Clinical trials: Total Knee Arthroplasty\(TKA\)
Blood Loss, Surgical
Arista Hemostatic Powder for Total Knee Post Operative Outcomes Study
To examine in Arista hemostatic powder results in less post-total knee arthroplasty blood loss, hematoma formation, and improved range of motion when compared to patients who did not receive the product.
- Trial name
- NCT05522153
- Testing
- Arista
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- Virtua Health, Inc.
Knee Osteoarthritis
Comparison of Functional Outcomes of Three Surgical Approaches in Knee Arthroplasty
A functional outcomes comparison study of three surgical techniques using minimally invasive surgery mini-incision (MIS) for total knee arthroplasty (TKA), standard para-patellar TKA and the unicompartmental knee arthroplasty…
- Trial name
- NCT00983762
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- Massachusetts General Hospital
Total Knee Arthroplasty (TKA)
Total Knee Arthroplasty Biomechanics
In total knee arthroplasty (TKA), the relationship between implant design, soft tissue balance, neuromuscular contributions, and rehabilitation strategies on patient satisfaction and functional outcomes is highly complex and…
- Trial name
- NCT03671954
- Testing
- Home Strengthening Exercises, Standard Physical Therapy, Preoperative Assessments
- Where
- 4 sites in United States
- Volunteers
- 38 people, healthy volunteers welcome
- Sponsor
- University of Florida
Osteoarthritis, Traumatic Arthritis
Prospective Multicenter Post Approval Study of the LPS-Flex Mobile Bearing Knee
The purpose of the study is to assess the long-term performance of the NexGen LPS-Flex Mobile Bearing Knee in the treatment of patients with severe knee pain or degenerative knee disease.
- Conditions
- Osteoarthritis, Traumatic Arthritis, Avascular Necrosis of the Femoral Condyle, Moderate Varus
- Trial name
- NCT00854295
- Testing
- NexGen LPS-Flex Mobile Bearing Knee
- Where
- 3 sites in United States
- Volunteers
- 266 people, healthy volunteers welcome
- Sponsor
- Zimmer Biomet
Orthopedic Procedure
Implementation of Fast-track Surgery Program for Total Hip and Knee Replacement and the Evaluation of the Risks and Benefits for the Patient
Implementation of Fast-track surgery for total hip replacement and total knee replacement and evaluation of the risks and benefits for the patients.
- Trial name
- NCT03028779
- Testing
- Fast-track Total Hip and knee arthroplasty
- Where
- Canada
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Maisonneuve-Rosemont Hospital
Total Knee Replacement
Robotic Assisted TKA
As an intraoperative tool, a modern robotic total knee arthroplasty (TKA) system should be able to identify a patient's native femoral and tibial anatomy, as well as, assess ligament tension and gap balance.
- Trial name
- NCT06062615
- Testing
- Total knee replacement using Omnibot Knee System, Conventional Total knee replacement, Omnibot Robotic Knee System
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Osteoarthritis, Knee
Clinical Outcomes With Omni Apex Ultracongruent Knee System
A prospective, matched case comparison of total knee arthroplasty with the OMNI Apex Ultracongruent vs. Triathlon® CS tibial insert vs. the Triathlon® PS tibial insert.
- Trial name
- NCT01367938
- Testing
- OMNI Apex Ultracongruent Knee Device
- Where
- United States
- Volunteers
- 69 people, healthy volunteers welcome
- Sponsor
- Spokane Joint Replacement Center
Joint Diseases, Arthritis Knee
Anterior Knee Pain in Mobile Bearing Versus Fixed Bearing in TKA
Osteoarthritis is the most common cause of chronic joint disease, and its incidence has increased due to the high average life expectancy, in addition to the high incidence of obesity.
- Conditions
- Joint Diseases, Arthritis Knee, Arthroplasty Complications
- Trial name
- NCT05696418
- Testing
- Total knee arthroplasty with a Mobile Bearing system., Total knee arthroplasty with a Fixed Bearing system.
- Where
- Syria
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- Damascus University
Osteo Arthritis Knee, Central Nervous System Sensitization
Pregabalin for Central Sensitization in TKA
The study purpose is to determine if giving pregabalin before and after total knee arthroplasty (TKA) can improve pain and meaningful function after surgery in patients that have central sensitization (CS).
- Trial name
- NCT05460871
- Testing
- Pregabalin 75mg
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- University of Iowa
Total Knee Arthroplasty
Treatment With Iovera° for Total Knee Arthroplasty (TKA) Post-Operative Pain
This study is designed to investigate whether iovera° treatment prior to TKA decreases cumulative participant opioid use over the course of 6 weeks following TKA while maintaining similar levels of pain relief.
