Clinical trials: Total Knee Replacement Surgery
Osteoarthritis, Blood Loss, Surgical
Non-inferiority Trial of Oral Tranexamic Acid vs. Intravenous Tranexamic Acid in Joint Replacement Surgery
The purpose of this research is to determine if the oral form of a medication (tranexamic acid) to reduce bleeding can be used in place of an intravenous (IV) form, to learn the best way to give tranexamic acid: either a pill by…
- Conditions
- Osteoarthritis, Blood Loss, Surgical, Blood Loss, Postoperative
- Trial name
- NCT02438566
- Testing
- Tranexamic Acid (Oral), Tranexamic Acid (Intravenous)
- Where
- United States
- Volunteers
- 118 people
- Sponsor
- The New England Baptist Hospital
Knee Osteoarthritis, Arthritis Knee
How Does the Addition of Adductor Canal Block to Local Infiltration Affect Recovery in Patients Undergoing Total Knee Arthroplasty? A Feasibility Study.
The use of periarticular injection and adductor canal block are well-established techniques used both in combination or in isolation in the management of postoperative pain for patients undergoing total knee arthroplasty.
- Conditions
- Knee Osteoarthritis, Arthritis Knee, Knee Disease, Opioid Use
- Trial name
- TRUE KnORTH (NCT04648072)
- Testing
- Adductor Canal Block, Periarticular Injection
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Health Sciences North Research Institute
Old Age, Knee Replacement Surgery
Mini-dose Dexmedetomidine-Esketamine Infusion and Perioperative Sleep Quality
Sleep disturbances are prevalent in older patients with osteoarthrosis or fracture who are scheduled for knee or hip replacement surgery.
- Conditions
- Old Age, Knee Replacement Surgery, Hip Replacement Surgery, Dexmedetomidine
- Trial name
- NCT05950646
- Testing
- Dexmedetomidine, Esketamine, Normal saline
- Where
- 2 sites in China
- Volunteers
- 154 people
- Sponsor
- Peking University First Hospital
Stress
The SENSE Study: Surgical ENvironment Stress Evaluation
Surgical procedures such as total hip and knee arthroplasty require a complex set of physical and cognitive skills, expert execution, and inevitably place a high stress load on the surgeon.
- Trial name
- SENSE (NCT07506330)
- Testing
- total joint arthroplasty
- Where
- United Kingdom
- Volunteers
- 6 people
- Sponsor
- University College, London
Adductor Canal Block, Total Knee Replacement Surgery
Coupling of IPACK Block With Adductor Canal Block Versus Adductor Canal Block Alone on Pain, Functional Recovery and Inflammatory Response After Knee Replacement
The aim of this study is to compare the Competency of coupling of IPACK Block with Adductor Canal Block versus Adductor Canal Block Alone on Postoperative Pain after total knee replacement as well as Functional Recovery and…
- Conditions
- Adductor Canal Block, Total Knee Replacement Surgery, Functional Recovery
- Trial name
- NCT07096375
- Testing
- Adductor Canal Block (ACB) + iPACK Block
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Sleep Apnea, Obstructive
Prevalence of Sleep Apnea in Patients Presenting for Hip or Knee Replacement Surgery
The study hypothesis is that the prevalence of obstructive sleep apnea in patients presenting for total knee or total hip arthroplasty is higher than generally suspected.
- Trial name
- NCT00874822
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- University of Nebraska
Surgical Wound
A Post-Market Clinical Investigation on Mepilex Border Post-Op
This is a retrospective, observational (non-interventional), single-arm, single-centre, post-market clinical investigation designed to verify clinical performance and safety of Mepilex Border Post-Op when used according to…
- Trial name
- ARCTIS (NCT04994145)
- Where
- Belgium
- Volunteers
- 560 people
- Sponsor
- Molnlycke Health Care AB
Orthopedic Surgery
Impact of a Technique of Massage During the First Week of Hospitalization on the Recycling of the Mobility of the Knee Further to the Installation of Knee Replacement
During fthe first postoperative days, physiotherapists supported patients with knee replacement in orthopaedics of Saint-Junien's and Limoges' hospitals.
- Trial name
- PTGMass (NCT02278627)
- Testing
- manual lymphatic drainage
- Where
- France
- Volunteers
- 44 people
- Sponsor
- University Hospital, Limoges
Arthroplasty, Replacement, Thromboembolism
Pradaxa (Dabigatran Etexilate) 150 mg/q.d. in Patients With Moderate Renal Impairment After Hip or Knee Replacement Surgery
An observational cohort study on safety and efficacy to generate additional data on the benefit/risk profile of the 150 mg dose of Pradaxa in patients with renal impairment
- Trial name
- NCT00847301
- Where
- 53 sites in Austria, France and 5 more
- Volunteers
- 472 people
- Sponsor
- Boehringer Ingelheim
Pain, Postoperative
Comparison of Fasia Iliac Compartment Block and 4in1 Block
Patients who will undergo elective total knee arthroplasty surgery under spinal anesthesia will be included in the study according to the postoperative analgesia method applied: Group Control, Group FICB and Group 4in1.
