Clinical trials: Tourette Syndrome
Tourette's Disorder, Insomnia
Forehead Temperature-Regulating Therapy for Insomnia in Adults With Tourette's Disorder
The primary aim of the present research project is to investigate the preliminary effects of four weeks of forehead temperature-regulating therapy on insomnia in adults with Tourette's disorder and co-occurring insomnia disorder.
- Trial name
- NCT05499741
- Testing
- Forehead Temperature-Regulating Therapy
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- University of California, Los Angeles
Tourette Syndrome, Motor Tic Disorder
Study of ABX-1431 in Adult Patients With Tourette Syndrome or Chronic Motor Tic Disorder
Two-part study consisting of a double-blind, randomized, placebo-controlled, study at two target dose levels (Part 1) and an open-label, non-randomized study (Part 2) to determine the efficacy of ABX-1431 in treating adult…
- Trial name
- NCT03625453
- Testing
- ABX-1431
- Where
- 8 sites in Germany, Poland and 1 more
- Volunteers
- 50 people
- Sponsor
- Abide Therapeutics
Tourette's Syndrome, Tourette Syndrome
Subthalamic Stimulation in Tourette's Syndrome
The main objective of this project is to evaluate the efficacy of subthalamic nucleus deep brain stimulation (STN DBS) in treating motor and phonic tics in medically refractory Tourette's syndrome (TS).
- Conditions
- Tourette's Syndrome, Tourette Syndrome, Gilles de la Tourette Syndrome, Tourette Disorder
- Trial name
- STN-DBSinTS (NCT02619084)
- Testing
- STN DBS
- Where
- Italy
- Volunteers
- 10 people
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Tourette Syndrome
Longitudinal Impact of Stressors in Adults With Tourette Syndrome
The Investigators propose a two-year, longitudinal pilot study of TS adults (>18) to determine impact of lifetime environmental stress exposure on tic severity, psychiatric comorbidity severity, and health-related quality of life…
- Trial name
- LISA-TS (NCT04851678)
- Testing
- None - observational study
- Where
- United States
- Volunteers
- 140 people
- Sponsor
- Vanderbilt University Medical Center
Tourette Syndrome, Tic Disorder
Effectiveness of Symptom Management Application on Parental Care Ability of Children With Tourette Syndrome
This study developed a Tourette Syndrome (TS) symptom management application (APP) to improve the care needs, sleep quality, anxiety, quality of life, and parenting relationship of parents of children with Tourette Syndrome.
- Conditions
- Tourette Syndrome, Tic Disorder, Neurodevelopmental Disorder
- Trial name
- NCT06613126
- Testing
- Symptom Management APP group, health education instructions group
- Where
- Taiwan
- Volunteers
- 180 people, healthy volunteers welcome
- Sponsor
- National Taipei University of Nursing and Health Sciences
Tourette Syndrome
Transcranial Magnetic Stimulation (TMS) for Individuals With Tourette's Syndrome
This study will evaluate the clinical efficacy of 1 Hz repetitive transcranial magnetic stimulation (rTMS) applied to the supplementary motor area (SMA) in Tourette's Syndrome (TS) patients who have not fully responded to…
- Trial name
- TMS (NCT00529308)
- Testing
- Transcranial Magnetic Stimulation (active)
- Where
- 2 sites in United States
- Volunteers
- 20 people
- Sponsor
- Yale University
Tourette Syndrome
Evaluate the Efficacy, Safety and Tolerability of TSUPPORT for Adults With Tourette Syndrome
A 28-week single-arm trial to evaluate the efficacy, safety and tolerability of TSupport (a Traditional Chinese Medicine) for adults with Tourette Syndrome.
- Trial name
- NCT05183594
- Testing
- TSupport (a Traditional Chinese Medicine)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- Tasly Pharmaceuticals, Inc.
Tourette Syndrome
Aripiprazole Oral Solution in the Treatment of Children and Adolescents With Tourette's Syndrome
This study is a multicenter, randomized, double-blind, placebo-controlled trial designed to assess the safety, efficacy, tolerability and steady-state plasma trough concentration of flexible-dosed aripiprazole once-daily…
- Trial name
- NCT03487783
- Testing
- Aripiprazole Oral Solution
- Where
- China
- Volunteers
- 121 people
- Sponsor
- Otsuka Beijing Research Institute
Tourette Syndrome, Tic Disorder
Sensorimotor and Psychosocial Trajectories in Adolescents With Tic Disorder
Individuals with tic disorders have lower quality of life, sensory and movement difficulties, and poorer mental, social, and physical health compared to the general population.
- Trial name
- NCT06576726
- Testing
- This study involves no intervention.
- Where
- United States
- Volunteers
- 351 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Tourette Syndrome
Evaluation of Safety and Tolerability of Long-term TEV-50717 (Deutetrabenazine) for Treatment of Tourette Syndrome in Children and Adolescents
This is an otherwise open-label, single-arm study that includes a 2-week, double-blind, placebo controlled, randomized drug withdrawal period followed by a 3 week blinded maintenance or re-titration, and then a maintenance…
- Trial name
- ARTISTS (NCT03567291)
- Testing
- TEV-50717
- Where
- 76 sites in United States, Argentina and 13 more
- Volunteers
- 228 people
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Tourette Syndrome, Motor or Vocal Tic Disorder, Chronic
Group Intervention for Children With Chronic Tics Syndrome or Tourette Syndrome: CBIT vs Psycho-Educational Intervention
Tourette Syndrome (TS) is a disorder characterized by motor and vocal tics. The most studied and promising intervention is Habit Reversal Training (HRT) and its variations: Behavioral Comprehensive Intervention for Tics (CBIT).