- Trial name
- NCT03327220
- Testing
- iovera°
- Where
- United States
- Volunteers
- 124 people, healthy volunteers welcome
- Sponsor
- Pacira Pharmaceuticals, Inc
Knee Injuries
Optimized Loading Response by JOURNEY II BCS Knee Increases Daily Physical Activity and Functions
Smith \& Nephew's first edition of the Journey posterior stabilizing total knee arthroplasty was analyzed by the Center for Musculoskeletal Research in a past research study, and it was determined that subjects experienced more…
- Trial name
- NCT02335710
- Testing
- Journey II BCS TKA
- Where
- 3 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The University of Tennessee, Knoxville
Total Knee Arthroplasty
Peripheral Nerve Blocks vs Periarticular Local Anesthetic Injection for Total Knee Arthroplasty (TKA)
The purpose of this study is to find a better way to make patients comfortable after their knee surgery. The investigators compared three ways of providing pain relief, either by use of a nerve block at the femoral and sciatic…
- Trial name
- NCT02223364
- Testing
- Peripheral nerve blocks with Bupivacaine, Intra articular injection with Ropivacaine, Intra articular injection with liposomal bupivacaine
- Where
- United States
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Mayo Clinic
Total Knee Arthroplasty, Post-operative Pain Control
Adductor Canal Block Versus Liposomal Bupivacaine in TKA
This is a randomized prospective study of 60 patients undergoing total knee arthroplasty evaluating the clinical outcomes of liposomal bupivacaine periarticular injections (PAI) when compared to single shot adductor canal block…
- Trial name
- NCT04086186
- Testing
- Liposomal Bupivacaine Peri-articular Injection, Adductor canal block
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Good Samaritan Regional Medical Center, Oregon
Osteoarthritis, Knee
Study of the KinexConnect Telerehabilitation System (KCTRS)
A randomized, single-blind study comparing telerehabilitation at home with continuous passive motion (CPM) and a tablet-based patient engagement application (KinexConnect) versus traditional outpatient physical therapy (PT)…
- Trial name
- KCTRS (NCT04191798)
- Testing
- Telerehabilitation using the KinexConnect system for rehabilitation after TKA., Traditional outpatient PT for rehabilitation after TKA.
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Kinex Medical Company, LLC
Total Knee Replacement, Wound Complication
Wound Healing in Primary TKA
Wound complications after total knee arthroplasty (TKA) can arise from many patient-specific factors, such as vascular or immune-related medical conditions, obesity, and smoking, among others.
- Trial name
- NCT06007599
- Testing
- Skin closure using skin adhesive, Skin closure without skin adhesive
- Where
- United States
- Volunteers
- 216 people, healthy volunteers welcome
- Sponsor
- Rothman Institute Orthopaedics
Osteoarthritis, Knee
Unicompartmental Knee Arthroplasty (UKA) Versus Total Knee Arthroplasty (TKA) of Medial Osteoarthritis
This study allows patients to take part of the decision making between a unicompartment knee (partial ) or a total Knee replacement .
- Trial name
- NCT03457051
- Testing
- Total Knee Arthroplasty (TKA), Unicompartmental Knee Arthroplasty (UKA)
- Where
- Canada
- Volunteers
- healthy volunteers welcome
- Sponsor
- Ottawa Hospital Research Institute
Pain, Postoperative, Total Knee Arthroplasty
Duloxetine RCT on Postop TKA Outcomes
The aim of this study is to determine if duloxetine is associated with differences in post-operative pain, patient-reported outcome measures, and opioid consumption in patients undergoing primary total knee arthroplasty compared…
- Trial name
- NCT05086393
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- Rush University Medical Center
Total Knee Arthroplasty, Knee Osteoarthritis
Patient-navigation-based Preoperative Rehabilitation Exercise Program in Patients Undergoing TKA
This study aimed to assess the effectiveness of a patient navigation-based preoperative rehabilitation exercise program for patients undergoing total knee arthroplasty.
- Trial name
- NCT07047079
- Testing
- Autonomous preoperative rehabilitation exercises, The navigator provided full-period preoperative rehabilitation exercise guidance+navigation services
- Where
- China
- Volunteers
- 86 people, healthy volunteers welcome
- Sponsor
- Anna Sun
Arthritis Knee, Pain
The Efficiency of Periarticular Multimodal Drug Injection in Pain Management Following Primary Unilateral TKA
This interventional study aims to compare the effectiveness of local multimodal drug periarticular injection in TKA patients with the standard pain control regime that includes opioids, NSAIDs, and other analgesics.
- Conditions
- Arthritis Knee, Pain, Arthroplasty Complications
- Trial name
- NCT06112548
- Testing
- primary unilateral TKA, Bupivacain, ketorolac
- Where
- Syria
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Damascus University
Total Knee Arthroplasty (TKA), Total Knee Arthroplasty \(TKA\)
Suzetrigine in TKA
Total knee replacements are among the most common and painful orthopedic procedures performed worldwide, often requiring intensive analgesia to support early ambulation and recovery.
- Conditions
- Total Knee Arthroplasty (TKA), Total Knee Arthroplasty \(TKA\), Total Knee Replacement, Total Knee Replacement Surgery
- Trial name
- NCT07864896
- Testing
- Suzetrigine
- Where
- United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York