Clinical trials: Total Knee Replacement Surgeries
Distal Femur Fracture, Periprosthetic Fracture Around Prosthetic Joint Implant Knee
pDIFFIR: Geriatric Periprosthetic DIstal Femur: FIxation Versus Replacement
Periprosthetic distal femur fractures are a significant source of morbidity and mortality for elderly patients. One treatment option involved a surgical fixation with plates or nails, screws and cables/wires along the side of…
- Conditions
- Distal Femur Fracture, Periprosthetic Fracture Around Prosthetic Joint Implant Knee, Knee Fracture
- Trial name
- pDIFFIR (NCT05805774)
- Testing
- Distal Femur Replacement, Surgical fixation
- Where
- Canada
- Volunteers
- 148 people
- Sponsor
- Unity Health Toronto
Obesity, Osteoarthritis
Surgical Weight-Loss to Improve Functional Status Trajectories Following Total Knee Arthroplasty (SWIFT Trial)
The purpose of the SWIFT Trial is to answer two research questions. 1. Does bariatric surgery before total knee arthroplasty (TKA) improve both perioperative and long-term outcomes of TKA in extreme obesity? 2.
- Trial name
- SWIFT (NCT02598531)
- Where
- United States
- Volunteers
- 289 people
- Sponsor
- Geisinger Clinic
Osteoarthritis, Knee
Inpatient vs Outpatient Total Knee Replacement
This is a prospective cohort study comparing standard inpatient (overnight hospital stay) total knee arthroplasty with same day discharge.
- Trial name
- NCT04228731
- Testing
- Outpatient, Inpatient
- Where
- Canada
- Volunteers
- 123 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Osteoarthritis, Knee
Liposomal Bupivacaine Versus Standard of Care in Total Knee Surgery
The purpose of this study is to determine whether liposomal bupivacaine is effective in the management of pain following total knee arthroplasty, as compared to standard of care analgesia.
- Trial name
- NCT02219087
- Testing
- Liposomal bupivacaine, Standard of Care
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- OhioHealth
Arthroplasty, Replacement, Knee
Dartmouth-Hitchcock GreenCare Registry for Total Knee Replacement
Evolving reimbursement policies are driving health systems to improve quality and efficiency. Transitioning to an electronic health record (EHR) provided Dartmouth-Hitchcock Medical Center (DHMC) an opportunity to redesign staff…
- Trial name
- GreenCare (NCT02912806)
- Testing
- Total Knee Replacement
- Volunteers
- 545 people
- Sponsor
- Dartmouth-Hitchcock Medical Center
Osteoarthritis, Knee, Osteoarthritis Knees Both
Astaxanthin for Management of Inflammation in Knee Osteoarthritis
Over 30 million Americans are currently affected by osteoarthritis (OA), with prevalence expected to increase 40% by 2025 as a result of the aging population and obesity epidemic.
- Conditions
- Osteoarthritis, Knee, Osteoarthritis Knees Both, Joint Inflammation
- Trial name
- NCT05138549
- Testing
- Astaxanthin
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Prisma Health-Midlands
Osteoarthritis
Ergometer Cycling After Replacement of the Hip or Knee Joint
Despite the widespread use of hip and knee replacement surgery, there is a considerable lack of consensus regarding postoperative treatment and rehabilitation, mostly because of the lack of well-designed studies testing the…
- Trial name
- NCT00951990
- Testing
- Ergometer Cycling, No ergometer cycling
- Where
- 5 sites in Germany
- Volunteers
- 457 people
- Sponsor
- Verein zur Förderung der Rehabilitationsforschung in Schleswig-Holstein
Surgical Stress Response, Stress Physiological
Feasibility of Breathwork Intervention With Older Adults After Knee Surgery
Postoperative complications after surgical procedures, including following total knee arthroplasty (TKA), have a negative impact on the health and well-being of surgical patients.
- Conditions
- Surgical Stress Response, Stress Physiological, Stress Physiology, Stress Psychological
- Trial name
- NCT07464860
- Testing
- A 5-minute Asynchronous Breathwork Intervention, A 5-minute Asynchronous Card Game Video
- Where
- United States
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- University of Arizona
Knee Osteoarthritis
Robotic Assisted Surgery In Total Knee Replacement
The goal of this clinical trial is to compare robotic arm assisted surgery with manual surgery in patients operated with knee replacement.
- Trial name
- NCT05842538
- Testing
- Triathlon
- Where
- 2 sites in Sweden
- Volunteers
- 200 people
- Sponsor
- Sahlgrenska University Hospital
Arthroplasty, Knee, Pain
Local Injection of Local Anesthetic 24 Hours After Knee Replacement Surgery May Decrease Pain for Several More Hours
The purpose of this study is to determine if an additional injection of local anesthetic immediately prior to removal of the local anesthetic infiltration catheter on postoperative day one is effective in increasing pain…
- Trial name
- NCT02420951
- Testing
- Bupivacaine, No Intervention
- Volunteers
- 50 people
- Sponsor
- Brigham and Women's Hospital
Total Knee Replacement
Qualitative Interviews With Healthcare Professionals
PLANNING PHASE- Qualitative interviews with Healthcare Professionals to assist in the development of a new Patient Reported Outcome Measure (PROM) to assess patient's emotional wellbeing, and perceptions of Total Knee Replacement…
- Trial name
- NCT05597046
- Testing
- Interview
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Invibio Ltd
Perioperative Pain
Effect of Dexamethasone Shortly Before Surgery on the Intraoperative Dose of Remifentanil
This explorative post hoc analysis included patients randomized in the DEX-2-TKA trial (NCT03506789) who were operated under general anesthesia with remifentanil and propofol.
