Clinical trials: Total Knee Replacement Surgeries
Anesthesia
Enhanced Recovery After Surgery (ERAS) Total Knee Replacement (TKR) With a Transitional Pain Service
A comparison of two anesthetic techniques for total knee replacements: (1) Peri-Articular Injection (PAI), local infiltration between the popliteal artery and capsule of the knee block (IPACK) and single-shot adductor canal block…
- Trial name
- EKAT-TeleTPS (NCT03747146)
- Testing
- Continuous Adductor Canal Catheter (ACC)
- Where
- United States
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Hospital for Special Surgery, New York
Opioid Use, Pain, Post Operative
A Pilot Study Investigating the nCAP Signal Relief Patch in Subjects Undergoing Primary Hip or Knee Replacement Surgery
Opioid addiction in post-operative patients is recognized but not fully understood; therefore, in order to address this growing crisis, it is essential to explore alternative approaches to managing pain and apply them to the…
- Trial name
- NCT05252858
- Testing
- nCAP Signal Relief Patch, Standard of Care
- Where
- United States
- Volunteers
- 79 people
- Sponsor
- Jacques E. Chelly
Knee Osteoarthritis
Investigation of the Effect of Proximal and Distal Adductor Canal Block in Knee Replacement Surgery
to investigate the effect of adductor canal block applied with two different approaches in the treatment of pain after TKA surgery on pain control and functional mobility.
- Trial name
- NCT06188806
- Testing
- ADDUKTOR CANAL BLOCK, CONTROL GROUP
- Where
- Turkey (Türkiye)
- Volunteers
- 78 people
- Sponsor
- Umraniye Education and Research Hospital
Arthritis of Knee
Study of Surgical Technique With Use of Single-radius Prosthesis in Total Knee Replacement
The purpose of this study is to clinically demonstrate a phenomenon of measurement error that can occur during placement of a specific type of total knee replacement prosthesis (single radius femoral component) using a certain…
- Trial name
- NCT01505452
- Where
- 2 sites in United States
- Volunteers
- 43 people
- Sponsor
- Athens Orthopedic Clinic, P.A.
Total Hip or Knee Arthroplasty
Transfusion Requirements in Orthopedic Surgery (PHASE 2)
The objective of our research program is to determine the transfusion threshold required to maximize functional recovery after major orthopedic surgery (total hip/knee replacement) in these, most often, elderly patient with…
- Trial name
- TRIOS (NCT00726349)
- Testing
- No intervention
- Where
- Canada
- Volunteers
- 305 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Neuromuscular Blockade, Arthroplasty, Replacement, Hip
Reversal of Neuromuscular Blockade With Sugammadex or Usual Care in Hip Fracture Surgery or Joint (Hip/Knee) Replacement (P07038)
This study will assess the effect of reversal of neuromuscular blockade with sugammadex compared with reversal according to usual care (neostigmine or spontaneous reversal) on the incidence of post-surgical bleeding events and on…
- Conditions
- Neuromuscular Blockade, Arthroplasty, Replacement, Hip, Arthroplasty, Replacement, Knee, Blood Coagulation
- Trial name
- NCT01422304
- Testing
- Sugammadex, neostigmine and glycopyrrolate or atropine
- Volunteers
- 1,198 people
- Sponsor
- Merck Sharp & Dohme LLC
Knee Replacement, Arthropathy of Knee
Investigating the Effect of Dronabinol on Post-surgical Pain
This study is designed to investigate the effect of dronabinol on post operative pain in patients undergoing total knee replacement (for their own clinical care).
- Trial name
- NCT04099355
- Testing
- Dronabinol 5mg Cap, Non-active comparator
- Where
- United States
- Sponsor
- New York State Psychiatric Institute
Knee Arthroplasty, Total, Telerehabilitation
Action Observation Therapy Via Telerehabilitation on Total Knee Arthroplasty Surgery
The goal of this clinical trial is to compare patient-reported and performance-based outcomes of patients followed with a standard exercise program based on telerehabilitation and patients followed with action observation therapy…
- Trial name
- NCT06162208
- Testing
- Standard exercise program based on telerehabilitation
- Where
- Turkey (Türkiye)
- Volunteers
- 36 people
- Sponsor
- Pamukkale University
Immunosenescence, Aging
The Immu-KNEE-ty Study
The goal of this observational study is to determine changes in immune functioning after total knee replacement surgery in elderly.
- Trial name
- NCT05920148
- Testing
- Knee arthroplasty
- Where
- Netherlands
- Volunteers
- 14 people
- Sponsor
- Wageningen University
Replacement, Knee
The Effect of Mobile-based Education and Exercise Program Given to Patients With Total Knee Replacement Surgery
Total knee replacement (TDP) surgery is recognized as an effective surgical option for patients who develop moderate to severe osteoarthritis of the knee.
- Trial name
- NCT05187065
- Testing
- The mobile-based education and exercise program
- Where
- Turkey (Türkiye)
- Volunteers
- 108 people
- Sponsor
- Alkay Kara
Osteoarthritis, Sarcopenia
The Strong Brain Study
To evaluate operational aspects of studying pre to post surgery/hospitalization changes in the integrity of a major white matter pathways and how these contribute to reductions in the ability to produce forceful muscle…
- Trial name
- NCT02320864
- Testing
- Total knee replacement surgery
- Where
- United States
- Volunteers
- 18 people, healthy volunteers welcome
- Sponsor
- University of Florida
Arthroplasty, Replacement, Knee, Blood Loss, Surgical
Early Outcome of Simultaneous Bilateral Total Knee Replacement With and Without Tourniquet
This randomized controlled trial compared early outcomes after replacement of both knees during the same operation, with and without tourniquet use.
