835
- Testing
- Total Knee Arthroplasty Medial Parapatellar Approach, Total Knee Arthroplasty Subvastus Approach
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- Total Joint Specialists
Total Knee Anthroplasty, Epidural Analgesia
Programmed Intermittent Epidural Bolus Versus Continuous Epidural Infusion for Postoperative Analgesia After Total Knee Arthroplasty
The goal of this clinical trial is to compare two different epidural analgesia delivery methods for pain control after total knee arthroplasty in adults undergoing elective surgery.
- Trial name
- NCT07605208
- Testing
- Programmed intermittent epidural bolus 6 ml, continuous epidural infusion
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Sakarya University
Total Knee Anthroplasty, Total Knee Arthroplasty Recovery
The Effects of Mir Shakeel Teleintegrated Therapy Plan in Patients Undergoing Total Knee Arthroplasty
This randomized controlled trial aims to evaluate the effectiveness of a newly developed Modified Structured Telerehabilitation Intervention Protocol (MSTITP) compared with conventional in-person physical therapy in patients…
- Trial name
- RCT (NCT07239258)
- Testing
- Mir Shakeel Teleintegrated Therapy plan, Conventional Physical Therapy
- Where
- Pakistan
- Volunteers
- 150 people
- Sponsor
- Lincoln University College Malaysia
Pain Postoperative, Total Knee Anthroplasty
Comparative Analgesic Effect After Total Knee Arthroplasty Between Intraosseous and Peri-articular Injection
The goal of this RCT is to compare analgesic effect after total knee arthroplasty between intraosseous multimodal analgesic agent injection versus periarticular injection.
- Conditions
- Pain Postoperative, Total Knee Anthroplasty, Functional Outcomes
- Trial name
- NCT06800846
- Testing
- Intraosseous Morphine, Periarticular Injection
- Where
- Thailand
- Volunteers
- 90 people
- Sponsor
- Thammasat University Hospital
Total Knee Anthroplasty, Knee Osteoarthritis
IPACK vs Adductor Magnus Plane Block Added to Adductor Canal Block for Total Knee Arthroplasty
Total knee arthroplasty (TKA) is among the most frequently performed surgical procedures for degenerative joint diseases, including advanced knee osteoarthritis, rheumatoid arthritis, and post-traumatic arthritis.
- Conditions
- Total Knee Anthroplasty, Knee Osteoarthritis, Postoperative Pain Management
- Trial name
- NCT07643883
- Testing
- ACB+IPACK, ACB+AMM
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Ataturk University
Total Knee Anthroplasty
Genicular Nerve Block Added to Femoral Nerve Block for Analgesia After Total Knee Arthroplasty
Total knee arthroplasty (TKA) is a common orthopedic procedure in which effective postoperative pain management is important for early mobilization and rehabilitation.
- Trial name
- GNB-FNB (NCT07478783)
- Testing
- Ultrasound-guided Femoral Nerve Block, ltrasound-guided Genicular Nerve Block
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Ankara City Hospital Bilkent
Total Knee Anthroplasty
Ultrasound Guided Combined Adductor Canal, Superior Genicular Nerves and Anterior Femoral Cutaneous Nerves Blocks in Comparison With Periarticular Local Anesthesia Infiltration in Primary Total Knee Arthroplasty
Background: Pain management in total knee arthroplasty continues to evolve especially as an early postoperative analgesia is of paramount importance in achieving patient satisfaction and improving clinical outcomes.
- Trial name
- NCT07705230
- Testing
- Periarticular Infiltration, Ultrasound-Guided Triple Block Technique
- Where
- Saudi Arabia
- Volunteers
- 112 people
- Sponsor
- SAMEH ELSHERBINI
Total Knee Anthroplasty
Investigation of the Individual Fatigue Response During Blood Flow Restriction Training
The aim of the present pilot study is to investigate the feasibility of an exercise pressure response approach for assessing physiological strain during BFR training in a clinically supervised setting.
- Trial name
- NCT07611526
- Testing
- Cycling BFR
- Where
- Germany
- Volunteers
- 15 people
- Sponsor
- University Hospital, Bonn
Joint Contractures, Total Knee Anthroplasty
Knee Flexionater to Avoid Motion Restoring Surgery
The goal of this clinical trial is to learn whether adding a stretching device to standard physical therapy can help people regain knee bending after total knee replacement surgery.
- Conditions
- Joint Contractures, Total Knee Anthroplasty, Knee Arthrofibrosis
- Trial name
- NCT07454356
- Testing
- Hydraulic high Intensity Stretch Device, Standard Physical Therapy
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Ermi LLC
Knee Osteoarthritis (Knee OA), Total Knee Anthroplasty
Drain Removal Before Versus After CPM in Primary Total Knee Arthroplasty
The aim of this prospective randomized controlled study was to determine whether the timing of drain removal in relation to continuous passive motion (CPM) application influences postoperative residual hematoma formation…
- Conditions
- Knee Osteoarthritis (Knee OA), Total Knee Anthroplasty, Postoperative Hematoma
- Trial name
- NCT07302724
- Testing
- Drain Removal Before CPM, Drain Removal After CPM
- Where
- Turkey (Türkiye)
- Volunteers
- 104 people
- Sponsor
- Ankara Etlik City Hospital
Total Knee Anthroplasty
Smart Knee Evaluation of Exparel and Zynrelef in TKA Recovery
This study looks at how three different numbing injections affect how quickly patients recover after knee replacement surgery (total knee arthroplasty, or TKA).
- Trial name
- NCT07878507
- Testing
- Intra-articular injection of bupivacaine in the knee joint, intra-articular injection of Exparel in the knee joint, Zynrelef
- Where
- United States
- Volunteers
- 200 people
- Sponsor
- Foundation for Orthopaedic Research and Education
Knee Osteoarthristis, Total Knee Anthroplasty
Prospective, In-Vivo, Post-Market Safety and Efficacy Surveillance Registry of the MAXX Orthopedics, Freedom Total Knee® System
In an effort to satisfy regulatory requirements for post-market surveillance of product safety and efficacy, a representative sample of patients will be recruited for prospective monitoring.
- Trial name
- NCT06627699
- Testing
- Total Knee Arthroplasty
- Where
- 2 sites in United States
- Volunteers
- 300 people
- Sponsor
- Maxx Orthopedics Inc