- Trial name
- NCT05002361
- Testing
- Dexamethasone, Isotonic saline
- Where
- 5 sites in Denmark
- Volunteers
- 94 people
- Sponsor
- Naestved Hospital
Knee Osteoarthritis, Knee Arthropathy
Improving Total Knee Arthroplasty Dissatisfaction Through a Personalized Approach Focusing on PROMs Phenotypes
This study is a randomized controlled trial to assess whether the implementation of a TKA Personalized Outcome Prediction Tool to set expectation, in addition to targeted interventions to address patients with poor baseline…
- Conditions
- Knee Osteoarthritis, Knee Arthropathy, Surgery
- Trial name
- NCT06298721
- Testing
- Personalized outcome prediction tool + targeted interventions, Standard of Care TKA
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- The Cleveland Clinic
Total Knee Arthroplasty, Reinfection
Reinfection and Re-revision Rates of Periprosthetic Knee Infection Under Four Different Surgical Strategies
A single-center retrospective cohort study was conducted in the Department of Orthopedics, the First Affiliated Hospital of Fujian Medical University.
- Conditions
- Total Knee Arthroplasty, Reinfection, Aseptic Loosening, Revision
- Trial name
- NCT07232771
- Where
- China
- Volunteers
- 200 people
- Sponsor
- First Affiliated Hospital of Fujian Medical University
Knee Osteoarthritis, Total Knee Arthroplasty\(TKA\)
Comparison of Image Based Robotic Total Knee Arthroplasty vs Imageless Augmented Reality Assisted Total Knee Arthroplasty
This study compares the accuracy of two different techniques in placing a total knee replacement. In one technique, accurate instrument placement is facilitated by a robot, and in the other technique, augmented reality is used…
- Conditions
- Knee Osteoarthritis, Total Knee Arthroplasty\(TKA\), Total Knee Replacement Surgery
- Trial name
- RobAR (NCT06891807)
- Testing
- Robotics Assisted TKA, Augmented Reality assisted TKA
- Where
- Belgium
- Volunteers
- 250 people
- Sponsor
- Medisch Centrum Latem
Tourniquets, Knee Arthroplasty, Total
Tourniquet Pressure in Primary Total Knee Arthroplasty
This proposed novel randomized control trial (RCT) seeks to address this gap in TKA protocol by gaining a better understanding of the relationship between tourniquet pressure and time, and intraoperative performance and…
- Conditions
- Tourniquets, Knee Arthroplasty, Total, Knee Replacement, Total
- Trial name
- NCT02830087
- Testing
- Tourniquet Cuff Pressure
- Where
- 2 sites in United States
- Volunteers
- 21 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Knee Disease
Effectiveness of Treatment With Rich Platelet Fibrin (PRF) VS Gold Standard in Patients Undergoing Knee Replacement
Randomized controlled single blind trial for the evaluation of the treatment of the surgical wound healing process with Platelet-Rich-Fibrin compared to the gold standard (without Platelet-Rich-Fibrin) in patients undergoing knee…
- Trial name
- Fibrin4Fast (NCT04165863)
- Testing
- total knee replacement surgery
- Where
- Italy
- Volunteers
- 12 people
- Sponsor
- Istituto Ortopedico Rizzoli
Arthroplasty Complications, Amputation
Clinical Trial Comparing Negative Pressure Wound Therapy and Standard Dry Dressings
Negative pressure dressings are currently widely used in wound management. Their use is gradually being extended to surgical scars.
- Conditions
- Arthroplasty Complications, Amputation, Prosthesis-Related Infections
- Trial name
- BERLYTZ (NCT04520841)
- Testing
- Prevena TM, Dry dressing
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Lausanne Hospitals
Auriculotherapy, Arthroplasty, Replacement, Knee
The Role of Auricular Point Diagnosis and Treatment in ERAS During TKA
To further improve the surgical outcomes of patients undergoing total knee arthroplasty (TKA). This study aims to use ear acupoint therapy to address the following clinical issues: 1 The degree of postoperative inflammation and…
- Conditions
- Auriculotherapy, Arthroplasty, Replacement, Knee, Enhanced Recovery After Surgery
- Trial name
- NCT06273488
- Testing
- Auriculotherapy
- Where
- China
- Volunteers
- 116 people
- Sponsor
- Peking Union Medical College
Total Knee Replacement Surgery
Adductor Canal Catheter Effectiveness and Safety Study
PRIMARY OBJECTIVE: Compare the effect of usual care with an adductor canal catheter (ACC) containing ropivacaine to the effect of usual care without an ACC on the second-postoperative-day pain levels among patients undergoing…
- Trial name
- ACCESS (NCT04639128)
- Testing
- Adductor Canal Catheter
- Where
- United States
- Volunteers
- 126 people
- Sponsor
- Kaiser Permanente