- Conditions
- Arthroplasty, Replacement, Knee, Blood Loss, Surgical, Pain, Postoperative
- Trial name
- NCT07905495
- Testing
- Simultaneous Bilateral Total Knee Replacement with Tourniquet, Simultaneous Bilateral Total Knee Replacement without Tourniquet
- Where
- Pakistan
- Volunteers
- 84 people
- Sponsor
- Shifa International Hospital
Total Knee Replacement Approach, Muscle Torque
Knee Muscle Force Recovery After Minimally Invasive Surgery (MIS) Total Knee Replacement (TKR)
To compare muscle torque recovery between patients under subvastus approach and those under midvastus approach after total knee replacement
- Trial name
- MISTKR (NCT00912769)
- Where
- Taiwan
- Volunteers
- 30 people
- Sponsor
- Far Eastern Memorial Hospital
Osteoarthritis, Blood Loss, Surgical
Non-inferiority Trial of Oral Tranexamic Acid vs. Intravenous Tranexamic Acid in Joint Replacement Surgery
The purpose of this research is to determine if the oral form of a medication (tranexamic acid) to reduce bleeding can be used in place of an intravenous (IV) form, to learn the best way to give tranexamic acid: either a pill by…
- Conditions
- Osteoarthritis, Blood Loss, Surgical, Blood Loss, Postoperative
- Trial name
- NCT02438566
- Testing
- Tranexamic Acid (Oral), Tranexamic Acid (Intravenous)
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- The New England Baptist Hospital
Linear or Emi-linear Incisions, Total Hip Arthroplasty
Prevena™ Incision Management System Over Primarily Closed Hip and Knee Incisions in Patients Immediately Post Total Hip and Knee Arthroplasty
The intent of this study is to evaluate the Prevena ™ 125 Unit and dressing system, when applied to either the hip or knee area over a surgical cut for the time you are hospitalized.
- Conditions
- Linear or Emi-linear Incisions, Total Hip Arthroplasty, Total Knee Arthroplasty
- Trial name
- Prevena2009-45 (NCT01380665)
- Testing
- Prevena Incisional Management System
- Sponsor
- KCI USA, Inc
Total Knee-replacement, Total Hip-replacement
Clinical Trial for Fibrin Sealant in Knee Surgery
Thermogenesis is a company that sells a machine for the production of fibrin sealant of single donor plasma, the CryoSeal Fibrin Sealant System (CS-1). Fibrin sealant consists of two components: cryoprecipitate and thrombin.
- Trial name
- NCT00440921
- Testing
- Single donor Allogenous Fibrin Sealant
- Sponsor
- Sanquin Research & Blood Bank Divisions
Osteoarthritis, Knee
Dual-task Gait Performance in People With Knee Osteoarthritis Before and After Knee Replacement Surgery
Knee Osteoarthritis (OA) is one of the most common conditions causing disability and limitation in the elderly population, with 13% of women and 10% of men over the age of 60 suffering from symptomatic knee osteoarthritis.
- Trial name
- NCT04877873
- Testing
- Gait analysis pre- and post- surgery
- Where
- Israel
- Volunteers
- 38 people
- Sponsor
- University of Haifa
Postoperative Pain Management During Rehabilitation in Patients Undergoing Total Knee Arthroplasty
A Clinical Trial to Evaluate the Safety and Effectiveness of OLIZ, a Photobiomodulation Medical Device for Surgical Site Pain Relief in Patients After Total Knee Arthroplasty
A Clinical Trial to Evaluate the Safety and Effectiveness of OLIZ, a Photobiomodulation Medical Device for Surgical Site Pain Relief in Patients After Total Knee Arthroplasty
- Trial name
- NCT07091773
- Testing
- OLIZ Photobiomodulation Device
- Volunteers
- 68 people
- Sponsor
- LTBIO Co., Ltd.
Osteo Arthritis Knee, Osteoarthritis
Mako Functionally Aligned Total Knee Arthroplasty vs Mako Mechanically Aligned Total Knee Arthroplasty
This study evaluates outcomes of robotic-arm assisted mechanically aligned total knee arthroplasty [MA TKA] versus robotic-arm assisted functionally aligned total knee arthroplasty [FA TKA].
- Conditions
- Osteo Arthritis Knee, Osteoarthritis, Surgery
- Trial name
- NCT04092153
- Testing
- Total knee arthroplasy
- Where
- United Kingdom
- Volunteers
- 100 people
- Sponsor
- University College, London
Total Knee Arthroplasty (Postoperative Pain)
Phase 2B Study Assessing Pain Relief After Replacement of the Knee
The goal of the ATX101-TKA-004 clinical trial aims to evaluate the efficacy and safety of ATX101 1,500 mg in participants undergoing primary unilateral total knee arthroplasty.
- Trial name
- SPARK2 (NCT06799845)
- Testing
- ATX101, bupivacaine hydrochloride
- Where
- 11 sites in United States
- Volunteers
- 226 people
- Sponsor
- Allay Therapeutics, Inc.