- Trial name
- NCT02407951
- Testing
- CBIT group, Psycho-Educational group
- Volunteers
- 96 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Tourette Syndrome in Adolescence
Neurofeedback From the Supplementary Motor Area for Tourette Syndrome
This is a clinical trial where adolescents aged 10-16 years old with Tourette Syndrome (or chronic tic disorder) are randomized to receive either real-time functional magnetic resonance imaging (fMRI) neurofeedback targeting the…
- Trial name
- NCT05558566
- Testing
- Neurofeedback from the SMA, Neurofeedback from control region
- Where
- United States
- Volunteers
- 64 people
- Sponsor
- Yale University
Tourette Syndrome
Multimodal Electrophysiological Study of Cortico-subcortical Biomarkers of Tics in Tourette Syndrome
Tourette syndrome (TS) is a complex neurodevelopmental disorder characterized by the occurrence of involuntary movements (motor tics) and vocalizations (phonic tics).
- Trial name
- BioTic (NCT06909656)
- Testing
- Multimodal electrophysiological recordings
- Where
- France
- Volunteers
- 10 people
- Sponsor
- University Hospital, Bordeaux
Tourette Syndrome, Sensory Disorders
Neural Correlates of Sensory Phenomena in Tourette Syndrome
The most pervasive sensory manifestation of TS is sensory over-responsivity (SOR). SOR is defined as excessive behavioral response to commonplace environmental stimuli.
- Conditions
- Tourette Syndrome, Sensory Disorders, Hypersensitivity, Tics
- Trial name
- NCT03914664
- Testing
- Electroencephalogram (EEG) testing procedure, Autonomic function testing procedure
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Tourette Syndrome, Tic Disorders
Median Nerve Stimulation Pilot
Results from the University of Nottingham suggested that rhythmic median nerve stimulation (MNS) improves tic symptoms in Tourette syndrome (TS).
- Conditions
- Tourette Syndrome, Tic Disorders, Tic Disorder, Chronic Motor or Vocal
- Trial name
- MNS (NCT04731714)
- Testing
- Rhythmic median nerve stimulation, Arrhythmic median nerve stimulation
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Washington University School of Medicine
Tourette Syndrome in Children, Tourette Syndrome in Adolescence
A Clinical Study to Evaluate the Safety and Efficacy of T92 in Pediatric Patients With Tourette Syndrome
A 12-week clinical study to evaluate the safety and efficacy of T92 in pediatric patients with Tourette Syndrome.
- Trial name
- NCT05188274
- Testing
- T92
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Tasly Pharmaceuticals, Inc.
Tourette Syndrome, Cannabis
The Effect of Medical Cannabis on Tics, Premonitory Urge and Psychiatric Comorbidity in Adults With Tourette Syndrome
Medical cannabis (MC) is a standard treatment in Israel to adults with resistant Gilles de la Tourette syndrome (GTS). While small randomized control trials assessed THC efficacy on tics and premonitory urge, only small…
- Trial name
- NCT05115318
- Testing
- Medical Cannabis
- Where
- Israel
- Volunteers
- 18 people
- Sponsor
- Tel-Aviv Sourasky Medical Center
Tourette Syndrome, Chronic Tic Disorder
Transcutaneous Auricular Vagus Nerve Stimulation for Chronic Tic Disorders/Tourette's Syndrome in Children and Adolescents
The objective of this trial is to evaluate the effect of transcutaneous auricular vagus nerve stimulation compared to sham stimulation in improving chronic tic disorder or Tourette's syndrome in children and adolescents.
- Trial name
- NCT07854665
- Testing
- Transcutaneous auricular vagus nerve stimulation
- Where
- China
- Volunteers
- 124 people
- Sponsor
- The First Affiliated Hospital of Zhejiang Chinese Medical University
Tourette Syndrome
Tourette Syndrome Deep Brain Stimulation
The purpose of this study is to evaluate the effectiveness and safety of deep brain stimulation (DBS) as a possible new treatment for Tourette Syndrome (TS).
- Trial name
- NCT02056873
- Testing
- Continuous DBS, Responsive Brain Stimulation (RBS Setting)
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Florida
Tics, Tic Disorders
Evaluation of an Online Comprehensive Behavioral Intervention for Tics (CBIT) Therapist Training Program
Tic disorders are a class of childhood-onset neuropsychiatric disorders that occur in 1-3% of the population. Studies have shown that a non-drug treatment known as Comprehensive Behavioral Intervention for Tics (CBIT) is more…
- Conditions
- Tics, Tic Disorders, Tourette Syndrome
- Trial name
- CBIT-Trainer (NCT05547854)
- Testing
- Behavior Therapy Training Institute, CBIT-Trainer
- Where
- 2 sites in United States
- Volunteers
- 284 people
- Sponsor
- University of Utah