- Trial name
- NCT06436105
- Testing
- FICB, 4 in 1 block, Control
- Where
- Turkey (Türkiye)
- Volunteers
- 60 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Acute Postoperative Pain, Surgery
Continuous Versus Single Injection Adductor Canal Blocks for Outpatient Total Knee Arthroplasty
This is a single-center pilot study to determine if an adductor canal continuous nerve block is superior to single injection nerve block following total knee arthroplasty.
- Trial name
- NCT06784882
- Testing
- continuous peripheral nerve block with OnQ pump, single injection nerve block
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of California, San Diego
Knee Osteoarthritis, Total Knee Arthroplasty
Effect of Preoperative Cold Therapy on Early Postoperative Outcomes in Total Knee Arthroplasty
This prospective, single-center, randomized controlled trial investigates the effects of preoperative cold therapy on early postoperative outcomes in patients undergoing unilateral primary total knee arthroplasty (TKA).
- Conditions
- Knee Osteoarthritis, Total Knee Arthroplasty, Cryotherapy, Postoperative Pain Management
- Trial name
- NCT07134283
- Testing
- Preoperative and Postoperative Cold Therapy with Gel Cold Pack, Postoperative Cold Therapy with Gel Cold Pack
- Where
- Turkey (Türkiye)
- Volunteers
- 208 people
- Sponsor
- Ankara City Hospital Bilkent
Total Knee Arthroplasty, Knee Osteoarthritis
IMProving Outcomes With ACT After Knee Surgery
Regarding psychosocial factors and outcomes in total knee arthroplasty (TKA), most of the current literature and the investigators' previous work suggest that depression, anxiety and pre-operative pain strongly predict worse…
- Trial name
- IMPACTS (NCT06483191)
- Testing
- Acceptance and Commitment Therapy
- Where
- United Kingdom
- Volunteers
- 50 people
- Sponsor
- Belfast Health and Social Care Trust
Immunosenescence, Aging
The Immu-KNEE-ty Study
The goal of this observational study is to determine changes in immune functioning after total knee replacement surgery in elderly.
- Trial name
- NCT05920148
- Testing
- Knee arthroplasty
- Where
- Netherlands
- Volunteers
- 14 people
- Sponsor
- Wageningen University
Deep Vein Thrombosis, Fibrillation, Atrial
Odiparcil For The Prevention Of Venous Thromboembolism
Odiparcil is being studied to determine if it can prevent blood clots from forming after a total knee replacement and also to prove that odiparcil is safe.
- Conditions
- Deep Vein Thrombosis, Fibrillation, Atrial, Venous Thromboembolism, Pulmonary Embolism
- Trial name
- NCT00244725
- Testing
- Odiparcil, Warfarin, Coumadin
- Where
- 101 sites in United States, Australia and 11 more
- Volunteers
- 961 people
- Sponsor
- GlaxoSmithKline
Osteoarthritis, Knee
Conventional Alignment System Versus Surgical Navigation System in Total Knee Arthroplasty
This is a randomized, controlled, blinded prospective study comparing the use of the usual cutting guides with a palm-sized digital surgical navigation system in unilateral total knee arthroplasty.
- Trial name
- NCT01797731
- Testing
- Digital hand-held surgical navigation system, Conventional tibial extramedullary alignment system
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Hospital for Special Surgery, New York
Knee Osteoarthritis, Pressure Ulcer
Pressure Ulcers in Knee Replacement Surgery
From the point of view of nursing to know exactly the different risk factors for the onset of pressure ulcers is very important as it allows to accurately orient preventive care interventions.
- Trial name
- peripress (NCT03039153)
- Where
- Italy
- Volunteers
- 565 people
- Sponsor
- Istituto Ortopedico Rizzoli
Pain, Postoperative
The Effect of Post-Surgery Exercise in Patients With Total Knee Replacement Surgery
postoperative pain; It is acute pain that begins with surgical trauma and decreases during tissue healing. Although it is predictable and treatable, it still seems to be an important problem today.
- Trial name
- NCT05331261
- Testing
- Total diz replacement ameliyatı
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Alev Keskin
Knee Arthropathy, Post Operative Pain
Function and Pain Following Knee Replacement
The goal of this interventional study is to compare pain management techniques (femoral nerve block, intra-articular block, none) in TKA patients.
- Conditions
- Knee Arthropathy, Post Operative Pain, Pain, Postoperative
- Trial name
- NCT05478005
- Testing
- Femoral nerve block, Intra-articular block
- Where
- Israel
- Volunteers
- 54 people
- Sponsor
- University of Haifa
Knee Prosthesis
Effect of Normothermia Care Bundle in Knee Replacement Surgery
Osteoarthritis is a disease characterized by disruption of the integrity of articular cartilage as a result of erosion of articular cartilage.
- Trial name
- NCT06454877
- Testing
- active heating, pasive heating
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Istanbul Saglik Bilimleri University